Important advances in oncology最新文献_第6页

The MDR superfamily of genes and its biological implications. 耐多药基因超家族及其生物学意义。

Important advances in oncology Pub Date : 1994-01-01

S Childs, V Ling

引用次数: 0

The significance of the rising incidence of breast cancer in the United States. 美国乳腺癌发病率上升的意义。

Important advances in oncology Pub Date : 1994-01-01

B A Miller, E J Feuer, B F Hankey

引用次数: 0

Chemotherapy and radiation in the nonoperative management of stage III non-small-cell lung cancer: the right chemotherapy works in the right setting. 化疗和放疗在III期非小细胞肺癌非手术治疗中的作用:正确的化疗在正确的环境下起作用。

Important advances in oncology Pub Date : 1993-01-01

M R Green

{"title":"Chemotherapy and radiation in the nonoperative management of stage III non-small-cell lung cancer: the right chemotherapy works in the right setting.","authors":"M R Green","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Approximately one-quarter of all American patients with NSCLC present with stage III disease. At least to this juncture, standard management for the large majority of these patients is nonoperative, except for staging mediastinoscopy. Radiation therapy alone to 6000 cGy or above given in once-daily fractions 5 days per week is usually considered \"standard\" therapy. While this approach causes disease shrinkage in one-third to two-thirds of patients treated, long-term local control with this benchmark radiotherapy is poor, the median time to progression is less than 6 months, and median survival for treated patients is less than 1 year. Combination CT is more effective in inducing tumor regression in stage III than in stage IV NSCLC patients. The administration of a short course of induction CT (two to three cycles) prior to definitive XRT improves median and overall survival among stage III patients. In individuals with stage III disease selected for good performance status (0 to 1), minimum weight loss (< 5%), and no supraclavicular node involvement, sequential CT/XRT is associated with a survival plateau above 20% at 2 years, 3 years, and beyond. Local failure and distant failure both remain as problems despite the survival improvements produced by sequential CT/XRT. Concurrent chemoradiation, especially utilizing daily low-dose cisplatin, improves local control significantly and lengthens survival. Increased intensity of TRT using multifraction-per-day schedules or more active induction CT programs also may improve local control and perhaps affect overall survival. Trials now underway are testing sequences of induction CT followed by concurrent CT/XRT or rapid fractionation schemes and concurrent cisplatin-based combination CT. These strategies will hopefully produce yet another step up for the plateau phase of the survival curve for patients with stage III NSCLC.</p>","PeriodicalId":77172,"journal":{"name":"Important advances in oncology","volume":" ","pages":"125-37"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19374996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of cytokines in radiation oncology. 细胞因子在放射肿瘤学中的作用。

Important advances in oncology Pub Date : 1993-01-01

D E Hallahan, A Haimovitz-Friedman, D W Kufe, Z Fuks, R R Weichselbaum

引用次数: 0

Early diagnosis of prostate cancer. 早期诊断前列腺癌。

Important advances in oncology Pub Date : 1993-01-01

G S Gerber, G W Chodak

引用次数: 0

Hormonal manipulation in the adjuvant treatment of breast cancer. 激素调控在乳腺癌辅助治疗中的应用。

Important advances in oncology Pub Date : 1993-01-01

S F Honig, S M Swain