Scandinavian journal of clinical and laboratory investigation. Supplementum最新文献_第7页

When should we measure vitamin D concentration in clinical practice? 在临床实践中，我们应该何时测量维生素D浓度?

Scandinavian journal of clinical and laboratory investigation. Supplementum Pub Date : 2012-01-01 DOI: 10.3109/00365513.2012.682888

Jean-Claude Souberbielle, Marie Courbebaisse, Catherine Cormier, Charles Pierrot-Deseilligny, Jean-Paul Viard, Guillaume Jean, Etienne Cavalier

{"title":"When should we measure vitamin D concentration in clinical practice?","authors":"Jean-Claude Souberbielle, Marie Courbebaisse, Catherine Cormier, Charles Pierrot-Deseilligny, Jean-Paul Viard, Guillaume Jean, Etienne Cavalier","doi":"10.3109/00365513.2012.682888","DOIUrl":"https://doi.org/10.3109/00365513.2012.682888","url":null,"abstract":"The many recently published data on vitamin D have raised much interest in the medical community. One of the consequences has been a great increase in the prescription of vitamin D concentration measurements in clinical practice. It must be reminded that only the measurement of 25-hydroxyvitamin D (25(OH)D) concentration is indicated to evaluate vitamin D status. Furthermore, since vitamin D insufficiency is so common, since treatment is inexpensive and has a large safety margin, and since we already have much data suggesting that besides its classic effects on bone and mineral metabolism, vitamin D may potentially be helpful for the prevention/management of several diseases, perhaps should it be prescribed to everyone without prior testing? In our opinion, there are however groups of patients in whom estimation of vitamin D status is legitimate and may be recommended. This includes patients in whom a \"reasonably\" evidence-based target concentration (i.e., based on randomized clinical trials when possible) should be achieved and/or maintained such as patients with rickets/osteomalacia, osteoporosis, chronic kidney disease and kidney transplant recipients, malabsorption, primary hyperparathyroidism, granulomatous disease, and those receiving treatments potentially inducing bone loss. Other patients in whom vitamin D concentration may be measured are those with symptoms compatible with a severe vitamin D deficiency or excess persisting without explanation such as those with diffuse pain, or elderly individuals who fall, or those receiving treatments which modify vitamin D metabolism such as some anti-convulsants. Measurement of Vitamin D concentrations should also be part of any exploration of calcium/phosphorus metabolism which includes measurement of serum calcium, phosphate and PTH.","PeriodicalId":76518,"journal":{"name":"Scandinavian journal of clinical and laboratory investigation. Supplementum","volume":"243 ","pages":"129-35"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365513.2012.682888","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40185897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Vitamin D was named in 1921. Foreword. 维生素D于1921年被命名。前言。

Scandinavian journal of clinical and laboratory investigation. Supplementum Pub Date : 2012-01-01 DOI: 10.3109/00365513.2012.682805

Ian S Young

引用次数: 0

Vitamin D and cardiovascular disease: update and outlook. 维生素D与心血管疾病:最新进展与展望。

Scandinavian journal of clinical and laboratory investigation. Supplementum Pub Date : 2012-01-01 DOI: 10.3109/00365513.2012.681972

Stefan Pilz, Katharina Kienreich, Andreas Tomaschitz, Elisabeth Lerchbaum, Andreas Meinitzer, Winfried März, Armin Zittermann, Jacqueline M Dekker

{"title":"Vitamin D and cardiovascular disease: update and outlook.","authors":"Stefan Pilz, Katharina Kienreich, Andreas Tomaschitz, Elisabeth Lerchbaum, Andreas Meinitzer, Winfried März, Armin Zittermann, Jacqueline M Dekker","doi":"10.3109/00365513.2012.681972","DOIUrl":"https://doi.org/10.3109/00365513.2012.681972","url":null,"abstract":"Accumulating evidence suggests that vitamin D may play a role for cardiovascular health. Expression of the vitamin D receptor (VDR) and enzymes for vitamin D metabolism have been identified in the vasculature as well as in the heart. VDR knock-out mice suffer from cardiovascular disease (CVD) and even selective VDR deletion in cardiomyocytes causes myocardial hypertrophy. Many, but not all observational studies showed that vitamin D deficiency is associated with CVD and its risk factors. Low concentrations of 25-hydroxyvitamin D (25(OH)D) are an independent risk factor for cardiovascular events, in particular for strokes and sudden cardiac deaths. Only few randomized controlled trials (RCTs) are available on this topic. These RCTs are frequently limited by the additional supplementation of calcium which may increase the risk of CVD events. RCTs with pure vitamin D supplementation have partially but not consistently shown beneficial effects on cardiovascular risk factors such as arterial hypertension. A number of large RCTs on the impact of vitamin D supplementation on cardiovascular events and mortality have already started but limitations of the study designs such as inclusion of individuals with relatively high 25(OH)D concentrations have to be considered. At present, the evidence is not sufficient for general recommendations to supplement vitamin D in order to prevent and treat CVD. It should, however, be noted that justification for the prevention and treatment of vitamin D deficiency comes from evidence based benefits of vitamin D supplementation on musculoskeletal health.","PeriodicalId":76518,"journal":{"name":"Scandinavian journal of clinical and laboratory investigation. Supplementum","volume":"243 ","pages":"83-91"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365513.2012.681972","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40185891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39

