Zeitschrift fur Versuchstierkunde最新文献_第8页

Cytochrome P-450-dependent biotransformation in Uje:WIST rats with chronic liver injury induced by thioacetamide. 硫乙酰胺致慢性肝损伤Uje:WIST大鼠细胞色素p -450依赖性生物转化

Zeitschrift fur Versuchstierkunde Pub Date : 1989-01-01

H Kraul, T Zimmermann, C Pocha, J Truckenbrodt, A Hoffmann

引用次数: 0

Alternatives to single caging of rhesus monkeys (Macaca mulatta) used in research. 用于研究的恒河猴(Macaca mulatta)单笼的替代方案。

Zeitschrift fur Versuchstierkunde Pub Date : 1989-01-01

V Reinhardt, D Houser, D Cowley, S Eisele, R Vertein

{"title":"Alternatives to single caging of rhesus monkeys (Macaca mulatta) used in research.","authors":"V Reinhardt, D Houser, D Cowley, S Eisele, R Vertein","doi":"","DOIUrl":"","url":null,"abstract":"Alternatives to single caging of laboratory rhesus monkeys were explored. 1. Surplus infants (12-18 months old) from breeding troops were paired with 48 adult females (6-28 years old) and 12 adult males (8-28 years old) that had lived alone for several years. Adults and infants were not related. The partners were compatible in 87% (42/48) and 83% (10/12) of cases, respectively, throughout follow-up periods of 16-25 months. The young companions reached 28-44 months of age during that time. 2. Forty-six unrelated adult female rhesus monkeys (7-23 years old) and 10 unrelated adult male rhesus monkeys (8-16 years old) that had lived alone for several years were familiarized in isosexual dyads and then paired in different cages. Paired companions were compatible in 83% (19/23) and 80% (4/5) of cases, respectively, throughout follow-up periods of 9-24 months. Of all animals tested, 2% (3/176) received a bleeding but not life-threatening wound by an incompatible partner. Pairing previously individually caged rhesus monkeys did not interfere with the following research protocols: tethering of one partner for remote collection; head-cap implantation on one or both partners; chair-restraining of one partner while the other is kept close by for psychological support; in-cage venipuncture of both partners (attempted with females only); temporary (1-7 d) partner separation for timed breeding or for experimental surgery. Pairing singly caged adult rhesus monkeys with infant or with other adult companions is recommended as an effective way to promote the animals' wellbeing by enabling them to express their inherent need for social contact.","PeriodicalId":76864,"journal":{"name":"Zeitschrift fur Versuchstierkunde","volume":"32 6","pages":"275-9"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13760552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serotonin and melatonin contents in the pineal glands from different stocks and strains of laboratory rats. 不同品种大鼠松果体血清素和褪黑素的含量。

Zeitschrift fur Versuchstierkunde Pub Date : 1989-01-01

L Vollrath, A Huesgen, A Seidel, B Manz, K Pollow

{"title":"Serotonin and melatonin contents in the pineal glands from different stocks and strains of laboratory rats.","authors":"L Vollrath, A Huesgen, A Seidel, B Manz, K Pollow","doi":"","DOIUrl":"","url":null,"abstract":"In the present study the pineal gland was examined in 2 outbred stocks and 6 inbred strains of rats some of which were pigmented to varying degrees, to see whether inbreeding affects the variability and whether differences exist between albino and pigmented rats. The animals were kept under 12 h light: 12 h darkness (12 L:12 D) and killed 7 h after the onset of light and darkness, respectively. The parameters examined were pineal protein content, serotonin and melatonin levels and hydroxyindole-O-methyltransferase (HIOMT) activity. All the parameters examined revealed interstrain differences, independently of whether the data were expressed per pineal or per mg protein. The variation coefficients for the various parameters were relatively high. They were mostly smaller when the data were expressed per pineal rather than per mg protein. No striking differences existed between the variation coefficients in inbred and outbred rats. When pineal size and the melatonin-related parameters expressed per pineal were used to assess the melatonin-synthesizing capacity of the pineal glands, it was found that the outbred Wistar and Sprague-Dawley rats and the inbred LEWIS-derived (LEW/Han) rats, all of which were albinos, had the most active pineals. Intermediate activity was noted in the hooded E3/Han and BDE/Han and the albino BDII/Han rats. The smallest and least active pineals were found in the totally pigmented BN/Han and DA/Han rats. The results taken together show that different stocks and strains exhibit significant differences in pineal size and melatonin-forming capacity. Albino rats appear to have larger and more active pineals than pigmented rats.","PeriodicalId":76864,"journal":{"name":"Zeitschrift fur Versuchstierkunde","volume":"32 2","pages":"57-63"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13896350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A new system for catheterization of the V. cava of rats for long-term infusions (Implantofix)]. [一种用于长期输注大鼠腔静脉导管的新系统[Implantofix]。

