Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering最新文献

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Kinetic modeling of fluid and solute transport in peritoneal dialysis. 腹膜透析中液体和溶质转运的动力学模型。
A Werynski, J Waniewski, B Lindholm
{"title":"Kinetic modeling of fluid and solute transport in peritoneal dialysis.","authors":"A Werynski,&nbsp;J Waniewski,&nbsp;B Lindholm","doi":"10.1163/15685570052061964","DOIUrl":"https://doi.org/10.1163/15685570052061964","url":null,"abstract":"<p><p>Mathematical models for fluid and solute transport during peritoneal dialysis are described. A model for the transport of the so-called volume marker enables the correct estimation of the kinetics of the intraperitoneal dialysate volume as well as the rate of peritoneal fluid absorption. On the basis of these estimations, the solute transport components (diffusion, convective solute transport with ultrafiltrate and peritoneal solute absorption) may be separated within the net solute transport using a modified version of the Babb-Randerson-Farrell (BRF) model. The diffusive mass transport coefficient and sieving coefficient are given by the model. A simplified method for the estimation of the diffusive mass transport coefficient during the so-called isovolemia period is also described and compared to the BRF modeling. The three-pore model and the distributed model, which describe the structure-function relationship for the peritoneum, are also addressed.</p>","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"10 2","pages":"105-15"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1163/15685570052061964","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21740041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Manifestation of internal organs malfunction by laser Doppler study on microcirculation. 微循环激光多普勒研究内脏功能障碍的表现。
R Maniewski, A Liebert
{"title":"Manifestation of internal organs malfunction by laser Doppler study on microcirculation.","authors":"R Maniewski,&nbsp;A Liebert","doi":"10.1163/15685570052062701","DOIUrl":"https://doi.org/10.1163/15685570052062701","url":null,"abstract":"<p><p>Monitoring of microvascular blood perfusion provides very specific information on the proper function or malfunction of some internal organs, e.g. the pancreas and kidney. The laser Doppler method was used to measure microperfusion in the skin of the lower limb of diabetic patients and patients undergoing hemodialysis. This method offers non-invasive, real-time monitoring and is already accepted in many clinical experiments. The method and the laser Doppler instruments used are described. Special attention is paid to the investigation of microvascular abnormality in diabetes by using a multichannel laser Doppler system during postocclusive reactive hyperemia. The study group consisted of 41 diabetes and 24 healthy subjects with no history of family diabetes. The most valuable data were obtained from the probe located on the most distal part of the foot. Some hyperemic parameters (maximum of hyperemic response, time to peak flow) were significantly different for the diabetic group as comparing to the norm. In the microcirculation study during hemodialysis, three patients with kidney dysfunction were investigated. Increase in red blood cell velocity was observed, probably caused by better distribution of blood to the peripheral circulation.</p>","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"10 3","pages":"233-8"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1163/15685570052062701","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21845932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Unconstrained physiological monotoring in daily living for health care. 无约束的生理监测在日常生活中的医疗保健。
K Yamakoshi
{"title":"Unconstrained physiological monotoring in daily living for health care.","authors":"K Yamakoshi","doi":"10.1163/15685570052062710","DOIUrl":"https://doi.org/10.1163/15685570052062710","url":null,"abstract":"<p><p>This paper deals with the recent development of two types of non-invasive physiological monitoring systems for possible application in an unconstrained manner to normal subjects for health care as well as to patients and/or outpatients with disorders or with life support systems (artificial organs and organ transplantations). One is an ambulatory monitoring system which allows automatic acquisition of blood pressure, cardiac output and other cardiovascular hemodynamic parameters on a beat-by-beat basis using the volume-compensation and transthoracic electrical admittance method. The other is a home monitoring system installed in a lavatory which can measure body and excreta weight together with the ballistocardiogram as an index of cardiac ejecting function in an unaware fashion without attachment of any sensors to the subject's body and without special operations for measurement during toilet use. Outlines of these two systems and monitoring results of laboratory and field testings are presented, and these suggest that the ambulatory and non-conscious physiological monitoring techniques described herein appear promising as a valuable and helpful means for use in research as well as in the practical field of health monitoring at home during daily living.</p>","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"10 3","pages":"239-59"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1163/15685570052062710","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21845933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 31
Urea biosensors and their application in hemodialysis--perspective of EnFET application. 尿素生物传感器及其在血液透析中的应用——EnFET应用的展望。
W Torbicz, D G Pijanowska, M Dawgul
