Medical oncology and tumor pharmacotherapy最新文献_第6页

Prognostic significance of cytochemical analysis of leukemic M2 blasts. 白血病M2母细胞细胞化学分析的预后意义。

Medical oncology and tumor pharmacotherapy Pub Date : 1992-01-01 DOI: 10.1007/BF02989652

M Suĭć, D Boban, M Marković-Glamocak, M Petrovecki, M Marusić, B Labar

引用次数: 8

The management of pediatric brain tumors in a tertiary center. 三级中心小儿脑肿瘤的处理。

Medical oncology and tumor pharmacotherapy Pub Date : 1992-01-01 DOI: 10.1007/BF02987750

M Mandel, A Toren, G Findler, Y Neumann, G Kende, M Faibel, R Tadmor, H Brenner, A Sahar, B Ramot

引用次数: 0

Treatment of malignant peritoneal effusion in digestive and ovarian cancer. 消化道及卵巢癌恶性腹膜积液的治疗。

Medical oncology and tumor pharmacotherapy Pub Date : 1992-01-01 DOI: 10.1007/BF02987754

F N Gilly, P Y Carry, A Brachet, A C Sayag, G Panteix, B Salle, J Bienvenu, V Banssillon, G Burgard, M Manchon

{"title":"Treatment of malignant peritoneal effusion in digestive and ovarian cancer.","authors":"F N Gilly, P Y Carry, A Brachet, A C Sayag, G Panteix, B Salle, J Bienvenu, V Banssillon, G Burgard, M Manchon","doi":"10.1007/BF02987754","DOIUrl":"https://doi.org/10.1007/BF02987754","url":null,"abstract":"Intra Peritoneal Chemo Hyperthermia (IPCH) with Mitomycin C (MMC) or Cisplatinum (CP) was used to treat 32 patients with far advanced digestive or ovarian cancers and peritoneal carcinomatosis. Surgical resection of the primary tumor has been possible in 18 cases. After closure of the abdominal wall, a 90 minutes IPCH as performed under general anaesthesia and 32 degrees C general hypothermia, through 3 intraperitoneal drainages realizing a closed circuit, using 10 mg/l of MMC or 15 to 25 mg/l of CP in 6 l of peritoneal dialysate heated at the inflow temperature of 46 to 49 degrees C. The mortality rate was 3% and the morbidity rate was 3%. In 11 out of 12 patients with preoperative malignant ascites, no more ascites could be found after IPCH. For peritoneal carcinomatosis from digestive origin, median survival was 11.2 months and 1 year survival rate was 46.9%. These encouraging preliminary results show that IPCH is a safe and reliable treatment for peritoneal carcinomatosis in far advanced digestive or ovarian cancers.","PeriodicalId":77257,"journal":{"name":"Medical oncology and tumor pharmacotherapy","volume":"9 4","pages":"177-81"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02987754","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12514712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Bone marrow cells in the DNA-synthesis-phase in the myelodysplastic syndrome and lymphome. 骨髓增生异常综合征和淋巴系统中dna合成期的骨髓细胞。

Medical oncology and tumor pharmacotherapy Pub Date : 1992-01-01 DOI: 10.1007/BF02989654

A M Wenthzel, A Porwit, K Lindahl, S Widell, P Reizenstein

引用次数: 0

Genetic aspects of multidrug resistance. 多药耐药的遗传方面。

Medical oncology and tumor pharmacotherapy Pub Date : 1992-01-01 DOI: 10.1007/BF02989649

M Pauly, F Ries, M Dicato

引用次数: 17

Diverse effect of cytokine treatment of tumor cells on specific versus non-specific cytotoxicity. 细胞因子对肿瘤细胞特异性和非特异性细胞毒性的不同影响。

Medical oncology and tumor pharmacotherapy Pub Date : 1992-01-01 DOI: 10.1007/BF02989650

H Naganuma, E Halapi, G Masucci, M Hansson, P Wersäll, C Hising, S Venkateswaran, H Mellstedt, R Kiessling

