American Journal of PharmTech Research最新文献_第10页

Psychiatric Disturbance of Corticosteroid Therapy: Itâ€™s The Time to Overcome 皮质类固醇治疗的精神障碍:是时候克服了

American Journal of PharmTech Research Pub Date : 2019-06-08 DOI: 10.46624/ajptr.2019.v9.i3.025

Nima Kv, Lincy George, K. Krishnakumar, Jasna Jose

{"title":"Psychiatric Disturbance of Corticosteroid Therapy: Itâ€™s The Time to Overcome","authors":"Nima Kv, Lincy George, K. Krishnakumar, Jasna Jose","doi":"10.46624/ajptr.2019.v9.i3.025","DOIUrl":"https://doi.org/10.46624/ajptr.2019.v9.i3.025","url":null,"abstract":"Nima KV*, Lincy George, K Krishnakumar, Jasna Jose Department of pharmacy practice, St James College of Pharmaceutical Sciences, St James Hospital Trust Pharmaceutical Research Centre (DSIR recognized), Chalakudy, Kerala. ABSTRACT Corticosteroids are the drugs used for multifarious diseases because of their widespread action. It is suggested that these drug use should not be ceased rapidly, rather than it should be finished gently. Due to their diversity of actions and uses, more no of interactions with the drugs and diseases were recorded It is well known that there is a strong relationship between corticosteroid use and psychiatric effects. Both the steroid induced psychiatric symptoms and diagnosis are uncertain. Hence Pharmacists are the best person to mould a suitable drug therapy and a management regimen for corticosteroids induced adverse events in patients. They can also play an important role in educating the patients about corticosteroids and their psychic disturbances. Since physicians do not take any interest in to alert the patients about the usage, interactions and highly severe psychiatric problems of steroids, the need of pharmacists becomes very important.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75894255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prostheticaly Driven Implant Placement -A Case Report 假体驱动种植体置入1例报告

American Journal of PharmTech Research Pub Date : 2019-06-08 DOI: 10.46624/ajptr.2019.v9.i3.030

A. Kumar, Sanjna Nayar

{"title":"Prostheticaly Driven Implant Placement -A Case Report","authors":"A. Kumar, Sanjna Nayar","doi":"10.46624/ajptr.2019.v9.i3.030","DOIUrl":"https://doi.org/10.46624/ajptr.2019.v9.i3.030","url":null,"abstract":"Technology has been used to change the world and to alter the manner of our existence. At present, the technological possibilities that lie ahead are also quite mind bending. The lines between \"artificial\" and \"natural\" are blurring by the day, with each new technical advancement and scientific discovery. Thus, in our field of dentistry the latest advancement is a boon to our patients. This is a case report on implant placement using 3D printed completely limiting tooth supported surgical guide with a flapless and immediate loading protocol. Dental implant has been established as one of the most predictable and conservative approaches for the rehabilitation of missing teeth. With the evolution of newer material and advancement in digital technology, especially in computed tomography, implant planning software and guided implant surgery, the outcome and success in implant dentistry have become more predictable. Computer aided design (CAD) technique is being integrated into treatment planning, and computer-assisted manufacturing (CAM) is becoming more popular for rehabilitation procedures. This case report illustrates the diagnosis, planning and application of 3D guided technology in dental implant surgery. This article also emphasises the importance of proper planning in prosthetically driven implant placement.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74351688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Study On Prevalence and Drug Utilization in Cardiovascular Diseases In A Tertiary Care Teaching Hospital 某三级教学医院心血管疾病患病率及用药情况研究

American Journal of PharmTech Research Pub Date : 2019-04-08 DOI: 10.46624/ajptr.2019.v9.i2.019

