American Journal of Cardiology最新文献

{"title":"Vigorous But Not Moderate Physical Activity Is Associated With Reduced Cardiovascular Disease Risk In Young Hispanic Men.","authors":"Chiara Gattoni, Katelin Bebe, Rachelle Bross, Christina Wang, Ronald S Swerdloff, Ronald J Oudiz, William E Kraus, Harry B Rossiter","doi":"10.1016/j.amjcard.2025.05.021","DOIUrl":"https://doi.org/10.1016/j.amjcard.2025.05.021","url":null,"abstract":"<p><p>Physical Activity Guidelines for Americans recommend at least 150 min/week of moderate (MPA) to vigorous (VPA) physical activity to maintain health, regardless of cardiovascular disease (CVD) risk. This study assessed whether physical activity (PA) intensity distinguishes between low and high CVD risk in 196 lean and obese Hispanic men aged 18-40 from the Study of Male Reproductive Epigenomics. PA was measured for 7 days using triaxial accelerometry. The 30-year \"full\" Framingham Risk Score (FRS) was calculated. Diet quality was assessed using the Healthy Eating Index (HEI-2020). Mean age was 30 ± 5 years with a median FRS of 14% (range: 3-85%). The high-risk group (n=89) had a mean full FRS of 20.3 ± 11.1%, compared to 7.0 ± 3.6% in the low-risk group (n=107; p<0.001). Both groups met guideline-recommended PA levels. However, the low-risk group performed more VPA (25 ± 20 vs 12 ± 12 min/day; p<0.001). Logistic regressions showed that each additional 1 min/day of VPA reduced the odds of high CVD risk by 4.4% (p=0.007), adjusted for smoking, diet, age and Body Mass Index (BMI), while MPA did not significantly predict CVD risk (p=0.823). Stepwise regressions showed that smoking status, BMI, VPA, and diet explained 47.8% of FRS variance (p<0.001), while MPA was excluded. In conclusion, VPA, but not MPA, significantly distinguished low from high CVD risk in young Hispanic men, highlighting the potential role of higher-intensity exercise to reduce CVD risk in this population.</p>","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking Coronary Dissections in Drug-coated Balloon Angioplasty - A Paradigm Shift.","authors":"Abdulla Shehab, Hussien Heshmat Kassem, Rajeev Gupta","doi":"10.1016/j.amjcard.2025.05.017","DOIUrl":"https://doi.org/10.1016/j.amjcard.2025.05.017","url":null,"abstract":"","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to 'Lipid Management in United States Commercial and Medicare Enrollees With Atherosclerotic Cardiovascular Disease: Treatment Patterns and Low-Density Lipoprotein Cholesterol Control' [The American Journal of Cardiology 242 (2025) 1-9].","authors":"Ann Marie Navar, Batul Electricwala, Jasjit K Multani, Zifan Zhou, Chi-Chang Chen, Barnabie C Agatep, Allison A Petrilla, Taylor T Schwartz, Laetitia N'dri, Joaquim Cristino, Fatima Rodriguez","doi":"10.1016/j.amjcard.2025.05.010","DOIUrl":"10.1016/j.amjcard.2025.05.010","url":null,"abstract":"","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer Patients With Atrial Fibrillation Need More Aggressive Treatment to Prevent Stroke.","authors":"Gerald V Naccarelli","doi":"10.1016/j.amjcard.2025.05.014","DOIUrl":"10.1016/j.amjcard.2025.05.014","url":null,"abstract":"","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally Invasive Direct Coronary Artery Bypass or Percutaneous Coronary Intervention With Drug-Eluting Stents for Isolated Left Anterior Descending Artery Stenosis.","authors":"Gjin Ndrepepa","doi":"10.1016/j.amjcard.2025.05.016","DOIUrl":"10.1016/j.amjcard.2025.05.016","url":null,"abstract":"","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indications and Treatment Outcomes of Below-the-Knee Peripheral Artery Interventions in the XLPAD Registry","authors":"Zachary P. Rosol MD ,&nbsp;Sameh Sayfo MD ,&nbsp;David Fernandez-Vazquez MD ,&nbsp;Minseob Jeong MD ,&nbsp;Mufaddal Mamawala MBBS, MPH ,&nbsp;Anand Gupta MBBS, MPH ,&nbsp;Blake M. Bruneman BS ,&nbsp;Sarah G. Weideman BS ,&nbsp;Kennedy S. Adelman BS ,&nbsp;Shirling Tsai MD ,&nbsp;Aravinda Nanjundappa MD ,&nbsp;Hung B. Chu MD, RPVI ,&nbsp;Bertram L. Smith MD ,&nbsp;Bradley R. Grimsley MD ,&nbsp;Stephen E. Hohmann MD ,&nbsp;Javier Vasquez Jr MD ,&nbsp;Chris Metzger MD ,&nbsp;Christopher L. Henry MD ,&nbsp;Mujtaba M. Ali MD ,&nbsp;Timothy A. Mixon MD ,&nbsp;Subhash Banerjee MD","doi":"10.1016/j.amjcard.2025.05.011","DOIUrl":"10.1016/j.amjcard.2025.05.011","url":null,"abstract":"<div><div>There are unresolved questions regarding