Thyroidology最新文献

Percutaneous ethanol injection therapy of autonomous nodule and amiodarone-induced thyrotoxicosis. 经皮乙醇注射治疗自主结节和胺碘酮性甲状腺毒症。

Thyroidology Pub Date : 1994-12-01

F Monzani, P Del Guerra, N Caraccio, A Casolaro, E Pucci, F Franchi

{"title":"Percutaneous ethanol injection therapy of autonomous nodule and amiodarone-induced thyrotoxicosis.","authors":"F Monzani, P Del Guerra, N Caraccio, A Casolaro, E Pucci, F Franchi","doi":"","DOIUrl":"","url":null,"abstract":"A patient with amiodarone-induced thyrotoxicosis and autonomous nodule was treated with percutaneous ethanol injection (PEI) in 8 sessions. Preinjection thyroid hormone levels showed a marked elevation, peaking before the third session. The thyroid hormone increments following each procedure never exceeded 20% of the preinjection levels. FT4 plasma levels thereafter declined to within the normal range by the sixth session (day 21), while FT3 levels, though markedly reduced, were still slightly elevated; also, the thyroid hormone increments following ethanol injection were not observed after the fifth session. These findings suggest that a significant, but not sustained, increase in thyroid hormone levels is induced by PEI and may account for the lack of acute deterioration of clinical status, which remained under control with medical treatment alone. Normal serum thyroid hormone levels were observed at the 3 and 12 month follow-up. The use of percutaneous ethanol injection therapy for amiodarone-induced hyperthyroidism should be restricted to patients with preexisting thyroid hyperfunctioning nodule, and it may be a practical alternative to surgery in addition to medical treatment. Special caution should be exercised with patients with severe underlying heart disorders, since their clinical status might seriously worsen in case of acute elevations of serum thyroid hormones following ethanol injection. To this purpose, a close monitoring of serum thyroid hormones is recommended in order to institute a prompt adjustment in their medical therapy and/or in their PEI protocol.","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"6 3","pages":"99-102"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18551322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sudden death following thyroxine administration. 注射甲状腺素后猝死

Thyroidology Pub Date : 1994-12-01

A Iliopoulou, E Zervoudi, M Theodorakis, D A Koutras, S Moulopoulos

引用次数: 0

Growth hormone and thyroid function: is secondary thyroid failure underdiagnosed in growth hormone deficient patients? 生长激素与甲状腺功能:生长激素缺乏患者继发性甲状腺功能衰竭是否被低估?

Thyroidology Pub Date : 1994-12-01

P Laurberg, P E Jakobsen, H C Hoeck, P Vestergaard

引用次数: 0

Therapeutic 131I dose in hyperthyroidism: role of pretreatment with thionamide. 治疗性131I剂量在甲亢中的作用:硫胺预处理。

Thyroidology Pub Date : 1994-12-01

U Kabadi, R Cech

{"title":"Therapeutic 131I dose in hyperthyroidism: role of pretreatment with thionamide.","authors":"U Kabadi, R Cech","doi":"","DOIUrl":"","url":null,"abstract":"Radioiodine therapy has become a cornerstone of treatment of hyperthyroidism. However, the timing of its administration varies between 1) the time of initial diagnosis with concurrent therapy with beta adrenergic blocking drugs or 2) following induction of euthyroidism with thioamide, Propylthiouracil or Methimazole. This study assessed 24-HR 131I uptake values and the thyroid scan in 24 subjects with hyperthyroidism at the time of diagnosis and again after attaining the euthyroid state with Propylthiouracil or Methimazole. Propylthiouracil of Methimazole was withdrawn seven days prior to the second 24-HR 131I uptake and scan. In all subjects, as a group, 24-HR 131I uptake increased following antithyroid therapy as compared to the time of initial of diagnosis [76 + 5% Vs. 54 + 4%; p < 0.01]. The thyroid gland size decreased in nine of twenty-four subjects, but remained unchanged in the remaining subjects. Since 24-HR 131I uptake and the gland size are the major factors influencing the therapeutic radioiodine dosage, it is possible that initial therapy with thioamide drugs may reduce the therapeutic dose of 131I in subjects with hyperthyroidism belonging to both groups, i.e., Graves' disease and Multinodular toxic goiter by inducing a rise in 24-HR 131I uptake. Furthermore, the shrinkage of thyroid glands may further decrease the radioiodine dosage in patients with Graves' disease.","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"6 3","pages":"87-92"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18552604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum concentrations of apolipoproteins in patients with thyroid dysfunction. 甲状腺功能障碍患者血清载脂蛋白浓度的变化。

