{"title":"Prednisone-induced increase of proteinuria in patients with a nephrotic syndrome.","authors":"P G Gerlag, F J van Liebergen, R A Koene","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Administration of prednisone to patients with nephrotic syndromes of different aetiologies caused an abrupt increase of proteinuria. The proteinuric effect started four hours after oral or intravenous administration and reached its maximum effect after eight to sixteen hours. In nine patients with epimembranous glomerulopathy mean proteinuria on non-prednisone (NP) days was 43.7 per cent lower than on prednisone (P) days. Variations were significantly greater at higher creatinine clearances. However, in individual patients there were neither differences in creatinine excretion nor in creatinine clearance between P and NP days.</p>","PeriodicalId":76354,"journal":{"name":"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association","volume":"19 ","pages":"790-3"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17929605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G J Abels-Fransen, H Y Oei, E J Dorhout Mees, H A Koomans
{"title":"The predictive value of hippuran uptake in acute renal failure.","authors":"G J Abels-Fransen, H Y Oei, E J Dorhout Mees, H A Koomans","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this study the hippuran uptake capacity (HUC) in 32 patients with an acute deterioration of renal function was measured. The HUC2 is the ratio between the activity accumulated in the kidneys in the first two minutes, divided by the injected dose, which was measured by the gammacamera, during standardised renography. Thirteen patients had an acute glomerular disease (AGD) and 19 patients had acute tubular necrosis (ATN). During the acute deterioration of renal function, the HUC2 values ranged between 0 and 3.0 in the AGD group and between 1.9 and 8.7 in the ATN group. In only one patient of this latter group was the HUC2 value below three. Measurement of HUC2 is useful in the differential diagnosis of acute renal failure. It can be performed in the absence of urine production and indicates renal blood perfusion despite complete absence of filtration. When the HUC2 value is higher than three, ATN is the most probable aetiology of the acute renal failure and recovery of renal function can be expected. Values below this limit most probably indicate AGD.</p>","PeriodicalId":76354,"journal":{"name":"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association","volume":"20 ","pages":"641-5"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17712213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Usberti, S Federico, B Cianciaruso, C Pecoraro, V E Andreucci
{"title":"Water excretion in nephrotic syndrome. Relationship between blood volume and plasma vasopressin.","authors":"M Usberti, S Federico, B Cianciaruso, C Pecoraro, V E Andreucci","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In order to verify whether or not an increased secretion of ADH may cause the water retention commonly observed in nephrotic syndrome, 12 nephrotic patients and 11 normal subjects were studied in basal conditions and following a water load or iso-osmotic blood volume expansion. A significant direct correlation was observed between plasma ADH and Posm in controls but not in nephrotics. Plasma ADH was inversely correlated with BV in nephrotics but not in controls. Blood volume expansion in nephrotic patients was effective in reducing plasma ADH and promoting a water diuresis. These results demonstrate a sustained volume mediated secretion of ADH in nephrotic syndrome, which is responsible for the impairment in water excretion.</p>","PeriodicalId":76354,"journal":{"name":"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association","volume":"20 ","pages":"603-9"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17712322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Proceedings of the European Dialysis and Transplant Association--European Renal Association. Twentieth Congress, London, England, 1983.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76354,"journal":{"name":"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association","volume":"20 ","pages":"1-777"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17421385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Placebo versus allopurinol for recurrent urinary calculi.","authors":"M J Smith","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76354,"journal":{"name":"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association","volume":"20 ","pages":"422-6"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17422043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Influence of head-out water immersion on plasma renin activity, aldosterone, vasopressin and blood pressure in late pregnancy toxaemia.","authors":"F Kokot, J Ulman, A Cekański","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In 39 healthy pregnant women and 45 women with mild or moderate late pregnancy toxaemia (LPT) the influence of head-out water immersion on blood pressure, the renin-aldosterone system, vasopressin and plasma osmolality was examined. Water immersion induced a prompt and marked fall in systolic and diastolic blood pressure, which was significantly higher in LPT women. Simultaneously a significant decrease of plasma renin activity, aldosterone and vasopressin was noted both in healthy and toxaemic pregnant women. In contrast to healthy pregnant women in LPT haemodilution was not observed in the early phase of water immersion.</p>","PeriodicalId":76354,"journal":{"name":"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association","volume":"20 ","pages":"557-61"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17422048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D Scholz, M Mebel, I Töpelmann, I Grossmann, J Scholze, H Mrochen
