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Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry最新文献

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[Dopa-induced dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated hemiparkinsonian monkeys]. [多巴诱导的1-甲基-4-苯基-1,2,3,6-四氢吡啶治疗的半帕金森猴子运动障碍]。
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry Pub Date : 1992-02-01
S Chen
{"title":"[Dopa-induced dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated hemiparkinsonian monkeys].","authors":"S Chen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into the right common carotid artery of 5 rhesus monkeys produced hemiparkinsonian syndrome in the contralateral limbs which responded to madopa or apomorphine therapy. Moreover, these two drugs induced circling away from the MPTP-treated side, amphetamine induced rotation toward the MPTP-treated side. Long-term use of madopa developed a peak-dose dyskinesia of the face and the limbs contralateral to the MPTP-treated side. The ipsilateral toxic effects were confirmed biochemically by reduction of nigrostriatal DA and histologically by degeneration of nigral neurons of the MPTP-treated side. It is concluded that this hemiparkinsonian model of rhesus monkey will be of value in the elucidation of the neural mechanism underlying L-DOPA or DA agonist induced dyskinesia in Parkinson's disease and in the search for newer methods of treatment which would produce less dyskinesia and response fluctuations.</p>","PeriodicalId":76874,"journal":{"name":"Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry","volume":"25 1","pages":"50-2, 64"},"PeriodicalIF":0.0,"publicationDate":"1992-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12759412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[An investigation on changes in blood CuZn-superoxide dismutase contents in type I, II schizophrenics]. [1、2型精神分裂症患者血cuzn -超氧化物歧化酶含量变化的研究]。
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry Pub Date : 1992-02-01
H Wang
{"title":"[An investigation on changes in blood CuZn-superoxide dismutase contents in type I, II schizophrenics].","authors":"H Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Blood CuZn superoxide dismutase (CuZn-SOD) changes during neuroleptic drugs treatment were measured by means of double-antibody immunoradiometric assay, in 121 schizophrenics (77 cases with Type I and 44 cases with Type II), and 128 normal subjects as control group. The results revealed: (1) before treatment, the overall blood content of CuZn-SOD in patient group showed higher significantly than that of control group (t = 12.34, P less than 0.001); (2) the content of CuZn-SOD in Type I schizophrenics was higher than that of Type II (t = 13.93, P less than 0.001); (3) after treatment, the CuZn-SOD content decreased obviously in Type I (t = 7.715, P less than 0.001), while no significant change in Type II was encountered (t = 0.541, P less than 0.05). The pathophysiological mechanisms of dopamine-Oxygen free radicals relating to the Type I and Type II schizophrenics was discussed briefly.</p>","PeriodicalId":76874,"journal":{"name":"Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry","volume":"25 1","pages":"6-8, 60"},"PeriodicalIF":0.0,"publicationDate":"1992-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12759413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A control study of intravenous versus oral clomipramine in major depression]. 静脉注射氯丙咪嗪与口服氯丙咪嗪治疗重度抑郁症的对照研究
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry Pub Date : 1992-02-01
J Zhao
{"title":"[A control study of intravenous versus oral clomipramine in major depression].","authors":"J Zhao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Intravenous clomipramine (n = 105) and oral clomipramine (n = 64) were compared in a control study of 169 inpatients with major depression. The therapeutic effects were evaluated with four-degree scale and the rating scales of HDS and CGI. The results showed intravenous group has earlier response and better antidepressive effects than oral group within treatment period of 2 weeks. No significant differences between two groups were found in anticholinergic side-reaction. Clinical useful values of intravenous clomipramine were discussed.</p>","PeriodicalId":76874,"journal":{"name":"Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry","volume":"25 1","pages":"9-12, 60"},"PeriodicalIF":0.0,"publicationDate":"1992-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12759414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Infantile spasms. A retrospective study of 105 cases]. 婴儿痉挛症。对105例病例进行回顾性研究]。
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry Pub Date : 1992-02-01
Y Feng
