American Journal of Cardiology最新文献

{"title":"Acute Myocardial Infarction with High Thrombus Burden: Improved Outcomes with Intravascular Imaging-Guided Percutaneous Coronary intervention.","authors":"Gjin Ndrepepa","doi":"10.1016/j.amjcard.2025.09.036","DOIUrl":"https://doi.org/10.1016/j.amjcard.2025.09.036","url":null,"abstract":"","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Capacity in Heart Failure: A Rising Tide Lifts All Boats.","authors":"Marco Giuseppe Del Buono, Gianluigi Saponara, Tommaso Sanna","doi":"10.1016/j.amjcard.2025.09.029","DOIUrl":"https://doi.org/10.1016/j.amjcard.2025.09.029","url":null,"abstract":"","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The \"Block the Main Way\" Technique for Left Ventricular Lead Implantation in Cardiac Resynchronization Therapy: A Case Report.","authors":"Haoran Jing, Songqing Yang, Haoruo Zhang, Yanfeng Tian, Yuran Chen, Geer Sheng, Zhaojun Wang","doi":"10.1016/j.amjcard.2025.09.021","DOIUrl":"https://doi.org/10.1016/j.amjcard.2025.09.021","url":null,"abstract":"","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the Diagnostic Utility of Cardiac Magnetic Resonance Imaging in Unselected Patients with Premature Ventricular Contractions and Non-Sustained Ventricular Tachycardia?","authors":"Liyan Obeidat, Raef Fadel, Kartik Gupta, Alyssa Naimi, Elizabeth Ronchetto, Sara Ama, Mayar Helaly, Allison Malick, Dawood Jamil, Karthikeyan Ananthasubramaniam, Zain Azzo","doi":"10.1016/j.amjcard.2025.09.040","DOIUrl":"https://doi.org/10.1016/j.amjcard.2025.09.040","url":null,"abstract":"<p><strong>Purpose: </strong>Premature ventricular contractions (PVCs) and non-sustained ventricular tachycardia (NSVT) are common arrhythmias that may signal underlying structural heart disease (SHD). Cardiac magnetic resonance imaging (CMR) has emerged as a valuable tool for detecting myocardial abnormalities in this population. This study aimed to evaluate the diagnostic utility of CMR in patients with PVCs/NSVT and identify clinical predictors of pathologic late gadolinium enhancement (LGE).</p><p><strong>Methods: </strong>We retrospectively reviewed patients who underwent CMR for PVCs or NSVT between 2012 and 2023 at a single health system. The primary outcome was the presence of pathologic LGE. Clinical data were extracted using ICD-10 codes, and cardiac sarcoidosis (CS) was adjudicated by a multidisciplinary team using WASOG criteria.</p><p><strong>Results: </strong>Among 553 patients (mean age 61.1 ± 14.6 years; 40.7% female), pathologic LGE was identified in 214 (38.6%). Patients with LGE were older and had a greater burden of comorbidities. On multivariable analysis, independent risk factors for LGE included age (aOR 1.04, p=0.001), male sex (aOR 2.37, p<0.001), heart failure (aOR 2.53, p<0.001), and polymorphic PVCs (aOR 1.94, p=0.015). Among patients with LGE, 12.6% had highly probable CS. Other diagnoses included non-ischemic cardiomyopathy (53.7%), ischemic cardiomyopathy (11.7%), and idiopathic (34.6%).</p><p><strong>Conclusion: </strong>CMR frequently detects clinically significant myocardial abnormalities in patients with PVCs or NSVT, particularly in those with high-risk features. In this real-world study, nearly 40% of patients had LGE on CMR. An etiology was identified in one-third of these cases. These findings can inform patient selection for CMR in clinical practice to guide diagnosis, risk stratification, and management.</p>","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colchicine in Coronary Artery Disease: A Contemporary Review of Evidence from Clinical Outcomes and Imaging Trials.","authors":"John Adel Tawfik, Matthew Budoff","doi":"10.1016/j.amjcard.2025.09.041","DOIUrl":"https://doi.org/10.1016/j.amjcard.2025.09.041","url":null,"abstract":"<p><p>Colchicine treats a wide array of autoimmune and inflammatory conditions by inhibiting the NOD-like receptor protein 3 (NLRP3) inflammasome and key pro-inflammatory cytokines. In recent years, it has gained ground as an attenuator of vascular inflammation and a driver of atherosclerosis and cardiovascular disease (CVD). The recent Food and Drug Administration (FDA) approval of colchicine for cardiovascular risk reduction heralds a new era of its use in coronary artery disease (CAD). This paper reviews the evidence from completed and ongoing clinical trials on the therapeutic impact of colchicine on major adverse cardiovascular events (MACE) and atherosclerotic burden, including its mechanism of action on inflammatory pathways and cellular processes. We examine outcome trials on cardiovascular event reduction and novel imaging studies assessing atherosclerosis progression. In conclusion, this analysis aims to provide clinicians with a clearer understanding of the role of colchicine in cardiovascular health, including its potential therapeutic indications and limitations.