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Psychopharmacology communications最新文献

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A sensitive GLC method for the determination of imipramine and desmethylimipramine using a nitrogen detector. 用氮检测器测定丙咪嗪和去甲基咪嗪的高效液相色谱法。
Psychopharmacology communications Pub Date : 1975-01-01
T B Cooper, D Allen, G M Simpson
{"title":"A sensitive GLC method for the determination of imipramine and desmethylimipramine using a nitrogen detector.","authors":"T B Cooper,&nbsp;D Allen,&nbsp;G M Simpson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A sensitive method for determination of imipramine and desmethylimipramine using a GLC system fitted with a new nitrogen detector is described. The lower limit of sensitivity is less than 1 ng/ml with a lower limit enabling quantitation with acceptable precision of 3-5 ng/ml. Data from 20 control subjects given a single oral dose of imipramine are shown.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"1 4","pages":"445-54"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12400182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thyrotropin-releasing hormone (TRH)-induced hyperthermia and behavioral excitation in rabbits. 促甲状腺素释放激素(TRH)诱导兔热疗和行为兴奋。
Psychopharmacology communications Pub Date : 1975-01-01
A Horita, M A Carino
{"title":"Thyrotropin-releasing hormone (TRH)-induced hyperthermia and behavioral excitation in rabbits.","authors":"A Horita,&nbsp;M A Carino","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The intraventricular administration of thyrotropin-releasing hormone (TRH) to conscious rabbits produces a dose-related increase in body temperature, a compulsive scratching syndrome, and behavioral excitation. These effects are not antagonized by most adrenergic or serotonergic blockers, amine depletors, or most depressants. Given to rabbits pretreated with anesthetic doses of barbiturates or high doses of other sedatives or neuroleptics, TRH exerts an analeptic effect. The duration of pentobarbital anesthesia is markedly shortened. Of all the depressants tested, only morphine was resistant to the analeptic effect of TRH, although the morphine-induced hypothermia was reversed.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"1 4","pages":"403-14"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12003888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic O-demethylation of the psychotomimetic amine 1-(2, 5-dimetroxy-4-methylphenyl)-2-aminopropane. 拟精神胺 1-(2,5-二甲氧基-4-甲基苯基)-2-氨基丙烷的代谢 O-去甲基化。
Psychopharmacology communications Pub Date : 1975-01-01
J S Zwieg, N Castagnoli
{"title":"Metabolic O-demethylation of the psychotomimetic amine 1-(2, 5-dimetroxy-4-methylphenyl)-2-aminopropane.","authors":"J S Zwieg, N Castagnoli","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In an effort to more fully characterize the metabolic fate of the psychotomimetic amine (1-(2, 5-dimethoxy-4-methylpheny.)-2-aminopropane (DOM, STP), the formation of the two possible monophenols and the p-hydroquinone metabolites of the parent drug by 10,000 X g supernatent fractions of rabbit liver homogenates has been investigated. All three metabolites have been fully characterized and quantitatively estimated by chemical ionization mass spectrometry with the aid of deuterium enriched compounds. The stereochemical course of the mono-O-demethylation reactions has been shown to proceed with enantiomeric enrichment of the S-aminophenols. The mechanistic implications concerning the mode of action of the parent drug and metabolic O-demethylation are discussed.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"1 4","pages":"359-71"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12399038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rapid, simple and more sensitive method for the demonstration of central catecholamine-containing neurons and axons by glyoxylic acid induced fluorescence: I. Specificity. 一种快速、简便、灵敏的乙醛酸诱导荧光检测含中枢儿茶酚胺神经元和轴突的方法:1、特异性。
Psychopharmacology communications Pub Date : 1975-01-01
E L Battenberg, F E Bloom
{"title":"A rapid, simple and more sensitive method for the demonstration of central catecholamine-containing neurons and axons by glyoxylic acid induced fluorescence: I. Specificity.","authors":"E L Battenberg,&nbsp;F E Bloom","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Perfusion fixation with a mixture of paraformaldehyde and glyoxylic acid facilitates the histochemical demonstration of catecholamine-containing brain neurons. With this fixation, sections can be cut reproducibly with a cryostat and the fluorophore developed by immersion in glyoxylic acid without freeze-drying. Large sections of brain can be examined by fluorescence microscopy within 1 hour of fixation or stored for later examination. The properties of the fluorophore and the location of the fluorescent elements is identical with the neurons and terminal arborizations demonstrated by previous glyoxylic acid methods. Monoamine oxidase inhibition before fixation results in moderately increased fluorescence of terminals and perikarya, while all glyoxylic acid induced fluorescence is abolished by pre-treatment with reserpine. The rapidity and simplicity of this technique may make fluorescence histochemistry of central catecholamine pathways more accessible to psychopharmacologists.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"1 1","pages":"3-13"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12399184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dose-related effects of central noradrenaline stimulation on behavioural arousal in rats. 中枢性去甲肾上腺素刺激对大鼠行为唤醒的剂量相关影响。
Psychopharmacology communications Pub Date : 1975-01-01
M L Smee, P F Weston, D Skinner, T Day
