{"title":"TSH、IGF-1和激活的ras蛋白诱导培养甲状腺细胞DNA合成。","authors":"J L Meinkoth, J Dela Cruz, G N Burrow","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>TSH, IGF-1 and cellular ras genes have been proposed to function in thyroid cell transformation. Using cultured follicular cells, we demonstrate that TSH, IGF-1 and microinjected activated ras protein individually stimulate DNA synthesis. TSH-stimulated pathways include Gs at the plasma membrane and cyclic AMP response elements in the nucleus. The pathways and nuclear targets of IGF-1 and ras action appear at least partially distinct from those used by TSH.</p>","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"3 3","pages":"103-7"},"PeriodicalIF":0.0000,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"TSH, IGF-1 and activated ras protein induce DNA synthesis in cultured thyroid cells.\",\"authors\":\"J L Meinkoth, J Dela Cruz, G N Burrow\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>TSH, IGF-1 and cellular ras genes have been proposed to function in thyroid cell transformation. Using cultured follicular cells, we demonstrate that TSH, IGF-1 and microinjected activated ras protein individually stimulate DNA synthesis. TSH-stimulated pathways include Gs at the plasma membrane and cyclic AMP response elements in the nucleus. The pathways and nuclear targets of IGF-1 and ras action appear at least partially distinct from those used by TSH.</p>\",\"PeriodicalId\":77445,\"journal\":{\"name\":\"Thyroidology\",\"volume\":\"3 3\",\"pages\":\"103-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1991-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Thyroidology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Thyroidology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
TSH, IGF-1 and activated ras protein induce DNA synthesis in cultured thyroid cells.
TSH, IGF-1 and cellular ras genes have been proposed to function in thyroid cell transformation. Using cultured follicular cells, we demonstrate that TSH, IGF-1 and microinjected activated ras protein individually stimulate DNA synthesis. TSH-stimulated pathways include Gs at the plasma membrane and cyclic AMP response elements in the nucleus. The pathways and nuclear targets of IGF-1 and ras action appear at least partially distinct from those used by TSH.
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