Preparation and In Vitro Evaluation Of Transdermal Patch Of Aceclofenac

Abstract

The purpose of this research was to develop a matrix-type transdermal therapeutic system containing drug Aceclofenac with different ratios of hydrophilic (hydroxyl propyl methyl cellulose) and hydrophobic (methyl cellulose) polymeric systems by the solvent casting technique. Formulated transdermal patches were physically evaluated with regard to thickness, weight variation, drug content, flatness, tensile strength, folding endurance, percentage of moisture content and water vapour transmission rate. All prepared formulations indicated good physical stability. In-vitro drug studies of formulations were performed by using Franz diffusion cells. The results followed the release profile of Aceclofenac followed mixed zero-order. However, the release profile of the optimized formulation F9 (99.50±0.09) indicated that the permeation of the drug from the patches was governed by a diffusion mechanism. Formulation F9 showed highest flux among all the formulations and 217±7.42 fold enhancements in drug permeation.