{"title":"Diverse effect of cytokine treatment of tumor cells on specific versus non-specific cytotoxicity.","authors":"H Naganuma, E Halapi, G Masucci, M Hansson, P Wersäll, C Hising, S Venkateswaran, H Mellstedt, R Kiessling","doi":"10.1007/BF02989650","DOIUrl":"https://doi.org/10.1007/BF02989650","url":null,"abstract":"The effect of IFN-gamma and TNF-alpha treatment of an ovarian carcinoma line on the sensitivity to lysis by specific CTL clones and non-specific Tumor Associated Lymphocytes (TAL), isolated from the ascites fluid, was analyzed. The in vitro established TAL line displayed a non-specific lytic activity against the autologous tumor as well as against several allogeneic tumor lines. Pretreatment with IFN-gamma alone, or in combination with TNF-alpha, rendered the carcinoma line less susceptible to lysis by the autologous TAL line. Conversely, susceptibility to lysis by tumor specific T cell clones, isolated from the TAL line, was increased as a result of cytokine pretreatment. Several TCR-alpha/beta+, CD8+ T-cell clones showing a more specific pattern of lysis against the autologous tumor were isolated. Lysis of the autologous tumor by these clones involved the TCR-alpha/beta via a MHC-class I restricted mechanism dependent on the adhesion molecules ICAM-1 and LFA-3, as inferred from antibody blocking studies. The enhanced sensitivity to specific CTL clones seen after cytokine treatment may be related to the enhanced expression of ICAM-1 molecules on the ovarian carcinoma. These results have implications for cytokine based immunotherapy, where IFN-gamma may enhance the effects of tumor associated specific CTL while decreasing that of non-specific effector cells.","PeriodicalId":77257,"journal":{"name":"Medical oncology and tumor pharmacotherapy","volume":"9 1","pages":"25-33"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02989650","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12513784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The quandary of experimental chemotherapy. 实验性化疗的困境。

Medical oncology and tumor pharmacotherapy Pub Date : 1992-01-01 DOI: 10.1007/BF02987742

B Modan

引用次数: 0

The impact of surgery on the multidisciplinary treatment of bronchogenic small cell carcinoma (updated review including ongoing studies). 手术对支气管源性小细胞癌多学科治疗的影响(包括正在进行的研究)。

Medical oncology and tumor pharmacotherapy Pub Date : 1992-01-01 DOI: 10.1007/BF02987744

W Theuer, O Selawry, K Karrer

{"title":"The impact of surgery on the multidisciplinary treatment of bronchogenic small cell carcinoma (updated review including ongoing studies).","authors":"W Theuer, O Selawry, K Karrer","doi":"10.1007/BF02987744","DOIUrl":"https://doi.org/10.1007/BF02987744","url":null,"abstract":"Recent results of studies on patients with SCLC treated by surgery with curative intent followed by adjuvant chemotherapy demonstrate a definite progress in comparison to non-surgical-treatment programs for patients with comparable stage of disease. Of 186 randomized patients enrolled for the multicenter cooperative ISC-Study I and II, 76 patients with stage pT1-3N0M0 received surgery for cure followed by chemotherapy and selective radiotherapy to the brain. The projected 4 year crude survival rate by September 1991 was 57%. In 27 of 43 patients with stage pT1-3N2M0, the tumors were completely resected, resulting in a 4 year survival rate of 32%. The survival curve for both groups of patients shows a sharp bent at 27 months postoperatively, whereafter the survival curves take a plateau-like course. These promising results were confirmed by several other groups. They are in favour of initial surgery for resectable tumors, followed by postoperative chemotherapy, while patients on preoperative chemotherapy followed by adjuvant surgery showed less favourable results.","PeriodicalId":77257,"journal":{"name":"Medical oncology and tumor pharmacotherapy","volume":"9 3","pages":"119-37"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02987744","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12515126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Abnormal regulation of the myc gene in myeloid leukemia. 髓性白血病中myc基因的异常调控。

Medical oncology and tumor pharmacotherapy Pub Date : 1992-01-01 DOI: 10.1007/BF02987745

V Gopal, P Kadam, H Preisler, B Hulette, Y Q Li, P Steele, J Freeman, S Banavali

引用次数: 14

Production of prostaglandin E by squamous carcinoma of the head and neck and adenocarcinoma of gastrointestinal tissue. 头颈部鳞状癌和胃肠道组织腺癌前列腺素E的产生。

Medical oncology and tumor pharmacotherapy Pub Date : 1992-01-01 DOI: 10.1007/BF02989651

F Culo, I Klapan, V Katić, T Kolak, B Bakula

引用次数: 1