American Journal of PharmTech Research最新文献

{"title":"Floating Drug Delivery System: A Brief Review","authors":"Haridwar Lodh, FR Sheeba, P. Chourasia, H. A. Pardhe, N. Pallavi","doi":"10.46624/ajptr.2020.v10.i4.010","DOIUrl":"https://doi.org/10.46624/ajptr.2020.v10.i4.010","url":null,"abstract":"Scientific and technological developments in the research and development of new drug delivery systems have been made in recent years by resolving physiological disorders, such as short gastric residence periods and unpredictable gastric emptying times. Dosage forms that can be hold within the stomach are called as Gastro-retentive Dosage Forms (GRDF). Multiple methods used in the prolongation of gastric residence time are floating drug delivery system, swelling and expanding system, polymeric bio-adhesive system, high density system and other delayed gastric emptying system. Medication-based disease treatment is entering a new era in which a increasing range of innovative drug delivery technologies are being used and are available for clinical use. Floating Drug Delivery Systems (FDDS) is one of the gastro-retentive dosage forms used to achieve extended duration of gastric residency. The aim of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with particular focus on the main floating mechanism to achieve gastric retention. Sustained oral release of gastrointestinal dosage types provides many benefits for drugs with absorption from the upper sections of the gastrointestinal tract and those that function locally throughout the stomach. This review includes the physiology, factors controlling gastric retention time, excipient variables influencing gastric retention, approaches to designing single-unit, hydro-dynamically balanced system and multi-unit floating structure, and aspects of their classification, formulation and evaluation are discussed in detail, and few applications of these systems.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73431797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral cemento-ossifying fibroma associated with TUBEROUS SCLEROSIS","authors":"M. Pukazhmurasu, S. Senthilkumar, Krishnan, S. Srinivasan, J. Kavitha, A. Elakiya","doi":"10.46624/ajptr.2020.v10.i4.003","DOIUrl":"https://doi.org/10.46624/ajptr.2020.v10.i4.003","url":null,"abstract":"Tuberous sclerosis complex (TSC) was a rare autosomal dominant neurocutaneous disease characterized by benign tumors affecting various body systems, skin changes, neurological disorders, and multi organ development of hamartomas leading to morbidity and death. Intraoral fibromas, gingival hyperplasia and enamel hypoplasia or enamel pits are the most common oral manifestations.Those patient management always involves a multidisciplinary approach from vario us fields. Here we present a case study of 35 years old female patient with tuberous sclerosis complex characteristic clinical, radiological, and histological features.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83971115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and Evaluation of 5-Florouracil loaded Nano-Structured lipid carrier by double emulsification techniques","authors":"Saripadiya Nimesh D, Dr. Mayur M Patel","doi":"10.46624/ajptr.2020.v10.i3.014","DOIUrl":"https://doi.org/10.46624/ajptr.2020.v10.i3.014","url":null,"abstract":"","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79134931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-steroidal Anti-inflammatory Drugs (NSAIDS): Chemistry, Mechanism and their Adverse events.","authors":"R. Tonk, Sumit Tewatia, S. Majeed, Manish Dagar","doi":"10.46624/ajphr.2020.v8.i5.004","DOIUrl":"https://doi.org/10.46624/ajphr.2020.v8.i5.004","url":null,"abstract":"More than 15 different non-steroidal anti-inflammatory drugs (NSAIDs) are available commercially, and these agents are used worldwide for their analgesic antipyretic and antiinflammatory effects in patients with multiple medical conditions. NSAIDs, including aspirin, do not generally change the course of the disease process in those conditions, where they are used for symptomatic relief. The main mechanism of action of NSAIDs is the inhibition of the enzyme cyclooxygenase (COX). Cyclooxygenase is required to convert arachidonic acid into thromboxane’s, prostaglandins, and prostacyclin’s. Assessment of toxicity and therapeutic response to a given NSAID must take into account the time needed to reach the steady state plasma concentration (roughly equal to three to five half-lives of the drug). NSAIDs have wellknown adverse effects affecting the gastric mucosa, renal system, cardiovascular system, hepatic system, and hematologic system.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141204029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palladium used As A Catalyst: A Review","authors":"B. Bhat, Wasseem Akbar Khanday","doi":"10.46624/ajphr.2020.v8.i4.002","DOIUrl":"https://doi.org/10.46624/ajphr.2020.v8.i4.002","url":null,"abstract":"In this review, the most important Pd-catalyzed C-C cross-coupling named reactions have been presented and discussed. It has been proposed that in Pd-catalysed reactions, the Pd decreases the activation energy or reacting species by simply stabilizing the transition state as it is an unstable and short-lived. The catalyst may get coordinated to one or more of the reactants and remains coordinated throughout the transition state of the catalytic process. During this process, the dissociation of the product either regenerates the Pd directly or generates a species that will be converted into the Pd. This is a typical in enzyme–catalyzed processes occurs in organometallic chemistry.