Medical oncology and tumor pharmacotherapy最新文献_第7页

The monocyte tumor necrosis factor-alpha production in patients with acute leukemia in complete remission. 急性白血病完全缓解期患者单核细胞肿瘤坏死因子- α的产生。

Medical oncology and tumor pharmacotherapy Pub Date : 1992-01-01 DOI: 10.1007/BF02987756

M Aiso, Y Iizuka, H I Kang, S Sawada, T Ohshima, T Horie

{"title":"The monocyte tumor necrosis factor-alpha production in patients with acute leukemia in complete remission.","authors":"M Aiso, Y Iizuka, H I Kang, S Sawada, T Ohshima, T Horie","doi":"10.1007/BF02987756","DOIUrl":"https://doi.org/10.1007/BF02987756","url":null,"abstract":"Tumor necrosis factor-alpha (TNF-alpha) production by unstimulated and lipopolysaccharide (LPS)-stimulated peripheral monocytes has been studied in 17 acute myeloid leukemia (AML) patients, 54 AML patients in complete remission (AML-CR), 9 acute lymphoblastic leukemia (ALL) patients and 13 ALL patients in complete remission (ALL-CR). TNF-alpha production by the unstimulated monocytes in ALL patients (n = 6, mean: 6.6 +/- 4.9 u/ml) was higher than that of normal controls (n = 13, 0.9 +/- 0.7 u/ml), AML patients (n = 14, 2.0 +/- 2.1 u/ml) and AML-CR patients (n = 21, 1.4 +/- 1.2 u/ml). TNF-alpha production by the LPS-stimulated monocytes of the AML-CR patients (n = 54, 12.4 +/- 13.4 u/ml) was significantly higher than that of the normal controls (n = 21, 3.5 +/- 2.5 u/ml) and the AML patients (n = 17, 2.6 +/- 2.4 u/ml), p < 0.01, but there were not any significant differences among the AML-CR patients and the ALL patients or the ALL-CR patients. We separated the AML-CR patients into 3 groups, depending on the length of their remission, and found that AML-CR patients with longer than 6 months (M) but less than 60 M (n = 21, 15.7 +/- 16.9 u/ml) and the patients with a remission longer than 60 M (n = 11, 18.2 +/- 15.9 u/ml) had significantly higher TNF-alpha production than that of the controls.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":77257,"journal":{"name":"Medical oncology and tumor pharmacotherapy","volume":"9 4","pages":"191-7"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02987756","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12515334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short communication: possible activity of beta-carotene in patients with the AIDS related complex. A pilot study. 短通讯:β -胡萝卜素在艾滋病相关复合体患者中的可能活性。一项初步研究。

Medical oncology and tumor pharmacotherapy Pub Date : 1992-01-01 DOI: 10.1007/BF02987747

A Bianchi-Santamaria, S Fedeli, L Santamaria

引用次数: 9

Dexamethasone reverses glucocorticoid receptor RNA depression in multi-drug resistant (MDR) myeloma cell lines. 地塞米松逆转多药耐药(MDR)骨髓瘤细胞系糖皮质激素受体RNA抑制。

Medical oncology and tumor pharmacotherapy Pub Date : 1992-01-01 DOI: 10.1007/BF02987757

L Danel-Moore, M Brönnegard, J A Gustafsson

{"title":"Dexamethasone reverses glucocorticoid receptor RNA depression in multi-drug resistant (MDR) myeloma cell lines.","authors":"L Danel-Moore, M Brönnegard, J A Gustafsson","doi":"10.1007/BF02987757","DOIUrl":"https://doi.org/10.1007/BF02987757","url":null,"abstract":"Glucocorticoid receptors and glucocorticoid receptor RNA (GR RNA) were measured in doxorubicin resistant myeloma cell lines to investigate the relationship between multi-drug resistance and glucocorticoid sensitivity. Glucocorticoid binding sites and GR RNA were found to be lowered in all the tested doxorubicin resistant cell lines: R10, R40 and R60 compared to the untreated wild type RPMI 8226 cells (Dalton, et al., 1984). The least resistant cell line, R10, maintained a down regulation of GR RNA after 48 hours of dexamethasone (10(-6) M) treatment of the cells. Interestingly, the R10 cell line has been reported to be very sensitive to dexamethasone treatment. However, the GR RNA levels increased in presence of dexamethasone in the most resistant cell line, R40, R60 by comparison to the wild type. Thus, the reduction of GR RNA by doxorubicin treatment appears to be overcome by dexamethasone in the most resistant cell lines. Steroids may be helpful in reversing resistance and maintaining drug sensitive human tumor populations that will continue to respond to cancer chemotherapeutic agents.","PeriodicalId":77257,"journal":{"name":"Medical oncology and tumor pharmacotherapy","volume":"9 4","pages":"199-204"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02987757","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12515335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

