American journal of physiology. Regulatory, integrative and comparative physiology最新文献

{"title":"Investigation into the acute effects of various waveforms on tibial nerve stimulation for treating overactive bladder in cats.","authors":"Dongsheng Shang, Haoyu Sun, Han Deng, Chen Li, Ziyu Wang, Linquan Jin, Yun Guo, Xing Li","doi":"10.1152/ajpregu.00132.2025","DOIUrl":"10.1152/ajpregu.00132.2025","url":null,"abstract":"<p><p>This study aimed to investigate the efficacy of different electrical waveforms in suppressing bladder overactivity during acute tibial nerve stimulation (TNS) in cats. Cystometric measurements were performed during intravesical infusion of either acetic acid (AA) or normal saline (NS) control solution. Bipolar hook electrodes were implanted on the left tibial nerve for stimulation. TNS with monophasic square waves, biphasic square waves, sine waves, and triangular waves were applied consecutively. Cystometrograms were utilized to evaluate the impacts of these different waveforms on the micturition reflex. Under physiological conditions, all four TNS waveforms significantly increased bladder capacity compared with NS control levels (10.96 ± 3.33 mL; <i>P</i> < 0.001). The relative increases were as follows: 151.10% ± 4.66%, 132.20% ± 3.47%, 131.30% ± 4.85%, and 128.60% ± 3.55% of control values. Under pathological conditions, the monophasic square wave demonstrated inhibitory effects compared with the other three waveforms (<i>P</i> < 0.001). In contrast, no significant differences in inhibitory efficacy were observed between waveforms under pathological conditions (<i>P</i> > 0.05). Quantitative analysis revealed significantly lower <i>T</i> values for both monophasic and biphasic square waves compared with sinusoidal and triangular waveforms (<i>P</i> < 0.001). Furthermore, the triangular wave exhibited significantly higher <i>T</i> values than the sine wave (<i>P</i> = 0.02). The efficacy of TNS waveforms showed condition-dependent variation, with no consistent performance pattern between physiological and pathological states. When considering practical clinical application factors, including stimulator longevity and minimization of tissue damage, the biphasic square wave may be more beneficial.<b>NEW & NOTEWORTHY</b> In this study, we determined the effects of tibial nerve stimulation (TNS) at different stimulation waveforms on bladder reflex in cats. Innovations are as follows: <i>1</i>) as far as we know, the effects of TNS with different waveforms on overactive bladder has been not explored forever. <i>2</i>) Our results may provide a basis for altering parameters to improve the therapeutic efficacy of TNS for overactive bladder.</p>","PeriodicalId":7630,"journal":{"name":"American journal of physiology. Regulatory, integrative and comparative physiology","volume":" ","pages":"R371-R377"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific impact of selective reduced uterine placental perfusion model of preeclampsia on fetal cardiac maturation and mitochondrial function.","authors":"Paulami Chatterjee, Rebecca Molberg, Raven Kirschenman, Claudia D Holody, Anita Quon, Floor Spaans, Stephane L Bourque, Hélène Lemieux, Sandra T Davidge","doi":"10.1152/ajpregu.00118.2025","DOIUrl":"10.1152/ajpregu.00118.2025","url":null,"abstract":"<p><p>Preeclampsia is a serious pregnancy complication and increases the risk of cardiovascular disease in offspring later in life. Cardiac development includes maturation of cardiomyocytes, a process that is intricately dependent on proper mitochondrial function. However, it remains unclear whether preeclampsia impairs mitochondrial function and alters cardiac maturation of fetal hearts during late gestation. Herein we induced selective reduced uterine placental perfusion (sRUPP), as a model of preeclampsia in rats, to investigate fetal cardiac myosin heavy chain (MYH) expression, reactive oxygen species (ROS) production, mitochondrial