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Zeitschrift fur Versuchstierkunde最新文献

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Daily change of cage depresses mass gain in mice. 日换笼对小鼠体重增加有抑制作用。
Zeitschrift fur Versuchstierkunde Pub Date : 1990-01-01
A C Beynen, G van Tintelen
{"title":"Daily change of cage depresses mass gain in mice.","authors":"A C Beynen,&nbsp;G van Tintelen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of daily cage changing versus no changing for a period of 2 weeks was studied in female and male NMRI:Cpb mice. The animals were subjected to either true or sham cage changing so as to balance for possible effects of handling. Daily cage changing significantly reduced mass gain in female and male mice. It is suggested that the frequency of cage changing should be kept constant both within and between experiments.</p>","PeriodicalId":76864,"journal":{"name":"Zeitschrift fur Versuchstierkunde","volume":"33 2","pages":"106-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13503321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experiments with volume overload in SHR/Frid and WKY/Frid. SHR/Frid和WKY/Frid的体积过载实验。
Zeitschrift fur Versuchstierkunde Pub Date : 1990-01-01
E Rohde, E Karasek, R Buske
{"title":"Experiments with volume overload in SHR/Frid and WKY/Frid.","authors":"E Rohde,&nbsp;E Karasek,&nbsp;R Buske","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Heart rate, systolic and diastolic blood pressure, and left ventricular pressure were continuously measured in volume overload experiments with SHR and WKY rats. The index for contractility dp/dtmax was determined. The initial data and the changes during overload are tabulated and compared between the strains. Overload led to a marked increase of the end-diastolic left ventricular pressure in WKY rats. The SHR overload model reacts less to the standard drug Dopamine than the normotensive strain. It combines chronic hypertension with acute volume overload and is suitable for circulation basic research and special screening experiments with prospective new cardiovascular drugs. It is bound to a high technical and preparative expenditure.</p>","PeriodicalId":76864,"journal":{"name":"Zeitschrift fur Versuchstierkunde","volume":"33 3","pages":"128-32"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13550839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term investigations of serum cholesterol, serum triglyceride, and HDL cholesterol in heritable hyperlipidemic rabbits. 遗传性高脂血症家兔血清胆固醇、血清甘油三酯和高密度脂蛋白胆固醇的长期研究。
Zeitschrift fur Versuchstierkunde Pub Date : 1990-01-01
B M Lind, R Littbarski, G Hohlbach, K O Möller
{"title":"Long-term investigations of serum cholesterol, serum triglyceride, and HDL cholesterol in heritable hyperlipidemic rabbits.","authors":"B M Lind,&nbsp;R Littbarski,&nbsp;G Hohlbach,&nbsp;K O Möller","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The purpose of this investigation was to follow the course of the serum cholesterol, serum triglyceride and HDL cholesterol concentrations of heritable hyperlipidemic (HHL) rabbits (34 animals in total) in order to obtain an early prediction of these parameters, which appear to be highly associated with the presence of arteriosclerotic lesions. Measurements were done at 6-week intervals for one year, beginning at the 10th week of age. At week 10 the serum cholesterol concentration of females was 652.80 mg x dl-1 +/- 103.82 (standard deviation) and that of males was 648.84 mg x dl-1 +/- 146.04. The 10-week serum triglyceride concentration of males was 267.90 mg x dl-1 +/- 93.03, which decreased in two marked steps after week 10 and 40, while that of females was 246.70 mg x dl-1 +/- 67.51, which reached a maximum at 7 months and then decreased. Both the serum cholesterol and the serum triglyceride concentrations decreased significantly in males and females during the investigation period. The 10-week HDL cholesterol concentrations (males: 18.08 mg x dl-1 +/- 12.81; females: 14.61 mg x dl-1 +/- 8.56) remained relatively constant in both sexes during the investigation period. We consider one or two samplings, usually at weaning and at the beginning of an investigation, to ensure reliable biochemical parameters for the state of the animals.</p>","PeriodicalId":76864,"journal":{"name":"Zeitschrift fur Versuchstierkunde","volume":"33 6","pages":"245-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13238961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Postnatal loss and the possible effect of overcrowding in a high fertility mouse population]. [产后损失和高生育能力小鼠种群过度拥挤的可能影响]。