Hope and challenge: the importance of ultraviolet (UV) radiation for cutaneous vitamin D synthesis and skin cancer. 希望与挑战:紫外线辐射对皮肤维生素D合成和皮肤癌的重要性。

Scandinavian journal of clinical and laboratory investigation. Supplementum Pub Date : 2012-01-01 DOI: 10.3109/00365513.2012.682876

Jörg Reichrath, Sandra Reichrath

{"title":"Hope and challenge: the importance of ultraviolet (UV) radiation for cutaneous vitamin D synthesis and skin cancer.","authors":"Jörg Reichrath, Sandra Reichrath","doi":"10.3109/00365513.2012.682876","DOIUrl":"https://doi.org/10.3109/00365513.2012.682876","url":null,"abstract":"Abstract Solar ultraviolet (UV)-radiation is the most important environmental risk factor for the development of non-melanoma skin cancer (most importantly basal and squamous cell carcinomas), that represent the most common malignancies in Caucasian populations. To prevent these malignancies, public health campaigns were developed to improve the awareness of the general population of the role of UV-radiation. The requirements of vitamin D is mainly achieved by UV-B-induced cutaneous photosynthesis, and the vitamin D-mediated positive effects of UV-radiation were not always adequately considered in these campaigns; a strict \"no sun policy\" might lead to vitamin D-deficiency. This dilemma represents a serious problem in many populations, for an association of vitamin D-deficiency and multiple independent diseases has been convincingly demonstrated. It is crucial that guidelines for UV-exposure (e.g. in skin cancer prevention campaigns) consider these facts and give recommendations how to prevent vitamin D-deficiency. In this review, we analyze the present literature to help developing well-balanced guidelines on UV-protection that ensure an adequate vitamin D-status without increasing the risk to develop UV-induced skin cancer.","PeriodicalId":76518,"journal":{"name":"Scandinavian journal of clinical and laboratory investigation. Supplementum","volume":"243 ","pages":"112-9"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365513.2012.682876","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40185894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Dietary reference intervals for vitamin D. 维生素D的膳食参考区间。

Scandinavian journal of clinical and laboratory investigation. Supplementum Pub Date : 2012-01-01 DOI: 10.3109/00365513.2012.682891

Kevin D Cashman

{"title":"Dietary reference intervals for vitamin D.","authors":"Kevin D Cashman","doi":"10.3109/00365513.2012.682891","DOIUrl":"https://doi.org/10.3109/00365513.2012.682891","url":null,"abstract":"Dietary reference intervals relate to the distribution of dietary requirement for a particular nutrient as defined by the distribution of physiological requirement for that nutrient. These have more commonly been called Dietary Reference Values (DRV) or Dietary Reference Intakes (DRI), amongst other names. The North American DRI for vitamin D are the most current dietary reference intervals and arguably arising from the most comprehensive evaluation and report on vitamin D nutrition to date. These are a family of nutrient reference values, including the Estimated Average Requirement (EAR), the Recommended Dietary Allowance (RDA), the Adequate Intake, and Tolerable Upper Intake Level. In particular, the EAR is used for planning and assessing diets of populations; it also serves as the basis for calculating the RDA, a value intended to meet the needs of nearly all people. The DRVs for vitamin D in the UK and the European Community have been in existence for almost two decades, and both are currently under review. The present paper briefly overviews these three sets of dietary reference intervals as case studies to highlight both the similarities as well as possible differences that may exist between reference intervals for vitamin D in different countries/regions. In addition, it highlights the scientific basis upon which these are based, which may explain some of the differences. Finally, it also overviews how the dietary reference intervals for vitamin D may be applied, and especially in terms of assessing the adequacy of vitamin D intake in populations.","PeriodicalId":76518,"journal":{"name":"Scandinavian journal of clinical and laboratory investigation. Supplementum","volume":"243 ","pages":"136-43"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365513.2012.682891","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40186378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Dietary strategies to maintain adequacy of circulating 25-hydroxyvitamin D concentrations. 维持充足循环25-羟基维生素D浓度的饮食策略。