{"title":"Urea biosensors and their application in hemodialysis--perspective of EnFET application.","authors":"W Torbicz,&nbsp;D G Pijanowska,&nbsp;M Dawgul","doi":"10.1163/15685570052061991","DOIUrl":"https://doi.org/10.1163/15685570052061991","url":null,"abstract":"<p><p>Parameters such as blood urea nitrogen concentration, normalized protein catabolic rate and Kt/V that are utilized for urea concentration measurements in blood and dialysate for the optimization of the hemodialysis process are reviewed in the paper. Basic methods of urea concentration measurement are described. Urea biosensors of the EnFET type based on the pH-sensitive Si3N4 gate FET and pNH4-sensitive FET with a Siloprene membrane containing nonactine, both of our own construction, are presented. Application of these biosensors for urea concentration measurement in blood and dialysate is described. An experimental microdialysis system with urease in detector solution and a pH-ISFET detector are described. A comparison of two dialysis procedures, with a commercial dialysate an initial of pH 5.6 and with pH kept lowered during the dialysis process applied to rats, is given.</p>","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"10 2","pages":"139-45"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1163/15685570052061991","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21740044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Functions of masseter and temporalis muscles in the control of temporomandibular joint loading--a static analysis using a two-dimensional rigid-body spring model. 咬肌和颞肌在控制颞下颌关节负荷中的作用——使用二维刚体弹簧模型的静态分析。
K I Itoh, T Hayashi
{"title":"Functions of masseter and temporalis muscles in the control of temporomandibular joint loading--a static analysis using a two-dimensional rigid-body spring model.","authors":"K I Itoh,&nbsp;T Hayashi","doi":"10.1163/15685570052061513","DOIUrl":"https://doi.org/10.1163/15685570052061513","url":null,"abstract":"<p><p>Masticatory forces or bite forces applied to the teeth are known to generate a compressive force on the temporomandibular joint (TMJ). This intra-articular force is referred to as TMJ loading. TMJ loading is considered to be controlled to a certain extent by the stomatognathic system, so as not to exceed a certain limit. In order to clarify the control mechanism of the TMJ during biting, the controllability of TMJ loading through coordinated activities of the masticatory muscles has been numerically analyzed using a static two-dimensional jaw model. This model consists of a rigid-body model of the jaws and a spring model of the articular disk, which includes three dominant muscle force vectors representing the masseter, temporalis and lateral pterygoid muscles. The bite force vector is assumed to be applied solely at the first molar. Static equilibrium analyses suggest that coordinated activities of the masseter muscle and anterior portion of the temporalis muscle can minimize TMJ loading and concentrate the stress within the articular disk to the intermediate zone of the disk, and that the activity of the posterior portion of the temporalis muscle has the possibility of reducing TMJ loading.</p>","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"10 1","pages":"17-31"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1163/15685570052061513","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21739324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Preliminary study of continuous glucose monitoring with a microdialysis technique and a null method--a numerical analysis. 微透析技术及零值法连续血糖监测的初步研究——数值分析。
T Tamura, K Koseki, T Sumino, M Ogawa, T Togawa, K Tsuchiya
{"title":"Preliminary study of continuous glucose monitoring with a microdialysis technique and a null method--a numerical analysis.","authors":"T Tamura,&nbsp;K Koseki,&nbsp;T Sumino,&nbsp;M Ogawa,&nbsp;T Togawa,&nbsp;K Tsuchiya","doi":"10.1163/15685570052062008","DOIUrl":"https://doi.org/10.1163/15685570052062008","url":null,"abstract":"<p><p>Monitoring of the subcutaneous tissue glucose concentration is an attractive method for continuous monitoring of the glucose concentration in diabetic patients. Several researchers have studied this, but no satisfactory method has been developed. We have proposed a new method, which can measure the glucose concentration of subcutaneous tissue continuously, even as the efficiency of membrane perfusion and sensor performance decline. Two reference solutions were prepared with concentrations higher and lower than the objective solution. They were perfused alternately for different ratios of perfusion times. The glucose concentration, after perfusing microdialysis, was detected and the trend of changes in the concentration was used to control the ratio of the two perfusion solutions. When the trend was a unity, the glucose concentration was calculated from the ratio of the two perfusion solutions. The numerical study was performed with a compartment model and a basic control theory. In simulation, the 90% response time to step change was approximately 7 min, which is fast enough when compared with the fluctuation of glucose in the electrolyte. This result suggested that this new system might be useful for continuous monitoring of the glucose concentration in subcutaneous tissue.</p>","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"10 2","pages":"147-56"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1163/15685570052062008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21740045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Blood purification by a membrane technique--a new method for the effective removal of low-density lipoprotein cholesterol. 膜技术净化血液——一种有效去除低密度脂蛋白胆固醇的新方法。
J M Wójcicki, A Ciechanowska, W Strobl, S Sabalińska, D Falkenhagen
