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Important advances in oncology最新文献

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Tumor angiogenesis and the role of vascular cell integrin alphavbeta3. 肿瘤血管生成与血管细胞整合素的作用。
Important advances in oncology Pub Date : 1996-01-01
J A Varner, D A Cheresh
{"title":"Tumor angiogenesis and the role of vascular cell integrin alphavbeta3.","authors":"J A Varner,&nbsp;D A Cheresh","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Angiogenesis is a critical process for the growth and metastatic properties of all solid tumors. Recent biological and molecular studies have begun to elucidate the basic mechanisms of vascular cell proliferation, motility, and differentiation in vitro and in vivo. With this knowledge, it should be feasible to devise therapeutic strategies to selectively target and perturb the biological processes of angiogenic vascular cells, thereby leading to effective inhibitors of angiogenesis. This strategy has led to the development of antagonists to integrin alpha v beta 3, which promote the unscheduled programmed cell death of newly sprouting blood vessels. These antagonists cause regression of preestablished human tumors growing in laboratory animals and thus may lead to an effective therapeutic approach for most solid tumors in humans. Studies are currently aimed at designing highly specific small organic integrin inhibitors that will disrupt the signals enabling vascular cells to respond to the tumor-associated extracellular environment and to promote tumor-induced angiogenesis.</p>","PeriodicalId":77172,"journal":{"name":"Important advances in oncology","volume":" ","pages":"69-87"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19762873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adoptive cell therapy with donor lymphocytes for EBV-associated lymphomas developing after allogeneic marrow transplants. 供体淋巴细胞过继细胞治疗异基因骨髓移植后发生的ebv相关淋巴瘤。
Important advances in oncology Pub Date : 1996-01-01
R J O'Reilly, J F Lacerda, K G Lucas, N S Rosenfield, T N Small, E B Papadopoulos
{"title":"Adoptive cell therapy with donor lymphocytes for EBV-associated lymphomas developing after allogeneic marrow transplants.","authors":"R J O'Reilly,&nbsp;J F Lacerda,&nbsp;K G Lucas,&nbsp;N S Rosenfield,&nbsp;T N Small,&nbsp;E B Papadopoulos","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77172,"journal":{"name":"Important advances in oncology","volume":" ","pages":"149-66"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19762878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is there a role for physician-assisted suicide in cancer? No. 医生协助自杀在癌症中是否有作用?不。
Important advances in oncology Pub Date : 1996-01-01
M Siegler
{"title":"Is there a role for physician-assisted suicide in cancer? No.","authors":"M Siegler","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77172,"journal":{"name":"Important advances in oncology","volume":" ","pages":"281-91"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19762888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
p53 and response to chemotherapy and radiotherapy. P53和对化疗和放疗的反应。
Important advances in oncology Pub Date : 1996-01-01
H E Ruley
{"title":"p53 and response to chemotherapy and radiotherapy.","authors":"H E Ruley","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77172,"journal":{"name":"Important advances in oncology","volume":" ","pages":"37-56"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19763071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evidence for and implications of SV40-like sequences in human mesotheliomas. sv40样序列在人类间皮瘤中的证据和意义。
Important advances in oncology Pub Date : 1996-01-01
H I Pass, R C Kennedy, M Carbone
{"title":"Evidence for and implications of SV40-like sequences in human mesotheliomas.","authors":"H I Pass,&nbsp;R C Kennedy,&nbsp;M Carbone","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77172,"journal":{"name":"Important advances in oncology","volume":" ","pages":"89-108"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19762874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laparoscopic resection for colon cancer: a favorable view. 腹腔镜结肠癌切除术:一个有利的观点。
Important advances in oncology Pub Date : 1996-01-01
D M Ota
{"title":"Laparoscopic resection for colon cancer: a favorable view.","authors":"D M Ota","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77172,"journal":{"name":"Important advances in oncology","volume":" ","pages":"227-9"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19762882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is axillary lymph node dissection necessary in routine management of breast cancer? No. 腋窝淋巴结清扫在乳腺癌常规治疗中是否必要?不。
Important advances in oncology Pub Date : 1996-01-01
B Cady
{"title":"Is axillary lymph node dissection necessary in routine management of breast cancer? No.","authors":"B Cady","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77172,"journal":{"name":"Important advances in oncology","volume":" ","pages":"251-65"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19762885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BCL-6 in diffuse large-cell lymphomas. 弥漫性大细胞淋巴瘤中的BCL-6。
Important advances in oncology Pub Date : 1996-01-01
R Dalla-Favera, B H Ye, G Cattoretti, F Lo Coco, C C Chang, J Zhang, A Migliazza, K Cechova, H Niu, S Chaganti, W Chen, D C Louie, K Offit, R S Chaganti
{"title":"BCL-6 in diffuse large-cell lymphomas.","authors":"R Dalla-Favera,&nbsp;B H Ye,&nbsp;G Cattoretti,&nbsp;F Lo Coco,&nbsp;C C Chang,&nbsp;J Zhang,&nbsp;A Migliazza,&nbsp;K Cechova,&nbsp;H Niu,&nbsp;S Chaganti,&nbsp;W Chen,&nbsp;D C Louie,&nbsp;K Offit,&nbsp;R S Chaganti","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77172,"journal":{"name":"Important advances in oncology","volume":" ","pages":"139-48"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19762877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of tumor-regression antigens in melanoma. 黑色素瘤肿瘤消退抗原的鉴定。
Important advances in oncology Pub Date : 1996-01-01
Y Kawakami, P F Robbins, R F Wang, S A Rosenberg
{"title":"Identification of tumor-regression antigens in melanoma.","authors":"Y Kawakami,&nbsp;P F Robbins,&nbsp;R F Wang,&nbsp;S A Rosenberg","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77172,"journal":{"name":"Important advances in oncology","volume":" ","pages":"3-21"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19763069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Telomerase and cancer. 端粒酶和癌症。
Important advances in oncology Pub Date : 1996-01-01
C B Harley, N W Kim
{"title":"Telomerase and cancer.","authors":"C B Harley,&nbsp;N W Kim","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The data reviewed here suggest that telomere dynamics and telomerase expression are fundamentally involved in cellular aging and cancer. Of particular importance is the stabilization of telomeres by activation of telomerase and the association of this process with cell immortality and human malignancies. Thus, we believe that cell immortalization is required for long-term growth of the vast majority of malignant or metastatic tumors and that advances in telomere biology and telomerase inhibition will improve the way cancers are diagnosed and treated. We look forward to the clinical evaluation of these bold predictions.</p>","PeriodicalId":77172,"journal":{"name":"Important advances in oncology","volume":" ","pages":"57-67"},"PeriodicalIF":0.0,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19763072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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