respiration, mitochondrial content, and dynamics in male and female fetuses at <i>gestational day 20</i> (GD 20) (term = GD 22). Litter size was reduced, whereas pup reabsorptions were increased in sRUPP compared with sham controls. In only the male fetuses of sRUPP dams, cardiac <i>Myh7/Myh6</i> ratio was reduced and <i>Myh6</i> expression increased. Complex IV activity was elevated in sRUPP male fetuses, with no changes in mitochondrial citrate synthase or ATP synthase activities in either sex. However, ROS production increased in only sRUPP female fetuses. In male fetal hearts, sRUPP increased fusion protein MFN1 expression, tended to decrease fusion protein OPA1 expression, and decreased fission protein FIS1 expression. In contrast, MFN2 and OPA1 were reduced in sRUPP female fetuses. In conclusion, the sRUPP model of preeclampsia affected cardiac maturation and mitochondrial function in late gestation fetuses in a sex-specific manner. As prenatal strategies are being developed to improve pregnancy outcomes, sex-specific fetal effects should be taken into consideration.<b>NEW & NOTEWORTHY</b> This study assessed the impact of preeclampsia on late gestation fetal cardiac development using a rat model of reduced uterine placental perfusion. Our findings revealed sex-specific differences: male fetuses exhibited accelerated cardiac maturation and complex IV activity, whereas female fetuses showed evidence of oxidative stress in the cardiac tissue. Disruptions in mitochondrial dynamics were observed in both sexes. These results underscore the necessity of considering sex-specific fetal effects when developing prenatal therapeutic interventions for preeclampsia.</p>","PeriodicalId":7630,"journal":{"name":"American journal of physiology. Regulatory, integrative and comparative physiology","volume":" ","pages":"R474-R486"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum for Huot et al., volume 328, 2025, p. R628-R641.","authors":"","doi":"10.1152/ajpregu.00035.2025_COR","DOIUrl":"https://doi.org/10.1152/ajpregu.00035.2025_COR","url":null,"abstract":"","PeriodicalId":7630,"journal":{"name":"American journal of physiology. Regulatory, integrative and comparative physiology","volume":"329 3","pages":"R422"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral perfusion mismatch: challenging the validity of cerebral vascular resistance index in orthostatic stress.","authors":"Shigehiko Ogoh, Hayato Tsukamoto, Erika Iwamoto, Narumi Kunimatsu, Jun Sugawara, Takeshi Hashimoto, Hironori Watanabe","doi":"10.1152/ajpregu.00134.2025","DOIUrl":"10.1152/ajpregu.00134.2025","url":null,"abstract":"<p><p>The cerebral vascular resistance index (CVRi), a single-parameter model based on systemic blood pressure rather than cerebral perfusion pressure (CPP), is widely used to assess cerebrovascular resistance. However, it does not accurately reflect the pressure-flow/velocity relationships in the cerebral circulation, as cerebral blood flow (CBF) is primarily regulated by CPP. This study evaluated the validity of CVRi during orthostatic stress induced by head-up tilt (HUT), which alters CPP independently of arterial blood pressure at the heart level and CBF. Twenty young, healthy participants (aged 23 ± 3 yr) were included, and vascular tone indices, CVRi, critical closing pressure (CrCP), resistance-area product (RAP), and pulsatility index (PI) were measured during HUT. HUT significantly increased CVRi and CrCP (<i>P</i> ≤ 0.003) but did not affect RAP and PI (<i>P</i> ≥ 0.277). However, correlation analysis between changes in CVRi and other vascular indices (i.e., CrCP, RAP, and PI), calculated as the difference between HUT and supine positions, revealed no significant relationships (all <i>r</i> = 0.189-0.701; all <i>P</i> = 0.090-0.425). Moreover, the CVRi response to orthostatic stress differed from that of the corrected CVRi during HUT, which accounts for changes in hydrostatic pressure. Specifically, CVRi increased during HUT (<i>P</i> = 0.003), whereas corrected CVRi, adjusted for changes in hydrostatic pressure, significantly decreased (<i>P</i> < 0.001). These findings highlight the limitations of CVRi, which fails to account for deviations in CPP from systemic blood pressure or for other physiological factors (e.g., intracranial pressure), potentially leading to inaccuracies in estimating cerebral vascular resistance.