{"title":"[Preparing the donor with glycine improves survival after liver transplantation in the animal model].","authors":"P Schemmer, H Bunzendahl, R G Thurman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The etiology of primary graft non-function has been linked to storage and reperfusion injury. Recently, graft manipulation during harvest was shown to aggravate reperfusion injury in livers effecting outcome after transplantation detrimentally. Since Kupffer cells play a pivotal role in reperfusion injury, glycine (1 ml, 300 mM) was infused into donors for one hour before harvest to prevent Kupffer cell activation. Valine was used as isonitrogenous control. To assess the influence of gentle manipulation, livers from female Lewis rats were dissected for 12 minutes minimally and harvested within 25 minutes. During the last 13 minutes, the organ was gently manipulated or left alone in the controls. Minimal dissection during harvest without manipulation had no influence on survival after liver transplantation (100%); however, gentle manipulation for 13 minutes decreased survival to less than 50%. Further, transaminases were elevated seven-fold after transplantation by manipulation. Glycine infusion totally prevented the effects of organ manipulation on survival and enzyme release. These data indicate for the first time that pretreatment of donors with intravenous glycine prevents the detrimental effects of graft manipulation during harvest on outcome.</p>","PeriodicalId":77239,"journal":{"name":"Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress","volume":"115 Suppl I","pages":"589-93"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40831915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K H Dietl, H H Wolters, B Marschall, K Kisters, H Heidenreich, N Senninger
{"title":"[Results of double kidney transplantation from elderly donors].","authors":"K H Dietl, H H Wolters, B Marschall, K Kisters, H Heidenreich, N Senninger","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>From July 1996 to November 1997 13 patients underwent \"two-in-one\"-kidney transplantation from marginal donors. Up to now all renal grafts show a stable function measuring an average creatinin of 1.73 mg/dl after an average follow up of 8.2 month. To take the decision between \"one-in-one\" or \"two-in-two\" transplantation in marginal donors we developed a specific score. This score needs more evaluation because of the still small amount of patients undergoing double-kidney-transplantation.</p>","PeriodicalId":77239,"journal":{"name":"Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress","volume":"115 Suppl I","pages":"165-7"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40832026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Reuter, S Bahrami, M Ackermann, U Obertacke, F U Schade, G Schlag
{"title":"[Transfusion of plasma of endotoxin tolerant rats improves survival of hemorrhagic shock in the rat model].","authors":"M Reuter, S Bahrami, M Ackermann, U Obertacke, F U Schade, G Schlag","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To evaluate the protective effect of endotoxin tolerant plasma after hemorrhagic shock, plasma of endotoxin tolerant animals was used for resuscitation of normal rats. The transfusion of plasma of endotoxin tolerant rats improved the survival rate from 20 to 60 per cent. In the sera of endotoxin tolerant animals a TNF inhibitory activity was detected, which could be transferred by the plasma. This effect may be responsible for the protection to hemorrhagic shock.</p>","PeriodicalId":77239,"journal":{"name":"Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress","volume":"115 Suppl I","pages":"177-80"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40832029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P M Schneider, A H Hölscher, S Wegerer, U König, K Becker, J R Siewert
{"title":"[Clinical significance of p53 tumor suppressor gene mutations in adenocarcinoma in Barrett esophagus].","authors":"P M Schneider, A H Hölscher, S Wegerer, U König, K Becker, J R Siewert","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>p53 mutations are involved in the pathogenesis of adenocarcinomas in Barrett's esophagus. Our study included patients with histopathologically classified Barrett's cancer and shows that p53 mutations are clinically important for curatively resected (R0) Barrett's cancer. It appears that the p53 mutation status is a promising parameter for the definition of risk groups after potentially curative resections.</p>","PeriodicalId":77239,"journal":{"name":"Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress","volume":"115 Suppl I","pages":"495-9"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40832039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Classification of neuroendocrine tumors and the effect on surgical technique].","authors":"G Schürmann, M Brüwer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Neuroendocrine tumors of the gastrointestinal tract are heterogenous regarding hormone production and tumor biology and have a varying disease course and survival time. In 1995 Capella et al. proposed a new classification of neuroendocrine tumors combining characteristics of the primary (i.e. histological differentiation, size, extension into surrounding tissues, hormonal activity and angioinvasion) and its suspected biological behavior (benign, uncertain, low-grade malignant, high-grade malignant). The extent of surgical therapy depends on the malignant potential of the primary tumor. To evaluate the usefulness of this classification in practical work neuroendocrine tumors have to be categorized by this classification and these data have to be correlated with the individual long-term course of patients.