AIMS Neuroscience最新文献

{"title":"Revolutionizing stress-related disorder regulation through neuroinformatics and data analysis: An editorial.","authors":"Arosh S Perera Molligoda Arachchige,&nbsp;Yash Verma","doi":"10.3934/Neuroscience.2023019","DOIUrl":"https://doi.org/10.3934/Neuroscience.2023019","url":null,"abstract":"<jats:p xml:lang=\"fr\" />","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"10 3","pages":"252-254"},"PeriodicalIF":2.7,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric multiple sclerosis: an integrated outlook at the interplay between genetics, environment and brain-gut dysbiosis.","authors":"Uzochukwu Adabanya,&nbsp;Ayoola Awosika,&nbsp;Anosh Khan,&nbsp;Ejike Oluka,&nbsp;Mayowa Adeniyi","doi":"10.3934/Neuroscience.2023018","DOIUrl":"10.3934/Neuroscience.2023018","url":null,"abstract":"<p><p>Multiple sclerosis (MS) is a debilitating autoimmune condition caused by demyelination, neurodegeneration and persistent inflammation of the central nervous system. Pediatric multiple sclerosis (PMS) is a relatively rare form of the disease that affects a significant number of individuals with MS. Environmental exposures, such as viral infections and smoking, can interact with MS-associated human leukocyte antigens (HLA) risk alleles and influence the immune response. Upregulation of immune response results in the disruption of immune balance leading to cascade of inflammatory events. It has also been established that gut microbiome dysbiosis poses a higher risk for pro-inflammation, and it is essentially argued to be the greatest environmental risk factor for MS. Dysbiosis can cause an unusual response from the adaptive immune system and significantly contribute to the development of disease in the host by activating pro-inflammatory pathways that cause immune-mediated disorders such as PMS, rendering the body more vulnerable to foreign attacks due to a weakened immune response. All these dynamic interactions between biological, environmental and genetic factors based on epigenetic study has further revealed that upregulation or downregulation of some genes/enzyme in the central nervous system white matter of MS patients produces a less stable form of myelin basic protein and ultimately leads to the loss of immune tolerance. The diagnostic criteria and treatment options for PMS are constantly evolving, making it crucial to have a better understanding of the disease burden on a global and regional scale. The findings from this review will aid in deepening the understanding of the interplay between genetic and environmental risk factors, as well as the role of the gut microbiome in the development of pediatric multiple sclerosis. As a result, healthcare professionals will be kept abreast of the early diagnostic criteria, accurately delineating other conditions that can mimic pediatric MS and to provide comprehensive care to individuals with PMS based on the knowledge gained from this research.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"10 3","pages":"232-251"},"PeriodicalIF":2.7,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depletion of dopamine in Parkinson's disease and relevant therapeutic options: A review of the literature.","authors":"Sairam Ramesh,&nbsp;Arosh S Perera Molligoda Arachchige","doi":"10.3934/Neuroscience.2023017","DOIUrl":"10.3934/Neuroscience.2023017","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects motor and cognition functions. The etiology of Parkinson's disease remains largely unknown, but genetic and environmental factors are believed to play a role. The neurotransmitter dopamine is implicated in regulating movement, motivation, memory, and other physiological processes. In individuals with Parkinson's disease, the loss of dopaminergic neurons leads to a reduction in dopamine levels, which causes motor impairment and may also contribute to the cognitive deficits observed in some patients. Therefore, it is important to understand the pathophysiology that leads to the loss of dopaminergic neurons, along with reliable biomarkers that may help distinguish PD from other conditions, monitor its progression, or indicate a positive response to a therapeutic intervention. Important advances in the treatment, etiology, and pathogenesis of Parkinson's disease have been made in the past 50 years. Therefore, this review tries to explain the different possible mechanisms behind the depletion of dopamine in PD patients such as alpha-synuclein abnormalities, mitochondrial dysfunction, and 3,4-dihydroxyphenylacetaldehyde (DOPAL) toxicity, along with the current therapies we have and the ones that are in development. The clinical aspect of Parkinson's disease such as the manifestation of both motor and non-motor symptoms, and the differential diagnosis with similar neurodegenerative disease are also discussed.