{"title":"Blood purification by a membrane technique--a new method for the effective removal of low-density lipoprotein cholesterol.","authors":"J M Wójcicki,&nbsp;A Ciechanowska,&nbsp;W Strobl,&nbsp;S Sabalińska,&nbsp;D Falkenhagen","doi":"10.1163/15685570052061982","DOIUrl":"https://doi.org/10.1163/15685570052061982","url":null,"abstract":"<p><p>A membrane plasma fractionation (MPS) technique is applied in order to obtain selective removal of pathological plasma components from the extracorporeal circuit. An effective plasma fractionation procedure should be characterized by the highest possible removal of the pathological plasma components and, equally as important, the lowest unwanted protein losses caused mainly by adsorption to the membrane structure. In order to obtain a higher efficiency of the MPS procedure (high selectivity between removal of pathological plasma components and unwanted losses mainly represented by albumin) several methods such as thermofiltration, application of pulsate flow at the end of secondary filter, etc. have been developed. Clinical verification of these methods led to some improvement in MPS procedure but these results did not seem to be optimal. The main objective of this paper is to present a new two-stage membrane system utilizing a high flow recirculation circuit developed particularly, but not only, for effective removal of low-density lipoprotein cholesterol. The designed and developed system has been tested in vitro using several different plasma fractionation membranes. The results obtained indicated the importance of the membrane structure and membrane material on the efficiency of the tested plasma fractionation procedure. It was also found that it is possible to obtain negligible protein losses for some selected membrane structures applied in the assessed system. Based on preliminary results, it seems that the new two-stage membrane system proposed could be characterized by a very low range of unwanted protein losses leading to high effectiveness of the plasma fractionation procedure.</p>","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"10 2","pages":"131-7"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1163/15685570052061982","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21740043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Maximal flow pulsation in the pial arterioles of rats at increased intracranial pressure. 颅内压升高时大鼠心脏小动脉最大血流脉动。
J Seki, Y Sasaki, T Oyama, J Yamamoto
{"title":"Maximal flow pulsation in the pial arterioles of rats at increased intracranial pressure.","authors":"J Seki,&nbsp;Y Sasaki,&nbsp;T Oyama,&nbsp;J Yamamoto","doi":"10.1163/15685570052061540","DOIUrl":"https://doi.org/10.1163/15685570052061540","url":null,"abstract":"<p><p>Red cell velocity in the brain pial arterioles ( 12-58 microm in diameter) of rats was measured by a fiber-optic laser-Doppler anemometer microscope to study the effects of intracranial pressure (ICP) on flow pulsation. The amplitude of velocity pulsation in the pial arterioles was 24+/-9% (mean +/- SD) of the temporal mean velocity under normal physiological conditions (ICP = 5 mmHg). It increased gradually up to 40+/-11% with increasing ICP up to 50 mmHg on average. It also increased with the vessel diameter at fixed values of ICP. In each arteriole, the velocity amplitude increased steeply at a critical value of ICP as ICP increased. The critical value of ICP ranged between 20 and 40 mmHg,. increased with the vessel diameter, and decreased downstream along arterial trees. These results suggest a correlation between the critical ICP and the internal pressure of the pial arteriole.</p>","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"10 1","pages":"59-66"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1163/15685570052061540","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21739327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Acquisition of long-term cardiac signals for chronodiagnostic utility. 用于时间诊断的长期心脏信号采集。
M Ishijima
{"title":"Acquisition of long-term cardiac signals for chronodiagnostic utility.","authors":"M Ishijima","doi":"10.1163/15685570052062729","DOIUrl":"https://doi.org/10.1163/15685570052062729","url":null,"abstract":"<p><p>Periodical and long-term examination of the cardiac function is important for detecting early-stage disorders, and contributing to chronodiagnosis and chronotherapeutics. Frequent or daily examination utilizing the present test procedures, however, places the patient under stress even when it is administered at home and not during a hospital visit. In order to cope with this issue, monitoring systems whereby a patient is not aware of being examined were developed taking the electrocardiogram (ECG) as an example. The ECG was monitored while the patient was taking a bath or sleeping in bed. The system did not utilize any body surface electrodes but introduced in-water electrodes in the bath and textile electrodes on the bed. These systems made long-term observation feasible without imposing any stress on the patient.</p>","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"10 3","pages":"261-7"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1163/15685570052062729","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21845934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulation of neural activities during visual processing in the human extrastriate visual cortex. 人类纹外层视觉皮层视觉加工过程中神经活动的调节。
F Takeuchi, Y Hirata, S Kuriki
{"title":"Modulation of neural activities during visual processing in the human extrastriate visual cortex.","authors":"F Takeuchi,&nbsp;Y Hirata,&nbsp;S Kuriki","doi":"10.1163/15685570052061522","DOIUrl":"https://doi.org/10.1163/15685570052061522","url":null,"abstract":"<p><p>Magnetoencephalographic responses to single letters (Japanese monosyllabic characters) presented in the left visual field were measured during visual cognition tasks, in which subjects judged matching of characters in two different processes based on phonological and graphical cues. Equivalent current dipoles, which represent focal neural activities, were localized in the extrastriate visual cortex of the occipital to occipitotemporal regions. The main activities were observed in the right lateral area when the subjects detected shape, and also in the medial and inferior areas of both hemispheres when they detected rhyme. These results suggest that the neural activities in the extrastriate cortex, which are related to early processing of familiar visual forms, can be modified by the top-down control.</p>","PeriodicalId":77139,"journal":{"name":"Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering","volume":"10 1","pages":"33-41"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1163/15685570052061522","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21739325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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