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Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry最新文献

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[A study on the activity of three antioxidant enzymes in the brain of experimental acute cerebral ischemia]. [实验性急性脑缺血大鼠脑内三种抗氧化酶活性的研究]。
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry Pub Date : 1992-12-01
Y Bai
{"title":"[A study on the activity of three antioxidant enzymes in the brain of experimental acute cerebral ischemia].","authors":"Y Bai","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The activities of Superoxide Dismutase (SOD), Glutathione Peroxidase (GSH-Px) and Catalase (CAT) in the ischemic cerebral tissue following the unilateral middle cerebral artery occlusion of rats were assessed. In comparison with the sham-operated rats, both SOD and GSH-Px activity in the ischemic area (striatum and fronto-parietal cortex) were significantly reduced by 30 min. of ischemia, GSH-Px activity in the peri-ischemic area (parieto-parasagittal) was significantly reduced as well. It was shown that in the striatum the GSH-Px activity was much higher than that in the cortex. According to our data, it was suggested that in the ischemic condition, cerebral Superoxide (O2-) and Hydrogen Peroxide (H2O2) were accumulated, and thus the polyunsaturated fatty acids in the neuronal membrane were trapped by these free radical. And such a process resulted in neuronal damage. It implicated that the oxygen free radical might be involved in the neuronal damage induced by Dopamine, since the O2- and H2O2 were excessively generated during the oxidative deamination of Dopamine and the free radical scavengers, SOD and GSH-Px were decreased concomitantly in the cerebral ischemic tissue.</p>","PeriodicalId":76874,"journal":{"name":"Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry","volume":"25 6","pages":"351-4, 384"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12480006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Research on myasthenia gravis in children with HLA supratype]. HLA超型儿童重症肌无力的研究
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry Pub Date : 1992-12-01
X G Zhang
{"title":"[Research on myasthenia gravis in children with HLA supratype].","authors":"X G Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>38 cases of MG Children's patients were typed for HLA-I, II and III antigens. It shows that MG significantly associated with HLA-A2, Bw46 and DRw9. Their relative risk were 3.60, 8.18. 4.60, Pc < 0.05 or 0.001 respectively. The association with C4 and Bf were not found. Aw19 is seemed as a protection factor of this disease. These results are similar with the research on Chinese MG patients in Hong Kong but are quite different with those of caucasian data.</p>","PeriodicalId":76874,"journal":{"name":"Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry","volume":"25 6","pages":"358-60, 385"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12480008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Treatment of experimental ischemic cerebral lactic acidosis in rats with dichloroacetate]. [二氯乙酸酯治疗实验性缺血性脑乳酸酸中毒]。
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry Pub Date : 1992-12-01
C L Hu
{"title":"[Treatment of experimental ischemic cerebral lactic acidosis in rats with dichloroacetate].","authors":"C L Hu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the cerebral ischemic pathophysiologic mechanism, lactic acidosis is a important factor to exacerbate cerebral damage. Our research showed that the lactic level of cerebral cortex in rats increased rapidly after the focal cerebral ischemia or during blood reperfusion after cerebral ischemia, 26.99 +/- 5.89 and 28.63 +/- 5.08 mumol/g brain wight respectively, it exacerbated significantly brain edema and pathological damage. The lactic level decreased rapidly to treat with dichloroacetate (50 mg/kg body weight) after cerebral ischemia or during blood reperfusion, 14.11 +/- 2.06 and 13.23 +/- 1.71 mumol/g brain wight respectively, brain edema and pathology improved significantly. It suggested that dichloroacetate might across blood-brain barrier into the cerebral ischemic region and lowered lactic level, improved brain internal environment, relieved cerebral damage after focal cerebral ischemia or during blood reperfusion. It may improve the prognosis of patient with ischemic cerebral vascular disease to be treated with dichloroacetate early.</p>","PeriodicalId":76874,"journal":{"name":"Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry","volume":"25 6","pages":"355-7, 384-5"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12480007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Clinical analysis of 30 cases of stiff-man syndrome]. 【硬人综合征30例临床分析】。
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry Pub Date : 1992-12-01
B J Chen
{"title":"[Clinical analysis of 30 cases of stiff-man syndrome].","authors":"B J Chen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thirty cases of SMS, including 22 cases reported previously in China, were analysed clinically manifested by involvement of neck and facial muscles, slurred speech, dysphagia or dyspnea, exaggerated tendon reflexes, ankle clonus and/or Hoffmann's sign. Half of them had past history of infection. Five out of 18 CSF examined showed elevation of protein content, immunoglobulin and white cell count, suggesting the presence of inflammation or demyelination changes in CNS. The pathology of the syndrome is probably located in the spinal cord or brain stem. The criteria for diagnosis are proposed. For treatment, the dosage and way of administration of diazepam should be judged according to the severeness of the disease; nitrazepam and clonazepam are effective, too.</p>","PeriodicalId":76874,"journal":{"name":"Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry","volume":"25 6","pages":"363-5, 385"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12480009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Function of lymphocyte beta-adrenergic receptor in depression]. 淋巴细胞β -肾上腺素能受体在抑郁症中的作用。
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry Pub Date : 1992-12-01
X D Fan
