Bone and mineral最新文献_第4页

10th International Bone Densitometry Workshop. Venezia Lido, Italy, April 24-29, 1994. Abstracts. 第十届国际骨密度测量研讨会。意大利威尼斯丽都，1994年4月24日至29日。摘要。

Bone and mineral Pub Date : 1994-04-01

引用次数: 0

Prostaglandin E2 stimulates the production of interleukin-6 by neonatal mouse parietal bones 前列腺素E2刺激新生小鼠顶骨产生白细胞介素-6

Bone and mineral Pub Date : 1994-04-01 DOI: 10.1016/S0169-6009(08)80207-3

Ian Holt , Michael W.J. Davie , Isobel P. Braidman , Michael J. Marshall

{"title":"Prostaglandin E2 stimulates the production of interleukin-6 by neonatal mouse parietal bones","authors":"Ian Holt , Michael W.J. Davie , Isobel P. Braidman , Michael J. Marshall","doi":"10.1016/S0169-6009(08)80207-3","DOIUrl":"10.1016/S0169-6009(08)80207-3","url":null,"abstract":"<div>The pleiotropic cytokine interleukin-6 (IL-6) is thought to be involved in bone homeostasis. A number of bone resorbing agents have been shown to induce the release of IL-6 from bone. We wished to determine whether prostaglandin E2 (PGE2), which is a mediator of bone resorption, can elicit the production of IL-6. IL-6 was measured by the proliferative response of B9 hybridoma cells and could be completely neutralised by an anti-IL-6 antibody. Parietal bones from neonatal mice were maintained in culture in the presence of indomethacin (10−6 M) with or without PGE2. The time course and dose-response to PGE2 of IL-6 production were determined. After 6 h in culture, 10−8 M PGE2 produced significantly more IL-6 than the controls (P < 0.005). PGE2 (10−6 M) stimulated the production of a mean of 12.8 ng/ml IL-6 over 6 h. Preincubating bones with indomethacin for 20 h prior to a 6 h culture with indomethacin led to a lowering of the production of IL-6 (mean 1.8 ng/ml) compared to bones cultured without the preincubation period (5.8 ng/ml). When the indomethacin preincubation period was used, a significant increase in IL-6 production was found with 10−9 M PGE2 (P < 0.005), and 10−6 M PGE2 caused the production of 39.9 ng/ml IL-6 over 6 h. Stripping endocranial and ectocranial membranes from bones demonstrated the membranes to be the major site of IL-6 production. However, intact bones were required for maximal stimulated IL-6 production.</div>","PeriodicalId":77047,"journal":{"name":"Bone and mineral","volume":"25 1","pages":"Pages 47-57"},"PeriodicalIF":0.0,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0169-6009(08)80207-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19055217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

New and developing techniques (ultrasounds, MR ect)/standardization and quality assurance 新技术(超声，磁共振等)/标准化和质量保证

Bone and mineral Pub Date : 1994-04-01 DOI: 10.1016/S0169-6009(09)80005-6

引用次数: 0

Bone architecture, biomechanics and bone morphometry 骨结构，生物力学和骨形态计量学

Bone and mineral Pub Date : 1994-04-01 DOI: 10.1016/S0169-6009(09)80004-4

引用次数: 0

Clinical applications of bone density 骨密度的临床应用

Bone and mineral Pub Date : 1994-04-01 DOI: 10.1016/S0169-6009(09)80008-1

引用次数: 0

Free topics 自由的主题

Bone and mineral Pub Date : 1994-04-01 DOI: 10.1016/S0169-6009(09)80010-X

引用次数: 0

Authors index 10th International Bone Densitometry Workshop (Venice) 第十届国际骨密度测量研讨会(威尼斯)

Bone and mineral Pub Date : 1994-04-01 DOI: 10.1016/S0169-6009(09)80012-3

引用次数: 0

Assessment of body composition 评估身体成分

Bone and mineral Pub Date : 1994-04-01 DOI: 10.1016/S0169-6009(09)80007-X

引用次数: 39

5th workshop on cells and cytokines in bone and cartilage. Davos, Switzerland, April 11-13, 1994. Abstracts. 第五届骨和软骨细胞和细胞因子研讨会。1994年4月11日至13日，瑞士达沃斯。摘要。

Bone and mineral Pub Date : 1994-04-01

引用次数: 0

The association between age and bone mineral density in men and women aged 55 years and over: The Rotterdam Study 年龄与55岁及以上男性和女性骨密度的关系:鹿特丹研究

Bone and mineral Pub Date : 1994-04-01 DOI: 10.1016/S0169-6009(08)80203-6

H. Burger , P.L.A van Daele , D. Algra , F.A. van den Ouweland , D.E. Grobbee , A. Hofman , C. van Kuijk , H.E. Schütte , J.C. Birkenhäger , H.A.P. Pols

{"title":"The association between age and bone mineral density in men and women aged 55 years and over: The Rotterdam Study","authors":"H. Burger , P.L.A van Daele , D. Algra , F.A. van den Ouweland , D.E. Grobbee , A. Hofman , C. van Kuijk , H.E. Schütte , J.C. Birkenhäger , H.A.P. Pols","doi":"10.1016/S0169-6009(08)80203-6","DOIUrl":"10.1016/S0169-6009(08)80203-6","url":null,"abstract":"<div>In this cross-sectional study, bone mineral density (BMD) measurements were performed in 1762 ambulatory subjects (678 men and 1084 women) aged 55 years and over from the Rotterdam Study, a population based study of diseases in the elderly. BMD measurements of the proximal femur and lumbar spine were performed using dual energy X-ray absorptiometry. No age-related decline in BMD could be observed in the lumbar spine. Yearly percentage BMD reduction in women and men was −0.6% and −0.3% in the femoral neck, −0.8% and −0.5% in the Ward's triangle, and −0.4% and −0.3% in the trochanter, respectively. Late menopause was associated with high BMD in Ward's triangle and lumbar spine. We conclude that: (1) accurate assessment of age-related bone reduction in the spine is impossible from cross-sectional studies since BMD measurements in the elderly may be influenced by spinal osteoarthritis; and (2) the rate of age-related bone reduction in the femoral neck appears to be approximately two times higher in women than in men.</div>","PeriodicalId":77047,"journal":{"name":"Bone and mineral","volume":"25 1","pages":"Pages 1-13"},"PeriodicalIF":0.0,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0169-6009(08)80203-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19055213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 191