Zeitschrift fur Versuchstierkunde Pub Date : 1990-01-01
L Schüler
{"title":"[Postnatal loss and the possible effect of overcrowding in a high fertility mouse population].","authors":"L Schüler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mice characterized by a mean litter size of 17 pups in the first litter were held in cages of different size. No overcrowding effect on preweaning growth and survival rate have been found when the population was held in type I cages (195 cm2 bottom area) as compared with keeping in type II cages (416 cm2). The increased mortality during suckling is due to an insufficient lactation performance of the mothers.</p>","PeriodicalId":76864,"journal":{"name":"Zeitschrift fur Versuchstierkunde","volume":"33 3","pages":"146-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13550843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A cucumber mount for the preparation of histological sections of the small intestine of rodents. 用于制备啮齿类动物小肠组织切片的黄瓜底座。
Zeitschrift fur Versuchstierkunde Pub Date : 1990-01-01
H H Dietz
{"title":"A cucumber mount for the preparation of histological sections of the small intestine of rodents.","authors":"H H Dietz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A method for orientation of formaldehyde-fixed intestinal tissue from mink puppies (Mustela vision) is described. Sections of the intestine were glued to dehydrated slices of cucumber (Cucumis sativus L. or Cucurbita pepo L.) with egg albumin. This cucumber-intestine unit was processed in a routine way. Embedding in paraplast was facilitated thereby ensuring a correct orientation of the tissue.</p>","PeriodicalId":76864,"journal":{"name":"Zeitschrift fur Versuchstierkunde","volume":"33 2","pages":"97-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13344573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mortality and tumour incidence of Han:SPRD rats. 汉族:SPRD大鼠的死亡率和肿瘤发生率。
Zeitschrift fur Versuchstierkunde Pub Date : 1990-01-01
J Kaspareit-Rittinghausen, F Deerberg, K Rapp, A Wcislo
{"title":"Mortality and tumour incidence of Han:SPRD rats.","authors":"J Kaspareit-Rittinghausen,&nbsp;F Deerberg,&nbsp;K Rapp,&nbsp;A Wcislo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In a longevity study a total of 394 Han:SPRD rats (200 males and 194 females) were kept in a barrier type animal quarter from weaning until their natural death. The mean life span of males was 29.6 +/- 5 months, that of females 27.6 +/- 6.2 months. The most frequent neoplasms in females were mammary gland tumours (63.4%). Neoplasms of endocrine organs were common in animals of both sexes. Thyroid neoplasms, predominantly of C-cell origin, occurred in 60% of the males and 51.5% of the females. Pituitary gland tumours were observed in 53% of male and 45.1% of female rats. Further frequent tumours of the endocrine system included phaeochromocytomas (23% in males, 15.5% in females), adrenal cortex neoplasms (6% in males, 13.5% in females) and tumours of islet cells of the pancreas (20.8% in males, 8.2% in females). An uncommonly high incidence of squamous cell neoplasms (16% in males; 9.3% in females) of the preputial and clitoral gland was observed in this stock. Further organs frequently affected by neoplasms were the skin/subcutis and brain.</p>","PeriodicalId":76864,"journal":{"name":"Zeitschrift fur Versuchstierkunde","volume":"33 1","pages":"23-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13470373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A study on melanin affinity of 14C-trimethoprim in male Mol:WIST and Mol:PVG rats. 14c -甲氧苄啶对Mol:WIST和Mol:PVG雄性大鼠黑色素亲和力的研究。
Zeitschrift fur Versuchstierkunde Pub Date : 1990-01-01
K Ingebrigtsen, L A Skoglund, I Nafstad