Scandinavian journal of clinical and laboratory investigation. Supplementum Pub Date : 2012-01-01 DOI: 10.3109/00365513.2012.681893

Mairead Kiely, Lucinda J Black

{"title":"Dietary strategies to maintain adequacy of circulating 25-hydroxyvitamin D concentrations.","authors":"Mairead Kiely, Lucinda J Black","doi":"10.3109/00365513.2012.681893","DOIUrl":"https://doi.org/10.3109/00365513.2012.681893","url":null,"abstract":"The importance of vitamin D intake to nutritional status is a corollary of sunshine deficit. There is a dose-response of serum 25-hydroxyvitamin D (25(OH)D) concentrations to total vitamin D intake in persons who do not receive UVB exposure. This updated summary of vitamin D intakes and sources in adults and children focuses on data from North America and Europe. We explore the evidence that intakes of vitamin D are inadequate with reference to the Institute of Medicine (IOM) Dietary Reference Intakes. Due to mandatory fortification, usual vitamin D intakes are higher in the US and Canada than most of Europe, with the exception of the Nordic countries. Intakes of vitamin D in national surveys are typically below 5 μg/d in most European countries and vary according to country-specific fortification practices, sex and age. The main source of variation is the contribution from nutritional supplements. Usual vitamin D intake estimates need to capture data on the contributions from fortified and supplemental sources as well as the base diet. The current dietary supply of vitamin D makes it unfeasible for most adults to meet the IOM Estimated Average Requirement of 10 μg/d. While supplements are an effective method for individuals to increase their intake, food fortification represents the best opportunity to increase the vitamin D supply to the population. Well-designed sustainable fortification strategies, which use a range of foods to accommodate diversity, have potential to increase vitamin D intakes across the population distribution and minimize the prevalence of low 25(OH)D concentrations.","PeriodicalId":76518,"journal":{"name":"Scandinavian journal of clinical and laboratory investigation. Supplementum","volume":"243 ","pages":"14-23"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365513.2012.681893","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40186514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 112

Vitamin D status as an international issue: national surveys and the problem of standardization. 维生素D作为一个国际问题的地位：国家调查和标准化问题。

Scandinavian journal of clinical and laboratory investigation. Supplementum Pub Date : 2012-01-01 DOI: 10.3109/00365513.2012.681935

Christopher T Sempos, Hubert W Vesper, Karen W Phinney, Linda M Thienpont, Paul M Coates

{"title":"Vitamin D status as an international issue: national surveys and the problem of standardization.","authors":"Christopher T Sempos, Hubert W Vesper, Karen W Phinney, Linda M Thienpont, Paul M Coates","doi":"10.3109/00365513.2012.681935","DOIUrl":"10.3109/00365513.2012.681935","url":null,"abstract":"Wide spread variation in measurement results of total 25-hydroxyvitamin D (25(OH)D) confounds international efforts to develop evidence-based clinical guidelines. Accordingly, NIH Office of Dietary Supplements (ODS) in collaboration with CDC National Center for Environmental Health (NCEH), National Institute of Standards and Technology (NIST) and Ghent University established the Vitamin D Standardization Program (VDSP) in November 2010. VDSP objectives include: (1) standardize 25(OH)D concentration measurements in national health surveys around the world, (2) evaluate survey differences, (3) extend standardization efforts to assay manufacturers, and to clinical, commercial, and research laboratories, (4) promote standardization of emerging metabolites of vitamin D status, and (5) enable the use of standardized data in patient care and public health. An interlaboratory comparison study is being conducted to assess measurement variability among current assays. Participants include national health surveys from Australia, Canada, Germany, Ireland, Mexico, South Korea, UK and USA, 15 assay manufacturers, and two external quality assurance programs. CDC will implement a formal laboratory certification program. Standardization activities will use single-donor, fresh-frozen serum collected using the CLSI C37 protocol. Initial assay performance criteria, based on biological variability data, are ≤ 10 % imprecision and ≤ 5 % bias in relation to the reference values. An ancillary study on commutability of NIST SRM 972a, external quality assurance testing materials is included. To increase the comparability of existing data from different national surveys, master equations will be developed to facilitate the conversion of already existing national survey data to the NIST-Ghent University reference measurement procedures.","PeriodicalId":76518,"journal":{"name":"Scandinavian journal of clinical and laboratory investigation. Supplementum","volume":"243 ","pages":"32-40"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40186516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel markers, a payer's perspective: commissioning a new service. 新颖的标记，付款人的视角:委托一项新服务。

