Bone and mineral最新文献_第5页

New DXA developments / new QCT/CT developments 新的DXA发展/新的QCT/CT发展

Bone and mineral Pub Date : 1994-04-01 DOI: 10.1016/S0169-6009(09)80003-2

引用次数: 0

The effect of voluntary exercise on bone mineral density and skeletal muscles in the rat model at ovariectomized and sham stages 随意运动对去卵巢期和假手术期大鼠骨密度和骨骼肌的影响

Bone and mineral Pub Date : 1994-03-01 DOI: 10.1016/S0169-6009(08)80138-9

Naomi Omi, Naomi Morikawa, Ikuko Ezawa

引用次数: 38

Growth plate abnormalities in a new dwarf mouse model: tich 一种新的侏儒小鼠模型的生长板异常:tich

Bone and mineral Pub Date : 1994-03-01 DOI: 10.1016/S0169-6009(08)80140-7

Robert A. Brown , Lance Bird , Gordon W. Blunn , James R. Archer

{"title":"Growth plate abnormalities in a new dwarf mouse model: tich","authors":"Robert A. Brown , Lance Bird , Gordon W. Blunn , James R. Archer","doi":"10.1016/S0169-6009(08)80140-7","DOIUrl":"10.1016/S0169-6009(08)80140-7","url":null,"abstract":"<div>Growth plate cartilage calcification has been examined in a recently described mouse mutant, tich, which is co-isogenic with the A.TL strain. Long bones were studied from 1-day-old and 1-month-old mice which carried a homozygous recessive gene mutation making them short limbed and dumpy. Specimens were studied by routine histology, scanning electron microscopy and radiography. In 1-day-old tich mice the front of calcified cartilage was recessed behind the advancing periosteum and bone. No similar recess was seen in control mice. At 1 month of age, a number of the long bone growth plates were irregularly thickened, particularly in the central area. This produced a central tongue of non-calcified cartilage (particularly prominent in the proximal tibia) which gave rise to a corresponding pit in the calcified cartilage layer, in macerated specimens. This was accompanied by poor resorption of calcified cartilage. At both ages the presence of the respective defects was radiographically confirmed. At present it is not known whether this is primarily a defect of calcification or resorption but its presence, apparently from a single mutation in a genetically defined mouse strain, makes it a potentially valuable model.</div>","PeriodicalId":77047,"journal":{"name":"Bone and mineral","volume":"24 3","pages":"Pages 235-244"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0169-6009(08)80140-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19013935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Contents of volume 24 第24卷内容

Bone and mineral Pub Date : 1994-03-01 DOI: 10.1016/S0169-6009(08)80143-2

引用次数: 0

Mechanisms of hypocalcemia and markers of bone turnover in alcohol-intoxicated drinkers 酒精中毒饮酒者低钙血症的机制和骨转换的标志物

Bone and mineral Pub Date : 1994-03-01 DOI: 10.1016/S0169-6009(08)80134-1

Kalevi Laitinen , Riitta Tähtelä , Kimmo Luomanmäki , Matti J. Välimäki

{"title":"Mechanisms of hypocalcemia and markers of bone turnover in alcohol-intoxicated drinkers","authors":"Kalevi Laitinen , Riitta Tähtelä , Kimmo Luomanmäki , Matti J. Välimäki","doi":"10.1016/S0169-6009(08)80134-1","DOIUrl":"10.1016/S0169-6009(08)80134-1","url":null,"abstract":"<div>Studies of hypocalcemia and osteoporosis frequently encountered in heavy users of alcohol have previously been performed on alcoholic people who have already recovered from alcohol intoxication. Bone and mineral metabolism during and after the intoxication may be different. We measured serum parameters of bone and mineral metabolism in 26 alcohol-intoxicated men and in 19 healthy control men. Although serum ionized calcium was 12% (P < 0.0001) lower in the patients than in the controls, serum intact parathyroid hormone was similar in the study groups. As reflected by decreased serum levels of osteocalcin (−43%; P < 0.001), bone formation was depressed in the patients. Serum cross-linked carboxyterminal telopeptide of human type I collagen (ICTP), a novel parameter of bone matrix degradation, was 9% higher in the patients (P = 0.03) than controls. The positive correlation between serum osteocalcin and ICTP in the controls (r = 0.59, P < 0.01) was absent in the patients (r = 0.05, P = 0.8). We conclude that in alcohol-intoxicated alcohol users, the parathyroid glands do not respond normally to a hypocalcemic stimulus, and that depressed bone formation is uncoupled from accelerated bone resorption.</div>","PeriodicalId":77047,"journal":{"name":"Bone and mineral","volume":"24 3","pages":"Pages 171-179"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0169-6009(08)80134-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18908508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36

