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Pathologia Europaea最新文献

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Histological modifications of the lymph nodes in mice bearing syngeneic grafts of tumours induced by methylcholanthrene. 甲基胆蒽诱导的同基因肿瘤移植小鼠淋巴结的组织学改变。
Pathologia Europaea Pub Date : 1975-01-01
L J Simar, C Focan, J Boniver, E H Betz
{"title":"Histological modifications of the lymph nodes in mice bearing syngeneic grafts of tumours induced by methylcholanthrene.","authors":"L J Simar,&nbsp;C Focan,&nbsp;J Boniver,&nbsp;E H Betz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Light and electron microscopical studies demonstrate that regional but also non-regional lymph nodes of C57BL mice grafted by tumours, induced by methylcholanthrene, are able to elicit a complex immunological response of the cellular, as well as of the humoral types. No significant difference was found according to the growth rate and the immunogenicity of the six tumours investigated. The cellular immunization is predominant during the two first weeks. It is mainly characterized by the appearance in the paracortical area of numerous immunoblasts which are in close connexions with'dendritic' macrophages showing multiple long cytoplasmic expansions. During the same period of time, the reticulum cells become hyperplasic in the sinus. From the 15th day to the death of the animals, the cellular immunizaiton progressively regresses while a humoral immunity develops. It shows itself as an hypertrophy of the lymph follicles and an increase in the number of medullary cord plasma cells.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"10 4","pages":"317-25"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12385458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatic vein thrombosis in Buffalo strain female rats ingesting dimethylnitrosamine. 水牛系雌性大鼠摄入二甲基亚硝胺后肝静脉血栓形成。
Pathologia Europaea Pub Date : 1975-01-01
M D Reuber
{"title":"Hepatic vein thrombosis in Buffalo strain female rats ingesting dimethylnitrosamine.","authors":"M D Reuber","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Buffalo strain male and female rats 12 weeks of age ingested 0.0114% dimethylnitrosamine in a semisynthetic diet for 12 weeks. Hepatic vein thrombosis developed along with focal fibrosis of the liver in female rats. Male rats had focal hepatic fibrosis, but not thrombosis of hepatic veins. A high incidence of hepatic vein thrombosis has been observed previously in Buffalo strain rats given carbon tetrachloride and methylcholanthrene simultaneously.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"10 3","pages":"241-4"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12364344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acid esterase in the aorta of the hyperlipidemic rat: a histochemical study. 高脂血症大鼠主动脉酸性酯酶的组织化学研究。
Pathologia Europaea Pub Date : 1975-01-01
E Gaton, J J Bubis, M Wolman
{"title":"Acid esterase in the aorta of the hyperlipidemic rat: a histochemical study.","authors":"E Gaton,&nbsp;J J Bubis,&nbsp;M Wolman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In rats maintained for about three weeks on a diet inducing hyperlipidemia E-600 resistant acid esterase activities were markedly reduced in the aorta in comparison with untreated animals. In rats which were maintained on an ordinary diet containing the same amount of thiouracil as given to the hyperlipidemic animals, only a slight reduction of acid esterase activities was noted. Another group of animals was fed an ordinary diet for three weeks after three weeks on a hyperlipidemic diet. In the aorta of these animals the acid esterase activities were almost normal. There was little fat deposition in the aortas of animals given the various diets. No such effects on esterase activities were observed in the liver and lung of animals of the various groups. Inhibition of acid esterase activity was also observed in rats kept on a hyperlipidemic diet for 65 days. In these animals patchy deposition of partly anisotropic lipid was observed in the intima and media.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"10 2","pages":"129-33"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12364566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electron microscopical investigations on the glycocalyx of cultivated cells after incubation with extracts from rapidly growing normal and tumour tissues. 快速生长的正常组织和肿瘤组织提取物培养细胞后糖萼的电镜观察。
Pathologia Europaea Pub Date : 1975-01-01
N Mangakis, C U Von Mickwitz
{"title":"Electron microscopical investigations on the glycocalyx of cultivated cells after incubation with extracts from rapidly growing normal and tumour tissues.","authors":"N Mangakis,&nbsp;C U Von Mickwitz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Electron microscopical investigations by means of the ruthenium red method on Huggin-tumour cells cultivated in vitro resulted in a different thickness of the glycocalyx depending on the fixation of the cells in monolayer or, after mechanical detachment, in suspension. Cells fixed in suspension display a thicker glycocalyx, which is supposed to be due to a contraction of the cells before fixation. Tissue extracts from rapidly growing tissues (mammary gland of pregnant cows, tumour tissue) cause a significant reduction of the glycocalyx in transformed hamster fibroblasts and Huggin-tumour cells after an 18-hour period of action. These findings are in accordance with previous findings on the glycolytic effect of tissue extracts on sections of cartilaginous tissue. It is discussed whether the action of the tissue extracts on the glycocalyx is due to its detachment or to an inhibition of its renewal.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"10 2","pages":"105-14"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12413741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strontium, lead and nickel incorporation into mouse calvaria in vitro. 锶、铅和镍在体外小鼠颅骨中的掺入。
Pathologia Europaea Pub Date : 1975-01-01
N Jacobsen, J Jonsen