Thyroidology Pub Date : 1994-12-01

H Tada, Y Irie, A Yagoro, H Ohya, S Hayashi, R Fushimi, H Tamaki, N Amino

引用次数: 0

Interactions between atrial natriuretic factor (ANF) and thyrotropin or somatostatin in their effects on thyroid growth processes; studies in vitro and ex vivo in vitro. 心房利钠因子(ANF)与促甲状腺素或生长抑素在甲状腺生长过程中的相互作用体外和离体研究。

Thyroidology Pub Date : 1994-12-01

P Biliński, A Lewiński, M Karbownik, M Klencki, E Wajs, J Kunert-Radek

{"title":"Interactions between atrial natriuretic factor (ANF) and thyrotropin or somatostatin in their effects on thyroid growth processes; studies in vitro and ex vivo in vitro.","authors":"P Biliński, A Lewiński, M Karbownik, M Klencki, E Wajs, J Kunert-Radek","doi":"","DOIUrl":"","url":null,"abstract":"The goal of our present study has been to examine the effects of the atrial natriuretic factor (ANF) on the growth processes in rat thyroid lobes. In the initial in vitro experiment, thyroid lobes were preincubated with rat ANF (Sigma) for 30 min in RPMI 1640 medium with 3H-thymidine (2 microCi/ml), and later on 15% fetal calf serum (FCS), Hepes buffer and the remaining tested substances [TSH 20 mIU/ml, somatostatin (SS) 10(-7)M] were added. Preincubations with ANF were not conducted in the controls and in the group exposed to TSH alone. Incubations of all the examined groups (controls, TSH alone, ANF alone, ANF together with TSH or ANF together with SS) with 3H-thymidine were carried out for 4 hours. We obtained the following results: at none of the examined concentrations (10(-5)M, 10(-7)M, 10(-9)M), did ANF significantly affect the rate of 3H-thymidine incorporation in vitro. Neither did TSH alone nor ANF with TSH jointly significantly influence the process in question. However, we observed increased rates of the 3H-thymidine uptake, following the joint exposure of thyroid lobes to ANF (10(-7)M or 10(-9)M) and SS (10(-7)M), when compared to ANF alone. In the ex vivo in vitro experiment, direct intrathyroidal microinjections of ANF alone or jointly with TSH or SS, were carried out. Twenty four (24) hours after the microinjections, all the animals were sacrificed by decapitation, the thyroid lobes being collected and incubated for 4 hours with 3H-thymidine (2 microCi/ml).(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"6 3","pages":"81-5"},"PeriodicalIF":0.0,"publicationDate":"1994-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18552603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The incidence of ground glass nuclei in thyroid diseases. 磨玻璃核在甲状腺疾病中的发病率。

Thyroidology Pub Date : 1994-08-01

T Kiyono, M Katagiri, T Harada

{"title":"The incidence of ground glass nuclei in thyroid diseases.","authors":"T Kiyono, M Katagiri, T Harada","doi":"","DOIUrl":"","url":null,"abstract":"Ground glass nuclei are an important finding in the diagnosis of papillary carcinoma of the thyroid. However, they appear only in specimens in paraffin-embedded histological sections, and not in frozen sections or cytological specimens. This has led to the conclusion that they are an artifact of fixation and/or embedding. However, if this is the case, a question arises as to whether or not such an artifact can be of value as a definitive sign for establishing a diagnosis of papillary carcinoma. This study was undertaken to try to answer that question. 1) To confirm whether or not the author's microscopic observations were correct, we carried out automatic imaging analysis with the Interaktives Bild-Analysen System (IBAS). The author's microscopic observations were consistent with the data obtained by the IBAS. 2) Among 20 cases of papillary carcinoma, clear nuclei were observed in 11 cases (55%), and pseudoclear nuclei were noted in 20 cases (100%). When 1,000 papillary cancer cells were counted in 10 cases, the average incidences of clear nuclei and pseudoclear nuclei were found to be 0.51% and 18.3% respectively. Clear nuclei were seen in papillary carcinomas in all kinds of fixatives except one but were not seen in benign lesions. Even though ground glass nuclei are a type of artifact, we believe that their presence may be considered to be a characteristic feature of papillary carcinomas of the thyroid.","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"6 2","pages":"43-8"},"PeriodicalIF":0.0,"publicationDate":"1994-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18542367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occurrence of papillary carcinoma in a hyperfunctioning thyroid nodule: report of a case and diagnostic considerations. 甲状腺功能亢进结节中乳头状癌的发生:1例报告及诊断考虑。

