The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku最新文献_第3页

Experimental study of renal sympathetic nerve activity during left ventricular assist device pumping. 左心室辅助装置泵送时肾交感神经活动的实验研究。

The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku Pub Date : 1990-12-01

T Yambe

引用次数: 0

Damage to DNA strand and the effects of anticancer drugs. DNA链的损伤和抗癌药物的作用。

The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku Pub Date : 1989-12-01

R Kanamaru, C Ishioka, Y Konishi, A Ishikawa, H Shibata, A Wakui

引用次数: 0

Functional characteristics of tumor vessels: selective increase in tumor blood flow. 肿瘤血管功能特点:肿瘤血流选择性增加。

The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku Pub Date : 1989-12-01

M Suzuki, K Hori, S Saito, S Tanda, I Abe, H Sato, H Sato

{"title":"Functional characteristics of tumor vessels: selective increase in tumor blood flow.","authors":"M Suzuki, K Hori, S Saito, S Tanda, I Abe, H Sato, H Sato","doi":"","DOIUrl":"","url":null,"abstract":"This experiment was carried out to elucidate how tumor microcirculation differs from that of normal tissues. Pressure-flow relationship was examined in normal rat tissues, uninvolved tissues in tumor-bearing rats, transplanted AH109A solid tumors, and primary tumors induced by 3-methylcholanthrene. Tumor blood flow was measured by the hydrogen clearance technique. The blood pressure was elevated by continuous iv infusion of angiotensin II. Elevation of blood pressure produced a several-fold increase in tumor blood flow without increasing blood flow in normal tissue and uninvolved tissue in tumor-bearing rats. The increase was selective to tumor tissues as long as the mean arterial blood pressure remained under about 150 mmHg. The lower the resting tumor blood flow, the greater the increase in the flow was at induced hypertension. There were no significant differences in the resting blood flow and in the rate of flow change at induced hypertension between the intramuscularly transplanted tumor, the intrahepatically transplanted tumor, and the sc transplanted tumor. These results indicate that the delivery of systemically administered anticancer drugs could be selectively enhanced in tumor tissues by induced hypertension.","PeriodicalId":76727,"journal":{"name":"The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku","volume":"36 1-4","pages":"37-45"},"PeriodicalIF":0.0,"publicationDate":"1989-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13782135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the toxicity of p-dichlorobenzene (p-DCB) administered to male F344 rats orally or by the inhalation route. 雄性F344大鼠口服或吸入对二氯苯(p-DCB)的毒性比较。

The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku Pub Date : 1989-12-01

T Umemura, K Takada, Y Nakaji, Y Ogawa, E Kamata, T Kaneko, M Tobe, Y Kurokawa

{"title":"Comparison of the toxicity of p-dichlorobenzene (p-DCB) administered to male F344 rats orally or by the inhalation route.","authors":"T Umemura, K Takada, Y Nakaji, Y Ogawa, E Kamata, T Kaneko, M Tobe, Y Kurokawa","doi":"","DOIUrl":"","url":null,"abstract":"The organ distribution and toxicity of p-DCB were compared in rats after either inhalation or oral administration. Male F344 rats were exposed to 500 or 125 ppm for 24 hr in a whole body inhalation chamber (H and L groups) or received a single dose of 300 mg/kg by gavage (PO group). The concentrations of p-DCB in the serum, liver, kidney and fatty tissues were measured by gas chromatography at intervals during and up to 24 hr after the treatment. Peak serum values for the L and H groups were lower than in the PO animals, but the organ/serum distribution ratios of p-DCB tended to be higher, in some cases markedly, in rats receiving the inhalation treatment. Significant increases in the levels of blood urea nitrogen, hepatic glutamic oxaloacetic transaminase and glutamic pyruvate transaminase and significant decreases in the levels of serum total cholesterol were observed only in the inhalation groups. Microscopically, the appearance of numerous eosinophilic droplets, together with swelling and desquamation of the proximal tubular epithelium of the kidney was especially noteworthy in H and L p-DCB treated groups. Thus, both biochemical and histopathological abnormalities induced by p-DCB were more pronounced in rats administered the compound by the inhalation route.","PeriodicalId":76727,"journal":{"name":"The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku","volume":"36 1-4","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"1989-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13782132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of cytomegalovirus in paraffin-embedded lung tissue sections. 石蜡包埋肺组织切片巨细胞病毒的检测。

The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku Pub Date : 1989-12-01

Y Honda

{"title":"Detection of cytomegalovirus in paraffin-embedded lung tissue sections.","authors":"Y Honda","doi":"","DOIUrl":"","url":null,"abstract":"Attempts were made to detect cytomegalovirus (CMV) in paraffin-embedded lung tissue sections from five patients with malignant disease by the immunofluorescence and immunoperoxidase methods with application of monoclonal antibodies against CMV and by localization of DNA by the method of in situ hybridization using a biotinylated probe. In the immunofluorescence method, the monoclonal antibody 1C6 stained a large number of CMV-infected cells. However, nonspecific staining of the bronchoepithelial cells was a disadvantage of this method. In the immunoperoxidase staining, the monoclonal antibodies E. 13 and CCH2 gave highly sensitive and specific results. These monoclonal antibodies stained the nuclei of the infected cells even in the absence of viral inclusions. In the viral DNA probe technique, three specimens were found to contain hybridizing cells. The DNA probe detected not only cytopathic cells but also normal-appearing infected cells. The number of cells stained by the DNA probe was much smaller than that stained by the immunoperoxidase method. The author concludes that the immunoperoxidase technique using monoclonal antibodies against CMV is useful for the diagnosis of CMV infection in the paraffin-embedded lung tissue. Localization of DNA by the method of in situ hybridization is not as useful as the immunoperoxidase method because of lower sensitivity.","PeriodicalId":76727,"journal":{"name":"The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku","volume":"36 1-4","pages":"17-28"},"PeriodicalIF":0.0,"publicationDate":"1989-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13705528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor induction in mice administered neonatally with 1,2-dimethylhydrazine. 1,2-二甲基肼对小鼠肿瘤的诱导作用。

The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku Pub Date : 1989-12-01

K Fujii, H Komano

引用次数: 0

Acute toxicity tests on 113 environmental chemicals. 113种环境化学品的急性毒性试验。

The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku Pub Date : 1989-12-01

R Hasegawa, Y Nakaji, Y Kurokawa, M Tobe

引用次数: 0

Current and future aspects of cancer diagnosis with PET. PET诊断癌症的现状和未来。

The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku Pub Date : 1988-12-01

T Matsuzawa

引用次数: 0

Biochemical modulation of anticancer drugs. 抗癌药物的生化调节。

The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku Pub Date : 1988-12-01

R Kanamaru, C Ishioka, Y Konishi, A Ishikawa, H Shibata, A Wakui

引用次数: 0

Preclinical and clinical biochemical modulation of 5-fluorouracil by leucovorin and uridine. 亚叶酸素和尿苷对5-氟尿嘧啶临床前和临床生化的调节。

The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku Pub Date : 1988-12-01

G J Peters

引用次数: 0