<b>NEW & NOTEWORTHY</b> CVRi is a useful index for estimating cerebral vascular resistance, as it can be easily calculated using middle cerebral artery blood velocity and systemic blood pressure. However, the results of the present study suggest that, due to physiological variations, particularly conditions in which cerebral perfusion pressure deviates from systemic blood pressure (e.g., during orthostatic stress), CVRi may not accurately reflect true cerebral perfusion pressure. Researchers should be mindful of this limitation.</p>","PeriodicalId":7630,"journal":{"name":"American journal of physiology. Regulatory, integrative and comparative physiology","volume":" ","pages":"R468-R473"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sniffing good makes me food.","authors":"Ana Fernández-Sánchez, Francisco J Ortega","doi":"10.1152/ajpregu.00171.2025","DOIUrl":"10.1152/ajpregu.00171.2025","url":null,"abstract":"","PeriodicalId":7630,"journal":{"name":"American journal of physiology. Regulatory, integrative and comparative physiology","volume":" ","pages":"R506-R508"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"It is time to move the needle forward on cardiovascular stress reactivity and health behaviors in Hispanic and Latine adults.","authors":"Jeremy A Bigalke, Nina L Stute, Kanokwan Bunsawat, Austin T Robinson","doi":"10.1152/ajpregu.00180.2025","DOIUrl":"10.1152/ajpregu.00180.2025","url":null,"abstract":"","PeriodicalId":7630,"journal":{"name":"American journal of physiology. Regulatory, integrative and comparative physiology","volume":" ","pages":"R437-R440"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12451760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunohistochemistry as a technique in the studies on the neuroendocrine control of hydromineral balance: the legacy of José Antunes-Rodrigues.","authors":"Cristiane Mota Leite, Silvia Graciela Ruginsk, Laura Vivas, Andrea Godino, Ernane Torres Uchôa","doi":"10.1152/ajpregu.00247.2024","DOIUrl":"10.1152/ajpregu.00247.2024","url":null,"abstract":"<p><p>Several forebrain and brainstem neurochemical circuitries interact with peripheral, neural, and humoral signals to collaboratively maintain both the volume and osmolality of extracellular fluids. Over the past decades, much progress has been made in understanding the complex mechanisms underlying the neuroendocrine control of hydromineral homeostasis. Classical experiments performed by Dr. Antunes-Rodrigues in the early 1960s, such as lesions of hypothalamic and extrahypothalamic areas and drug microinfusions, associated with behavioral analysis and electrolytes/hormones measurements, were crucial to elucidate several aspects of the regulation of hydromineral balance. Fifty years after this pioneering research, the use of immunohistochemistry shifted methodological efforts to the central nervous system, in an attempt to elucidate how neurons (and lately, also glial cells) receive and interpret sensory signals originating from the periphery. This report focuses on the main findings obtained by Dr. Antunes-Rodrigues and colleagues using immunohistochemistry as an important tool in the first two decades of this century to elucidate the brain-specific neurochemical circuits underlying functional mechanisms by which osmotic and volume challenges could impact hormonal and behavioral responses.