Zeitschrift fur Versuchstierkunde最新文献_第6页

[Radioiodine administration for the production of an athyreotic animal model]. [放射性碘用于生产一种肌肉萎缩动物模型]。

Zeitschrift fur Versuchstierkunde Pub Date : 1989-01-01

G Hanauer

{"title":"[Radioiodine administration for the production of an athyreotic animal model].","authors":"G Hanauer","doi":"","DOIUrl":"","url":null,"abstract":"The resection of thyroid gland with radioiodine is a painless method to eliminate the Gl. thyroidea. By the present investigation it could be demonstrated that the thyroid gland of Wistar rats with a body mass between 100 and 500 g can be safely eliminated by administering them 2 doses of 18.5 MBq (0.5 mCi) 131I with a waiting period of 7 d in between. Application of 37.0 MBq (1.0 mCi) 131I once is, with regard to the radio-hygiene, to prefer, since the rats were contaminated on the surface when administering them iodine for the second time. The success of the experiment has been controlled in vitro and in vivo. Measuring the extirpated larynx region in the borehole of a gamma counter after a diagnostic labelling has been found to be an useful control method in vitro. Histological investigation of the larynx is extremely time-consuming. Besides it was not always possible to distinguish the single radio-iodine treated groups with this method. Since there were some animals showing residual thyroid tissue, the control by means of the development of the body masses cannot be recommended. Apart from this the development of the body masses depended very much on the surrounding temperature in which the animals were kept. The rectal temperature of the rats also depended on various external disturbances, so that this parameter failed to control the function of the thyroid gland.","PeriodicalId":76864,"journal":{"name":"Zeitschrift fur Versuchstierkunde","volume":"32 1","pages":"7-15"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13853114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hardness of diet pellets and its influence on growth of pre-weaned and weaned mice. 饲粮颗粒硬度及其对断奶前和断奶小鼠生长的影响。

Zeitschrift fur Versuchstierkunde Pub Date : 1989-01-01

J P Koopman, P M Scholten, P C Roeleveld, Y W Velthuizen, A C Beynen

{"title":"Hardness of diet pellets and its influence on growth of pre-weaned and weaned mice.","authors":"J P Koopman, P M Scholten, P C Roeleveld, Y W Velthuizen, A C Beynen","doi":"","DOIUrl":"","url":null,"abstract":"The hardness of 3 commercial diet pellets for laboratory rats and mice was studied. Hardness was measured as the force (kp) required to crush a diet pellet. Between-batch variation, expressed as coefficient of variation, ranged between 12 and 70%. In one type of diet hardness of the pellets varied between 4 and 50 kp. Hardness did not change during storage for a period of 8 weeks. To investigate the effect of hardness on growth performance of young mice experimental diets were prepared with identical ingredient composition but with hardness of either 15 or 45 kp. Female mice provided with hard pellets (45 kp) were not able to raise their litters. Feeding the experimental diet as 15 kp pellets resulted in a slightly retarded growth when compared with the experimental diet in the form of meal. Weaned mice were fed with the experimental diet in 4 different forms: meal, 15 kp, 45-kp and ground 45-kp pellets. Male mice, unlike females, fed the 45-kp diet grew slower than their counterparts fed the other diet forms. It is concluded that batches of extremely hard pellets may be occasionally delivered, and that such diets have undesirable effects on performance of young mice.","PeriodicalId":76864,"journal":{"name":"Zeitschrift fur Versuchstierkunde","volume":"32 2","pages":"71-5"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13896352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transportation of rats affects behaviour of non-transported rats in the absence of physical contact (preliminary communication). 在没有身体接触(初步交流)的情况下，老鼠的运输会影响未运输老鼠的行为。

Zeitschrift fur Versuchstierkunde Pub Date : 1989-01-01

J M de Laat, G van Tintelen, A C Beynen

引用次数: 0

Prolonged rat heart allograft survival and reduced graft immunogenicity after photochemical donor and transplant pretreatment. 光化学供体和移植物预处理后大鼠同种异体心脏存活时间延长，移植物免疫原性降低。

Zeitschrift fur Versuchstierkunde Pub Date : 1989-01-01

H Oesterwitz, C Eichler, W Schneider, J Kaden

{"title":"Prolonged rat heart allograft survival and reduced graft immunogenicity after photochemical donor and transplant pretreatment.","authors":"H Oesterwitz, C Eichler, W Schneider, J Kaden","doi":"","DOIUrl":"","url":null,"abstract":"The purpose of these experiments was to evaluate the influence of pretreatment of the heart donor with the photosensitizer 8-methoxypsoralen plus ex vivo longwave ultraviolet irradiation of the graft (PUVA) on survival time and immunogenicity of rat heart allografts in a donor-recipient combination that was different at the major histocompatibility complex (MHC). PUVA treatment of the donor hearts significantly prolonged their survival in allogeneic recipients. The efficacy of this therapy was dependent on the time of ultraviolet irradiation. Immunohistological studies using monoclonal antibodies to rat MHC class I and II antigens showed a significant reduction of class II antigen expression in heart cryostat sections after PUVA treatment. No differences were seen in the tissue distribution of class I antigen. This reduction of donor MHC class II antigens may influence the antigen presentation as well as the activation of T helper cells. In conclusion, PUVA treatment is effective to reduce the immunogenicity and to improve the graft survival time of rat heart allografts. These experimental findings are new and suggest a possible clinical application of photochemical pretreatment.","PeriodicalId":76864,"journal":{"name":"Zeitschrift fur Versuchstierkunde","volume":"32 2","pages":"77-82"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13809252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduction of fluid intake in the guineapig as a measure of adaptability to new housing conditions. 减少豚鼠的液体摄入量，以衡量其对新住房条件的适应性。

Zeitschrift fur Versuchstierkunde Pub Date : 1989-01-01

M Fenske

引用次数: 0

Intestinal lymphomas in golden hamsters (Mesocricetus auratus). 金仓鼠肠道淋巴瘤的研究。

Zeitschrift fur Versuchstierkunde Pub Date : 1989-01-01

F Jelínek

引用次数: 0

Streptozotocin-diabetic BB/OK rats accept permanently BB/OK-islet grafts without immunosuppression. 链脲佐菌素糖尿病BB/OK大鼠接受永久BB/OK胰岛移植物，无免疫抑制。

Zeitschrift fur Versuchstierkunde Pub Date : 1989-01-01

H J Hahn, B Ziegler, S Lucke