H Harada, M Igarashi, S Sugae, K Okamoto, M Tsuji, T Nakajima
{"title":"A schizophrenic patient who developed extreme hypothermia after an increase in the dose of haloperidol: a case report.","authors":"H Harada, M Igarashi, S Sugae, K Okamoto, M Tsuji, T Nakajima","doi":"10.1111/j.1440-1819.1994.tb03020.x","DOIUrl":"https://doi.org/10.1111/j.1440-1819.1994.tb03020.x","url":null,"abstract":"<p><p>A patient with chronic schizophrenia, who had been treated for a long time with chlorpromazine, haloperidol, levodopa, benserazide hydrochloride, diazepam and biperiden, developed extreme hypothermia (about 32 degrees C) when the dose of haloperidol was increased because of a deterioration of the patient's mental symptoms. No other physical manifestations were observed, except bradycardia. The turnover of noradrenaline in the cerebrospinal fluid and blood was increased in association with the hypothermia in this patient. A hypothesis about the involvement of monoamine imbalance in changes in body temperature is discussed.</p>","PeriodicalId":77425,"journal":{"name":"The Japanese journal of psychiatry and neurology","volume":"48 3","pages":"595-8"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1819.1994.tb03020.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18889935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A method for analyzing biological rhythms in healthy subjects and depressed patients.","authors":"H Nagayama, K Tsuchiyama, K Yamada, N Hasama","doi":"10.1111/j.1440-1819.1994.tb03026.x","DOIUrl":"https://doi.org/10.1111/j.1440-1819.1994.tb03026.x","url":null,"abstract":"<p><p>Rectal temperature rhythms of healthy subjects and patients with depression were fitted to a waveform having cosine components of periods 8, 12, and 24 hours using the least squares method. The nadir was then used as an index of phase. The results suggest that this method gives more exact data than the conventional method of analyzing biological rhythms, which uses a least squares fit to a single, 24-hour-period cosine waveform.</p>","PeriodicalId":77425,"journal":{"name":"The Japanese journal of psychiatry and neurology","volume":"48 3","pages":"635-8"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1819.1994.tb03026.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18889941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of psychotropic drugs on impairment of acquisition of shuttle avoidance produced by pretreatment with pairs of tone signal and shock in mice.","authors":"H Kuribara","doi":"10.1111/j.1440-1819.1994.tb03027.x","DOIUrl":"https://doi.org/10.1111/j.1440-1819.1994.tb03027.x","url":null,"abstract":"<p><p>The acquisition of discrete shuttle avoidance of mouse was significantly impaired by presentation of 120 pairs of a tone signal and an unavoidable/unescapable shock at 30 sec intervals for 3 consecutive days prior to the training session. Caffeine (3 and 10 mg/kg s.c.) reduced such an impairment of the avoidance acquisition, whereas diazepam (0.5-2 mg/kg s.c.), imipramine (30 mg/kg i.p.) and chlorpromazine (2 mg/kg s.c.) enhanced it, when these drugs were administered 10 min before each shock-presenting session. Ethanol (0.8-2.4 g/kg p.o.), nicotine (0.1-1 mg/kg s.c.), methamphetamine (0.1-1 mg/kg s.c.) and morphine (1-10 mg/kg s.c.) did not modify the avoidance acquisition. These results indicate that the nature of impairment of the avoidance acquisition caused by this condition is different from learned helplessness, and elicits different responses to psychotropics.</p>","PeriodicalId":77425,"journal":{"name":"The Japanese journal of psychiatry and neurology","volume":"48 3","pages":"639-43"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1819.1994.tb03027.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18889942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R Kan, M Watabe, R Takahashi, M Hagiwara, I Amanuma, Y Takahashi, H Kumashiro
{"title":"Serial changes of n-isopropyl-p-iodoamphetamine single photon emission computed tomography in two epileptic psychotics.","authors":"R Kan, M Watabe, R Takahashi, M Hagiwara, I Amanuma, Y Takahashi, H Kumashiro","doi":"10.1111/j.1440-1819.1994.tb03015.x","DOIUrl":"https://doi.org/10.1111/j.1440-1819.1994.tb03015.x","url":null,"abstract":"<p><p>Serial changes of single photon emission computed tomography (SPECT) in two epileptic psychotics are reported. One patient had a decreased blood flow of the left temporal lobe with schizophrenia-like symptoms, and the other patient had a decreased blood flow of the right temporal lobe with depressive symptoms. In each case, these abnormal findings disappeared following recovery from a psychotic state. It might be suggested that the psychotic state of an epileptic patient influences the SPECT findings.</p>","PeriodicalId":77425,"journal":{"name":"The Japanese journal of psychiatry and neurology","volume":"48 3","pages":"567-70"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1819.1994.tb03015.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18889960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Missing peaks in auditory brainstem responses and negative symptoms in schizophrenia.","authors":"M Igata, M Ohta, Y Hayashida, K Abe","doi":"10.1111/j.1440-1819.1994.tb03016.x","DOIUrl":"https://doi.org/10.1111/j.1440-1819.1994.tb03016.x","url":null,"abstract":"<p><p>Auditory brainstem responses (ABRs) were examined in 30 schizophrenic patients and 29 normal subjects. The psychotic symptoms were assessed by the Brief Psychiatric Rating Scale (BPRS) and the Scale for Assessment of Negative Symptoms (SANS) in the patients. At least one of the waves I, II or III was found missing on either side at 80 dBHL (hearing level) in 8 (27%) of the patients but in only one (3%) of the normal subjects. There was a significant association between the missing peaks and the BPRS negative symptom cluster or the total score of the SANS. These results suggest that some schizophrenics, especially those with negative symptoms, have an abnormality of input processing of auditory information in the lower brainstem.</p>","PeriodicalId":77425,"journal":{"name":"The Japanese journal of psychiatry and neurology","volume":"48 3","pages":"571-8"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1819.1994.tb03016.