Scandinavian journal of clinical and laboratory investigation. Supplementum Pub Date : 2010-01-01 DOI: 10.3109/00365513.2010.493420

Christopher P Price, Les Martin

{"title":"Novel markers, a payer's perspective: commissioning a new service.","authors":"Christopher P Price, Les Martin","doi":"10.3109/00365513.2010.493420","DOIUrl":"https://doi.org/10.3109/00365513.2010.493420","url":null,"abstract":"Diagnostic technologies assist clinicians and care givers in making decisions about the care of individual patients. The demands for an evidence-based approach to practice, is proving to be challenging in the field of laboratory medicine as: (i) there has been little formal requirement to demonstrate evidence of effectiveness prior to the introduction of new tests, (ii) generating evidence of effectiveness of tests depends, in most cases, on complementary actions being accomplished e.g. making the correct decision on receipt of the result, and taking the right action, (iii) the principles of evidence-based laboratory medicine highlight the fact that diagnostic tests have the potential to solve a wide range of problems, in a number of clinical settings, with the potential to generate a varied range of benefits (outcomes), and (iv) outcomes invariably accrue to parts of the health economy outside of the laboratory, which can prove challenging for health service managers. Commissioning a new service involves (a) assessing the local health care needs - and the expected outcomes, (b) specifying the services required-including the resources, and transformational change required, (c) securing the services required - and the implementation strategy to be employed, and (d) monitoring against the contract issued, as well as evaluating the outcomes against the expectations. In this way the purchaser can ensure that diagnostic services are meeting clinical needs, and are being used appropriately to generate the best outcome for the patient and the exchequer, thereby meeting clinical and fiscal governance requirements.","PeriodicalId":76518,"journal":{"name":"Scandinavian journal of clinical and laboratory investigation. Supplementum","volume":"242 ","pages":"103-8"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365513.2010.493420","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29027517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Recent advances in evaluating the prognostic value of a marker. 评价标志物预后价值的最新进展。

Scandinavian journal of clinical and laboratory investigation. Supplementum Pub Date : 2010-01-01 DOI: 10.3109/00365513.2010.493389

Jarrod E Dalton, Michael W Kattan

引用次数: 11

Angiogenic proteins as aid in the diagnosis and prediction of preeclampsia. 血管生成蛋白在子痫前期诊断和预测中的应用。

Scandinavian journal of clinical and laboratory investigation. Supplementum Pub Date : 2010-01-01 DOI: 10.3109/00365513.2010.493400

Ana Sofia Cerdeira, S Ananth Karumanchi

{"title":"Angiogenic proteins as aid in the diagnosis and prediction of preeclampsia.","authors":"Ana Sofia Cerdeira, S Ananth Karumanchi","doi":"10.3109/00365513.2010.493400","DOIUrl":"https://doi.org/10.3109/00365513.2010.493400","url":null,"abstract":"Preeclampsia/eclampsia remains a major cause of maternal and fetal morbidity worldwide. It also remains a leading cause of iatrogenic prematurity as delivery is currently the only way to successfully treat the disorder. The mechanisms that initiate preeclampsia in humans have been remarkably elusive, but some parts of the puzzle have begun to come together. Recently, it has been suggested that its major phenotypes, such as hypertension, proteinuria and endothelial dysfunction, are due to circulating anti-angiogenic proteins such as soluble fms-like tyrosine kinase-1 and soluble endoglin. Abnormalities in these circulating angiogenic proteins are not only present during clinical preeclampsia, but also antedate clinical symptoms by at least 5-6 weeks. The availability of automated platforms for the measurement of these angiogenic proteins has allowed clinicians to evaluate the role of these biomarkers as an aid in the diagnosis and prediction of preeclampsia. This review will highlight the recent clinical studies that have evaluated the utility of these biomarkers in preeclampsia and its related complications.","PeriodicalId":76518,"journal":{"name":"Scandinavian journal of clinical and laboratory investigation. Supplementum","volume":"242 ","pages":"73-8"},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365513.2010.493400","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29027512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7