M Schwarzbach, F Willeke, M Eble, M Wannenmacher, T Lehnert, C Herfarth
{"title":"[Morbidity and tumor control in limb-saving resection with intraoperative radiotherapy in a multimodality therapy concept in soft tissue sarcoma].","authors":"M Schwarzbach, F Willeke, M Eble, M Wannenmacher, T Lehnert, C Herfarth","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study evaluates limb-saving surgery (LSS) combined with intraoperative radiotherapy (IORT) and external beam radiotherapy (EBRT) for extremity sarcoma. Prospectively gathered data was analyzed for 50 patients. Advanced stages (UICC IIB-IIIB) predominated (80%) and 50% of the tumors were recurrent. Early local morbidity amounted to 32%, including wound infection (6), skin necrosis (3), hematoma (3) and others (4). Late morbidity of 10% consisted of a fracture, a fibrosis, two chronic lymphedemas and a neuropathy. One patient died (pulmonary embolism). Local control was obtained in 91% with an overall 3-year survival rate of 81% in cases treated with curative intent (follow-up 29 months). No survival benefit was found for patients with microscopically clear margins; however, local failure occurred less frequently (p = 0.02). Our results support the use of LSS with IORT and EBRT for extremity sarcoma and emphasize the importance of the surgical margin.</p>","PeriodicalId":77239,"journal":{"name":"Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress","volume":"115 ","pages":"1312-5"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20837376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Does sentinel node biopsy (SNB) solve the problem of elective lymph node excision in malignant melanoma?].","authors":"J Göhl, T Meyer, W Hohenberger","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Elective lymph node dissection in high-risk melanoma has been hotly debated for years. The technique of sentinel node (SN) biopsy may be a solution to the problem. Consequently, radical lymph node dissection is restricted to patients with an actual metastatic involvement of the SN (20-25%). The use of a hand-held gamma probe increases accuracy of SN detection.</p>","PeriodicalId":77239,"journal":{"name":"Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress","volume":"115 ","pages":"1319-23"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20837378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Plasma separation and bilirubin adsorption therapy in excessive hyperbilirubinemia after liver transplantation].","authors":"R Ott, G Born, V Müller, F Köckerling","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Reduction of bilirubin levels by various means has been proposed as symptomatic therapy for excessive jaundice in various end-stage liver diseases, since it exerts multiple toxic effects and may thereby promote multiple organ failure. Plasma separation and bilirubin adsorption by an anion-exchange column (BR-350) performed in four patients with excessive hyperbilirubinemia after liver transplantation resulted in a 29%-70% reduction in total serum bilirubin, accompanied by significant improvement of multiple organ failure or encephalopathy in three patients. Bilirubin adsorption may be beneficial in complicated jaundice after hepatic transplantation and should further be evaluated for its clinical indications.</p>","PeriodicalId":77239,"journal":{"name":"Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress","volume":"115 ","pages":"1563-5"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20837392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Video-assisted thoracoscopy for effective palliation of malignant pleural effusion. Pleurodesis--pleuroperitoneal shunt].","authors":"A S Böhle, R Kurdow, P Dohrmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Dyspnea and reduced physical capability mean a significant reduction in quality of life of patients with advanced tumor disease. Video-assisted thoracoscopic talc poudrage or alternatively placement of pleuroperitoneal shunts were retrospectively evaluated as procedures for definitive palliation.</p>","PeriodicalId":77239,"journal":{"name":"Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress","volume":"115 ","pages":"1268-70"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20837530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Kruschewski, N Runkel, C Becker, E Riede, F Opri, R Heicappell, H J Buhr
{"title":"[Rectal resection within the scope of multi-visceral interdisciplinary resection in the pelvis].","authors":"M Kruschewski, N Runkel, C Becker, E Riede, F Opri, R Heicappell, H J Buhr","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Multivisceral resectioning is the only curative treatment for progressive carcinomas extending beyond the organ. The results of 25 consecutively operated patients are presented in this prospective observational study. Twelve patients underwent surgery for a primary tumor and 13 for a recurrence. Radical resectioning was achieved in 5 of 12 and in 3 of 13 patients. Restoration of continuity obtained in 11 of 12 and in 7 of 13 patients. Morbidity was 33% and 62%. None of the patients died from complications. An aggressive surgical approach is justifiable on account of the acceptable morbidity and mortality as well as the high rate of preserved continence through modern reconstruction procedures.