indications and outcomes of endovascular below-the-knee (BTK) interventions in patients with symptomatic peripheral artery disease (PAD) in real-world clinical practice. We analyzed 884 patients from the multicenter XLPAD registry between 2006 and 2023 with nonstent BTK PAD interventions. Primary outcome: freedom from major adverse limb events (MALE) at 1 year, a composite of all-cause death, major amputation, or clinically driven revascularization. Majority (62.8%) of the BTK interventions were performed for chronic limb threatening ischemia (CLTI), while remaining (37.2%) in patients with intermittent claudication (IC), performed together with an inflow femoropopliteal artery intervention in 58% or involving complex lesion crossings (11.8%). Nearly, 74% were men, mean age 68.0 ± 10.7 years. Mean Rutherford class was 4.65 in CLTI and 2.71 in IC groups. Moderate to severe calcification was present in 25% of cases. Significantly greater number of lesions were treated in the CLTI group (1.84 ± 1.52 vs 2.08 ± 1.61; p = 0.029). Lesion lengths (CLTI: 129.3 ± 85.1 mm vs IC: 115.5 ± 82.5; p = 0.075) were comparable. Nearly, 92% of lesions were treated with balloon angioplasty. Drug-coated balloon use was higher in IC (5% vs 15%, p &lt;0.001), whereas atherectomy use was high in both groups (CLTI: 45.4% vs IC: 49.9%; p = 0.201). Procedural success was similar (CLTI: 92% vs IC: 88.8%; p = 0.098), however 1-year MALE was significantly higher in CLTI patients (30.5% vs 15.8% vs; p &lt;0.0.001), driven by higher all-cause mortality (5.6% vs 2.1% vs; p = 0.014) and major amputations (14% vs 3.7%; p &lt;0.001). Endovascular treatment for BTK PAD is more often performed in patients with CLTI compared with IC, where it is often combined with an inflow artery intervention or complex lesion crossings. Despite similar procedural success, 1-year MALE is significantly higher in CLTI, driven mainly by over a 2-fold increase in all-cause mortality and major amputations.</div></div>","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":"251 ","pages":"Pages 38-45"},"PeriodicalIF":2.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Evidence on Lead Extraction Following Cardiac Implantable Electronic Device (CIED) Infections and Its Association With 1-year Mortality.","authors":"Md Shajedur Rahman Shawon, Jennifer Yu, Sean Gomes, Sze-Yuan Ooi, Louisa Jorm","doi":"10.1016/j.amjcard.2025.05.015","DOIUrl":"10.1016/j.amjcard.2025.05.015","url":null,"abstract":"<p><p>Complete lead extraction is strongly recommended for managing cardiac implantable electronic device (CIED) infections. However, actual practices and associated patient outcomes in real-world settings are not well documented. This study aims to quantify use of lead extraction among Australian patients with CIED infections. In this retrospective cohort study, we analyzed linked hospital and mortality data from New South Wales (July 2008 to September 2022). We included patients aged ≥18 years diagnosed with CIED infections, identified using diagnosis codes T82.71 (from July 2017 onwards) and T82.7 with relevant supplementary codes prior to July 2017. We quantified the association between lead extraction and 1-year mortality using time-varying Cox proportional hazards regression models. We included 2,339 patients (mean age 72.5 years, 31.5% female) who were hospitalized with CIED infections, of which 24.0% (n = 561) underwent lead extraction within 30 days. The likelihood of lead extraction was higher among those with sepsis, endocarditis, Staphylococcus aureus infection, prior revision/replacement CIED procedures, and patients admitted to private hospitals. In contrast, older patients (aged 75+ years), female patients, and those with chronic kidney disease were less likely to undergo lead extraction. Lead extraction was associated with reduced 1-year mortality rate (adjusted-HR = 0.64, 95% CI: 0.51 to 0.81), with evidence of greater survival benefit in patients with sepsis and lesser benefit in older patients and females. In conclusion, utilization of lead extraction was limited among patients with CIED infections. Lead extraction was linked to significantly reduced mortality rate, highlighting the importance of improving adherence to recommended management for patients with CIED infections.