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82046075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and In-Vitro Evaluation of Gastro Retentive Floating Drug Delivery System of Losartan Potassium.","authors":"K.S. Srilatha, Hemanth. S, B. Milton, Snehalatha","doi":"10.46624/ajphr.2020.v8.i4.003","DOIUrl":"https://doi.org/10.46624/ajphr.2020.v8.i4.003","url":null,"abstract":"The objective of the study was to formulate and evaluate gastro retentive floating drug delivery tablets of Losartan potassium. It is an orally active non-peptide angiotensin -II receptor antagonist, used in the treatment of hypertension due to mainly blockade of AT1 receptors. The main reason for low therapeutic effectiveness of Losartan potassium is its narrow therapeutic index, poor bioavailability (25-35%), and short biological half life (1.5-2h). Conventional tablets should be administered 3-4 times to maintain plasma drug concentration. So, to increase therapeutic efficacy, reduce frequency of administration sustained release floating matrix tablets of Losartan potassium were prepared. Present study demonstrates the formulation of sustained release floating matrix tablets of Losartan potassium with various grades of hydroxyl propyl methylcellulose to restrict the drug release preferably in upper part of intestine and to improve its bioavailability and to provide constant drug plasma levels thereby improving the patient compliance. Losartan potassium showed maximum absorbance at 256 nm so absorbance was measured at the same wavelength and found to obey Beer lamberts law in the concentration range of 10-40 mcg/ml. In the pre formulation study of IR spectra of pure drug with the different polymers showed no interaction, Differential scanning calorimetry experiments were carried out to find out the presence of any interaction among drug and the excipients. Pure drug and individual polymers were subjected to the study and no interactions were observed .12 formulation of sustained release of Losartan potassium were prepared and they were examined for physical properties and appearance like hardness, thickness, weight variation, thickness, hardness, friability uniformity of drug content floating lag time floating duration time and in-vitro drug release studies . I n the study all the powder blends showed good flow ability angle of repose below 25.98±0.07°31.724±0.15°, compressibility index was found in the range of 12.5±0.1616.92±1.9 g/cm Weight variation 297.2±1.19-301.52±2.73mg, hardness 5.9±0.2-7±0.2kg/cm thickness 4.506±0.04-4.86±0.03, friability 0.91-0.41, floating time <12hrs in vitro release for all formulations were found to be 61.18 -99.02.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77940285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and In Vitro Evaluation Of Transdermal Patch Of Aceclofenac","authors":"K. Sravanthi, D. R. Reddy, A. Sirisha, A. Pavani, B. Mahalakshmi, B. Sowjanya","doi":"10.46624/ajptr.2020.v10.i2.014","DOIUrl":"https://doi.org/10.46624/ajptr.2020.v10.i2.014","url":null,"abstract":"The purpose of this research was to develop a matrix-type transdermal therapeutic system containing drug Aceclofenac with different ratios of hydrophilic (hydroxyl propyl methyl cellulose) and hydrophobic (methyl cellulose) polymeric systems by the solvent casting technique. Formulated transdermal patches were physically evaluated with regard to thickness, weight variation, drug content, flatness, tensile strength, folding endurance, percentage of moisture content and water vapour transmission rate. All prepared formulations indicated good physical stability. In-vitro drug studies of formulations were performed by using Franz diffusion cells. The results followed the release profile of Aceclofenac followed mixed zero-order. However, the release profile of the optimized formulation F9 (99.50±0.09) indicated that the permeation of the drug from the patches was governed by a diffusion mechanism. Formulation F9 showed highest flux among all the formulations and 217±7.42 fold enhancements in drug permeation.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90264379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transdermal Drug Delivery System: A Review","authors":"V. K. Ghume, A. R. Golhar, A. N. Merekar, M. D. Dokhe, S. K. Parjane","doi":"10.46624/ajptr.2020.v10.i2.004","DOIUrl":"https://doi.org/10.46624/ajptr.2020.v10.i2.004","url":null,"abstract":"Transdermal drug delivery system (TDDS) is the administration of therapeutic agents through intact skin for systematic effect. It has emerged as a potential novel drug delivery system by improving the therapeutic efficacy and safety, maintain steady state plasma level of drugs and overcome significant drawbacks of the conventional oral dosage forms and parenteral preparations. TDDS is ideally suited for diseases that demand chronic treatment with frequent dosing. This review deals with a brief insight on the formulation aspects, the physical and chemical enhancers being explored to enhance the transdermal delivery of drugs across the stratum corneum, the evaluation parameters (physicochemical, in vitro, in vivo studies) and therapeutic applications of TDDS.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89672503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and Evaluation of Herbal Hand wash Gel from Hyptis suaveolens Flowering-tops","authors":"Pritam V. Chindarkar","doi":"10.46624/ajptr.2020.v10.i2.026","DOIUrl":"https://doi.org/10.46624/ajptr.2020.v10.i2.026","url":null,"abstract":"The main objective of this present work is to formulate and evaluate herbal hand wash in order to make a formulation that has less side effects and has better cleaning of hands using the ethanol extract of the flowering-tops (flower, including the stems, leaves and blooms) of plant Hyptis suaveolens. The prepared formulation was evaluated by different parameters like organoleptic properties, physico-chemical parameters along with the antibacterial test. The formulated hand watch was found to be good in physical parameters with good cleaning of hands.","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75875911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and Evaluation of Mouth Dissolving Tablet of Lornoxicam Using Novel Natural Superdisintegrants.","authors":"K. D. Baviskar, Rahul Baviskar, P. K. Kanke, K. Patil","doi":"10.46624/ajptr.2020.v10.i1.005","DOIUrl":"https://doi.org/10.46624/ajptr.2020.v10.i1.005","url":null,"abstract":"","PeriodicalId":7701,"journal":{"name":"American Journal of PharmTech Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76266617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}