</p>","PeriodicalId":77239,"journal":{"name":"Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress","volume":"115 ","pages":"251-4"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20837637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Esophageal carcinoma. Staging and necessary preoperative diagnosis].","authors":"N Senninger","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The routine examination in esophageal carcinoma includes the following established recommendations: endoscopy with biopsy--X-ray of the esophagus--endosonography--cervico-thoraco-abdominal CT scan--bronchoscopy in tumors of the upper half of the esophagus. Diagnostic laparoscopy is gaining increasing importance, especially with regard to the distal adenocarcinoma of the esophagus. Other new diagnostic tools directly influencing clinical practice are magnetic resonance tomography, positron emission tomography and possibly the detection of circulating or bone marrow tumor cells.</p>","PeriodicalId":77239,"journal":{"name":"Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress","volume":"115 ","pages":"281-3"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20837642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Optimal postoperative nutrition: pro and contra enteral and parenteral feeding].","authors":"U Bolder, K W Jauch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Malnutrition is correlated with an increased incidence of postoperative complications. As a consequence, preoperative hyperalimentation results in a decrease of postoperative complications in patients with malnutrition. In contrast, the beneficial effects of postoperative nutritional support are still to be proven. The majority of prospective trials have shown limited advantageous effects for patients with delayed nutritional intake after the surgical procedure. In these patients enteral nutrition has been shown to reduce the rate of infectious complications. If enteral nutrition cannot be applied, the addition of glutamine as a dipeptide is beneficial with regard to intestinal barrier function.</p>","PeriodicalId":77239,"journal":{"name":"Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress","volume":"115 ","pages":"587-91"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20837644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
W Ertel, A Oberholzer, A Platz, R Stocker, O Trentz
{"title":"[Abdominal compartment syndrome after severe abdominal and/or pelvic trauma].","authors":"W Ertel, A Oberholzer, A Platz, R Stocker, O Trentz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The incidence of the abdominal compartment syndrome (ACS) after severe abdominal and/or pelvic trauma is 3%. ACS occurs within hours and causes severe organ dysfunction. Decompressive emergency laparotomy restores this impaired organ function.</p>","PeriodicalId":77239,"journal":{"name":"Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress","volume":"115 ","pages":"1189-90"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20837679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Fas/Fas ligand mRNA are expressed in Helicobacter pylori infected mucosa].","authors":"F Meyer, S P James","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Helicobacter pylori (Hp) seems to possess an inflammatory as well as immun-modulatory potential. The investigation revealed that both Fas and FasLigand are expressed in the gastric mucosa independently of the Hp infection status and with no significant difference to the expression profile in PBMC. In conclusion, Fas-FasLigand interaction could play a role in immune regulation of Hp gastritis and induction or mediation of epithelial injury.</p>","PeriodicalId":77239,"journal":{"name":"Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress","volume":"115 ","pages":"1150-2"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20837755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H P Wüllenweber, C Sutter, M Kadmon, J Gebert, M von Knebel-Doeberitz, C Herfarth
{"title":"[Modification of surgical strategy in HNPCC by molecular and clinical aspects].","authors":"H P Wüllenweber, C Sutter, M Kadmon, J Gebert, M von Knebel-Doeberitz, C Herfarth","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Because of the positive correlation between Amsterdam criteria and positive MSI analysis, a subtotal colectomy with ileorectal anastomosis seems to be indicated in patients with positive Amsterdam criteria to eliminate the high risk of metachronous colon cancer. In patients with an identified mutation in one of the known mismatch repair genes, a subtotal colectomy is indicated as well. In patients with positive Bethesda criteria, apart from the Amsterdam criteria, a subtotal colectomy seems only to be indicated if a positive MSI analysis is available.</p>","PeriodicalId":77239,"journal":{"name":"Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress","volume":"115 ","pages":"1408-10"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20837766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}