{"title":"A case of protein C deficiency associated with cerebral infarction and obstruction of deep leg and inferior mesenteric veins.","authors":"M Tsuda, M Miyazaki, T Takada, Y Uda, S Kuzuhara","doi":"10.1111/j.1440-1819.1993.tb01837.x","DOIUrl":"https://doi.org/10.1111/j.1440-1819.1993.tb01837.x","url":null,"abstract":"<p><p>Protein C, a vitamin K-dependent protein, is a blood coagulation inhibitor. Its deficiency causes systemic thrombosis. A 31-year-old woman developed cerebral infarction followed by late psychomotor seizures, and thrombosis in the inferior mesenteric vein and bilateral crural veins. Her parents were first cousins. Her mother died of cerebral thrombosis in her 30's. Her elder brother died of suspected purpura fulminans immediately after birth. Her protein C activity and protein C antigen level decreased markedly and were less than 5% of those of normal controls and 0.3 microgram/ml, respectively. Her father, a paternal aunt and a maternal uncle also showed a low protein C activity and protein C antigen level. This patient seems to have congenital protein C deficiency which produced thrombosis in the leg veins and the mesenteric vein, probably cerebral infarction.</p>","PeriodicalId":77425,"journal":{"name":"The Japanese journal of psychiatry and neurology","volume":"47 4","pages":"887-92"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1819.1993.tb01837.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19191225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N Hayashida, Y Nakazawa, T Sakamoto, N Uchimura, K Kuroda, Y Hashizume, S Tsuchiya, Y Tsutsumi
{"title":"Effects of zopiclone on slow wave sleep and spontaneous K-complexes for normal healthy young adults.","authors":"N Hayashida, Y Nakazawa, T Sakamoto, N Uchimura, K Kuroda, Y Hashizume, S Tsuchiya, Y Tsutsumi","doi":"10.1111/j.1440-1819.1993.tb01838.x","DOIUrl":"https://doi.org/10.1111/j.1440-1819.1993.tb01838.x","url":null,"abstract":"<p><p>Benzodiazepine (BZD) hypnotics have been known to decrease, to some degree, human slow wave sleep (SWS) although they elevate the arousal threshold during sleep. Zopiclone (ZPC), a cyclopyrrolone hypnotic, has attracted the interest of sleep researchers because an increase in human SWS has been reported. Since the increase has not been fully confirmed by all of the studies, the authors investigated the effects of ZPC 10 mg on SWS and the K-complexes for 7 healthy young adults because there is evidence indicating that delta waves consisting of SWS and the spontaneous K-complexes are identical. SWS and st. 4 sleep did not decrease on any of the ZPC nights but st. 3 sleep showed a tendency to reduce on the 1st ZPC night. The frequency of the K-complexes decreased significantly on the 2nd ZPC night and tended to reduce on the 1st ZPC night. Moreover, a significant positive correlation was noted between the decrease rates of SWS and the K-complexes on both the ZPC nights. The authors, therefore, could not obtain any findings suggesting an increase in SWS with ZPC.</p>","PeriodicalId":77425,"journal":{"name":"The Japanese journal of psychiatry and neurology","volume":"47 4","pages":"893-9"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1819.1993.tb01838.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19191226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An autopsy case of Binswanger's disease without hypertension and associated with cerebral infarction in the terminal stage.","authors":"M Iijima, H Ishino, H Seno, T Inagaki, S Haruki","doi":"10.1111/j.1440-1819.1993.tb01839.x","DOIUrl":"https://doi.org/10.1111/j.1440-1819.1993.tb01839.x","url":null,"abstract":"<p><p>We report here an autopsy case of Binswanger's disease (BD) without hypertension and associated with cerebral infarction in the terminal stage. The female patient, who was 74 years old at the time of death, had initially demonstrated manic-depressive disorder-like mental disorder, followed by dementia and neurological deficits. A brain CT scan showed white matter low attenuation bilaterally and symmetrically. BD was clinically diagnosed despite the lack of hypertension. In the terminal stage, she suffered an infarction in the left anterior cerebral artery region, and died of pneumonia. Neuropathologically, we found the infarction of the left anterior cerebral artery region, demyelination, fibrillary gliosis, lacunae and arteriosclerosis of the small arteries and arterioles in the white matter.</p>","PeriodicalId":77425,"journal":{"name":"The Japanese journal of psychiatry and neurology","volume":"47 4","pages":"901-7"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1819.1993.tb01839.