{"title":"Prevention of osteonecrosis following renal transplantation by using vitamin D2 (ergocalciferol).","authors":"D Scholz, M Mebel, I Töpelmann, I Grossmann, J Scholze, H Mrochen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Osteonecrosis is a frequently disabling complication of renal transplantation. Thirty-one of 244 patients (12.7%), who received cadaver renal transplants from 1968 to 1978 developed an osteonecrosis. An analysis of 14 possible risk factors suggested that only the following were significantly more frequent in the osteonecrosis group: greater than 3 pulse doses of 1.2 g prednisolone, serum creatinine greater than 133 mumol/L, steroid-induced diabetes mellitus and second and subsequent transplantation. An important decline in the incidence of osteonecrosis (26.7 per cent to 6.5 per cent) was seen with prophylactic vitamin D2 treatment and the onset of osteonecrosis was on average one year later. Dangerous side effects of the large doses of vitamin D2 were minimal. Hypercalcaemia due to overdosage with vitamin D2 during simultaneous prednisolone therapy was usually mild and returned to normal in a few days by dose reduction.</p>","PeriodicalId":76354,"journal":{"name":"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association","volume":"20 ","pages":"331-7"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17422218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V Wizemann, W Kramer, J Thormann, M Kindler, G Schütterle, M Schlepper
{"title":"Myocardial perfusion and left ventricular performance during long and short haemodialysis in patients with coronary heart disease.","authors":"V Wizemann, W Kramer, J Thormann, M Kindler, G Schütterle, M Schlepper","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In seven patients with confirmed coronary heart disease and stable blood pressure control acetate haemodialysis improved left ventricular performance and exercise tolerance. Similar positive effects were obtained by a four hour dialysis (one litre fluid removal/hour) and a two hour dialysis (two litre fluid removal/hour). In this group of patients weight gain and overhydration between dialyses appears to be the major risk for myocardial perfusion and rapid weight reduction by acetate dialysis appears adequate therapy. One practical consequence from our study is to minimise fluid overload in coronary heart disease and we try to avoid iatrogenic induction of thirst by decreasing dialysate sodium from 140 mmol/litre to 125-135 mmol/litre. As far as myocardial risk factors are concerned it appears that it is more important to focus on interdialysis weight gains than on acute dialysis therapy.</p>","PeriodicalId":76354,"journal":{"name":"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association","volume":"20 ","pages":"181-5"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17712731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"High-effective aluminium free phosphate binder. In vitro and in vivo studies.","authors":"H Schneider, K D Kulbe, H Weber, E Streicher","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>For the purpose of intestinal phosphate binding we have developed aluminium free natural polymers consisting of heteropolyuronic acid charged with different cations. The in vitro experiments showed an efficacy two to three times greater than Aludrox. During up to six months of clinical application no serious side effects have been detected, constipation ceased and serum phosphate was maintained in an acceptable range.</p>","PeriodicalId":76354,"journal":{"name":"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association","volume":"20 ","pages":"725-30"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17713129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P Grützmacher, H W Radtke, W Fassbinder, K M Koch, W Schoeppe
{"title":"Effect of secondary hyperparathyroidism on the anaemia of end-stage renal failure: in vivo and in vitro studies.","authors":"P Grützmacher, H W Radtke, W Fassbinder, K M Koch, W Schoeppe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Changes in haematocrit of 29 haemodialysis patients were followed 12 months before, close to and 12 months after parathyroidectomy. Mean haematocrit decreased significantly from 31.6 +/- 8.6 per cent to 29.1 +/- 8.4 per cent and increased to 33.3 +/- 7.9 per cent after PTX. Serum erythropoietin concentration, investigated pre and 6-12 months post PTX, at a time, when an increase of haematocrit values had been observed, did not significantly change (63 +/- 58 vs 67 +/- 37 mU/ml). The effect of 1-84 bovine parathyroid hormone on erythropoiesis was studied in vitro. A dose-related inhibition of colony formation of both fetal mouse liver and human bone marrow erythroid cells was observed in the presence of two to 8U parathyroid hormone/ml, suggesting direct bone marrow toxicity by excessive parathyroid hormone concentrations.</p>","PeriodicalId":76354,"journal":{"name":"Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association","volume":"20 ","pages":"739-45"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17713131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}