K. M, Abdul Harshid, Ananya Baburaj, Anjala Stephen

{"title":"A Study On Prevalence and Drug Utilization in Cardiovascular Diseases In A Tertiary Care Teaching Hospital","authors":"K. M, Abdul Harshid, Ananya Baburaj, Anjala Stephen","doi":"10.46624/ajptr.2019.v9.i2.019","DOIUrl":"https://doi.org/10.46624/ajptr.2019.v9.i2.019","url":null,"abstract":"Cardio Vascular Diseases(CVD) are the leading cause of death and its incidence is rapidly increasing in every region of the world and it remains the major threat to modern society. At present, CVD prevention becomes a major issue for world health and burden on risk factor remains alarmingly high. The main objective of this study was to assess the prevalence and drug utilization in CVD. A prospective observational study was carried out in 186 inpatients for a duration of 6 months (October-17 to March-18) in the Medicine Department of AH&RC, B.G.Nagara. The data was collected after obtaining consent from inpatients. Ethical clearance from Institutional Ethical Committee AIMS, B.G.Nagara was obtained. The data was analyzed by using MS-Excel. Among 186 CVD patients more of males(62.4%) than females(37.6%) were seen, most of them fell in age group of 61-90 years(52.7%). 22% were alcoholics, 32.8% were smokers, 15.6% used tobacco, 39.8% had raised blood-pressure and 21.5% had raised blood-glucose. Among CVD patients hypertension was more prevalent(31.2%) followed by heart failure(15.1%), cardiovascular accident(13.4%), and most prescribed drugs include diuretics (56.3%), Calcium Channel Blockers(CCB)(49%) and anti-coagulants(50.2%). This study can benefit patients in early detection, high risk patients deserving immediate attention and intervention. It was observed that more males suffered from CVD than females; the most common CVD was found to be Hypertension. Major risk factors were alcohol, smoking, raised blood pressure and raised blood glucose. Most prescribed drugs include diuretics, CCB, and anticoagulants.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83847122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cultivation, Harvesting and Processing to Produce Top Quality Coffee in Coffee Robusta L. Linden And Their Value Added Products-A Review 高品质咖啡的栽培、采收和加工及其附加值产品综述

American Journal of PharmTech Research Pub Date : 2019-04-08 DOI: 10.46624/ajptr.2019.v9.i2.014

Sruthi Ns, S. A

{"title":"Cultivation, Harvesting and Processing to Produce Top Quality Coffee in Coffee Robusta L. Linden And Their Value Added Products-A Review","authors":"Sruthi Ns, S. A","doi":"10.46624/ajptr.2019.v9.i2.014","DOIUrl":"https://doi.org/10.46624/ajptr.2019.v9.i2.014","url":null,"abstract":"Coffee is grown in various geological and climatic adversities in India. The top coffee producing countries include Brazil, Columbia, Indonesia, India and Ethiopia. Coffee, one of the world’s most important trade products. Two species are economically important for the production of the beverage coffee, Coffea arabica L. (Arabica coffee) and Coffea canephora A. Froehner (Robusta coffee). Coffee is not merely a beverage, it also has medicinal, cosmetics uses too. Certain research studies shows that coffee is a source of antioxidants and regular consumption of coffee may lower chances of heart diseases and stroke. It can prevent certain type of cancers such as colorectal cancer. Coffea robusta is the variety that is chosen as the study material. It is a woody perennial evergreen plant. It’s the second most commercially important coffee species in India is Robusta. The cost of Robusta cultivation is relatively lower compared to Arabica. Coffee in India is mainly propagated through seeds. Use of quality seed plays an important role in establishing a productive plantation. Coffee harvesting and processing is both an art and a science. The present study deals with the cultivation, harvesting and processing to produce top quality coffee in Coffea robusta and their value added product.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83978454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ocimum Sanctum- A Traditional Remedy and Ethno Medicinal Uses, A Concise Review 中药——一种传统药物和民族药用，简要回顾

American Journal of PharmTech Research Pub Date : 2019-04-08 DOI: 10.46624/ajptr.2019.v9.i2.024

V. P. Sonar, Buddhabhushan V. Bansod, pavankumar N. Desale, S. Chalikwar

{"title":"Ocimum Sanctum- A Traditional Remedy and Ethno Medicinal Uses, A Concise Review","authors":"V. P. Sonar, Buddhabhushan V. Bansod, pavankumar N. Desale, S. Chalikwar","doi":"10.46624/ajptr.2019.v9.i2.024","DOIUrl":"https://doi.org/10.46624/ajptr.2019.v9.i2.024","url":null,"abstract":"Medicinal plants are major source of bioactive compounds and chemical structures that gives potential beneficial effects. Ocimum sanctum (Tulsi) belongs to the Lamiaceae family, cultivated around tropical and semitropical zone of India and other surrounding Asian countries. In the present review on O. sanctum, the traditional uses, chemical constituents and pharmacological activities are explored. Various medicinal and therapeutic characteristics of Tulsi are found in the aerial parts, roots, leaves and seeds which havea broad range of activity on human being. O. sanctumhas multiple medicinal and therapeutic properties such as antibacterial, anticholinesterase, antioxidant, antifungal, antimicrobial, antiaflatoxigenic, anti-inflammatory and antinoceceptive, anticandidal, toxicological, anti-stress and anticonvulsant, anticancer, wound healing activities. Recent research has proven the anticancer and anti-HIV activity of O. sanctum. The chemical compounds of O. sanctum like alkaloids, phenolics, phenyl, coumarins, flavonoids, fatty acids, essential oils, steroidal, and tannin contents play an important role in herbal medicine. This paper examines the various traditional uses, phytochemical constituents and therapeutic potentials of Tulsi plant will be helpful in the treatment of oral diseases and many medicinal disorders and also will be useful in the expansion of new active principles.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85016337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Study Of Method Development, Validation and Forced Degradation Studies of Clotrimazole by Using UV Spectrophotometry 紫外分光光度法测定氯霉唑的方法建立、验证及强制降解研究