Radial bone mineral content of normal Japanese infants and prepubertal children: influence of age, sex and body size 日本正常婴儿和青春期前儿童桡骨矿物质含量:年龄、性别和体型的影响

Bone and mineral Pub Date : 1994-03-01 DOI: 10.1016/S0169-6009(08)80136-5

Toshitsugu Sugimoto , Masamitsu Nishino , Tohru Tsunenari , Mitsuru Kawakatsu , Kazuhisa Shimogaki , Yoshio Fujii , Hirokuni Negishi , Masaharu Tsutsumi , Masaaki Fukase , Kazuo Chihara

{"title":"Radial bone mineral content of normal Japanese infants and prepubertal children: influence of age, sex and body size","authors":"Toshitsugu Sugimoto , Masamitsu Nishino , Tohru Tsunenari , Mitsuru Kawakatsu , Kazuhisa Shimogaki , Yoshio Fujii , Hirokuni Negishi , Masaharu Tsutsumi , Masaaki Fukase , Kazuo Chihara","doi":"10.1016/S0169-6009(08)80136-5","DOIUrl":"10.1016/S0169-6009(08)80136-5","url":null,"abstract":"<div>The present study was performed to measure appendicular bone mass of Japanese infants and children, and to assess the influence of age, sex and body size on bone mass during the period of bone growth. The bone mineral content (BMC) and bone width (BW) at the distal third of the radius were measured by single photon absorptiometry (SPA) in 229 healthy Japanese infants and children aged 0–12 years, and the BMC/BW ratio was calculated to give the bone mineral density (BMD). BMC and BW increased with age until 2 years, while BMD did not obviously change until 2 years. After 2 years of age, the overall effect of aging appeared more prominent in BMC and BMD than in BW. There were no significant differences in BMC, BW and BMD between males and females aged 0–12 years. Age, body height, and body weight were strongly correlated with three parameters of bone mass (BMC, BW, and BMD). Among the three parameters of bone mass, BMC showed the highest Pearson coefficient of correlation with age (r = 0.955), body height (r = 0.957) and body weight (r = 0.966), as compared with BW and BMD. The present cross-sectional study provides normative data of the appendicular bone mass in healthy Japanese children, which may serve as a standard for assessment of bone mineralization in Japanese infants and children with medical problems.</div>","PeriodicalId":77047,"journal":{"name":"Bone and mineral","volume":"24 3","pages":"Pages 189-200"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0169-6009(08)80136-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19013931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Modification of strain-specific femoral bone density by bone marrow-derived factors administered neonatally: a study on the spontaneously osteoporotic mouse, SAMP6 新生儿骨髓源性因子对菌株特异性股骨骨密度的影响:一项对自发性骨质疏松小鼠SAMP6的研究

Bone and mineral Pub Date : 1994-03-01 DOI: 10.1016/S0169-6009(08)80141-9

Kenshirou Takahashi , Tadao Tsuboyama , Mutsumi Matsushita , Ryuichi Kasai , Hideo Okumura , Takao Yamamuro , Yutaka Okamoto , Kazuhiro Toriyama , Kaori Kitagawa , Toshio Takeda