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19191227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Onset of depressive episodes in a woman with seasonal affective disorder of \"spring type\" coincident with atmospheric temperature, but not with sunshine duration.","authors":"M Fukuda, C Yoshinaga","doi":"10.1111/j.1440-1819.1993.tb01825.x","DOIUrl":"https://doi.org/10.1111/j.1440-1819.1993.tb01825.x","url":null,"abstract":"<p><p>This is a report on the clinical symptoms and the longitudinal course in a woman with seasonal affective disorder of \"spring type.\" The woman experienced 10 atypical depressive episodes between the ages of 44 and 55. Nine of the 10 depressive episodes were confirmed by the medical chart, and were classified into three categories: two episodes with a psychological stressor, six episodes with the onset in February or March, and an episode starting in August. The onset of the six episodes did coincide with the time the atmospheric temperature rose to 8 degrees Centigrade in spring, but did not relate with the sunshine duration. These findings suggest that the change in atmospheric temperature played an important role in triggering off her depressive episodes.</p>","PeriodicalId":77425,"journal":{"name":"The Japanese journal of psychiatry and neurology","volume":"47 4","pages":"777-82"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1819.1993.tb01825.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19192020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S Satoh, N Morita, K Kusumoto, Y Satsumi, I Matsuzaki, T Konishi, T Okada, H Tanabe, M Yamada, S Oda
{"title":"Mental health in family members living with elders.","authors":"S Satoh, N Morita, K Kusumoto, Y Satsumi, I Matsuzaki, T Konishi, T Okada, H Tanabe, M Yamada, S Oda","doi":"10.1111/j.1440-1819.1993.tb01827.x","DOIUrl":"https://doi.org/10.1111/j.1440-1819.1993.tb01827.x","url":null,"abstract":"<p><p>We assessed the mental health conditions of 217 subjects who took care of elders at home, using our depression scale by the surveillance of the elders living at home in Ibaraki Prefecture. An analysis was made on how depression in the caretakers was related with each item of demographical results of the caretakers and the elders living together at home, and with ADL, depression, dementia, personality change and the personality trait of the elders. Our study revealed that depression, personality change and the viscous character of the elders are three factors associated with depression in the female caretakers. Furthermore, we pointed out the necessity of an education campaign to provide the caretakers with information on the elders' personality and personality change for maintenance of the good mental health of the caretakers living with the elders.</p>","PeriodicalId":77425,"journal":{"name":"The Japanese journal of psychiatry and neurology","volume":"47 4","pages":"801-9"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1819.1993.tb01827.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19192681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Delusional depression and suicide.","authors":"M Hori, H Shiraishi, J Koizumi","doi":"10.1111/j.1440-1819.1993.tb01828.x","DOIUrl":"https://doi.org/10.1111/j.1440-1819.1993.tb01828.x","url":null,"abstract":"<p><p>During the 12-year period of retrospective observation, 38 cases of 93 major depressive inpatients were delusional and the remainders were nondelusional. We evaluated the differences on several variables, especially about suicide, between the two groups. The mean age at the onset of illness of delusional depressive patients was higher than that of nondelusional ones. The incidence of psychomotor retardation was lower in the former group than in the latter. The frequency of suicidal ideation and suicidal attempts were higher in the former group than the latter. The suicidal methods in the delusional depressives tended to be more active and violent than those in nondelusional depressives and were supposed to have a twofold mortality than those in the nondelusional ones. We discussed this high rate of suicides of delusional depression from the viewpoint of disinhibition of psychomotor retardation, chronicity, partial affinity of delusional depressives to schizophrenics and neuroendocrinological perspective.</p>","PeriodicalId":77425,"journal":{"name":"The Japanese journal of psychiatry and neurology","volume":"47 4","pages":"811-7"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1819.1993.tb01828.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18910136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Abnormalities in event-related potentials: N100, N200 and P300 topography in alcoholics.","authors":"Y Miyazato, C Ogura","doi":"10.1111/j.1440-1819.1993.tb01833.x","DOIUrl":"https://doi.org/10.1111/j.1440-1819.1993.tb01833.x","url":null,"abstract":"<p><p>Event-related potentials were recorded in 30 abstinent alcoholics, and 30 gender- and age-matched controls during a two-tone discrimination (odd ball) task. All the subjects were free from medication and dextral. The amplitudes of N100, N200 and P300 in the alcoholics were reduced and the P300 latency prolonged as compared with those of the controls. A P300 amplitude reduction occurred in the left and midline frontal, and the left and midline central regions. This is the first report of the amplitude of P300 being markedly decreased in the left hemispheres of the brains of the alcoholics. The results are discussed in terms of the cognitive dysfunctions of alcoholics.