</p>","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approach to Management of Cardiac Calcified Amorphous Tumor","authors":"Parker Wilson DO ,&nbsp;Priyamvada Pillai MD ,&nbsp;Jacob Reiss MD ,&nbsp;Matthew Zhou MD ,&nbsp;Aldo Rafael MD ,&nbsp;Purav Mody MD","doi":"10.1016/j.amjcard.2025.05.013","DOIUrl":"10.1016/j.amjcard.2025.05.013","url":null,"abstract":"<div><div>A 76-year-old female with a known medical history of treated essential hypertension, hyperlipidemia, and obesity presented to her primary care provider for 2 months of worsening left-sided vision loss. Ophthalmologic evaluation demonstrated a left retinal artery branch occlusion leading to echocardiographic evaluation which revealed a large mobile echodensity on the mitral valve. Given specific clinical features and echocardiographic characteristics, the suspicion was highest for calcified amorphous tumor (CAT). Excision of this mass confirmed the diagnosis of CAT. There is currently clinical equipoise in literature regarding the best treatment strategy for these tumors therefore a multidisciplinary approach should be used to formulate individualized treatment plans.</div></div>","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":"251 ","pages":"Pages 34-37"},"PeriodicalIF":2.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemodynamic Response to Exercise and Quality of Life in Patients With Hypertrophic Cardiomyopathy Without Left Ventricular Outflow Tract Obstruction.","authors":"Helga Gudmundsdottir, Anna Axelsson Raja, Kasper Rossing, Hanne Rasmusen, Martin Snoer, Lars Juel Andersen, Rikke Gottlieb, Alex Hørby Christensen, Henning Bundgaard, Finn Gustafsson, Jens Jakob Thune","doi":"10.1016/j.amjcard.2025.05.012","DOIUrl":"10.1016/j.amjcard.2025.05.012","url":null,"abstract":"<p><p>In hypertrophic cardiomyopathy (HCM), impaired exercise capacity and quality of life (QoL) are indicative of a poor prognosis irrespective of left ventricular outflow tract (LVOT) obstruction. Exercise limitations are considered a substantial contributor to reduced QoL in HCM but the relationship between hemodynamic determinants of exercise capacity and QoL in HCM remains unknown. This study assessed the relationship between exercise hemodynamics and QoL in patients with HCM without LVOT obstruction. Patients underwent hemodynamic assessment via right heart catheterization, with measurements taken at rest and during exercise. Patient-reported QoL was assessed using the Kansas City Cardiomyopathy Questionnaire overall summary score (KCCQ-OSS). Hemodynamic metrics correlating with QoL were identified. Fifty-nine patients were included (27% females, mean age 58 ± 12 years). The cohort demonstrated mild to moderate QoL impairments, with a median overall summary KCCQ score of 83 (IQR: 71 to 95). At rest, QoL correlated with cardiac output (r = 0.3, p = 0.01) and mean pulmonary arterial pressure (r = -0.4, p = 0.003). During mild exercise (25 watts), an inverse correlation was observed between the KCCQ-OSS and left ventricular filling pressure (r = -0.4, p < 0.001), and at peak exercise, a positive correlation was observed between the KCCQ-OSS and cardiac output (r = 0.4, p < 0.001). In multivariate analysis, left ventricular filling pressure measured during mild exercise (β = -0.8, [95% CI: -1.49, -0.09], p = 0.035) emerged as the sole independent hemodynamic predictor of QoL. In conclusion, in patients with HCM without LVOT obstruction, QoL is significantly associated with several hemodynamic parameters, with elevated left ventricular filling pressures during mild exercise emerging as a key determinant.</p>","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to Impella Versus Non-Impella for Nonemergent High-Risk Percutaneous Coronary Intervention The American Journal of Cardiology (2024) Volume 225, 15 August. Pages 4-9. DOI: 10.1016/j.amjcard.2024.05.038","authors":"Pavan Reddy MD ,&nbsp;Ilan Merdler MD, MHA ,&nbsp;Cheng Zhang PhD ,&nbsp;Matteo Cellamare PhD ,&nbsp;Itsik Ben-Dor MD ,&nbsp;Nelson L. Bernardo MD ,&nbsp;Hayder D. Hashim MD ,&nbsp;Lowell F. Satler MD ,&nbsp;Toby Rogers MD, PhD ,&nbsp;Ron Waksman MD","doi":"10.1016/j.amjcard.2025.04.008","DOIUrl":"10.1016/j.amjcard.2025.04.008","url":null,"abstract":"","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":"249 ","pages":"Page 18"},"PeriodicalIF":2.3,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143934897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}