{"title":"Biochemical pathogenesis of post-traumatic epilepsy.","authors":"A Mori, M Hiramatsu, I Yokoi, R Edamatsu","doi":"10.1007/BF02964604","DOIUrl":"https://doi.org/10.1007/BF02964604","url":null,"abstract":"<p><p>Head trauma is often followed by epilepsy and may be related to the breakdown of red blood cells and hemoglobin within the CNS. Injection of hemoglobin or iron salts into the rat cortex is known to induce a chronic epileptic focus. We observed the formation of superoxide anion (O2) and hydroxyl radical (.OH) after ferric chloride injection into the rat cerebral cortex and suggest that these radicals, especially .OH, may be responsible for the initiation of lipid peroxidation in neuronal membranes and for the accelerated production of guanidine compounds in the brain, which may in turn lead to epileptogenicity. Then, we found that treatment with epigallocatechin (EGC) or a phosphate diester of vitamins E and C (EPC), which are potent .OH scavengers, significantly inhibited the formation of malondialdehyde and epileptic discharges in the iron-induced epileptic focus.</p>","PeriodicalId":76714,"journal":{"name":"The Pavlovian journal of biological science","volume":"25 2","pages":"54-62"},"PeriodicalIF":0.0,"publicationDate":"1990-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02964604","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13277473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neurotic and psychosomatic disorders. Interdependence in terms of the search activity concept.","authors":"V S Rotenberg, A A Schattenstein","doi":"10.1007/BF02964602","DOIUrl":"https://doi.org/10.1007/BF02964602","url":null,"abstract":"<p><p>There are no correlations between MMPI Hysteria (Hs) and Depression (D) scales in psychosomatic patients in contrast to other patients with somatic disturbances, neurotic disturbances, and in healthy subjects. The roles of depression and hypochondria in the dynamics of psychosomatic disturbances are discussed according to the search activity concept. It is suggested that hypochondriacal complaints are prognostically favorable in comparison with anxiety-depression complaints.</p>","PeriodicalId":76714,"journal":{"name":"The Pavlovian journal of biological science","volume":"25 2","pages":"43-7"},"PeriodicalIF":0.0,"publicationDate":"1990-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02964602","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13387862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reaction time task as unconditional stimulus. Comparing aversive and nonaversive unconditional stimuli.","authors":"O V Lipp, D Vaitl","doi":"10.1007/BF02964606","DOIUrl":"https://doi.org/10.1007/BF02964606","url":null,"abstract":"<p><p>Nonaversive unconditional stimuli (USs) are seldom used in human classic conditioning of autonomic responses. One major objection to their use is that they produce deficits in electrodermal (ED) second- and third-interval response conditioning. However, a nonaversive reaction time (RT) task that includes feedback of success has been shown to be an effective US while avoiding this disadvantage (Lipp and Vaitl 1988). The present study compared this new RT task (RT-new) with a traditional RT task (RT-old) and with a standard aversive US (shock) in differential classic conditioning of ED, heart rate (HR), and digital pulse volume (DPV) responses. Eight-second-delay differential conditioning was applied in three groups of 12 subjects each. Simple geometric features (square, cross) displayed on a television screen served as conditional stimuli (CS+ and CS-). In acquisition, there were no statistically significant differences among the groups; differential conditioning did occur in HR, first- and second-interval ED responses, and first-interval DPV responses. Separate analyses within each group, however, revealed that there was no second-interval ED conditioning in the RT-old group. During extinction, neither DPV nor second-interval ED conditioning could be obtained, whereas HR and first-interval ED conditioning occurred in each group. In third-interval omission ED responses, RT-old and shock groups exhibited extinction, while response differentiation was maintained in the RT-new group throughout extinction. The RT task including feedback proved to be as reliable a US as a standard aversive US, whereas application of a traditional RT task again yielded some weaknesses in second-interval ED conditioning.</p>","PeriodicalId":76714,"journal":{"name":"The Pavlovian journal of biological science","volume":"25 2","pages":"77-83"},"PeriodicalIF":0.0,"publicationDate":"1990-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02964606","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13387866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retention of orienting reaction habituation in chronic alcoholics.","authors":"R Rogozea, V Florea-Ciocoiu","doi":"10.1007/BF02999809","DOIUrl":"https://doi.org/10.1007/BF02999809","url":null,"abstract":"<p><p>A polygraphic study on resistance to habituation of the somatic (EMG), autonomic (finger plethysmogram, galvanic skin reaction, respiration) and EEG (acoustic-evoked potential and EEG-blocking reaction) components of the orienting reaction, elicited by a repetitive auditory stimulus during successive (weekly) sessions was performed in 67 chronic alcoholics and in 70 matched normal subjects (control group). The study showed significant retention disturbances of orienting reaction habituation (i.e., of learning), or the \"saving\" of stimulations, achieved from one session to the other to obtain the habituation criterion, the savings being less in alcoholics than in control subjects. The severity of habituation retention disturbances depended on patients' ages, types of alcoholism, alcohol consumption intensity and chronicity, as well as the type of resting EEG.