{"title":"[Infantile spasms. A retrospective study of 105 cases].","authors":"Y Feng","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper is a summary of our observations on 105 cases of infantile spasms. The age of onset was around six months after birth, but the patients came for treatment mainly about one year after onset. Fever of unknown cause, asphyxia, birth injury, infection of the central nervous system, tuberous sclerosis, phenylketonuria and recent immunization etc. were possible etiology. Clinically, it is characterized by head nodding, mental retardation, myoclonic jerks and various neurologic deficits. EEG findings showed classical or modified arrhythmia or other epileptiform patterns. About one third of 22 cases examined had abnormal brain stem auditory evoked potentials. Among 42 patients who underwent CT scanning before ACTH treatment, 18 were normal and 7 abnormal; during ACTH treatment 3 normal and 4 abnormal; after completion of treatment, 4 normal and 6 abnormal, suggesting no further atrophy of the brain. Examination of trace elements of the hair by proton-induced X-ray emission (PIXE) method in 23 patients revealed a significant difference in lead, calcium and zinc contents between patients and 101 controls, but no statistical difference in iron and copper contents between the two groups. Sodium valproate, prednisone and ACTH appear to be effective in the treatment of infantile spasms. Eight patients fully recovered, and they can go to school without difficulty. Many patients derived various degrees of improvement of the satisfaction of their parents. Two patients were still amended and often attacked by myoclonus. The effects, side effects of these drugs, and the possible pathogenesis were discussed.</p>","PeriodicalId":76874,"journal":{"name":"Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry","volume":"25 1","pages":"25-7, 61-2"},"PeriodicalIF":0.0,"publicationDate":"1992-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12491809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Observation on the changes in the frequency of end-plate potentials evoked by sera with different antibodies from patients with myasthenia gravis in nerve-muscle preparation of rats]. [重症肌无力患者不同抗体血清在大鼠神经-肌肉制备过程中终板电位频率变化的观察]。
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry Pub Date : 1992-02-01
C Lu
{"title":"[Observation on the changes in the frequency of end-plate potentials evoked by sera with different antibodies from patients with myasthenia gravis in nerve-muscle preparation of rats].","authors":"C Lu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Using glass microelectrode recording the effect of sera with presynaptic membrane (PrM) antibody and acetylcholine receptor (AchR) antibody on the frequency of miniature end-plate potentials (MEPPs) was tested in the phrenic nerve-diaphragm preparation of rats. Sera from 5 health control persons did not affect the MEPP frequency. Twenty tested patient sera were identified to include 3 cases with AChR antibody, 6 cases with PrM antibody, 5 cases with both and 6 cases without both antibodies. The results showed that 2 cases with PrM antibody first increased for 1 to 2 minutes and then decreased the MEPP frequency. The MEPP frequency was decreased in total 11 cases, including 2 cases with AChR antibody, 3 cases with PrM antibody, 4 cases with both and 2 cases without both antibodies. The MEPP frequency was not changed in total 7 cases, including 4 cases without both antibodies and 1 case from each other 3 kinds of sera. The results demonstrated that serum from some patients with myasthenia gravis, especially from those with PrM antibody has some factors which act on the motor presynaptic ending.</p>","PeriodicalId":76874,"journal":{"name":"Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry","volume":"25 1","pages":"44-6, 63"},"PeriodicalIF":0.0,"publicationDate":"1992-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12491810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cerebrospinal fluid (CSF) cytochemistry of acute cerebrovascular diseases with clear CSF: observation of nonspecific esterase activity of mononuclear phagocytes]. 急性脑血管病伴脑脊液(CSF)细胞化学:单核吞噬细胞非特异性酯酶活性的观察。
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry Pub Date : 1992-02-01
B He
{"title":"[Cerebrospinal fluid (CSF) cytochemistry of acute cerebrovascular diseases with clear CSF: observation of nonspecific esterase activity of mononuclear phagocytes].","authors":"B He","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>CSF nonspecific esterase (ANAE) activities of mononuclear phagocytes of 35 patients with intracerebral hematoma (ICH) with clear CSF and 25 with cerebral thrombosis and 17 normals were observed. The ANAE activities of ICH were much higher than those of thrombosis significantly (P less than 0.01). Furthermore, the distributions of ANAE activities of all cases suggested that there were few overlaps between both diseases. The CSF cytochemical detection was obviously superior to routine CSF cytological examination in differentiating strokes with clear CSF. The authors concluded that these results provided a simple inexpensive and relatively accurate method to differentiate hemorrhagic from ischemic cerebrovascular diseases in case of without CT.</p>","PeriodicalId":76874,"journal":{"name":"Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry","volume":"25 1","pages":"35-7, 62"},"PeriodicalIF":0.0,"publicationDate":"1992-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12759409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Dysautonomia in Guillaine-Barre syndrome: a clinical analysis of 62 cases]. 【吉兰-巴雷综合征并发自主神经异常62例临床分析】。
