Thyroid diseases in the elderly

Bailliere's clinical endocrinology and metabolism Pub Date : 1997-07-01 DOI:10.1016/S0950-351X(97)80272-8

MD, PhD Luca Chiovato (Assistant Professor of Endocrinology), MD Stefano Mariotti (Professor of Endocrinology), MD, FRCP Aldo Pinchera (Professor of Endocrinology and Chairman)

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引用次数: 40

Abstract

The ageing thyroid is associated with a number of morphological and functional changes, such as decreased serum T, and mean thyroid-stimulating hormone concentrations, that are to some extent independent of intercurrent non-thyroidal illnesses. All thyroid diseases, including clinical and subclinical hypo- and hyperthyroidism, non-toxic nodular goitre and thyroid cancer, are encountered in the elderly, but their prevalence and clinical expression differ from those observed in younger patients. In the elderly, autoimmune hypothyroidism is particularly prevalent, hyperthyroidism is mainly characterized by cardiovascular symptoms and is frequently due to toxic nodular goitres, and differentiated thyroid carcinoma is more aggressive. The interpretation of thyroid function tests is difficult in old individuals, because of age-associated changes in thyroid function and frequent alterations secondary to non-thyroidal illnesses and/or drugs. Treatment of thyroid disease deserves special attention in old patients because of the increased risk of complications.

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老年人甲状腺疾病

甲状腺衰老与许多形态和功能变化有关，如血清T降低和平均促甲状腺激素浓度，这些变化在一定程度上与合并的非甲状腺疾病无关。所有甲状腺疾病，包括临床和亚临床甲状腺功能减退和亢进、无毒甲状腺结节和甲状腺癌，都在老年人中遇到，但其患病率和临床表现与年轻患者不同。在老年人中，自身免疫性甲状腺功能减退尤为普遍，甲状腺功能亢进主要以心血管症状为特征，多因中毒性结节性甲状腺肿，分化型甲状腺癌侵袭性更强。在老年人中，由于甲状腺功能与年龄相关的变化以及继发于非甲状腺疾病和/或药物的频繁改变，甲状腺功能检查的解释很困难。老年患者甲状腺疾病的治疗值得特别关注，因为并发症的风险增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bailliere's clinical endocrinology and metabolism

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