P-glycoprotein expression in refractory hematological neoplasms and circumvention of resistance with verapamil or cyclosporine A containing protocols. p -糖蛋白在难治性血液病肿瘤中的表达和维拉帕米或环孢素A的耐药规避方案。

Medical oncology and tumor pharmacotherapy Pub Date : 1992-01-01

M Beksaç, H Akan, H Koç, O Ilhan, S Ertürk, A Güneyli, Y Ikizünal, O S Sardaş

引用次数: 0

The European School of Haematology 欧洲血液学学院

Medical oncology and tumor pharmacotherapy Pub Date : 1991-03-01 DOI: 10.1007/BF02988574

引用次数: 1

5-Fluorouracil (FU) with folinic acid (FA) and mitomycin C (MMC) in the adjuvant treatment of colorectal carcinoma. Part I. Evaluation of toxicity. 5-氟尿嘧啶(FU)联合亚叶酸(FA)和丝裂霉素C (MMC)辅助治疗大肠癌。第一部分:毒性评价。

Medical oncology and tumor pharmacotherapy Pub Date : 1991-01-01 DOI: 10.1007/BF02988856

F Franchi, C Barone, E Ricevuto, A Cassano, A Astone, C Pozzo, L Sofo, G Netri, C Ratto, C Coco

引用次数: 4

Primary and secondary prevention, and early detection of tumors. 一级和二级预防，以及肿瘤的早期发现。

Medical oncology and tumor pharmacotherapy Pub Date : 1991-01-01

P Reizenstein

引用次数: 0

Free radicals as carcinogens and their quenchers as anticarcinogens. 自由基是致癌物，它们的猝灭剂是抗癌物。

Medical oncology and tumor pharmacotherapy Pub Date : 1991-01-01 DOI: 10.1007/BF02987170

L Santamaria, A Bianchi-Santamaria

{"title":"Free radicals as carcinogens and their quenchers as anticarcinogens.","authors":"L Santamaria, A Bianchi-Santamaria","doi":"10.1007/BF02987170","DOIUrl":"https://doi.org/10.1007/BF02987170","url":null,"abstract":"An oxygen dependent signal was detected, late in the 1950s by electron spin resonance (ESR) in a saline solution of hematoporphyrin (Hp) excited by light. This signal expressed a free radical consisting of 'some kind of an association between Hp and oxygen', that Smaller et al. called 'oxyradical' (HpOO.). It soon opened a new level of understanding in carcinogenesis triggered by photodynamic substances, including Hp itself, polycyclic hydrocarbons (PCHs), as well as any carcinogen involving molecular species activated by radiation and/or metabolic reaction. Early in the 1960s, this prompted the discovery of benzo(a)pyrene (BP) photocarcinogenic enhancement (BP-PCE) in mice, probably due to an increase in free oxygen radical generation following correct light exposure. This assumption was confirmed in 1980 by the fact that mice orally loaded with antioxidants and radical quenchers, such as beta-carotene (BC) and cantaxanthin (CX), were protected against BP-PCE at 100% and against total BP carcinogenicity at more than 60%. These achievements were presented as the bases of the current explosion of interest in biology and medicine in building up the new field of chemoprevention against cancer and other chronic diseases by supplementation with antioxidant vitamins, retinoids and especially carotenoids and their synergistic association. The relevant findings of this research obtained in the last decade in in vitro and in vivo experiments as well as human interventions are reported and discussed with personal contributions.","PeriodicalId":77257,"journal":{"name":"Medical oncology and tumor pharmacotherapy","volume":"8 3","pages":"121-40"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02987170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12964998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Growth kinetics and blast-colony forming cell binding capacity of aplastic anaemic stromal cells. 再生贫血基质细胞的生长动力学和胚集落形成细胞结合能力。

