American Journal of PharmTech Research最新文献_第8页

Methods to Determine Vertical Jaw Relation- Review 垂直颌关系测定方法综述

American Journal of PharmTech Research Pub Date : 2019-08-08 DOI: 10.46624/ajptr.2020.v10.i3.002

Dr.P. Shalini, N. Reddy

引用次数: 0

Pulsatile drug delivery, circadian rhythms, Tiotropium Bromide, Lag time, Press coated tablets. 脉动给药，昼夜节律，噻托溴铵，滞后时间，压片。

American Journal of PharmTech Research Pub Date : 2019-08-08 DOI: 10.46624/ajptr.2020.v10.i3.007

Binu Km, El-Kosasy Am, H. Doddayya, S. Antin

引用次数: 0

Diversity and Conservation Strategies of Pharmaceutically important Medicinal plants of Bundelkhand region, India 印度本德尔坎德地区重要药用植物多样性及保护策略

American Journal of PharmTech Research Pub Date : 2019-08-08 DOI: 10.46624/ajptr.2020.v10.i3.005

S. Mishra, R. Shankar

{"title":"Diversity and Conservation Strategies of Pharmaceutically important Medicinal plants of Bundelkhand region, India","authors":"S. Mishra, R. Shankar","doi":"10.46624/ajptr.2020.v10.i3.005","DOIUrl":"https://doi.org/10.46624/ajptr.2020.v10.i3.005","url":null,"abstract":"Bundelkhand is located Central part of India with an unique type of climatic condition having stony sandy and rocky soil deficient in water. Gradual climatic change due to acute pressure on land for various developmental activities are regularly increasing the degradation of biodiversity which is affecting the potential of medicinal plants and invite needs for the conservation of biodiversity of medicinal plants in the region. During the course of various studies authors have identified the medicinal plants of high value, used in top medical prescriptions and traditional medical practices viz. Acacia catechu (Khadira), Asparagus racemosus (Shatawari), Boswellia serrata (Shalaki), Desmodium gangeticum(Shalaparni), Gymnema sylvestre.(Retz.) R. Br. ex Sm.( Gudmaar), Hemidesmus indicus R.Br.(Anantmoola),Oroxylum indicum (L.) Kurz, Pluchia lanceolata(Rasana),Tribulus terrestris (Gokshuru), Uraria picta (Prishniparni), Withania somnifera (Ashwagandha), Writia tinctoriaetc. Efforts are needed in acclimatizing the medicinal plants in the garden land, nurseries, development of strategy of protection of natural habitat of the medicinal plants of region, developing ago-technical protocols for cultivation of medicinal plants suitable for farmers to enrich their economy as well as biodiversity under Government control is need of the day ensuring effective conservation of these valuable medicinal resources of the country. Cultivation of Cymbopogon flexuosus (Pootika),Saccharum munja (Munja), and Chrysopogon zizanioides (Ushir) is also the need of time for enriching the biodiversity through conserving the medicinal plants.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90836541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

90 Day Repeat DOSE Oral Toxicity Study of GM Derived Cotton Seed In Wistar Rats 转基因棉籽对Wistar大鼠90天重复剂量口服毒性研究

American Journal of PharmTech Research Pub Date : 2019-06-08 DOI: 10.46624/ajptr.2019.v9.i3.003

Priya Singh

引用次数: 2

Development and Validation of UV Spectroscopic Method for Estimation of Guaifenesin In Tablet Dosage Form 紫外光谱法测定片剂型中愈创甘油醚的含量及验证

American Journal of PharmTech Research Pub Date : 2019-06-08 DOI: 10.46624/ajptr.2019.v9.i3.024

Ganesh M. Sanap, Prajakta S. Shirode, Kalpesh V. Sonar

{"title":"Development and Validation of UV Spectroscopic Method for Estimation of Guaifenesin In Tablet Dosage Form","authors":"Ganesh M. Sanap, Prajakta S. Shirode, Kalpesh V. Sonar","doi":"10.46624/ajptr.2019.v9.i3.024","DOIUrl":"https://doi.org/10.46624/ajptr.2019.v9.i3.024","url":null,"abstract":"To develop and validate simple, rapid, linear, accurate, precise and economical UV Spectroscopic method for estimation of Guaifenesin in tablet dosage form. The drug is freely soluble in analytical grade Methanol. The drug was identified in terms of solubility studies and on the basis of melting point done on melting point apparatus of Equiptronics. It showed absorption maxima were determined in analytical grade Methanol. The drug obeyed the Beer’s law and showed good correlation of concentration with absorption which reflect in linearity. The UV spectroscopic method was developed for estimation of Guaifenesin in tablet dosage form and also validated as per ICH guidelines. The drug is freely soluble in analytical grade Methanol, moderately soluble in Benzene and soluble in Chloroform, Glycerol. So, the analytical grade Methanol is used as a diluent in method. The melting point of Guaifenesin was found to be 78-79 ̊C (uncorrected). It showed absorption maxima 269 nm in analytical grade Methanol. On the basis of absorption spectrum the working concentration was set on 10μg/ml (PPM). The linearity was observed between 6-14 μg/ml (PPM). The results of analysis were validated by recovery studies. The recovery was found to be 98.75, 101 and 99.17% for three levels respectively. The % RSD for precision was found to be 0.97%. A simple, rapid, linear, accurate, precise and economical UV Spectroscopic method has been developed for estimation of Guaifenesin in tablet dosage form. The method could be considered for the determination of Guaifenesin in quality control laboratories.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85887217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stability Indicating High Performance Thin Layer Chromatographic Determination of Alogliptin Benzoate as Bulk Drug and in Tablet Dosage Form 稳定性指示高效薄层色谱法测定原料药和片剂剂型阿格列汀的含量