Thyroidology Pub Date : 1994-08-01

V Castelli, D Moscogiuri, A P Taviani, L Donati

引用次数: 0

Puzzling biochemical thyroid profile in patients with multinodular goitre originating from a mild iodine deficient area in Tunisia. 来自突尼斯轻度缺碘地区的多结节甲状腺患者令人费解的甲状腺生化特征。

Thyroidology Pub Date : 1994-08-01

M V el May, A Kraiem, T Messaoud, S Fattoum, M Kammoun, H Zouaghi, S Mtimet

{"title":"Puzzling biochemical thyroid profile in patients with multinodular goitre originating from a mild iodine deficient area in Tunisia.","authors":"M V el May, A Kraiem, T Messaoud, S Fattoum, M Kammoun, H Zouaghi, S Mtimet","doi":"","DOIUrl":"","url":null,"abstract":"Thirty Tunisian patients with a voluminous multinodular goiter with cold nodules and inhabiting a region of mild iodine deficiency, have been studied. The 131 I fixation by the thyroid, three hours after ingestion was significatively higher than in normal population. Fourty six per cent of the patients have stable iodine urine contents less or equal to 0.39 mumol/L. Three serum concentrations were paradoxically abnormal: thyrotropin (TSH), thyroglobulin (TG) and gammaglobulin concentrations. Fourty seven per cent of the serum thyrotropin (TSH) levels were less than the normal values though the serum total triiodotyronine (TT3), tetraiodotyronine (TT4), free triiodotyronine (FT3), free tetraiodotyronine (FT4), antithyroglobulin antibodies, total protein, triglycerides and cholesterol concentrations were normal. Serum thyroglobulin (TG) rates were elevated, ranged from 2 to 10,180 ng/ml and twenty five per cent of our patients showed levels greater than 500 ng/ml. The gammaglobulin levels were greater than normal in sixty eight per cent of our patients though only 10% of our patients manifest antithyroglobulin antibodies.","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"6 2","pages":"61-7"},"PeriodicalIF":0.0,"publicationDate":"1994-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18544619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence of different forms of thyroid dysfunction and its degrees in an iodine sufficient area. 碘充足地区不同形式甲状腺功能障碍的发生率及其程度。

Thyroidology Pub Date : 1994-08-01

J C Galofré, R V García-Mayor, E Fluiters, L Fernàndez-Calvet, A Rego, C Pàramo, M A Andrade

{"title":"Incidence of different forms of thyroid dysfunction and its degrees in an iodine sufficient area.","authors":"J C Galofré, R V García-Mayor, E Fluiters, L Fernàndez-Calvet, A Rego, C Pàramo, M A Andrade","doi":"","DOIUrl":"","url":null,"abstract":"Study objective: The aim of the study was to determine the incidence of thyroid dysfunction in an iodine sufficient area (Vigo city, Galicia, North-West of Spain).Design: Case-finding study during a 3-year (1990-1992) period.Subjects: Subjects from a random sample of the population with abnormal results on FT4, sensitive-TSH or antithyroid autoantibodies.Measurements: Thyroid size by ultrasound study. FT4 by RIA; TSA Ab by radio receptor assays; TSH, Tg Ab and TMS Ab by IRMA.Major results: Overall incidence of thyroid dysfunction was 97.96 per 100,000 per year (CI 95% 78.86-117.06); female 162.45, male 17.44. Incidence rate of hyperthyroidism was 52.37 per 100,000 per year (CI 95% 38.41-66.36); 24.24 for Graves' disease, 11.63 for nodular hyperthyroidism, 13.57 for iatrogenic hyperthyroidism and 2.90 for others causes. Incidence rate of hypothyroidism was 45.58 per 100,000 per year (CI 95% 32.55-58.620 27.15 for hypothyroid autoimmune thyroiditis, 8.72 for postoperative hypothyroidism, 4.89 for miscellaneous hypothyroidism, 1.93 for amiodarone induced hypothyroidism and 2.90 for secondary hypothyroidism.Conclusions: This investigation provides extensive data on incidence of clinical and subclinical thyroid dysfunction and its different forms in an iodine sufficient area.","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"6 2","pages":"49-54"},"PeriodicalIF":0.0,"publicationDate":"1994-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18542368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0