</p>","PeriodicalId":7630,"journal":{"name":"American journal of physiology. Regulatory, integrative and comparative physiology","volume":" ","pages":"R308-R316"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular changes: a biomarker for seizures after hypoxia-ischaemia in preterm fetal sheep.","authors":"Olivia J Lear, Victoria J King, Christopher A Lear, Kelly Q Zhou, Benjamin A Lear, Joanne O Davidson, Alistair J Gunn, Laura Bennet, Simerdeep K Dhillon","doi":"10.1152/ajpregu.00073.2025","DOIUrl":"10.1152/ajpregu.00073.2025","url":null,"abstract":"<p><p>Seizures in preterm infants are highly associated with adverse neurodevelopmental outcomes. Clinical diagnosis remains a challenge because seizures in preterm infants are often clinically silent. The present study examined whether seizure-related cardiovascular changes could aid seizure detection. Chronically instrumented preterm fetal sheep at 0.7 gestation received sham hypoxia-ischaemia (HI) (<i>n</i> = 10) or HI induced by 25 min of complete umbilical cord occlusion (<i>n</i> = 10). Fetal electroencephalogram (EEG) recovery and cardiovascular physiology were assessed until 72 h post HI. HI was associated with stereotypic evolving seizure activity starting 14 ± 13 h (mean ± SD) after HI, with an average total seizure count of 42 ± 2, duration 67 ± 25 s, amplitude 187 ± 88 µV, and seizure burden of 150 ± 129 s/h. Individual seizures were associated with increased mean arterial pressure (MAP) (38.2 ± 2.7 to 40.1 ± 3.2 mmHg). The fetal heart rate (FHR) response during seizures was predominantly tachycardia, but either bradycardia or no change was seen in 21% of seizures. Using minute-to-minute variation in MAP and FHR above one standard deviation as thresholds, the presence of seizures on electroencephalogram (EEG) was predicted with a sensitivity of 75.1 ± 30.4% and 66.5 ± 26.2%, respectively. Using MAP and FHR as a composite measure detected 87.1 ± 4.2% of stereotypic seizures. These data suggest that seizure-related transient fluctuations in MAP and FHR are potentially useful biomarkers for electrographic seizure activity.<b>NEW & NOTEWORTHY</b> In preterm fetal sheep, seizures after hypoxia-ischaemia were associated with increased mean arterial pressure and either increased or decreased fetal heart rate. Minute-to-minute variation in mean arterial pressure and fetal heart rate measures detected 75.1 ± 30.4% and 66.5 ± 26.2% of seizures, respectively, whereas together they detected 87.1 ± 4.2%. Assessment of seizure-related cardiovascular changes may help to improve seizure detection in preterm infants.</p>","PeriodicalId":7630,"journal":{"name":"American journal of physiology. Regulatory, integrative and comparative physiology","volume":" ","pages":"R340-R349"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeated remote ischemic preconditioning improves temporal characteristics of the cutaneous microvascular responses to postocclusive reactive hyperemia.","authors":"Jahyun Kim, Warren D Franke, James A Lang","doi":"10.1152/ajpregu.00069.2025","DOIUrl":"10.1152/ajpregu.00069.2025","url":null,"abstract":"<p><p>Repeated remote ischemic preconditioning (RIPC) improves endothelial-dependent cutaneous vasodilation. However, the role of repeated RIPC on the postocclusive reactive hyperemia (PORH) response in the cutaneous microvasculature is unknown; here, we assessed whether repeated RIPC would increase PORH responses. Thirty participants (23 ± 3 yr old) performed either repeated RIPC (1 session/day for a week, <i>n</i> = 10 or 12 sessions over 2 wk, <i>n</i> = 12) or 2-wk control (<i>n</i> = 8). Each RIPC session comprised 4 repetitions of 5-min arm blood flow occlusion interspersed by 5-min reperfusion. PORH was elicited by brachial artery occlusion for 5 min. Cutaneous vascular conductance was determined using laser speckle contrast imaging before and after the repeated RIPC. The control group did not receive RIPC but underwent the PORH measurements 2 wk later. Area under the curve and peak of PORH were not different. Max/Time to Peak, the maximum hyperemia achieved (Max) over the rate of reperfusion following arterial occlusion (Tp), improved similarly after both 1 and 2 wk of repeated RIPC (1 wk: 0.09 ± 0.04 vs. 0.12 ± 0.07, 2 wk: 0.12 ± 0.03 vs. 0.14 ± 0.04 CVC/s, Pre vs. Post, <i>P</i> < 0.05). Tp improved only after 2 wk of RIPC (Tp: 16.5 ± 2.1 vs. 14.8 ± 2.4 s, Pre vs. Post, <i>P</i> < 0.05). The control group responses did not change after 2 wk. Repeated RIPC did not increase the magnitude of the hyperemic response but did alter temporal measures of PORH such as Max/Tp and Tp following cuff deflation.