</p>","PeriodicalId":77425,"journal":{"name":"The Japanese journal of psychiatry and neurology","volume":"47 4","pages":"853-62"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1819.1993.tb01833.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19192686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Examination of beta-protein deposits in Alzheimer's cerebral cortices by three-dimensional observation.","authors":"T Kimura, T Hisano, K Ueda, T Miyakawa","doi":"10.1111/j.1440-1819.1993.tb01840.x","DOIUrl":"https://doi.org/10.1111/j.1440-1819.1993.tb01840.x","url":null,"abstract":"<p><p>We examined the location of beta-protein deposits (small diffuse plaques) in the cerebral cortices of Alzheimer's patients and aged nondemented controls by observing the methenamine silver stained serial sections. Some vessels, astrocytes or neuronal elements existed near or within the diffuse plaques, and the preamyloids in the plaques were frequently detected in direct contact with vessels, astrocytes or neuronal elements. Although these findings do not demonstrate that the beta-protein within the senile plaques is produced in various cellular elements of the brain, they suggest some associations between beta-protein deposition and vessels, astrocytes or neuronal elements.</p>","PeriodicalId":77425,"journal":{"name":"The Japanese journal of psychiatry and neurology","volume":"47 4","pages":"909-14"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1819.1993.tb01840.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19191228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Takigawa, K Ueyama, H Fukuzako, H Maeda, K Matsumoto
{"title":"Intracranial self-stimulation and locomotor traces as indicators for evaluating the homopantothenic acid.","authors":"M Takigawa, K Ueyama, H Fukuzako, H Maeda, K Matsumoto","doi":"10.1111/j.1440-1819.1993.tb01841.x","DOIUrl":"https://doi.org/10.1111/j.1440-1819.1993.tb01841.x","url":null,"abstract":"<p><p>Our paper compares the effect of homopantothenic acid (HOPA) and haloperidol (HAL), i.e., representative neuroleptics, on intracranial self-stimulation (ICSS) and locomotor activity. These experiments showed that HOPA inhibited abnormal hyperactivity induced by methamphetamine (MAP) but did not inhibit ICSS which is considered with respect to physiological motivations. On the other hand, haloperidol (HAL) markedly inhibited both ICSS and abnormal hyperactivity induced by MAP. We propose that combined ICSS and locomotor traces can be chosen as indicators for evaluation and developing the new neuroleptics.</p>","PeriodicalId":77425,"journal":{"name":"The Japanese journal of psychiatry and neurology","volume":"47 4","pages":"915-20"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1819.1993.tb01841.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19191229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ipsilateral and bilateral EEG activity from the hippocampus.","authors":"Y Oana, Y Mayanagi","doi":"10.1111/j.1440-1819.1993.tb01843.x","DOIUrl":"https://doi.org/10.1111/j.1440-1819.1993.tb01843.x","url":null,"abstract":"<p><p>Using scalp and depth electroencephalography (EEG), we examined the relationship between the surface EEG activity and abnormal EEG discharges in the ipsilateral hippocampus in order to study the neuronal connection between the two cerebral regions. Ictal EEG was divided into 4 groups: 1) unitempo-ipsilateral-bifrontal slow waves, 2) unitempo-ipsilateral-bilateral slow waves, 3) bilateral slow waves, and 4) bilateral slow waves with repetitive spikes. Abnormal depth EEG activity in the hippocampus was classified into paroxysmal discharges and recruiting rhythms. Ictally and interictally, repetitive sharp waves or spikes in the unilateral hippocampus were associated with sharp waves or spikes in the ipsilateral temporal region. These findings suggest that the ipsilateral projection of seizure activity originating in the unilateral hippocampus is dependent upon the function of the subiculum.</p>","PeriodicalId":77425,"journal":{"name":"The Japanese journal of psychiatry and neurology","volume":"47 4","pages":"929-36"},"PeriodicalIF":0.0,"publicationDate":"1993-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1819.1993.tb01843.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19191231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}