Important advances in oncology最新文献

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Genetic alterations associated with bladder cancer. 与膀胱癌相关的基因改变
Important advances in oncology Pub Date : 1994-01-01
C Cordon-Cardo, G Dalbagni, A S Sarkis, V E Reuter
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引用次数: 0
Apoptosis and cancer. 细胞凋亡和癌症。
Important advances in oncology Pub Date : 1994-01-01
D R Green, R P Bissonnette, T G Cotter
{"title":"Apoptosis and cancer.","authors":"D R Green, R P Bissonnette, T G Cotter","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77172,"journal":{"name":"Important advances in oncology","volume":" ","pages":"37-52"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19195478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monoclonal antibodies to detect breast cancer cells in bone marrow. 检测骨髓中乳腺癌细胞的单克隆抗体。
Important advances in oncology Pub Date : 1994-01-01
I J Diel, M Kaufmann, S D Costa, G Bastert
{"title":"Monoclonal antibodies to detect breast cancer cells in bone marrow.","authors":"I J Diel, M Kaufmann, S D Costa, G Bastert","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77172,"journal":{"name":"Important advances in oncology","volume":" ","pages":"143-64"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19195471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genes coding for tumor rejection antigens: perspectives for specific immunotherapy. 肿瘤排斥抗原的基因编码:特异性免疫治疗的观点。
Important advances in oncology Pub Date : 1994-01-01
T Boon, P Coulie, M Marchand, P Weynants, T Wölfel, V Brichard
{"title":"Genes coding for tumor rejection antigens: perspectives for specific immunotherapy.","authors":"T Boon, P Coulie, M Marchand, P Weynants, T Wölfel, V Brichard","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77172,"journal":{"name":"Important advances in oncology","volume":" ","pages":"53-69"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19196084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitamins and cancer: a practical means of prevention? 维生素和癌症:一种实用的预防手段?
Important advances in oncology Pub Date : 1994-01-01
K B Michels, W C Willett
{"title":"Vitamins and cancer: a practical means of prevention?","authors":"K B Michels, W C Willett","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77172,"journal":{"name":"Important advances in oncology","volume":" ","pages":"85-114"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19196085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-IL-2 receptor monoclonal antibody (anti-Tac) treatment of T-cell lymphoma. 抗IL-2受体单克隆抗体(anti-Tac)治疗T细胞淋巴瘤。
Important advances in oncology Pub Date : 1994-01-01
T A Waldmann
{"title":"Anti-IL-2 receptor monoclonal antibody (anti-Tac) treatment of T-cell lymphoma.","authors":"T A Waldmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The abnormal and activated T cells in certain neoplasms of mononuclear cells, select autoimmune disorders, and organ allograft rejection express the IL-2R alpha subunit identified by the anti-Tac monoclonal antibody. In contrast, normal resting cells do not express this inducible receptor. Patients with ATL were treated with different forms of IL-2R-directed therapy to exploit the difference in IL-2R expression between normal and malignant cells. Using the unmodified anti-Tac monoclonal antibody, 7 of 19 patients with ATL treated have undergone a remission (2 cases complete), with no toxicity observed. Unmodified murine monoclonal antibodies are limited by their immunogenicity and poor effector functions. Genetic engineering was used to produce humanized anti-Tac that contains the complementarity-determining regions from the mouse with the remainder of the molecule derived from human IgG1-kappa. This antibody is less immunogenic than the murine version, has improved pharmacokinetics, and, in contrast with the parent antibody, manifests ADCC with human mononuclear cells. To enhance its effector function, anti-Tac was armed with toxins or with alpha- and beta-emitting radionuclides. In a clinical trial with 90Y-anti-Tac at the doses used (5, 10, and 15 microCi), 11 of the 17 patients with ATL underwent a partial or sustained a complete remission. Thus, the clinical application of IL-2R-directed therapy represents a new perspective for the treatment of T-cell lymphomas, including HTLV-I-associated ATL.</p>","PeriodicalId":77172,"journal":{"name":"Important advances in oncology","volume":" ","pages":"131-41"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19195470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of early stage prostate cancer: radical prostatectomy. 早期前列腺癌的治疗:根治性前列腺切除术。
Important advances in oncology Pub Date : 1994-01-01
P C Walsh, A W Partin
{"title":"Treatment of early stage prostate cancer: radical prostatectomy.","authors":"P C Walsh,&nbsp;A W Partin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77172,"journal":{"name":"Important advances in oncology","volume":" ","pages":"211-23"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19195475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of early stage prostate cancer: conservative management--delayed therapy. 早期前列腺癌的治疗:保守治疗-延迟治疗。
Important advances in oncology Pub Date : 1994-01-01
G W Chodak
{"title":"Treatment of early stage prostate cancer: conservative management--delayed therapy.","authors":"G W Chodak","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77172,"journal":{"name":"Important advances in oncology","volume":" ","pages":"241-4"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19195476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunotoxins and recombinant toxins for cancer treatment. 用于治疗癌症的免疫毒素和重组毒素。
Important advances in oncology Pub Date : 1994-01-01
L H Pai, I Pastan
{"title":"Immunotoxins and recombinant toxins for cancer treatment.","authors":"L H Pai, I Pastan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77172,"journal":{"name":"Important advances in oncology","volume":" ","pages":"3-19"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19195477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolated limb perfusion with high-dose tumor necrosis factor for extremity melanoma and sarcoma. 高剂量肿瘤坏死因子灌注离体肢体治疗四肢黑色素瘤和肉瘤。
Important advances in oncology Pub Date : 1994-01-01
D L Fraker, H R Alexander
{"title":"Isolated limb perfusion with high-dose tumor necrosis factor for extremity melanoma and sarcoma.","authors":"D L Fraker,&nbsp;H R Alexander","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77172,"journal":{"name":"Important advances in oncology","volume":" ","pages":"179-92"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19195473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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