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Further studies on the antigoitrogenic action of iodoarachidonates. 碘花生四烯酸酯抗甲状腺素作用的进一步研究。
Thyroidology Pub Date : 1992-04-01
M A Pisarev, L Krawiec, G J Juvenal, H A Chester, L V Bocanera, L B Pregliasco, G Sartorio
{"title":"Further studies on the antigoitrogenic action of iodoarachidonates.","authors":"M A Pisarev,&nbsp;L Krawiec,&nbsp;G J Juvenal,&nbsp;H A Chester,&nbsp;L V Bocanera,&nbsp;L B Pregliasco,&nbsp;G Sartorio","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Previous studies have shown that iodoarachidonates (IAs) prevent goiter production in rats. In the present studies we show that both IL-d and IL-w (IAs bearing the iodine atom at the positions 6 and 14, respectively), cause a significant involution of preformed goiter. This effect was evident when IAs were administered either orally or via i.p., although the first one required larger doses to obtain the same degree of inhibition. No changes were observed in serum protein, urea, cholesterol, cholinesterase, T3 or T4. In vitro studies with FRTL-5 cells showed that both IAs inhibit iodide and alpha-AIB uptake, as well as ATPase activity.</p>","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"4 1","pages":"27-9"},"PeriodicalIF":0.0,"publicationDate":"1992-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12459290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TSH, IGF-1 and activated ras protein induce DNA synthesis in cultured thyroid cells. TSH、IGF-1和激活的ras蛋白诱导培养甲状腺细胞DNA合成。
Thyroidology Pub Date : 1991-12-01
J L Meinkoth, J Dela Cruz, G N Burrow
{"title":"TSH, IGF-1 and activated ras protein induce DNA synthesis in cultured thyroid cells.","authors":"J L Meinkoth,&nbsp;J Dela Cruz,&nbsp;G N Burrow","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>TSH, IGF-1 and cellular ras genes have been proposed to function in thyroid cell transformation. Using cultured follicular cells, we demonstrate that TSH, IGF-1 and microinjected activated ras protein individually stimulate DNA synthesis. TSH-stimulated pathways include Gs at the plasma membrane and cyclic AMP response elements in the nucleus. The pathways and nuclear targets of IGF-1 and ras action appear at least partially distinct from those used by TSH.</p>","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"3 3","pages":"103-7"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12890953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proceedings of the International Symposium: Goitrogenesis. Munich, December 5-6, 1991. 国际研讨会论文集:甲状腺增生。慕尼黑，1991年12月5日至6日。
Thyroidology Pub Date : 1991-12-01
{"title":"Proceedings of the International Symposium: Goitrogenesis. Munich, December 5-6, 1991.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"3 3","pages":"95-139"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12890159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thyroid autocrine factors: regulation of secretion of insulin-like growth factor binding proteins from sheep thyroid cells by autocrine basic fibroblast growth factor. 甲状腺自分泌因子:自分泌碱性成纤维细胞生长因子对绵羊甲状腺细胞分泌胰岛素样生长因子结合蛋白的调控。
Thyroidology Pub Date : 1991-12-01
M C Eggo, S Islam, M C Sheppard
{"title":"Thyroid autocrine factors: regulation of secretion of insulin-like growth factor binding proteins from sheep thyroid cells by autocrine basic fibroblast growth factor.","authors":"M C Eggo,&nbsp;S Islam,&nbsp;M C Sheppard","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The mRNA for basic fibroblast growth factor has been detected in primary cultures of sheep thyroid cells. RNA species of 2.0 kb, 3.3 kb and 7.2 kb have been identified. The effects of this autocrine factor on the production of insulin-like growth factor binding proteins (IGFBPs) have been examined. bFGF enhanced the secretion of IGFBP-2 and, like epidermal growth factor (EGF) and the tumour promoting phorbol ester (TPA), induced the appearance of IGFBP-3. We conclude that bFGF is synthesized by sheep thyroid cells and has autocrine potential since it can regulate the secretion of other thyroid autocrine factors which, in turn, may regulate thyroid growth and function.</p>","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"3 3","pages":"119-22"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12890958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Various facets of the intercellular heterogeneity in thyroid primary culture. 甲状腺原代培养细胞间异质性的各个方面。
Thyroidology Pub Date : 1991-12-01
M Baptist, V Pohl, J E Dumont, P P Roger
{"title":"Various facets of the intercellular heterogeneity in thyroid primary culture.","authors":"M Baptist,&nbsp;V Pohl,&nbsp;J E Dumont,&nbsp;P P Roger","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The mechanisms that generate the intercellular heterogeneity of functional and proliferation responses in a tissue are generally unknown. In thyroid gland, this heterogeneity is peculiarly marked and it was suggested that it could result from the coexistence of (epi)genetically different subpopulations of thyrocytes. As summarized in this short review, qualitative or quantitative intercellular heterogeneities have been found at each levels of our \"in situ\" investigations of morphological, differentiation and proliferative responses of unselected dog thyrocytes in primary culture. These different heterogeneities are unrelated at the individual cell level, which does not indicate the coexistence in thyroid of cell subpopulations stably expressing special properties. Nevertheless, using a double labeling methodology that allows to trace the proliferative behavior of some cells, we show how cell division may stably affect further proliferation responses and how a local synchrony of the dividing cells can result in a stable heterogeneity with a regional, patchy pattern, which resembles the one characterizing multinodular goiter.</p>","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"3 3","pages":"109-13"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12890955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The molecular biology of the human anaplastic thyroid carcinoma cell. 人甲状腺间变性癌细胞的分子生物学研究。
Thyroidology Pub Date : 1991-12-01
N E Heldin, B Westermark
