Paramesh Puttasiddaiah, Manoj Kumar, Pushkas Gopalan, Simon T Browning
{"title":"Tonsillectomy and biopsy for asymptomatic asymmetric tonsillar enlargement: are we right?","authors":"Paramesh Puttasiddaiah, Manoj Kumar, Pushkas Gopalan, Simon T Browning","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to evaluate the incidence of malignancy in patients with clinically asymmetrical tonsils and who are otherwise asymptomatic.</p><p><strong>Design: </strong>Retrospective review of our experience based on case note review, carried out in a district general hospital setting during a period of two years.</p><p><strong>Material and methods: </strong>142 patients who had undergone tonsillectomy and biosy were included in the study. Histological studies of all these patients obtained and correlated with the clinical findings.</p><p><strong>Results: </strong>None of the patients with asymmetric enlargement of tonsils but are otherwise asymptomatic had shown histological evidence of malignancy. However all the 3 patients with associated suspicious symptoms in the presence of asymmetric tonsils were diagnosed as having tonsillar malignancy.</p><p><strong>Conclusion: </strong>Tonsillar asymmetry in the absence of other associated risk factors may not indicate malignancy and a period of watchful waiting is considered appropriate prior to any surgical intervention.</p>","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 3","pages":"161-3"},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26899685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Karaman, S. Yılmaz, Engin Ozçora, H. Ozek, N. Korkut, M. Sar
{"title":"Schwannoma of the lateral nasal wall: two case reports and review of the literature.","authors":"E. Karaman, S. Yılmaz, Engin Ozçora, H. Ozek, N. Korkut, M. Sar","doi":"10.2310/7070.2006.0044","DOIUrl":"https://doi.org/10.2310/7070.2006.0044","url":null,"abstract":"","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 3 1","pages":"E1-4"},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68602423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Faruk Kiroglu, Hakan Cankaya, Köksal Yuca, Muzaffer Kiriş
{"title":"Endoscopic dacryocystorhinostomy with a T-type ventilation tube.","authors":"A Faruk Kiroglu, Hakan Cankaya, Köksal Yuca, Muzaffer Kiriş","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The aim of this article is to present a different endoscopic dacryocystorhinostomy technique and its results on patients with blockage of the nasolacrimal drainage system.</p><p><strong>Methods: </strong>Eleven patients (seven female and four male) who had chronic epiphora with the diagnosis of chronic nasolacrimal duct blockage were operated on using T-type ventilation tubes. Oral antibiotics, nasal steroids, oral antihistamines, and antibiotic eyedrops were given to all cases. The ventilation tubes were removed 3 months after surgery.</p><p><strong>Results: </strong>Of 11 cases, 9 patients had unilateral and 2 patients had bilateral blockage. Eleven sides of nine patients were symptom free (85% success rate), and two patients had decreased continuation in complaints. Granulation tissue occurred in two revision patients.</p><p><strong>Conclusion: </strong>Endoscopic dacryocystorhinostomy using a T-type ventilation tube is an easy and cost-effective alternative and has low complication rates in the management of patients with nasolacrimal duct obstruction.</p>","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 3","pages":"164-7"},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26899686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recurrent inflammatory myofibroblastic tumour of the larynx: a clinicopathologic diagnostic dilemma.","authors":"B Pooja, P Bhatia, N Panda, R K Vasishta","doi":"10.2310/7070.2007.e0008","DOIUrl":"https://doi.org/10.2310/7070.2007.e0008","url":null,"abstract":"","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 3","pages":"E24-7"},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26900688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Randomized control trial of fluorescence-guided surgical excision of nonmelanotic cutaneous malignancies.","authors":"M. Brandt, C. Moore, K. Jordan","doi":"10.2310/7070.2007.0020","DOIUrl":"https://doi.org/10.2310/7070.2007.0020","url":null,"abstract":"OBJECTIVE\u0000Protoporphyrin IX (PpIX) is an endogenous photosensitizer commonly used in photodynamic therapy. This study sought to assess if PpIX fluorescence can be applied clinically to improve the delineation and excision of nonmelanotic cutaneous malignancies.\u0000\u0000\u0000DESIGN\u0000Prospective, randomized control trial.\u0000\u0000\u0000SETTING\u0000A tertiary care skin cancer clinic.\u0000\u0000\u0000METHODS\u0000Fifty-one individuals with 65 cutaneous nonmelanotic cervicofacial malignancies were randomized into two groups. The control group was offered surgical excision with surgeon-delineated excision margins. The study group had their excision margins delineated while under fluorescence.\u0000\u0000\u0000MAIN OUTCOME MEASURES\u0000The delineated lesion borders, proposed excision margins, and projected lesion-free areas were compared among the two groups. Pathologic resection margins and completeness of excision were also assessed.\u0000\u0000\u0000RESULTS\u0000Excisions performed using fluorescence delineation were 20% narrower (p < .01) and 17% shorter (p < .04), with 35% less lesion-free skin excised (p < .005). All lesions excised using photodelineation had clear pathologic resection margins. A significant number of lesions excised via the traditional approach required reexcision owing to pathologically positive peripheral margins (p < .001). Follow-up at 2 years revealed no lesion recurrence among the study group and one recurrence within the control group.\u0000\u0000\u0000CONCLUSION AND SIGNIFICANCE\u0000The results demonstrate a reliable and novel application for photodynamic photodelination and support its application in the excision of nonmelanotic cutaneous malignancies.","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 3 1","pages":"148-55"},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2310/7070.2007.0020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68602971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emin Karaman, Süleyman Yilmaz, Engin Ozçora, Hüsnü Ozek, Nazim Korkut, Mehmet Sar