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry Pub Date : 1991-12-01
B H Cheng
{"title":"[Dysautonomia in Guillaine-Barre syndrome: a clinical analysis of 62 cases].","authors":"B H Cheng","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In present paper, 62 cases of dysautonomia out of 115 patients with GBS. In the clinical manifestations of the dysautonomia, the disorder of heart was most (85.48%), the second was abnormality of the blood pressure and the digestive tract (both 37.1) and the abnormality of sweat and sexual dysfunction would not take less (30.65% and 17.74% respectively). It was also found that there were the facial flushing (4.84%) and abnormal pupilla (6.45%). The sexual dysfunction was firstly reported. Dysautonomia in GBS was higher in young adults (less than 20 years) (P less than 0.01) and that in the severe cases (P less than 0.01). The mortality of patients of GBS with dysautonomia was higher (P less than 0.01). The pathophysiological mechanism and treatment of GBS were discussed.</p>","PeriodicalId":76874,"journal":{"name":"Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry","volume":"24 6","pages":"332-5, 382"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12961777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Spectrin extractabilities from erythrocyte membranes in patients with myotonic dystrophy]. [肌强直性营养不良患者红细胞膜中Spectrin的提取]。
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry Pub Date : 1991-12-01
Y S Li
{"title":"[Spectrin extractabilities from erythrocyte membranes in patients with myotonic dystrophy].","authors":"Y S Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Using sodium dodecyl sulfate-polyacrylamide gel electrophoresis, spectrin extractabilities (SE) were determined after spectrins were removed from erythrocyte membranes by low ionic strength and chelating agent. The SE from red cell membranes was significantly reduced with respect to matched controls in 13 myotonic dystrophy patients, 81.3 +/- 7.2% and 54.2 +/- 9.1% (m +/- SD), respectively (P less than 0.01). There were no significant differences between the patients and controls in molecular weights and amounts of spectrin as well as Band3 protein. Our results are consistent with the concept of membrane defect affecting erythrocytes in this disorder.</p>","PeriodicalId":76874,"journal":{"name":"Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry","volume":"24 6","pages":"343-5, 383"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12961780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effect of the human leukocyte angiotensin II-like substance (LATII-LS) on isolated rabbit carotid arteries]. [人白细胞血管紧张素ii样物质(LATII-LS)对离体家兔颈动脉的影响]。
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry Pub Date : 1991-12-01
B Wang
{"title":"[Effect of the human leukocyte angiotensin II-like substance (LATII-LS) on isolated rabbit carotid arteries].","authors":"B Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The presence of angiotensin II-like substance (LATII-LS) in the human leucocytes was identified by means of immunofluorescence technique. And the LATII-LS PURIFIED purified by high-power liquid chromatography (HPLC). The effect of LATII-LS on isolated rabbit carotid arteries showed a definite vasoconstrictive character. It was surmised that this would play a role in causing the cerebral vasospasm after spontaneous subarachnoid hemorrhage.</p>","PeriodicalId":76874,"journal":{"name":"Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry","volume":"24 6","pages":"349-51, 383-4"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12961782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Acute pandysautonomia]. [急性泛自主神经功能障碍]。
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry Pub Date : 1991-12-01
S H Lin
{"title":"[Acute pandysautonomia].","authors":"S H Lin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>39 years old woman with onset of faint, numbness of the extremities was reported. Special test of autonomic functions, endocrinology, biochemistry and nerve biopsy were carried out. The diagnosis of acute pandysautonomia was made. Clinically it is characterized by dilated pupils, non-reactive pupils, orthostatic hypotension, positive noradrenaline infusion test and negative sweating test with atropine. These changes suggested the disturbance of generalized sympathetic post-ganglionic nerve. In other hand defective salivation and lacrimation, lower values of the ratio between the R-R interval, constipation and rapid constriction of pupils with pilocarpine were considered as evidence of failure of parasympathetic post-ganglionic nerve.</p>","PeriodicalId":76874,"journal":{"name":"Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry","volume":"24 6","pages":"373-5, 386"},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12963186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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