{"title":"Dose-related effects of central noradrenaline stimulation on behavioural arousal in rats.","authors":"M L Smee,&nbsp;P F Weston,&nbsp;D Skinner,&nbsp;T Day","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The general activity of rats in an open field test situation was observed following the central administration of isotonic saline and 0.5 and 2.0 mug of noradrenaline into the locus coeruleus. A significant increase in activity was found following the 0.5 mug, but not the 2.0 mug dose. The results are consistent with other reports indicating that low doses of centrally administered noradrenaline produce behavioural arousal whereas higher doses may result in behavioural depression. In addition, these findings suggest that the noradrenergic neurons arising from the locus coeruleus may be important for the arousal status of rats.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"1 2","pages":"123-30"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12399194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ascorbic acid levels in chronic psychotic patients. 慢性精神病患者的抗坏血酸水平。
Psychopharmacology communications Pub Date : 1975-01-01
P Clement, T A Ban, H E Lehmann
{"title":"Ascorbic acid levels in chronic psychotic patients.","authors":"P Clement,&nbsp;T A Ban,&nbsp;H E Lehmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Serum ascorbic acid concentrations, taken from 37 chronically hospitalized psychiatric patients, were found to be similar to those usually encountered in normal subjects.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"1 4","pages":"415-20"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12400178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radioimmunoassay for desmethylimipramine. 去甲基咪帕明的放射免疫测定。
Psychopharmacology communications Pub Date : 1975-01-01
S Spector, N L Spector, M P Almeida
{"title":"Radioimmunoassay for desmethylimipramine.","authors":"S Spector,&nbsp;N L Spector,&nbsp;M P Almeida","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper describes the production of antibodies against demethyl-imipramine (DMI). By using antisera, a radioimmunoassay was developed capable of detecting 0.2 ng of DMI which is linear up to 25 ng. The assay has been applied for the measurement of DMI in rat plasma and brain. The assay might find application especially when only limited amounts of blood, plasma or tissue are available.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"1 4","pages":"421-9"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12400179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paranoid vs hebephrenic schizophrenia: clinical and familial (genetic) heterogeneity. 偏执型与肝炎型精神分裂症:临床和家族(遗传)异质性。
Psychopharmacology communications Pub Date : 1975-01-01
G Winokur
{"title":"Paranoid vs hebephrenic schizophrenia: clinical and familial (genetic) heterogeneity.","authors":"G Winokur","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>By the use of familial and genetic methods, data are presented which suggest that hebephrenic and paramoid schizophrenia are separate illnesses. The two entities have different clinical pictures and different outcomes. Hebephrenia shows a higher familial risk for schizophrenia than paramoid schizophrenia and most available data reveal that hebephrenia breeds true in the family. The relevance of the possibility that schizophrenia is composed of more than one autonomous illness to some current pharmacological theories and treatment studies is presented.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"1 6","pages":"567-77"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12400183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hydroxyzine hydrochloride: possible adverse cardiac interactions. 盐酸羟嗪:可能对心脏产生不良反应。
Psychopharmacology communications Pub Date : 1975-01-01
L E Hollister
{"title":"Hydroxyzine hydrochloride: possible adverse cardiac interactions.","authors":"L E Hollister","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hydroxyzine hydrochloride may produce abnormal ventricular repolarization when given in substratial doses or to susceptible individuals. Phenothiazines, such as thioridazine, tricyclic antidepressants, or antiparkinson drugs, any of which may be given concurrently to psychiatric patients, may augment this effect as well as atropine, quinidine or procainamide. Such EKG abnormalities may increase the likelihood of dysrhythmias and sudden death.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"1 1","pages":"61-5"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11229217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
D & L amphetamine stereoisomers: comparative potencies in affecting the firing of central dopaminergic and noradrenergic neurons. D和L安非他命立体异构体:影响中枢多巴胺能和去甲肾上腺素能神经元放电的比较效力。
Psychopharmacology communications Pub Date : 1975-01-01
B S Bunney, J R Walters, M J Kuhar, R H Roth, G K Aghajanian
{"title":"D & L amphetamine stereoisomers: comparative potencies in affecting the firing of central dopaminergic and noradrenergic neurons.","authors":"B S Bunney,&nbsp;J R Walters,&nbsp;M J Kuhar,&nbsp;R H Roth,&nbsp;G K Aghajanian","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of the d- and l-isomers of amphetamine on the activity of dopaminergic neurons in the substantia nigra zona compacta and noradrenergic neurons in the locus coeruleus was studied in anesthetized and gallamine paralyzed rats using single unit recording techniques. d- and l-Amphetamine administered intravenously were equally effective in depressing the activity of locus coeruleus cells. However, although d-amphetamine was a potent inhibitor of substantia nigra dopamine containing cells, l-amphetamine was ineffective in causing more than a 45% inhibition of over half of the DA cells studied, even when given in nearly lethal doses. In the remaining dopamine neurons l-amphetamine was only 0.2 to 0.05 times as potent as d-amphetamine in producing both 50 and 100% inhibition of firing rate. These findings, when combined with recent biochemical studies by other authors, suggest that l-amphetamine, at low doses, has a preferential effect on noradrenergic as compared to dopaminergic neurons. The consequences of these findings for the interpretation of studies in which d- and l-amphetamine have been used as pharmacological tools to determine the catecholamine system responsible for a particular behavior in man and animals is discussed.</p>","PeriodicalId":76387,"journal":{"name":"Psychopharmacology communications","volume":"1 2","pages":"177-90"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12399031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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