</p>","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoprotein(a) levels are not predictive of baseline cardiovascular comorbidity risk in adults with peripheral arterial disease.","authors":"Lee Huei-Ying, Joshua Wang","doi":"10.1016/j.amjcard.2025.09.038","DOIUrl":"https://doi.org/10.1016/j.amjcard.2025.09.038","url":null,"abstract":"","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary Erythrocytosis in Patients with Heart Failure on SGLT2 inhibitors: Insights from a Multicenter \"Real World\" Study.","authors":"Melissa S Pherai, Fenne E I de Jong, Joris Jansen, Martijn Tukker, Selina Özoğul, Samantha Lenting, Thomas F Kok, Behiye Özcan, Dennis A Hesselink, Peter A W Te Boekhorst, René A Tio, Kadir Caliskan","doi":"10.1016/j.amjcard.2025.09.011","DOIUrl":"https://doi.org/10.1016/j.amjcard.2025.09.011","url":null,"abstract":"","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The additive value of FFR-CT in the evaluation of calcified coronary arteries with Coronary CT Angiography.","authors":"Ioannis Kyriakoulis, Michael G Nanna, Meghana Rao-Brito, Brian Cambi, Louis Mazzarelli, Damianos G Kokkinidis","doi":"10.1016/j.amjcard.2025.09.024","DOIUrl":"https://doi.org/10.1016/j.amjcard.2025.09.024","url":null,"abstract":"<p><p>Coronary computed tomography angiography (CCTA) has evolved as one of the most frequently utilized modalities for the evaluation of chest pain and the diagnosis of obstructive coronary artery disease in an outpatient (stable chest pain) or emergency /inpatient setting (unstable chest pain). However, severe coronary artery calcification (CAC) is known to be one of the most significant limitations of the technique, leading to false positive findings, mostly secondary to blooming artifact. Fractional flow reserve derived from coronary CT angiography (FFR-CT) has demonstrated acceptable correlation and agreement with invasive FFR, and due to its higher specificity and negative predictive value, enhances CCTA's diagnostic performance. There are published reports showing that the diagnostic performance of FFR-CT is affected less by severe CAC compared with CCTA alone. In this review, we present the current evidence of how FFR-CT can increase the accuracy of CCTA for the evaluation of calcified coronary arteries.</p>","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Drug-Coated Balloons Alone Versus Combined with Provisional Stenting for Complex Femoropopliteal Artery Lesions.","authors":"Qinghe Wang, Zishun Liang, Qian Ni, Chen Tang, Yutong Liu, Biao Zhao, Jing Cai, Tong Qiao","doi":"10.1016/j.amjcard.2025.09.026","DOIUrl":"https://doi.org/10.1016/j.amjcard.2025.09.026","url":null,"abstract":"<p><p>Complex femoropopliteal artery (FPA) lesions often require provisional stenting after suboptimal drug-coated balloon (DCB) angioplasty. This study compared midterm efficacy and safety of DCB alone versus DCB with provisional bare-metal stenting (BMS) in such lesions. In this retrospective cohort study, 326 propensity score-matched patients (163 per group) treated for FPA disease (2018-2022) were analyzed. Primary effectiveness endpoints were 24-month primary patency (PP) and freedom from clinically driven target lesion revascularization (FCD-TLR). Primary safety endpoints included amputation-free survival (AFS) and all-cause mortality. The stented group had longer lesions (21.2 vs. 17.6 cm, P=0.003), lower ankle-brachial index (0.32 vs. 0.48, P<0.001), and more severe calcification (29.8% vs. 20.6%, P=0.009). At 24 months, PP (83.9% vs. 83.5%, log-rank P=0.873) and FCD-TLR (86.3% vs. 85.9%, P=0.853) were comparable. AFS (92.3% vs. 94.1%, P=0.508) and mortality (1.8% vs. 2.4%, P=0.715) also showed no significant differences. Secondary outcomes were similar. In conclusion, DCB with provisional BMS demonstrates comparable midterm efficacy and safety to DCB alone for complex FPA lesions, supporting provisional BMS use when suboptimal results occur.</p>","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Aortic Valve Replacement Following TAVR: Long-Term Comparative Outcomes Versus Non-SAVR Cardiac Surgery.","authors":"Osamah Badwan, Issam Motairek, Fawzi Zghyer, Rishi Puri, Grant Reed, Amar Krishnaswamy, James Yun, Samir Kapadia","doi":"10.1016/j.amjcard.2025.09.009","DOIUrl":"https://doi.org/10.1016/j.amjcard.2025.09.009","url":null,"abstract":"<p><strong>Background: </strong>As TAVR use expands, some patients require later cardiac surgery, including SAVR with TAVR valve explant in certain scenarios. The long-term risks of SAVR after TAVR compared with other cardiac surgeries remain unclear.</p><p><strong>Methods: </strong>We studied adults in the TriNetX network who underwent TAVR followed by either SAVR or non-SAVR open-heart surgery (OHS) between 2010 and 2023. Propensity-score matching was done on 26 clinical and demographic factors. We compared outcomes at 3 and 5 years.</p><p><strong>Results: </strong>After matching, 132 patients were included in each group. The groups were well balanced at baseline. At 3 years, mortality was similar (18.9% SAVR vs 22.0% OHS; HR 0.83, 95% CI 0.46-1.51). At 5 years, mortality remained comparable (20.5% vs 24.2%; OR 0.80, 95% CI 0.45-1.44). Rates of stroke, acute coronary syndrome, heart failure hospitalization, major bleeding, new atrial fibrillation, and renal failure were also similar.</p><p><strong>Conclusions: </strong>SAVR after TAVR was associated with similar long-term outcomes compared with OHS. These findings suggest that risks may be more related to patient complexity than to the valve explant itself.</p>","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145172352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}