</p>","PeriodicalId":77239,"journal":{"name":"Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress","volume":"115 ","pages":"359-61"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20836298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Surgery of inguinal hernia with local anesthesia--technique and results of a minimal invasive procedure].","authors":"H M Rau, G Arlt, C Peiper, V Schumpelick","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In three prospective, randomized studies we analyzed the advantages of local anesthesia in patients with primary inguinal hernias. Each study consisted of 100 cooperative adults, using an open approach and the transinguinal procedure. Due to reduced postoperative complications, increased effectiveness of hospital resources, earlier discharges and a high acceptance by the patients, local anesthesia is the ideal treatment in adult hernia repair.</p>","PeriodicalId":77239,"journal":{"name":"Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress","volume":"115 ","pages":"1024-6"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20836812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Surgical procedure for hyperthyroidism in children and adolescents].","authors":"J Witte, P E Goretzki, H D Röher","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The high recurrence rate of hyperthyroidism after drug therapy in Graves disease and the high incidence of differentiated thyroid cancer in autonomously functioning thyroid nodules are the most common indications for surgical treatment in children and adolescents (less than 18 years old). Between April 1986 and March 1998, 101 adolescents were operated on: 24 children (23.8%) for Graves disease, 9 adolescents (8.9%) for autonomously functioning thyroid nodules. Surgery for hyperthyroidism is recommended in children and adolescents because of the low morbidity, the guarantee that this approach will successfully treat hyperthyroidism and the necessity for histological exploration.</p>","PeriodicalId":77239,"journal":{"name":"Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress","volume":"115 ","pages":"1048-50"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20836818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G O Hofmann, M H Kirschner, O Gonschorek, V Bühren
{"title":"[Bridging long bone and joint defects with allogeneic vascularized transplants].","authors":"G O Hofmann, M H Kirschner, O Gonschorek, V Bühren","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Three patients with large osseous defects following trauma and infection received vascularized allogeneic femoral diaphyses and five patients vascularized allogeneic total knee joints. From the surgical aspect these transplantations are technically feasible. The remaining problems are of immunological nature; at least in patients with allogeneic synovial joints, lifelong immunosuppression seems to be currently unavoidable.</p>","PeriodicalId":77239,"journal":{"name":"Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress","volume":"115 ","pages":"1285-7"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20836822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Minimal invasive surgical treatment of coronary multi-vessel disease].","authors":"V Gulielmos, M Knaut, R Cichon, T Jost, S Schüler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To reduce surgical trauma and median sternotomy related complications in cardiac surgery, a new minimally invasive surgical technique has been developed for the treatment of coronary artery multivessel disease using a small left lateral chest incision in the 3rd intercostal space. This technique enables direct LIMA harvesting and performance of bypass surgery upon all coronary vessels with cardiopulmonary bypass and cardioplegic arrest. So far, 123 patients have been treated with this procedure and survived with fewer complications, and we believe that routine application of this procedure will lead to reduced morbidity in patients receiving coronary artery bypass surgery, short hospital stay and early convalescence, combined with good cosmetic results.</p>","PeriodicalId":77239,"journal":{"name":"Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress","volume":"115 ","pages":"1509-12"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20836830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Peripheral prosthesis bypass for saving the extremity].","authors":"U Stockmann, C Albiker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report the results of more than 1000 PTFE tibial bypass implantations during the last 20 years. An extra-anatomic lateral bypass to the peroneal or tibial artery prevents angulation problems. Using the Linton patch technique, early results improved to 85%. In the context of redo-operations long-term results are enhanced through the consistent use of PIDDA catheter. In 57% we achieved our purpose: limb salvage until the death of the patient or for 3-7 years (3.8 years in the middle) at the time of reexamination. Two examples of lateral tibial bypasses are given that have been functioning for 18 years.</p>","PeriodicalId":77239,"journal":{"name":"Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress","volume":"115 ","pages":"544-6"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20837106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}