</p>","PeriodicalId":76714,"journal":{"name":"The Pavlovian journal of biological science","volume":"25 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02999809","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13463798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Observation, objectivity, and the conflict of ideas.","authors":"J J Furedy","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The first two terms of this title are clear, representing, respectively, the guiding motto of the Society, and the common thread that unites members with very diverse interests and approaches to the understanding of behavior. Then, the last part of the title is elaborated: the conflict of ideas. This aspect is important both in terms of social values, and in terms of the interests of a scientific society operating in the modern world. Within science, there are forces that weaken genuine scientific discussion, and these need at least to be explicated so that their deleterious effects can be minimized. Finally, it is suggested that although the Society has done well in facilitating oral discussion, there is room for improvement in its readiness to engage in written intellectual conflict.</p>","PeriodicalId":76714,"journal":{"name":"The Pavlovian journal of biological science","volume":"25 1","pages":"29-31"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13464450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Editorial policy of rapid publication and broad coverage within the life sciences","authors":"","doi":"10.1007/BF02999812","DOIUrl":"https://doi.org/10.1007/BF02999812","url":null,"abstract":"","PeriodicalId":76714,"journal":{"name":"The Pavlovian journal of biological science","volume":"150 1","pages":"24"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86141285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Invitation to write Letters to the editor","authors":"","doi":"10.1007/BF02999817","DOIUrl":"https://doi.org/10.1007/BF02999817","url":null,"abstract":"","PeriodicalId":76714,"journal":{"name":"The Pavlovian journal of biological science","volume":"1 1","pages":"38"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79112918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E Yanev, A Momchilova-Pankova, T Markovska, K Koumanov, P Kenarov, F J McGuigan, N Nicolov
{"title":"Influence of immobilization stress on the phospholipid composition of alveolar surfactant and lungs in rats.","authors":"E Yanev, A Momchilova-Pankova, T Markovska, K Koumanov, P Kenarov, F J McGuigan, N Nicolov","doi":"10.1007/BF02999813","DOIUrl":"https://doi.org/10.1007/BF02999813","url":null,"abstract":"<p><p>The influence of immobilization stress on the lipid composition of alveolar surfactant and lungs in rats immobilized for 12 and 24 hours, the effects of phospholipase A2, and lipid transfer activity in alveolar surfactant were investigated. The results indicate that alveolar surfactant phospholipids underwent more significant alterations compared to lung phospholipids. Furthermore, phospholipase A2 and lipid transfer activity were reduced in alveolar surfactant of immobilized rats. The reported data suggest that the lower lipid transfer activity might be responsible for the reduced phospholipids in the surfactant system.</p>","PeriodicalId":76714,"journal":{"name":"The Pavlovian journal of biological science","volume":"25 1","pages":"25-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02999813","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13464449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of specific hypnotic suggestions on blood pressure in normotensive subjects.","authors":"H Sletvold, G M Jensen, K G Götestam","doi":"10.1007/BF02999811","DOIUrl":"https://doi.org/10.1007/BF02999811","url":null,"abstract":"<p><p>Twenty normotensive subjects participated on a voluntary basis in an experiment designed to study the effects of specific suggestions on blood pressure (BP). After an induction procedure, the experimental group received suggestions presumed to be relatively nonactivating, although capable of lowering or raising BP. A control group was used to record the BP changes over time. All subjects met for one session. Eight subjects from the experimental group met for a second session. Both adaptation and induction resulted in significant BP decreases. A specific suggestion to increase BP gave a significant result when compared to the induction point. There was no significant change from induction to the BP decrease suggestion. Both systolic and diastolic BP behaved in the same way. A second experimental session resulted in no significant change compared with the first session. Also, no significant difference was found in suggestibility scores from the first to the second session. The results are in line with previously published studies.</p>","PeriodicalId":76714,"journal":{"name":"The Pavlovian journal of biological science","volume":"25 1","pages":"20-4"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02999811","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13464446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}