American Journal of PharmTech Research Pub Date : 2019-06-08 DOI: 10.46624/ajptr.2019.v9.i3.028

K. Patil, T. Deshmukh, V. Patil

{"title":"Stability Indicating High Performance Thin Layer Chromatographic Determination of Alogliptin Benzoate as Bulk Drug and in Tablet Dosage Form","authors":"K. Patil, T. Deshmukh, V. Patil","doi":"10.46624/ajptr.2019.v9.i3.028","DOIUrl":"https://doi.org/10.46624/ajptr.2019.v9.i3.028","url":null,"abstract":"Please cite this article as: Patil KR et al., Stability Indicating High Performance Thin Layer Chromatographic Determination of Alogliptin Benzoate as Bulk Drug and in Tablet Dosage Form. American Journal of PharmTech Research 2019. Stability Indicating High Performance Thin Layer Chromatographic Determination of Alogliptin Benzoate as Bulk Drug and in Tablet Dosage Form K R Patil*, T A Deshmukh, V R Patil 2 1.SES Arunamai College of Pharmacy Mamurabad, Jalgaon (MS) 2.Hon. LMC College of Pharnmacy, Faizpur, Jalgaon (MS) ABSTRACT Alogliptin Benzoate is a novel hypoglycemic drug that belongs to dipeptidylpeptidase-4 inhibitor class which stimulates glucose dependent insulin release. The Present work describes development and validation of a new simple, accurate, precise and stability indicaing HPTLC method for the determination of alogliptin benzoate in tablet dosage form. The chromatographic separation was achieved by using Chloroform: Methanol 3:7 v/v as mobile phase and UV detection at 275 nm. The developed method was validated with respect to linearity, accuracy, precision, limit of detection, limit of quantitation and robustness as per ICH guidelines. The drug was subjected to stress condition of acid hydrolysis, alkali hydrolysis, photolysis, thermal degradation. Results found to be linear in concentration range of 500-2500 ng/band. The developed method can be used for the quantification of bulk drug as well as tablet dosage form","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90966052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibiotic Utilization Pattern In LSCS Patients LSCS患者的抗生素使用模式

American Journal of PharmTech Research Pub Date : 2019-06-08 DOI: 10.46624/ajptr.2019.v9.i3.005

V. Krishnaraju, Haleema Fatima, Samreen Unisaa, Syed Adnan Mohiuddin Hussaini, Syed Aseem Ullah, Mohammad Maaz

{"title":"Antibiotic Utilization Pattern In LSCS Patients","authors":"V. Krishnaraju, Haleema Fatima, Samreen Unisaa, Syed Adnan Mohiuddin Hussaini, Syed Aseem Ullah, Mohammad Maaz","doi":"10.46624/ajptr.2019.v9.i3.005","DOIUrl":"https://doi.org/10.46624/ajptr.2019.v9.i3.005","url":null,"abstract":"Cesarean surgical site infections can be prevented by proper preoperative antibiotic prophylaxis. Differences in antibiotic selection in clinical practice exist according to clinicians preferences despite clear guidelines on preoperative antibiotic prophylaxis. The present study thus attempted to understand the antibiotic usage pattern among Lower segment Cesarian section (LSCS) patients in Hyderabad. Subjects for study were patients attending private hospitals in Hyderabad. Case records of LSCS patients who were prescribed antibiotics were used for extraction of relevant data. Other gynecological patients were excluded from the study. The mean age of LSCS patients was 24.57 years. The average number of antibiotics per patient was 2.2. The average number of other drugs per encounter was 6.45. The most commonly prescribed antibiotic was Ceftriaxone followed by Metronidazole. More than 80% of infections were treated with a combination of antimicrobials. In present study, all antibiotics were prescribed in generic name. Polypharmacy was evident from the study. All the antibiotics were given in multiple doses and the administration of antibiotics were given before incision in all patients. Considering spectrum of activity, sensitivity against resistant pathogens and less toxicity, third generation cephalosporins, especially ceftriaxone has been widely used in India for surgical prophylaxis. The common use of ceftriazone and metronidazole could be related to the possibility of mixed infections in LSCS patients. The overall antibiotic usage in LSCS patients were acceptable as per WHO “World Health Organization” standards and the general gynecological practice around the globe. Properly designed studies to access safety and efficacy of single dose vs multiple dose of antibiotics, pre and post incision antibiotic administration is need of the hour.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82386165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Biofuel from vegetable oils 从植物油中合成生物燃料