American Journal of PharmTech Research Pub Date : 2019-04-08 DOI: 10.46624/ajptr.2019.v9.i2.005

Devi velmuruganaƒ, S. Vairavel, Rajasekar chandran, Saranya ., Siva Kumar nayak

{"title":"A Study Of Method Development, Validation and Forced Degradation Studies of Clotrimazole by Using UV Spectrophotometry","authors":"Devi velmuruganaƒ, S. Vairavel, Rajasekar chandran, Saranya ., Siva Kumar nayak","doi":"10.46624/ajptr.2019.v9.i2.005","DOIUrl":"https://doi.org/10.46624/ajptr.2019.v9.i2.005","url":null,"abstract":"Please cite this article as: Devi V et al., A Study Of Method Development, Validation and Forced Degradation Studies of Clotrimazole by Using UV Spectrophotometry . American Journal of PharmTech Research 2019. A Study Of Method Development, Validation and Forced Degradation Studies of Clotrimazole by Using UV Spectrophotometry Devi velmurugan , Sekar vairavel, Rajasekar chandran, Saranya, Siva Kumar nayak Department of Pharmaceutical Analysis, JKK Nattaraja College of Pharmacy, Komarapalayam, Namakkal (DT), TN, India ABSTRACT To develop a simple, precise, accurate, and stability indicating a UV-method for estimation of Clotrimazole. In bulk and formulated dosage form. The method was under subjected to stress degradation at different conditions recommended by the International Conference on Harmonization (ICH). The drug samples are generated and used for the degradation studies. The λmax of the Clotrimazole was found to be 220 nm. The linearity of calibration curve (Absorbance Vs Concentration) in pure solution was checked over the concentration ranges of about 5-30μg/ml for Clotrimazole respectively, with the correlation coefficient higher than 0.999. The regression equation of the curve was Y = 0.0168x + 0.0041. The % RSD was found to be within the limit as per ICH guidelines. The obtained percentage recovery of Clotrimazole was found to be within the limit 100% ± SD. The proposed method can be successfully applied for the method development, validation and stress degradation studies of Clotrimazole. The percentage degradation limit should be 5-20%. The drug Clotrimazole was found to be within the limit.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88585175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Metoclopramide Hydrochloride Loaded Oral Wafers for Postoperative Care of Children: In Vitro and In Vivo Evaluation 盐酸甲氧氯普胺口腔片用于儿童术后护理:体外和体内评价

American Journal of PharmTech Research Pub Date : 2019-04-08 DOI: 10.46624/ajptr.2019.v9.i2.017

Amal M. Abd El Razek, Azza A. Hasan, Shereen A Sabry, M. Mahdy, Eslam E. Hamed

{"title":"Metoclopramide Hydrochloride Loaded Oral Wafers for Postoperative Care of Children: In Vitro and In Vivo Evaluation","authors":"Amal M. Abd El Razek, Azza A. Hasan, Shereen A Sabry, M. Mahdy, Eslam E. Hamed","doi":"10.46624/ajptr.2019.v9.i2.017","DOIUrl":"https://doi.org/10.46624/ajptr.2019.v9.i2.017","url":null,"abstract":"The present study focused on the formulation of metoclopramide HCl (MET HCl) loaded oral wafers (OWs) as a fast dissolving dosage form without drinking water to produce a prompt improvement of emesis. OWs were prepared by casting technique using Hydroxypropyl Methylcellulose (HPMC) as a film forming agent and plasticizers like propylene glycol (PG), polyethylene glycol (PEG) 400 and polyethylene glycol 600. The prepared formulations were visually inspected and subjected to evaluation parameters such as thickness, weight variation, drug content, folding endurance, surface pH, tensile strength, mucoadhesiveness, percentage of moisture absorption, percentage of moisture loss and in vitro release study. G3 batch was selected for further investigations e.g. DSC, FTIR and in vivo evaluation. The bioavailability of MET HCl loaded OWs was assessed by measuring the plasma concentrations of MET HCl in different studied rabbit's groups' .All wafers were transparent, smooth, uniform and flexible. G3 batch (300 mg HPMC, 20% PEG 400) showed the highest tensile strength, percent elongation, mucoadhesiveness and faster drug release. The pharmacokinetic data of MET HCl loaded OWs preparation (G3 batch) showed a significant higher Cmax, AUC0-24 and lower Tmax (p<0.001) than oral plain MET HCl solution. It could be concluded that MET HCl loaded OWs is a promising fast-release preparation with enhanced rate and extent of drug absorption hence, higher therapeutic efficiency against vomiting and nausea in pediatrics, especially postoperatively can be expected.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83140547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Caregiverâ€™S Perception Towards Respiratory Diseases Therapy In Pediatric Department Of A Tertiary Care Teaching Hospital 某三级教学医院儿科护理人员对呼吸系统疾病治疗认知的评估