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"10 3","pages":"200-231"},"PeriodicalIF":2.7,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41231754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroencephalography and mild cognitive impairment research: A scoping review and bibliometric analysis (ScoRBA).","authors":"Adi Wijaya, Noor Akhmad Setiawan, Asma Hayati Ahmad, Rahimah Zakaria, Zahiruddin Othman","doi":"10.3934/Neuroscience.2023012","DOIUrl":"10.3934/Neuroscience.2023012","url":null,"abstract":"<p><p>Mild cognitive impairment (MCI) is often considered a precursor to Alzheimer's disease (AD) and early diagnosis may help improve treatment effectiveness. To identify accurate MCI biomarkers, researchers have utilized various neuroscience techniques, with electroencephalography (EEG) being a popular choice due to its low cost and better temporal resolution. In this scoping review, we analyzed 2310 peer-reviewed articles on EEG and MCI between 2012 and 2022 to track the research progress in this field. Our data analysis involved co-occurrence analysis using VOSviewer and a Patterns, Advances, Gaps, Evidence of Practice, and Research Recommendations (PAGER) framework. We found that event-related potentials (ERP), EEG, epilepsy, quantitative EEG (QEEG), and EEG-based machine learning were the primary research themes. The study showed that ERP/EEG, QEEG, and EEG-based machine learning frameworks provide high-accuracy detection of seizure and MCI. These findings identify the main research themes in EEG and MCI and suggest promising avenues for future research in this field.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"10 2","pages":"154-171"},"PeriodicalIF":3.1,"publicationDate":"2023-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9811185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plastic rearrangement of basal forebrain parvalbumin-immunoreactive neurons in the kainite model of epilepsy","authors":"Ruben Carvalho, Alisa N. Lukoyanova, João Casalta-Lopes, Nikolay V. Lukoyanov, Joana Isabel Soares","doi":"10.3934/neuroscience.2023023","DOIUrl":"https://doi.org/10.3934/neuroscience.2023023","url":null,"abstract":"<abstract> <p>Temporal lobe epilepsy (TLE) is the most prevalent form of epilepsy, through the neuronal mechanisms of this syndrome remain elusive. In addition to the temporal lobe structures, it was found that the basal forebrain cholinergic cells are also involved in epileptogenesis. However, little is known about the involvement of the basal forebrain GABAergic neurons in epilepsy; despite this, they largely project to the temporal lobe and are crucial for the regulation of the hippocampal circuitry. In this study, we assessed epilepsy-induced changes in parvalbumin (PARV) immunoreactive neurons of the medial septum (MS) and of the magnocellular preoptic nucleus (MCPO) using the kainic acid (KA) model in rats. In addition, we estimated the respective changes in the cholinergic varicosities in the MS, where we observed a significant reduction in the PARV cell number (12849 ± 2715 vs. 9372 ± 1336, <italic>p</italic> = .029) and density (16.2 ± 2.62 vs. 10.5 ± 1.00 per .001 mm³, <italic>p</italic> =.001), and an increase in the density of cholinergic varicosities (47.9 ± 11.1 vs. 69.4 ± 17.8 per 30,000 µm², <italic>p</italic> =.036) in KA-treated animals. In the MCPO, these animals showed a significant increase in somatic volume (827.9 ± 235.2 µm³ vs. 469.9 ± 79.6 µm³, <italic>p</italic> = .012) and total cell number (2268.6 ± 707.1 vs. 1362.4 ± 262.0, <italic>p</italic> =.028). These results show that the basal forebrain GABAergic cell populations undergo numerical and morphological changes in epileptic animals, which may contribute to an increased vulnerability of brain circuits to epilepsy and epilepsy-related functional impairments.</p> </abstract>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"305 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134980155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flavonoid glycoside fraction of <i>Ginkgo biloba</i> extract modulates antioxidants imbalance in vanadium-induced brain damage.","authors":"Adeshina O Adekeye,&nbsp;Adedamola A Fafure,&nbsp;Morayo M Omodele,&nbsp;Lawrence D Adedayo,&nbsp;Victor O Ekundina,&nbsp;Damilare A Adekomi,&nbsp;Ephraim Samuel Jen,&nbsp;Thomas K Adenowo","doi":"10.3934/Neuroscience.2023015","DOIUrl":"https://doi.org/10.3934/Neuroscience.2023015","url":null,"abstract":"<p><p>Human and animal diseases have always been reported to be treated by medicinal herbs owing to their constituents. Excess sodium metavanadate is a potential environmental toxin when consumed and could induce oxidative damage leading to various neurological disorders and Parkinsons-like diseases. This study is designed to investigate the impact of the flavonoid Glycoside Fraction of Ginkgo Biloba Extract (GBE) (at 30 mg/kg body weight) on vanadium-treated rats. Animals were divided randomly into four groups: Control (Ctrl, normal saline), Ginkgo Biloba (GIBI, 30mg/kg BWT), Vanadium (VANA, 10 mg/kg BWT) and Vanadium + Ginkgo biloba (VANA + GIBI). Markers of oxidative stress (Glutathione Peroxidase and Catalase) were assessed and found to be statistically increased with GIBI when compared with CTRL and treatment groups. Results from routine staining revealed that the control and GIBI group had a normal distribution of cells and a pronounced increase in cell count respectively compared to