Medical oncology and tumor pharmacotherapy Pub Date : 1991-01-01 DOI: 10.1007/BF02987198

Y el-Khatib, J Gidáli, I Fehér, A Poros, A Mód, S Hollán

{"title":"Growth kinetics and blast-colony forming cell binding capacity of aplastic anaemic stromal cells.","authors":"Y el-Khatib, J Gidáli, I Fehér, A Poros, A Mód, S Hollán","doi":"10.1007/BF02987198","DOIUrl":"https://doi.org/10.1007/BF02987198","url":null,"abstract":"The kinetics of bone marrow cell growth and a special function of stromal cells (the capability of binding blast colony forming cells) were studied in patients with aplastic anaemia (AA). All 10 patients studied showed faster growth of bone marrow stromal cells. The time for a confluent stromal layer formation was 24.5 days for AA bone marrow as opposed to 33.0 days for normal bone marrow. This faster growth rate could also be observed if normal bone marrow cells, depleted of plastic non-adherent fraction, were plated, suggesting that at least one of the reasons for altered stromal cell growth kinetics in AA is the changes in the ratio of plastic adherent/non-adherent cells. Functionally, i.e. in supporting the growth of normal bone marrow blast colonies, AA stromal layers did not differ from that of normal stromal layers, independently of the clinical state of the disease (AA or SAA; in one patient before or after ATG treatment; in two patients after successful allogenic bone marrow transplantation). Moreover, in some AA patients this blast colony forming cell binding function of AA stromal layers could also be detected in samples cultured without hydrocortisone (i.e. in the absence of fat cells), suggesting that AA stroma also differs qualitatively from normal stroma without inducing a defective microenvironment for stem cell homing.","PeriodicalId":77257,"journal":{"name":"Medical oncology and tumor pharmacotherapy","volume":"8 4","pages":"281-5"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02987198","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12981373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Analysis of some metabolic conditions promoting selective sensitivity of tumor cells to peroxidative stress. 促进肿瘤细胞对过氧化应激选择性敏感性的一些代谢条件的分析。

Medical oncology and tumor pharmacotherapy Pub Date : 1991-01-01 DOI: 10.1007/BF02987192

P M Schwartzburd, K B Aslanidi

{"title":"Analysis of some metabolic conditions promoting selective sensitivity of tumor cells to peroxidative stress.","authors":"P M Schwartzburd, K B Aslanidi","doi":"10.1007/BF02987192","DOIUrl":"https://doi.org/10.1007/BF02987192","url":null,"abstract":"Some metabolic parameters enhancing the sensitivity of tumor cells and their lipoprotein refractive granules (RG) to peroxidative stress were investigated during the growth cycle of ascite tumors in vivo. The majority of tumor cells only in the stationary growth phase had the increased sensitivity to peroxidative stress, tested by fluorescence intensivity of peroxidation products. The increase of this intensity correlates well with the decrease of tumor proliferation, the functional activity of mitochondria, the cellular level of ATP and extracellular pH. These metabolic conditions are favourable for increasing the neutral lipid accumulation in the stationary tumor cells, their RG and nuclei, as compared to exponentially growing cells. The sensitivity of tumor cells to peroxidation can be also enhanced with the help of exogenous polyunsaturated fatty acid (PUFA). Based on literature and our own data on Ehrlich ascites carcinoma (EAC), a working hypothesis is proposed to explain the enhanced selective sensitivity of tumor cells to PUFA peroxidation products (PP) suppressing the cell growth (especially in the stationary phase of EAC growth).","PeriodicalId":77257,"journal":{"name":"Medical oncology and tumor pharmacotherapy","volume":"8 4","pages":"235-41"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02987192","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12982262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0