American Journal of PharmTech Research Pub Date : 2019-04-08 DOI: 10.46624/ajptr.2019.v9.i2.008

B. K. M, P. Swathi, Ankita Singh, H. Doddayya, G. Manjunath

引用次数: 0

FORMULATION AND EVALUATION OF TOPICAL ANTIFUNGAL GEL CONTAINING ITRACONAZOLE 含伊曲康唑外用抗真菌凝胶的研制与评价

American Journal of PharmTech Research Pub Date : 2019-04-08 DOI: 10.46624/ajptr.2019.v9.i2.026

L. Jamagondi, Aniket S. Katte

{"title":"FORMULATION AND EVALUATION OF TOPICAL ANTIFUNGAL GEL CONTAINING ITRACONAZOLE","authors":"L. Jamagondi, Aniket S. Katte ","doi":"10.46624/ajptr.2019.v9.i2.026","DOIUrl":"https://doi.org/10.46624/ajptr.2019.v9.i2.026","url":null,"abstract":"The objective of the present research work is to formulate and evaluate Itraconazole antifungal gel. Itraconazole is an imidazole derivative and used for the treatment of local and systemic fungal infection. The oral activity of Itraconazole is not much proven to be efficient as it has many side effects. This formulation is made for better patient compliance and to reduce the dose of the drug. The gel was formulated by changing the polymer ratio. Various formulation (F1, F2, F3, F4) were developed by using a suitable polymer (carbopol 971p and noveonAA1). The formulation was evaluated for, spreadability, extrudability and viscosity in vitro drug release study. Viscosity studies of various formulations revealed that formulation F4 was better to compare to others. From among all the developed formulation, F4 shows better drug diffusion, did good Rheological properties. pH of the F4 formulation is sufficient enough to treat the skin infections. Results indicated that the concentration of carbopol 971p and noveon AA1 significantly affects drug release and rheological properties of the gel. It was concluded that formulation F4 was the best formulation among this formulation. Hence formulation F4 has shown the better results compared to other batches.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78890960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and Evaluation of Ritonavir Floating Tablets. 利托那韦漂浮片的处方及评价。

American Journal of PharmTech Research Pub Date : 2019-04-08 DOI: 10.46624/ajptr.2019.v9.i2.025

Krishnamurthy A. Kamlapurkar, Manmat B. Rumane, Shrishail M. Ghurghure, Sagar Sontakke, Imran N. Mujewar

{"title":"Formulation and Evaluation of Ritonavir Floating Tablets.","authors":"Krishnamurthy A. Kamlapurkar, Manmat B. Rumane, Shrishail M. Ghurghure, Sagar Sontakke, Imran N. Mujewar","doi":"10.46624/ajptr.2019.v9.i2.025","DOIUrl":"https://doi.org/10.46624/ajptr.2019.v9.i2.025","url":null,"abstract":"Please cite this article as: Rumane MB et al., Formulation and Evaluation of Ritonavir Floating Tablets.. American Journal of PharmTech Research 2019. Formulation and Evaluation of Ritonavir Floating Tablets. Krishnamurthy A. Kamlapurkar, Manmat B. Rumane,, Shrishail M. Ghurghure, Sagar S. Sontakke, Imran N. Mujewar. 1. P.G. Department of pharmaceutics, D.S.T.S. Mandal’s college of pharmacy, Solapur-413004 Maharashtra India ABSTRACT The aim of present research work was to formulate gastro retentive floating tablets containing Ritonavir. The floating tablets of Ritonavir was formulated by direct compression technique using natural, semi-synthetic and synthetic polymers such as gellan gum, HPMC K4M, and carbopol 971p. Sodium bicarbonate was used as gas generating agent. FTIR studies revealed that there is no interaction between the drug and the polymers used in the formulation. Prepared Ritonavir tablets were evaluated by various quality parameters including weight variation, hardness, friability, drug content, tablet density, floating test, swelling index, in-vitro drug release and showed satisfactory results. Formulations F2, F5, F6 showed satisfactory drug release of 90.3%, 94.3%, and 97.7% respectively. The optimized batch F6 shows good results and extended drug release.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84279051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0