{"title":"The molecular biology of the human anaplastic thyroid carcinoma cell.","authors":"N E Heldin,&nbsp;B Westermark","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the present investigation we show data from our studies of anaplastic human thyroid carcinoma cell lines. The cell lines employed in the study were HTh 7, HTh 74, C 643 and SW 1736, all derived from tumours diagnosed as anaplastic thyroid carcinomas. Northern blot analysis with four different thyroid specific cDNA probes showed a varying pattern of expression. Thyroglobulin mRNA was found in three of the carcinoma cell lines, although the signal was very weak compared to the expression in tissue from a toxic goitre, used as positive control. Interestingly, two of the cell lines expressed the receptor for thyrotropin, but none of them contained thyroperoxidase mRNA. Three of the cell lines expressed mRNA for receptors platelet-derived growth factor, PDGFR-alpha and/or PDGFR-beta type. Messenger RNA of a thyroid specific transcription factor, TTF-1, known to regulate the normal function of thyrocytes, was found in the toxic goitre but not in the anaplastic thyroid carcinoma cell lines. Lack of expression of TTF-1 might the immediate cause of the anaplastic phenotype, considering the possibility that TTF-1 functions as a master regulatory gene in thyroid cell differentiation.</p>","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"3 3","pages":"127-31"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12890961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reconstruction of the thyroid follicle with long-term cultured cells. 长期培养细胞重建甲状腺滤泡。
Thyroidology Pub Date : 1991-12-01
G Fayet, S Hovsépian
{"title":"Reconstruction of the thyroid follicle with long-term cultured cells.","authors":"G Fayet,&nbsp;S Hovsépian","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The reconstruction of the thyroid follicle was studied in vitro using the porcine thyroid cell line ATHOS. When performed monolayers of ATHOS cells grown after more than 50 passages are cultured in a sandwich of collagen in the presence of thyrotropin (10 mU/ml), figures resembling follicles are observed under light microscopy. By electron microscopy cells appear correctly polarized, microvilli facing follicle lumina. These histiotypical figures that mimic the thyroid architecture are maintained 4-5 weeks.</p>","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"3 3","pages":"123-5"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12890959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The TSH cyclic AMP cascade in the control of thyroid cell proliferation: the story of a concept. TSH循环AMP级联控制甲状腺细胞增殖:一个概念的故事。
Thyroidology Pub Date : 1991-12-01
C Ledent, M Parmentier, C Maenhaut, M Taton, I Pirson, F Lamy, P Roger, J E Dumont
{"title":"The TSH cyclic AMP cascade in the control of thyroid cell proliferation: the story of a concept.","authors":"C Ledent,&nbsp;M Parmentier,&nbsp;C Maenhaut,&nbsp;M Taton,&nbsp;I Pirson,&nbsp;F Lamy,&nbsp;P Roger,&nbsp;J E Dumont","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thyrotropin stimulates the growth and proliferation of thyroid cells in vivo. Starting in the 1970, we have progressively shown that these effects could be reproduced in vitro in dog thyroid cells in primary culture. They are accompanied by the expression of differentiation. All the effects of thyrotropin are mediated by the cyclic AMP cascade. The best argument that this concept applies in vivo is the generation of hyperfunctioning adenoma involving the whole gland in transgenic mice expressing the constitutively active adenosine A2 receptor in the thyroid.</p>","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"3 3","pages":"97-101"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12890160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidermal growth factor stimulates thyroid follicle neogenesis in collagen gel culture. 表皮生长因子在胶原凝胶培养中刺激甲状腺滤泡新生。
Thyroidology Pub Date : 1991-12-01
K Westermark, M Nilsson, B Westermark
{"title":"Epidermal growth factor stimulates thyroid follicle neogenesis in collagen gel culture.","authors":"K Westermark,&nbsp;M Nilsson,&nbsp;B Westermark","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The mechanism involved in the neoformation of thyroid follicles is poorly understood. In the present study, whole porcine thyroid follicles were cultured as \"miniorgans\", embedded within collagen gels. Incubation was performed up to 4 days with or without EGF (10 ng/ml) and TSH (2 mU/ml). A single dose of 3H-thymidine was added at the start of the experiments in some cases. Light microscopy and autoradiography was performed. EGF induced a dramatic migration of follicles cells; these were seen to back out from the mother follicle and formed microfollicles with normal polarity including microvilli at the apical border. As evident from the analysis of 3H-thymidine incorporation, most microfollicles were comprised of newly divided cells. The results infer a new mechanism for the neoformation of follicles in the thyroid.</p>","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"3 3","pages":"133-5"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12890962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thyroid cell lines in research on goitrogenesis. 甲状腺增生研究中的甲状腺细胞系。
Thyroidology Pub Date : 1991-12-01
H Gerber, H J Peter, L Asmis, H Studer
{"title":"Thyroid cell lines in research on goitrogenesis.","authors":"H Gerber,&nbsp;H J Peter,&nbsp;L Asmis,&nbsp;H Studer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thyroid cell lines have contributed a lot to the understanding of goitrogenesis. The cell lines mostly used in thyroid research are briefly discussed, namely the rat thyroid cell lines FRTL and FRTL-5, the porcine thyroid cell lines PORTHOS and ARTHOS, The sheep thyroid cell lines OVNIS 5H and 6H, the cat thyroid cell lines PETCAT 1 to 4 and ROMCAT, and the human thyroid cell lines FTC-133 and HTh 74. Chinese hamster ovary (CHO) cells and COS-7 cells, stably transfected with TSH receptor cDNA and expressing a functional TSH receptor, are discussed as examples for non-thyroidal cells, transfected with thyroid genes.</p>","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"3 3","pages":"115-8"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12890957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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