<b>NEW & NOTEWORTHY</b> This study investigated the extent to which <i>1</i>) repeated RIPC improved PORH-induced cutaneous microvascular reactivity and <i>2</i>) a longer period of RIPC further improved cutaneous microvascular reactivity. Both 1 and 2 wk of RIPC improved cutaneous microvascular reactivity similarly. However, only 2 wk of RIPC altered temporal PORH variables. These results suggest that repeated RIPC increases cutaneous microvascular reactivity following occlusion, but longer duration RIPC may be needed to alter temporal cutaneous microvascular reactivity.</p>","PeriodicalId":7630,"journal":{"name":"American journal of physiology. Regulatory, integrative and comparative physiology","volume":" ","pages":"R363-R370"},"PeriodicalIF":2.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart failure decreases adipocyte progenitors with impaired differentiation capacity toward mature adipocytes.","authors":"Yusuke Takeda, Oto Inoue, Ayano Nomura, Daiki Hashimuko, Kosei Yamaguchi, Chiaki Goten, Shinichiro Takashima, Masayuki Takamura, Soichiro Usui","doi":"10.1152/ajpregu.00191.2024","DOIUrl":"10.1152/ajpregu.00191.2024","url":null,"abstract":"<p><p>Cardiac cachexia, characterized by adipose tissue atrophy, has the most unfavorable outcome in heart failure (HF). Adipose dysfunction might worsen HF as adipose tissue has been found to have cardioprotective effects mediated through its metabolic and endocrine functions, and therefore, could serve as a novel therapy target. In the context of adipose tissue homeostasis, adipocyte progenitor cells (APCs) play critical roles in maintaining the number and function of mature adipocytes, including lipid metabolism and hormone secretion. However, the mechanism by which HF affects APCs has not been elucidated. In this study, we aimed to evaluate the number and functions of Lin^-CD24⁺ APCs in the subcutaneous adipose tissue of mice subjected to transverse aortic constriction-induced HF. This HF model greatly reduced the number of APCs and increased their apoptosis, resulting in lipodystrophy. In vitro assays revealed that HF limited APC proliferation and senescence. With respect to the mechanism of impaired APC function in HF, we identified that augmented sympathetic nerve activity partially mediated the decrease in APC counts via unilateral adipose tissue denervation (ATD). Furthermore, ATD mitigated HF-induced APC senescence. We elucidated that HF and excess sympathetic nerve activity impaired the adipogenic differentiation capacity of APCs. In conclusion, HF induced APC loss and senescence by augmenting sympathetic nerve activity. The impaired adipogenic capacity of APCs results in reduced healthy adipose tissue mass, suggesting that this phenomenon could be responsible for the worsening of HF.<b>NEW & NOTEWORTHY</b> Our work elucidated the negative feedback between heart failure (HF) and the number and function of adipocyte progenitor cells (APCs). HF drastically decreases CD24⁺ APC number and proliferative capacity. Furthermore, we discovered that HF impaired the capacity of APCs to differentiate into mature adipocytes. In conclusion, impaired APC function in HF would be a new research target to ameliorate severe HF outcomes in patients with cachexia.</p>","PeriodicalId":7630,"journal":{"name":"American journal of physiology. Regulatory, integrative and comparative physiology","volume":" ","pages":"R287-R296"},"PeriodicalIF":2.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}