{"title":"A study on melanin affinity of 14C-trimethoprim in male Mol:WIST and Mol:PVG rats.","authors":"K Ingebrigtsen,&nbsp;L A Skoglund,&nbsp;I Nafstad","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hooded (Mol:PVG) and albino (Mol:WIST) rats were used to study the distribution pattern of 14C-trimethoprim by whole body autoradiography. Accumulation of radioactivity was demonstrated in the uveal tract of the eye and the pigmented parts of the skin in the hooded rats. No radioactivity was present in the corresponding tissues in the albino rats. This difference in the distribution pattern was interpreted to reflect binding to melanin of 14C-trimethoprim and/or its metabolites.</p>","PeriodicalId":76864,"journal":{"name":"Zeitschrift fur Versuchstierkunde","volume":"33 2","pages":"73-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13503323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Age-dependent reproductive performance of Shoe:WIST rats]. [Shoe:WIST大鼠年龄依赖性生殖性能研究]。
Zeitschrift fur Versuchstierkunde Pub Date : 1990-01-01
W Goltzsch, T Clauss
{"title":"[Age-dependent reproductive performance of Shoe:WIST rats].","authors":"W Goltzsch,&nbsp;T Clauss","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Reproductive performance of fertile female Shoe: WIST rats decreases with increasing age. The decreases in productivity and litter size of the females do not depend on the age of the male. Circannual investigation exhibits a significant depression of reproductive performance in autumn of all the age groups.</p>","PeriodicalId":76864,"journal":{"name":"Zeitschrift fur Versuchstierkunde","volume":"33 3","pages":"137-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13550841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiological studies of Bacillus piliformis infection and Tyzzer's disease in laboratory rats. 实验室大鼠毛状芽孢杆菌感染与泰泽病的流行病学研究。
Zeitschrift fur Versuchstierkunde Pub Date : 1990-01-01
A K Hansen, O Svendsen, K E Møllegaard-Hansen
{"title":"Epidemiological studies of Bacillus piliformis infection and Tyzzer's disease in laboratory rats.","authors":"A K Hansen,&nbsp;O Svendsen,&nbsp;K E Møllegaard-Hansen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Characteristics in connection with the presence of Bacillus piliformis in the barrier-protected animal rooms of a breeding centre for laboratory rats are discussed. The incidence of antibodies against B. piliformis in IFA test is high -77.8% for the total breeding centre. Clinical and pathological changes are, however, rare and mainly connected with certain rat strains. Immunosuppression with prednisolone and subsequent histopathological tests of liver sections indicate that rats with MHC-type RT1.A-u have an increased risk of developing Tyzzer's disease, while RT1.A-1-carriers seem to be resistant to this disease.</p>","PeriodicalId":76864,"journal":{"name":"Zeitschrift fur Versuchstierkunde","volume":"33 4","pages":"163-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13301437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The Wilcoxon, Mann and Whitney test: conditions under which and hypotheses for which it is applicable]. [Wilcoxon, Mann和Whitney检验:适用的条件和假设]。
Zeitschrift fur Versuchstierkunde Pub Date : 1990-01-01
M Horn
{"title":"[The Wilcoxon, Mann and Whitney test: conditions under which and hypotheses for which it is applicable].","authors":"M Horn","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The test of Wilcoxon, Mann and Whitney is applicable only under the assumption that the two distribution functions FX and FY do not intersect. In case of doubt this assumption should be examined by drawing the estimates of FX and FY. If the assumption is true, the test simultaneously examines whether X and Y have equal means, equal medians, and whether 'X greater than Y' and 'Y greater than X' have the same probability 1/2. Independent of the assumption one concludes 'FX not equal to FY' in case of significance and 'P(X greater than Y) = 1/2 in case of no significance and large sample sizes. If the assumption may be violated, no statement is possible concerning means or medians. The probability P(X greater than Y) can be compared even against some p0 (being possibly different from 1/2), and a confidence interval for P(X greater than Y) can be calculated, when using the large sample modification of the test by Hilgers (1981).</p>","PeriodicalId":76864,"journal":{"name":"Zeitschrift fur Versuchstierkunde","volume":"33 3","pages":"109-14"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13550837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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