American Journal of PharmTech Research Pub Date : 2019-06-08 DOI: 10.46624/ajptr.2019.v9.i3.010

A. N., . D. A. M., B. S., Nilakh Sayali P

引用次数: 0

Formulation Development and Optimization by 2X3 Factorial Design of Novel Prednisone Loaded Mucoadhesive Liposomal Formulation 新型强的松黏附脂质体处方开发及2X3析因设计优化

American Journal of PharmTech Research Pub Date : 2019-06-08 DOI: 10.46624/ajptr.2019.v9.i3.014

Priyanka Raj G, Parthiban S, S. Gp

{"title":"Formulation Development and Optimization by 2X3 Factorial Design of Novel Prednisone Loaded Mucoadhesive Liposomal Formulation","authors":"Priyanka Raj G, Parthiban S, S. Gp","doi":"10.46624/ajptr.2019.v9.i3.014","DOIUrl":"https://doi.org/10.46624/ajptr.2019.v9.i3.014","url":null,"abstract":"Priyanka Raj G*, Parthiban S, Senthil Kumar GP Dept of pharmaceutics, Bharathi College of Pharmacy, Bharathinagara, mandya, Karnataka. ABSTRACT The aim of the present investigation was to design a mucoadhesive liposomal system of Prednisone for the treatment of arthritis, severe allergic reaction multiple sclerosis that is capable of delivering entrapped drug over an extended period of time. Mucoadhesive liposomal formulations were prepared by different concentration of lecithin and cholesterol by thin film hydration technique followed by coating of liposomes by 0.2 % w/v of chitosan and Liposomes were evaluated for entrapment efficiency, particle size, zeta potential, surface morphology and invitro drug release and stability study of coated formulation. Particle size of the F4, F5 and F6 formulation was found to be 212 nm, 131 nm and 340 nm respectively and zeta potential were 164.9 mV, 165 mV and -9.6 mV, respectively. Highest entrapment efficiency was observed in the ranged of 83 % to 98% for formulation F1 ˗F8 and CF1-CF2 were 90.87 % to 94.68%. The percent drug release from F1-F8 was varied and affected by drug loading, soyalecitin and cholesterol concentration and followed non-Fickian diffusion mechanism. 2x3 factorial design were applied and studied the effect of parameter on entrapment efficiency and in vitro drug release at 2hrs, 6hrs, 12 hrs by using QI Macros R software.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77446239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RP-HPLC Method Development and Validation for Estimation of Lenvatinib In Bulk and Pharmaceutical Dosage Form 反相高效液相色谱法测定Lenvatinib原料药和制剂的含量

American Journal of PharmTech Research Pub Date : 2019-06-08 DOI: 10.46624/ajptr.2019.v9.i3.008

M. Lakshmikanth, B. Rajkamal

{"title":"RP-HPLC Method Development and Validation for Estimation of Lenvatinib In Bulk and Pharmaceutical Dosage Form","authors":"M. Lakshmikanth, B. Rajkamal","doi":"10.46624/ajptr.2019.v9.i3.008","DOIUrl":"https://doi.org/10.46624/ajptr.2019.v9.i3.008","url":null,"abstract":"Please cite this article as: Kanth LM et al., RP-HPLC Method Development and Validation for Estimation of Lenvatinib In Bulk and Pharmaceutical Dosage Form. American Journal of PharmTech Research 2019. RP-HPLC Method Development and Validation for Estimation of Lenvatinib In Bulk and Pharmaceutical Dosage Form Lakshmi Kanth M*, Raj Kamal B 1.Research Scholar, Mewar University, Chittorgarh, Rajasthan, India. 2.Research Supervisor, Mewar University, Chittorgarh, Rajasthan, India ABSTRACT The objective of present work was to develop and validate a rapid reverse phase high-performance liquid chromatography (RP-HPLC) method for the quantitative analysis of lenvatinib in bulk and pharmaceutical dosage forms. Chromatographic analyses were performed on an ODC column of 250mm 4.6mm: i.d and 5μ particle size with a mobile phase comprising of 0.5M ammonium acetate and acetonitrile in the ratio 90:10 v/v. The flow rate maintained at 1 ml/min, detected lenvatinib at RT 1.15 minutes. The lenvatinib was detected and quantitated using a photodiode array detector at a wavelength of 367 nm. The method was shown to be specific and linear in the range of 20-120μg/ml (r= 0.999). The precision (intraand inter-day) was demonstrated. The method is robust relative to changes in flow rate, column and temperature. The limits of detection and quantitation were 0.4 and 0.12μg/ml respectively. Validation parameters such as specificity, linearity, precision, accuracy, and robustness, limit of detection (LOD) and limit of quantitation (LOQ) were evaluated for the method according to the International Conference on Harmonization (ICH) Q2 R1 guidelines. The method fulfilled the requirements for reliability and feasibility for application to the quantitative analysis of lenvatinib in bulk and pharmaceutical dosage forms.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87156456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1