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18889961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Alopecia areata associated with haloperidol.","authors":"T Kubota, T Ishikura, I Jibiki","doi":"10.1111/j.1440-1819.1994.tb03017.x","DOIUrl":"https://doi.org/10.1111/j.1440-1819.1994.tb03017.x","url":null,"abstract":"<p><p>A patient with a 7-year history of depression relapsed after self-discontinuation of antidepressant drugs. He was admitted to our hospital and re-administered amoxapine 150 mg. p.o. per day, and further given haloperidol 5 mg i.m. or p.o. per day because he was suicidal and excited. One month later, an area of alopecia was found on the back of his head. Immediately, he received dermatological treatment. The psychotropic drugs were continued, but the hair loss was unchanged after one month. So, haloperidol alone was discontinued. One week later, the hair loss had stopped and a month later alopecia had virtually disappeared. We suggest that alopecia areata is associated with haloperidol.</p>","PeriodicalId":77425,"journal":{"name":"The Japanese journal of psychiatry and neurology","volume":"48 3","pages":"579-81"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1819.1994.tb03017.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18889962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Iijima, H Ishino, H Seno, T Inagaki, T Ebara, K Yamashita
{"title":"An autopsy case of Alzheimer disease with myoclonus and periodic spikes on EEG.","authors":"M Iijima, H Ishino, H Seno, T Inagaki, T Ebara, K Yamashita","doi":"10.1111/j.1440-1819.1994.tb03023.x","DOIUrl":"https://doi.org/10.1111/j.1440-1819.1994.tb03023.x","url":null,"abstract":"<p><p>This is a case of Alzheimer disease with myoclonus and periodic spikes on EEG. A 56-year-old man developed progressive dementia and, 3 years later, generalized convulsions. Eight years later, he showed myoclonus and periodic spikes on EEG. Cranial CT showed cortical atrophy and ventricular dilatation. He became apallic and died of pneumonia at the age of 65.9 years after the onset of the disease. The brain weighed 1,050 g. Neuropathologically, diffuse neuronal loss, abundant neurofibrillary tangles and senile plaques, particularly diffuse plaques, were found extensively in the cerebral cortex. The white matter was preserved. In the Ammon's horn, abundant neurofibrillary tangles and senile plaques were observed. Grumose degeneration of the cerebellar dentate nucleus, Kuru plaques or prions were not found. Numerous diffuse plaques of the cerebral cortex have rarely been reported in autopsy cases of Alzheimer disease with myoclonus and periodic spikes on EEG.</p>","PeriodicalId":77425,"journal":{"name":"The Japanese journal of psychiatry and neurology","volume":"48 3","pages":"615-21"},"PeriodicalIF":0.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1819.1994.tb03023.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18889938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Proceedings of the 8th Workshop for the Clinical Research on Chronobiology. Kyoto, September 30-October 1, 1993.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77425,"journal":{"name":"The Japanese journal of psychiatry and neurology","volume":"48 2","pages":"449-509"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18808743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Regional differences of immediate early gene expressions in the brain of El mice as examined with development and seizure history.","authors":"Y L Murashima, K Kasamo, J Suzuki","doi":"10.1111/j.1440-1819.1994.tb03067.x","DOIUrl":"https://doi.org/10.1111/j.1440-1819.1994.tb03067.x","url":null,"abstract":"Rapid genomic responses to neural stimulation may play a critical role in long-term synaptic plasticity.' Recent works have strengthened this idea by demonstrating that neurotransmitter-induced long-term synaptic plasticity requires RNA and protein synthesis during critical time window immediately following stimulation? These studies prompted the suggestion that genes, like c-fos, that are rapidly induced by cell-surface-receptor stimulation by either a growth factor or neurotransmitter~~ might be involved in the early genomic response underlying long-term synaptic plasticity*. Activation of Immediate Early Genes (IEGs) occurs by increased transcription and is thought to represent the primary genomic response to stimulations, since it does not require protein synthesis. Several IEGs code for transcription factors. These include members of thefos families, which dimerize to form the transcription regulatory","PeriodicalId":77425,"journal":{"name":"The Japanese journal of psychiatry and neurology","volume":"48 2","pages":"275-9"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1819.1994.tb03067.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18808740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A long-term follow-up and clinical study of epileptics whose medication was terminated.","authors":"H Mukasa, S Ueda, S Ishida, H Maeda, Y Nakazawa","doi":"10.1111/j.1440-1819.1994.tb03063.x","DOIUrl":"https://doi.org/10.1111/j.1440-1819.1994.tb03063.x","url":null,"abstract":"It has generally been accepted even by epileptologists that the prognosis of epilepsy is poor with a few exceptions such as typical absence or BECCT and that a majority of patients need to take antiepileptic drugs for a lifelong period, as reviewed by Rodin in 1968.'' Recent prospective follow-up studies carried out by Reynolds et ~ 1 . ~ 9-11 l3 or the Mayo clinic groups' ', however, indicated a much more favorable prognosis of epilepsy. We previously reported on 15 epileptics with various seizure types including West or Lennox syndrome who succeeded in discontinuation of drugs without any relapse of seizures thereafter at least for several years and proposed criteria for the termination of treatment (Table l).I4 Now we report the results of a follow-up study of 36 cases who were withdrawn from antiepileptic drugs according to the criteria, along with clinical features of these cases. Analyses were made on factors which had led to a recurrence of seizures in a few cases as well.","PeriodicalId":77425,"journal":{"name":"The Japanese journal of psychiatry and neurology","volume":"48 2","pages":"259-63"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1819.1994.tb03063.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18808738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}