{"title":"[Function of lymphocyte beta-adrenergic receptor in depression].","authors":"X D Fan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lymphocyte beta-adrenergic receptor function of 20 depressed patients and 18 healthy volunteers were measured using radioligand binding technique. It was found that the affinity and sensitivity of this receptor were significantly higher in endogenous depressed patients than those in normal controls. After the electro-acupuncture-treatment (EAT), lymphocyte beta-receptor function decreased in patients who responded well to EAT, but still not reached normal level.</p>","PeriodicalId":76874,"journal":{"name":"Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry","volume":"25 6","pages":"322-4, 382"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12512987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A study of the P300 cognitive potential on mental deficiency in children]. [P300认知潜能对儿童智力缺陷的研究]。
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry Pub Date : 1992-12-01
C B Li
{"title":"[A study of the P300 cognitive potential on mental deficiency in children].","authors":"C B Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The study of 36 cases of P300 Cognitive Potential (P300 CP) of mental deficiency children have been made. The results of examination were abnormal in 31 cases (85%). In the 31 cases the latency of P300 the cognitive waves (P300 CW) were prolonged, the amplitude were reduced and the P300 CW disordered. After discussion of the relation among the P300 CW, the intelligence quotient (IQ) and the EEG, it were pointed out that P300 CP is as sensitive, objective, valuable indexes for checking and testing intelligence of mental deficiency children.</p>","PeriodicalId":76874,"journal":{"name":"Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry","volume":"25 6","pages":"366-8, 385"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12479830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A clinical and follow-up study in 33 cases of rapid cyclic affective psychosis]. 快速循环情感性精神病33例临床与随访分析
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry Pub Date : 1992-12-01
Z X Liu, D C Wang
{"title":"[A clinical and follow-up study in 33 cases of rapid cyclic affective psychosis].","authors":"Z X Liu,&nbsp;D C Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Three hundred and fifty one cases of manic-depressive psychosis in our hospital were reviewed. Of these, 33 cases were rapid cyclothymic type (9.4%). Their clinical features, including sex, age, personality characteristics, phenomena and clinical types were analysed. The results suggested that: the major precipitating factors are psychosocial factors and antidepressants; the better therapy is the administration of the lithium combined with carbamazepine or neuroleptics; and more ideal prognosis occurs in any patient persisting in receiving the therapy.</p>","PeriodicalId":76874,"journal":{"name":"Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry","volume":"25 6","pages":"341-3, 383"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12480002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The study of occurrence mechanism in acute and chronic cerebral vasospasm]. 急慢性脑血管痉挛发生机制的研究。
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry Pub Date : 1992-12-01
K Jiang
{"title":"[The study of occurrence mechanism in acute and chronic cerebral vasospasm].","authors":"K Jiang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Using radioimmunoassay, fluorescence and transmittal++ electronmicroscopy, we studied the of prostaglandin(PG), lipid peroxidation(LPO) and ultrastructure. Fresh arterial blood (imaging acute spasm) produced basilar arterial spasm strongly(+ + +) and vacuole deterioration in vascular walls but there were no changes in 6-keto-PGF1 alpha and TXB2 and PGE2 and LPO. Incubated arterial blood (imaging chronic spasm) produced basilar arterial spasm markedly (+ + +) also. Vacuole deterioration in vascular walls either, and decreased the level of 6-keto-PGF1 alpha apparently (P < 0.01) and elevated the content of LPO significantly (P < 0.01) and there were no changes in the level of TXB2 and PGE alpha. This experiment suggests that the mechanism of acute spasm and chronic spasm is different.</p>","PeriodicalId":76874,"journal":{"name":"Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry","volume":"25 6","pages":"344-6, 383"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12480004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Advances in the research on the pathogenic role of Campylobacter jejuni in Guillain-Barre syndrome]. [空肠弯曲杆菌在格林-巴利综合征中的致病作用研究进展]。
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry Pub Date : 1992-12-01
J Tang, J M Yuan
{"title":"[Advances in the research on the pathogenic role of Campylobacter jejuni in Guillain-Barre syndrome].","authors":"J Tang,&nbsp;J M Yuan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76874,"journal":{"name":"Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry","volume":"25 6","pages":"375-7"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12479831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A study of cyclic nucleotide acids in the serum in patients with myasthenia gravis]. [重症肌无力患者血清环核苷酸酸的研究]。
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry Pub Date : 1992-12-01
J Z Xu
{"title":"[A study of cyclic nucleotide acids in the serum in patients with myasthenia gravis].","authors":"J Z Xu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The levels of cAMP and cGMP in serum of 100 patients with myasthenia gravis have been measured by 125I-RIA. The results showed that cAMP and cGMP were higher in the patients than in the controls significantly (P < 0.001). In 33 cases of these patients after using anticholinesterase drugs and prednisone, the levels of cAMP and cGMP reduced significantly. According to our study, we presumed that there would be cyclic nucleotide acid metabolic disturbances in patients with MG and cAMP might play a regulatory role in morbidity of MG.</p>","PeriodicalId":76874,"journal":{"name":"Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry","volume":"25 6","pages":"361-2, 385"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12512988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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