Bailliere's clinical endocrinology and metabolism最新文献_第10页

Non-insulin-dependent diabetes mellitus in the elderly 老年人非胰岛素依赖型糖尿病

Bailliere's clinical endocrinology and metabolism Pub Date : 1997-07-01 DOI: 10.1016/S0950-351X(97)80362-X

MD, PhD A.J. Scheen (Associate Professor)

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引用次数: 30

Forthcoming issue 即将出版

Bailliere's clinical endocrinology and metabolism Pub Date : 1997-07-01 DOI: 10.1016/S0950-351X(97)80227-3

引用次数: 0

Previous issues 以前的问题

Bailliere's clinical endocrinology and metabolism Pub Date : 1997-07-01 DOI: 10.1016/S0950-351X(97)80212-1

引用次数: 0

Ageing and calcium metabolism 衰老与钙代谢

Bailliere's clinical endocrinology and metabolism Pub Date : 1997-07-01 DOI: 10.1016/S0950-351X(97)80332-1

MD, PhD Roger Bouillon (Professor of Endocrinology), MD, PhD Geert Carmeliet (Lecturer), MD Steven Boonen (Consultant Geriatrician)

引用次数: 34

Fluid and electrolyte homeostasis in the elderly: Physiological changes of ageing and clinical consequences 老年人体液和电解质稳态:衰老的生理变化和临床后果

Bailliere's clinical endocrinology and metabolism Pub Date : 1997-07-01 DOI: 10.1016/S0950-351X(97)80347-3

MD Myron Miller (Director)

引用次数: 57

Thyroid diseases in the elderly 老年人甲状腺疾病

Bailliere's clinical endocrinology and metabolism Pub Date : 1997-07-01 DOI: 10.1016/S0950-351X(97)80272-8

MD, PhD Luca Chiovato (Assistant Professor of Endocrinology), MD Stefano Mariotti (Professor of Endocrinology), MD, FRCP Aldo Pinchera (Professor of Endocrinology and Chairman)

{"title":"Thyroid diseases in the elderly","authors":"MD, PhD Luca Chiovato (Assistant Professor of Endocrinology), MD Stefano Mariotti (Professor of Endocrinology), MD, FRCP Aldo Pinchera (Professor of Endocrinology and Chairman)","doi":"10.1016/S0950-351X(97)80272-8","DOIUrl":"10.1016/S0950-351X(97)80272-8","url":null,"abstract":"<div><p>The ageing thyroid is associated with a number of morphological and functional changes, such as decreased serum T, and mean thyroid-stimulating hormone concentrations, that are to some extent independent of intercurrent non-thyroidal illnesses. All thyroid diseases, including clinical and subclinical hypo- and hyperthyroidism, non-toxic nodular goitre and thyroid cancer, are encountered in the elderly, but their prevalence and clinical expression differ from those observed in younger patients. In the elderly, autoimmune hypothyroidism is particularly prevalent, hyperthyroidism is mainly characterized by cardiovascular symptoms and is frequently due to toxic nodular goitres, and differentiated thyroid carcinoma is more aggressive. The interpretation of thyroid function tests is difficult in old individuals, because of age-associated changes in thyroid function and frequent alterations secondary to non-thyroidal illnesses and/or drugs. Treatment of thyroid disease deserves special attention in old patients because of the increased risk of complications.</p></div>","PeriodicalId":77027,"journal":{"name":"Bailliere's clinical endocrinology and metabolism","volume":"11 2","pages":"Pages 251-270"},"PeriodicalIF":0.0,"publicationDate":"1997-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0950-351X(97)80272-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20331016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40

Declining gonadal function in elderly men 老年男性性腺功能下降

Bailliere's clinical endocrinology and metabolism Pub Date : 1997-07-01 DOI: 10.1016/S0950-351X(97)80302-3

MD, PhD Jean Marc Kaufman (Professor of Internal Medicine and Head, Laboratory for Hormonology), MD, PhD Alex Vermeulen (Emeritus Professor of Internal Medicine)