{"title":"Schwannoma of the lateral nasal wall: two case reports and review of the literature.","authors":"Emin Karaman, Süleyman Yilmaz, Engin Ozçora, Hüsnü Ozek, Nazim Korkut, Mehmet Sar","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 3","pages":"E1-4"},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26900683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Zhigang, H. Demin, G. Han, Fan Erzhong, C. Xiaohong, Xu Hongbo
{"title":"Significance and mechanism of microsatellite instability in laryngeal squamous cell carcinoma.","authors":"H. Zhigang, H. Demin, G. Han, Fan Erzhong, C. Xiaohong, Xu Hongbo","doi":"10.2310/7070.2007.0015","DOIUrl":"https://doi.org/10.2310/7070.2007.0015","url":null,"abstract":"OBJECTIVE\u0000To evaluate the significance and mechanism of microsatellite instability (MSI) in laryngeal squamous cell carcinoma (LSCC).\u0000\u0000\u0000METHODS\u0000We investigated the expression frequency and clinical significance of MSI in 50 LSCC patients. The status of MSI was evaluated by using microdissection, polymerase chain reaction, single-strand length polymorphism, and silver staining. Five markers on chromosomes 1p, 3p, 5q, 9p, and 17p were used. Two of the six components of mismatch repair (MMR)-hMLH1 and hMSH2-were investigated by an immunohistochemical approach.\u0000\u0000\u0000RESULTS\u0000The informative case numbers of the five markers (D17S796, D3S3544, D5S656, D1S375, D9S162) were 44, 42, 45, 44, and 40 in all 50 cases, respectively. The incidence of MSI on D17S796 (TP53) was 20.5% (9 of 44), on D3S3544 (FHIT) was 14.3% (6 of 42), on D5S656 (APC) was 31.1% (14 of 45), on D1S375 (BCAR3) was 20.5% (9 of 44), and on D9S162 (CDKN2A) was 15.0% (6 of 40). Although there was no relationship between MSI status and age, gender, smoking history, tumour location, tumour differentiation, and T stage (p > .05), there was a strong relationship between MSI and relapse condition (p < .01). Also, MSI status correlated with MMR expression to some degree (p < .01). But it was common that negative and positive staining of MMR coexisted on the same slide.\u0000\u0000\u0000CONCLUSION\u0000MSI and abnormal MMR may contribute to the carcinogenesis of a subset of LSCC. MSI may be a characteristic signal of tumour recurrence.","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"38 1","pages":"168-74"},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2310/7070.2007.0015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68603136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Return to home, school, and sports after electrosurgical adenoidectomy: when is it safe?","authors":"J. Ludemann, K. Wong, J. Moxham","doi":"10.2310/7070.2007.0017","DOIUrl":"https://doi.org/10.2310/7070.2007.0017","url":null,"abstract":"OBJECTIVE\u0000To determine when it is safe for healthy children to return to home, school, and sports after uncomplicated electrosurgical adenoidectomy (EA).\u0000\u0000\u0000DESIGN\u0000(1) A survey of Canadian otolaryngologists (COs) regarding their EA complication rates and their opinions regarding best practice standards for patient care after EA. (2) Informal retrospective analysis of approximately 200 children who have been allowed to resume sports 3 days after uncomplicated EA.\u0000\u0000\u0000RESULTS\u0000(1) Thirteen COs responded to the survey. The total estimated EA cases performed were 8617 over 10 years. Four patients were known to have bled mildly; none required reoperation. Eleven of 13 COs supported discharge home 2 hours after uncomplicated EA if other standard discharge criteria were met. Seven of 13 COs supported a return to school the next day if the child had returned to his or her usual state of health; however, 2 COs suggested 7 to 10 days at home. Four of 13 COs supported a return to sports 3 days after uncomplicated EA. (2) None of the 200 children who had been allowed to resume sports 3 days after uncomplicated EA have had any known bleeding. At least 10 toddlers have actually engaged in unplanned strenuous exercise within 4 to 6 hours of EA without adverse effect.\u0000\u0000\u0000CONCLUSIONS\u0000Considerable variation exists in Canada in terms of current practice standards regarding return to home, school, and sports after uncomplicated EA. Survey data suggest that, after uncomplicated EA, it is safe for healthy children to return home after 2 hours and to school the next day. Preliminary data suggest that it may be safe for children to resume sports 3 days after uncomplicated EA; however, ideally, this should be studied prospectively, on a large scale.","PeriodicalId":76656,"journal":{"name":"The Journal of otolaryngology","volume":"36 3 1","pages":"156-60"},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2310/7070.2007.0017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68603296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}