the VANA group. When compared to the VANA group, the NeuN photomicrographs revealed that the levels of GIBI were within the normal range (***p < 0.001; ** p < 001). The treatment with GIBI showed a better response by increasing the neuronal cells in the VANA+GIBI when compared with the VANA group. The NLRP3 Inflammasome photomicrographs denoted that there was a decrease in NLRP3-positive cells in the control and GIBI groups. The treatment group shows fewer cells compared to that of the VANA group. The treatment group shows fewer cells compared to that of the VANA group. The findings of the study confirmed that ginkgo biloba extract via its flavonoid glycoside fraction has favorable impacts in modulating vanadium-induced brain damage with the potential ability to lower antioxidant levels and reduce neuroinflammation.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"10 2","pages":"178-189"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10187520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep brain stimulation, lesioning, focused ultrasound: update on utility.","authors":"Akshay Reddy,&nbsp;Mohammad Reza Hosseini,&nbsp;Aashay Patel,&nbsp;Ramy Sharaf,&nbsp;Vishruth Reddy,&nbsp;Arman Tabarestani,&nbsp;Brandon Lucke-Wold","doi":"10.3934/Neuroscience.2023007","DOIUrl":"https://doi.org/10.3934/Neuroscience.2023007","url":null,"abstract":"<p><p>Procedures for neurological disorders such as Parkinsons Disease (PD), Essential Tremor (ET), Obsessive Compulsive Disorder (OCD), Tourette's Syndrome (TS), and Major Depressive Disorder (MDD) tend to overlap. Common therapeutic procedures include deep brain stimulation (DBS), lesioning, and focused ultrasound (FUS). There has been significant change and innovation regarding targeting mechanisms and new advancements in this field allowing for better clinical outcomes in patients with severe cases of these conditions. In this review, we discuss advancements and recent discoveries regarding these three procedures and how they have led to changes in utilization in certain conditions. We further discuss the advantages and drawbacks of these treatments in certain conditions and the emerging advancements in brain-computer interface (BCI) and its utility as a therapeutic for neurological disorders.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"10 2","pages":"87-108"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10168760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transitioning from PET/MR to trimodal neuroimaging: why not cover the temporal dimension with EEG?","authors":"Arosh S Perera Molligoda Arachchige","doi":"10.3934/Neuroscience.2023001","DOIUrl":"https://doi.org/10.3934/Neuroscience.2023001","url":null,"abstract":"<p><p>The possibility of multimodality imaging with PET/MR and the availability of ultra-high field MRI has allowed to investigate novel aspects of neuropsychiatric conditions. One of the major barriers in current studies is the lack of an instrument that allows to accurately cover the temporal aspect under the same physiological conditions. The aim of this commentary is to provide our perspective on how the integration of EEG-PET-MR could be a solution to the current challenge in molecular imaging and seems to hold great promise in future pharmacological challenging-based studies, understanding different functional states of the brain, and could furthermore aid in the diagnostic and prognostic evaluations of neurocognitive disorders.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"10 1","pages":"1-4"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9383973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of basilar artery dissection.","authors":"Sahibjot Bhatia,&nbsp;Nimrit Gahoonia,&nbsp;Jeffrey Stenger,&nbsp;Forshing Lui","doi":"10.3934/Neuroscience.2023008","DOIUrl":"https://doi.org/10.3934/Neuroscience.2023008","url":null,"abstract":"<p><p>This case describes a 30-year-old Hispanic male who presented with a significant headache that started after a period of weightlifting and squatting. The patient was diagnosed with a basilar artery dissection. His only complaint was a headache that was exacerbated with exertion and sexual activity; there were no neurologic deficits. The diagnosis of basilar artery dissection was established and supported by findings on the CT angiogram of his head and neck. Basilar artery dissections are rarely seen, as they are likely underrecognized due to their varying clinical presentations; however, it is important to consider these phenomena due to the risk of progression and high morbidity rates.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"10 2","pages":"109-117"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9811188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The blue brain project: pioneering the frontier of brain simulation","authors":"Arosh S. Perera Molligoda Arachchige","doi":"10.3934/neuroscience.2023024","DOIUrl":"https://doi.org/10.3934/neuroscience.2023024","url":null,"abstract":"<jats:p xml:lang=\"fr\" />","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134980161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}