{"title":"Declining gonadal function in elderly men","authors":"MD, PhD Jean Marc Kaufman (Professor of Internal Medicine and Head, Laboratory for Hormonology), MD, PhD Alex Vermeulen (Emeritus Professor of Internal Medicine)","doi":"10.1016/S0950-351X(97)80302-3","DOIUrl":"10.1016/S0950-351X(97)80302-3","url":null,"abstract":"<div><p>Ageing in men is accompanied by a progressive decline of gonadal function with, in particular, a decline of total and free testosterone (T) plasma levels resulting in a significant proportion of elderly men over age 60 years presenting with subnormal T levels compared with the levels in young adults. A great interindividual variation in T levels is observed in elderly men, a variability explained in part by physiological variables and differences in life style, while associated acute or chronic diseases may accentuate the age-related decline of T levels. The progressive decrease of plasma T levels has been shown to result from both primary testicular changes and altered neuroendocrine regulation of Leydig cell function. At present, little is known about the clinical relevance of the relative hypoandrogenism of elderly men and there is an urgent need for more longitudinal studies, which may clarify a possible role of decreased T levels in the modulation of the clinical consequences of ageing in men. In view of the lack of relevant controlled clinical trials having careful assessment of the risks and benefits of androgen replacement therapy in elderly men, this treatment should be reserved for selected patients with clinically and biochemically manifest hypogonadism, after careful screening for contraindications.</p></div>","PeriodicalId":77027,"journal":{"name":"Bailliere's clinical endocrinology and metabolism","volume":"11 2","pages":"Pages 289-309"},"PeriodicalIF":0.0,"publicationDate":"1997-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0950-351X(97)80302-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20331018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 197

Menopause and post-menopause 更年期和绝经后

Bailliere's clinical endocrinology and metabolism Pub Date : 1997-07-01 DOI: 10.1016/S0950-351X(97)80317-5

MD, MSc, DSc, FRCP Gordana M. Prelevic (Senior Lecturer in Reproductive Endocrinology), MD, FRCP, FRCOG Howard S. Jacobs (Professor of Reproductive Endocrinology)

{"title":"Menopause and post-menopause","authors":"MD, MSc, DSc, FRCP Gordana M. Prelevic (Senior Lecturer in Reproductive Endocrinology), MD, FRCP, FRCOG Howard S. Jacobs (Professor of Reproductive Endocrinology)","doi":"10.1016/S0950-351X(97)80317-5","DOIUrl":"10.1016/S0950-351X(97)80317-5","url":null,"abstract":"<div><p>From the endocrine point of view, menopause is considered a deficiency state and oestrogen therapy regarded as restoring the pre-menopausal endocrine milieu. Oestrogen therapy alleviates acute climacteric symptoms and also reduces the risk of cardiovascular disease, osteoporosis and Alzheimer's disease. Cardiovascular protection seems to be the major benefit of oestrogen replacement: it reduces morbidity and mortality from coronary heart disease by approximately 50%. The mechanisms are complex and not fully understood. In this review we discuss currently available data on the effects of hormone replacement therapy on serum lipids and lipoproteins, the vessel wall (endothelium dependent and endothelium independent), blood flow, cardiac function, blood pressure, haemostasis, insulin sensitivity and direct anti-atherosclerotic effect as possible mechanisms of cardioprotection. Oestrogen therapy reduces the rate of post-menopausal bone loss, increases bone mineral density (BMD) and decreases fracture rate. Recent evidence suggests that initiation of oestrogen therapy in older women produces larger increases in BMD which might provide a significant protective effect at the time when fracture is common. The incidence of Alzheimer's disease is reduced by 50% in post-menopausal women taking oestrogen replacement. Limited clinical trials of oestrogen treatment in women with this disease have documented beneficial effects on cognitive function. The results of epidemiological studies of the effects of oestrogens on breast cancer risk are conflicting but recent evidence suggests that the risk is increased in current users after 5 years of use and among older women. In contrast, increase in the risk of venous thromboembolism is most significant within the first 12 months of therapy, strongly suggesting the importance of individual susceptibility.</p></div>","PeriodicalId":77027,"journal":{"name":"Bailliere's clinical endocrinology and metabolism","volume":"11 2","pages":"Pages 311-340"},"PeriodicalIF":0.0,"publicationDate":"1997-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0950-351X(97)80317-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20331019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Pituitary tumours in the elderly 老年人的垂体瘤

Bailliere's clinical endocrinology and metabolism Pub Date : 1997-07-01 DOI: 10.1016/S0950-351X(97)80377-1

MA, MRCP Helen E. Turner (Senior Registrar), MD, FRCP J.A.H. Wass (Consultant in Endocrinology)

引用次数: 19

Index 指数

Bailliere's clinical endocrinology and metabolism Pub Date : 1997-07-01 DOI: 10.1016/S0950-351X(97)80392-8

引用次数: 0