Zeitschrift fur Versuchstierkunde Pub Date : 1989-01-01

F J Lehnhardt

引用次数: 0

[Experiences with cage combinations for guinea pigs]. [豚鼠笼养组合的经验]。

Zeitschrift fur Versuchstierkunde Pub Date : 1989-01-01

J von Zychlinski

引用次数: 0

Effects of drinking water acidification, restriction of water supply and individual caging on parameters of toxicological studies in rats. 饮水酸化、限制供水和单独笼养对大鼠毒理学研究参数的影响。

Zeitschrift fur Versuchstierkunde Pub Date : 1989-01-01

P Clausing, M Gottschalk

{"title":"Effects of drinking water acidification, restriction of water supply and individual caging on parameters of toxicological studies in rats.","authors":"P Clausing, M Gottschalk","doi":"","DOIUrl":"","url":null,"abstract":"A 21 week experiment was conducted with male SPF Ico/Shoe: WIST rats to study the influence on diagnostic parameters of toxicological studies of (i) acidification of drinking water by hydrochloric acid (untreated tap water vs. pH 3 vs. pH 2), (ii) individual vs. group caging (5 animals/cage), and (iii) ad libitum vs. 10 ml restrictive water supply. Acidification to pH 2 resulted in a slightly but significantly reduced excretion of phenol red, lowered proteinuria and a decreased urine volume, whereas all other parameters remained unchanged. Individual caging was less stressful than expected from published data. Red blood cell counts were increased, water consumption and urine volume were somewhat lowered, but stress-sensitive parameters like adrenal weight, leucocyte and lymphocyte counts were not altered. A 10 ml restrictive water supply decreased urine volume, food consumption, body weight development and organ weights. Furthermore transient increases in red blood cell counts and hemoglobin contents, leucopenia and--most important--an impaired renal function were observed. In conclusion acidification of drinking water with hydrochloric acid should not be lower than pH 3, male Ico/Shoe: WIST rats can be regarded as minimum susceptible to individual caging, and reduced water intake might give false positive nephrotoxic effects.","PeriodicalId":76864,"journal":{"name":"Zeitschrift fur Versuchstierkunde","volume":"32 3","pages":"129-34"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13672559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

gamma-Glutamyltranspeptidase in liver homogenates of rats of different ages: enzyme kinetics and age course of Km and Vmax. 不同年龄大鼠肝脏匀浆γ -谷氨酰转肽酶的酶动力学及Km和Vmax的年龄变化。

Zeitschrift fur Versuchstierkunde Pub Date : 1989-01-01

M Kretzschmar, W Klinger

引用次数: 0

[ONLINE: program for online connection of laboratory apparatus with personal computers with special reference to the requirements of toxicological animal studies]. [在线:实验室设备与个人电脑的在线连接程序，特别参考毒理学动物研究的要求]。

Zeitschrift fur Versuchstierkunde Pub Date : 1989-01-01

B Rattel, M Schliack

引用次数: 0

Spontaneous tumours of the European hamster (Cricetus cricetus L.). 欧洲仓鼠(Cricetus Cricetus L.)的自发性肿瘤。

Zeitschrift fur Versuchstierkunde Pub Date : 1989-01-01

H Ernst, I Kunstyr, S Rittinghausen, U Mohr

{"title":"Spontaneous tumours of the European hamster (Cricetus cricetus L.).","authors":"H Ernst, I Kunstyr, S Rittinghausen, U Mohr","doi":"","DOIUrl":"","url":null,"abstract":"The incidence and spectrum of spontaneously occurring neoplasms was evaluated in 285 European hamsters (strain Mhh:EPH) ranging in age between 1 and 5 years. The mean lifespan of the 107 male and 135 female hamsters examined amounted to 122 and 135 weeks, respectively. The overall incidence of tumour-bearing animals was 51.2% (males: 57.9%, females: 47.2%). Malignant tumours were more frequent than benign neoplasms and affected more males than females. Neoplasms of the haematopoietic/lymphoreticular system were the most common tumours (males: 16.8%, females: 13.5%). In males, these were followed in a decreasing order of incidence by pheochromocytomas (15.9%), malignant schwannomas (8.4%) and tumours of the prostate (6.5%). In females, pheochromocytomas as well as granulosa cell tumours were the second commonest tumour types (6.2% each), followed by malignant schwannomas (5.1%). Other tumours did not exceed the 5% incidence level. Two unusual rare tumours were a locally invasive cementoblastoma arising in the maxilla and a carcinosarcoma of the skin with components of a squamous cell carcinoma and a neurofibrosarcoma. The results of the study are compared with data on the Syrian and Chinese hamster.","PeriodicalId":76864,"journal":{"name":"Zeitschrift fur Versuchstierkunde","volume":"32 2","pages":"87-96"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13896354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can the association of athymic mice (Han:NMRI-nu) with Staphylococcus sciuri prevent infection with Staphylococcus aureus? Experiences from a field study. 乳糜小鼠(Han:NMRI-nu)与金黄色葡萄球菌的关联能否预防金黄色葡萄球菌感染?实地考察的经验。

Zeitschrift fur Versuchstierkunde Pub Date : 1989-01-01

M Wullenweber-Schmidt, W Lenz, K Brönnemann

引用次数: 0