{"title":"Modification of strain-specific femoral bone density by bone marrow-derived factors administered neonatally: a study on the spontaneously osteoporotic mouse, SAMP6","authors":"Kenshirou Takahashi , Tadao Tsuboyama , Mutsumi Matsushita , Ryuichi Kasai , Hideo Okumura , Takao Yamamuro , Yutaka Okamoto , Kazuhiro Toriyama , Kaori Kitagawa , Toshio Takeda","doi":"10.1016/S0169-6009(08)80141-9","DOIUrl":"10.1016/S0169-6009(08)80141-9","url":null,"abstract":"<div>SAMP6 is a recently developed strain of osteoporotic mice, and SAMP2 is a control for SAMP6 and has a higher peak bone mass. The bone mass of SAMP6 was increased until 2 months of age when a lysate of cells derived from the bone marrow of SAMP2 was injected at 1 or 4 days of age, but it was not increased when the lysate was injected at 21 days of age. No effect on bone mass was observed when lysates of other cells, bovine serum albumin or heat-inactivated lysate of bone marrow-derived cells of SAMP2, were injected. The ability to increase bone mass was not in the supernatant but in the pellet obtained by ultracentrifugation (105 000 g) of the lysate of bone marrow-derived cells of SAMP2. The lysate did not change the osteoclast surface but changed the appositional bone formation. In conclusion, the lysate of cells derived from the bone marrow of SAMP2 contains factors which can increase the bone mass of SAMP6, and these factors are present in the pellet obtained by ultracentrifugation.</div>","PeriodicalId":77047,"journal":{"name":"Bone and mineral","volume":"24 3","pages":"Pages 245-255"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0169-6009(08)80141-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19013936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

In vitro effect of KCA-098, a derivative of coumestrol, on bone resorption of fetal rat femurs 库美孕酮衍生物KCA-098对胎鼠股骨骨吸收的体外影响

Bone and mineral Pub Date : 1994-03-01 DOI: 10.1016/S0169-6009(08)80137-7

Naoyuki Tsutsumi , Kohtaro Kawashima , Nobuhiko Arai , Hideo Nagata , Masami Kojima , Arao Ujiie , Hiroyoshi Endo

引用次数: 12

Effects of 17β-estradiol replacement and treadmill exercise on vertebral and femoral bones of the ovariectomized rat 17β-雌二醇替代和跑步机运动对去卵巢大鼠椎股骨的影响

Bone and mineral Pub Date : 1994-03-01 DOI: 10.1016/S0169-6009(08)80139-0

James K. Yeh , John F. Aloia , Maria-Louise Barilla

{"title":"Effects of 17β-estradiol replacement and treadmill exercise on vertebral and femoral bones of the ovariectomized rat","authors":"James K. Yeh , John F. Aloia , Maria-Louise Barilla","doi":"10.1016/S0169-6009(08)80139-0","DOIUrl":"10.1016/S0169-6009(08)80139-0","url":null,"abstract":"<div>To evaluate the effect of 17β-estradiol replacement (10 μg, twice a week) (E2) and treadmill exercise (18 m/min, 45 min/day) (EX) on long bone and vertebral bone mass and density, 10-month-old rats were ovariectomized (OV) and divided into four groups: OV, OV + E2, OV + EX, OV + EX + E2 2 months after surgery. After 7 weeks intervention, the calcium content and the density of lumbar-5 were higher in both OV + E2 and OV + EX + E2 groups than in the OV group, but, only the OV + EX + E2 group had a significantly higher femoral bone weight and density than the OV group. After 16 weeks intervention, the bone-conserving effects of E2 and EX were significant on lumbar-5 and femoral dry weight and density. The effect of E2 on both two sides of bones was due to the suppression of the bone turnover rate, while EX suppressed bone turnover rate primarily on the femur. We conclude that the effect of the two interventions on lumbar-5 and femoral bone mass were additive and independent.</div>","PeriodicalId":77047,"journal":{"name":"Bone and mineral","volume":"24 3","pages":"Pages 223-234"},"PeriodicalIF":0.0,"publicationDate":"1994-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0169-6009(08)80139-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19013934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 47

Instuctions to authors 给作者的说明

Bone and mineral Pub Date : 1994-03-01 DOI: 10.1016/S0169-6009(08)80146-8

引用次数: 0