{"title":"Strontium, lead and nickel incorporation into mouse calvaria in vitro.","authors":"N Jacobsen,&nbsp;J Jonsen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Incorporation of strontium, lead and nickel radioisotopes was studied in mouse calvaria in tissue culture. About 90% of the incorporated strontium and 5-12% of the lead were recovered in the mineral phase of the calvaria (hot acid soluble fraction), whereas the nickel was recovered mainly in the organic phase (hot alkali soluble fraction). Metabolic inhibition enhanced the incorporation, which indicated that the mineral metabolism of the calvaria comprised ionic exchange or secondary mineralization phenomenons independent of the activity of bone cells but, possibly, guided by a metabolically active bone membrane.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"10 2","pages":"115-21"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11457017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Late familial pseudo-myopathic muscular glycogenosis with alpha 1,4 glucosidase deficiency. Morphological, histoenzymological and biochemical approach. 晚期家族性假性肌性糖原病伴α 1,4葡萄糖苷酶缺乏。形态学、组织酶学和生化方法。
Pathologia Europaea Pub Date : 1975-01-01
H Carrier, M Lebel, M Mathieu, J Pialat, M Devic
{"title":"Late familial pseudo-myopathic muscular glycogenosis with alpha 1,4 glucosidase deficiency. Morphological, histoenzymological and biochemical approach.","authors":"H Carrier,&nbsp;M Lebel,&nbsp;M Mathieu,&nbsp;J Pialat,&nbsp;M Devic","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"10 1","pages":"51-9"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12238879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On the ultrastructure of the atrophic muscle cell. 萎缩肌细胞的超微结构。
Pathologia Europaea Pub Date : 1975-01-01
U P Ketelsen
{"title":"On the ultrastructure of the atrophic muscle cell.","authors":"U P Ketelsen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"10 1","pages":"73-84"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12356037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of the number of cell divisions and of added isologous nucleic acids on ageing of normal human fibroblasts in vitro. 细胞分裂次数及添加异体核酸对体外正常人成纤维细胞衰老的影响。
Pathologia Europaea Pub Date : 1975-01-01
J Mellgren
{"title":"Effects of the number of cell divisions and of added isologous nucleic acids on ageing of normal human fibroblasts in vitro.","authors":"J Mellgren","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It is a matter of debate if the life span of a normal cell strain in vitro depends on the number of cell divisions passed or simply on metabolic time in culture. We have cultured sub-strains of the same normal human foetal fibroblast strain, separated but in a common dish with a common medium. One sub-strain was forced by infrequent transfers to grow slowly, the other was transferred frequently and grew freely. At intervals, cell kinetics of the strains was registered by time-lapse photography. The results indicate that ageing in vitro, manifested by changes of cell kinetics, and the total life span in vitro for normal human fibroblasts are dependent on the number of passed cell divisions, supporting the idea of a progressive decay of the transcription mechanism. A trial to postpone ageing of normal human foetal fibroblasts in vitro was made by adding nucleic acids, extracted from other organs of the same ovum, to the medium for 7 to 14 transfers. Four to 18 transfers after the end of the treatment, the cells still revealed a kinetic pattern typical of much younger normal strains, pointing to an influence on the genes. The effect is probably due to the DNA of the nucleic acid extract.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"10 3","pages":"215-9"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12364341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subcellular morphological changes in the rat kidney after phosphorus burn. 磷烧伤后大鼠肾脏亚细胞形态学的变化。
Pathologia Europaea Pub Date : 1975-01-01
J Appelbaum, N Ben-Hur, J Shani
{"title":"Subcellular morphological changes in the rat kidney after phosphorus burn.","authors":"J Appelbaum,&nbsp;N Ben-Hur,&nbsp;J Shani","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Experimental phosphorus burns were performed on male rats, in order to evaluate the subcellular changes which had occurred as a result of their lesions. In addition to the external wound caused by the burn itself, pathological changes were observed macroscopically and microscopically in various body organs, mainly the kidneys. These were investigated under the electron microscope for subcellular alterations at their damaged sites, and for biochemical aberrations that were observed in those rats. In the phosphorus-burnt rats the glomeruli were ischemic, showed capillary collapse and exhibited proliferation of mesangial areas and basement membrane thickening. Many necrotic cells were observed in the proximal tubule, where large vacuoles containing myelin-like structures were identified. The lumen of the proximal tubules were completely occluded by cell debris and the cytoplasm was necrotic. Due to the damage caused to the glomeruli, high concentrations of serum urea, serum SGPT and PO-4 were assayed in the phosphorus-burnt rats. These changes may account for the high mortality rate after phosphorus burns and may further understanding of the damage as well as ways of approaching it.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"10 2","pages":"145-54"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12364336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The influence of cycloheximide and chloramphenicol on rat serum proteins. 环己亚胺和氯霉素对大鼠血清蛋白的影响。
Pathologia Europaea Pub Date : 1975-01-01
G Mortara, C Agostini
{"title":"The influence of cycloheximide and chloramphenicol on rat serum proteins.","authors":"G Mortara,&nbsp;C Agostini","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of cycloheximide (CHM) and chloramphenicol (CAP) on rat serum proteins and on their electrophoretic patterns have been investigated. It has been shown that total serum protein is decreased by both treatments. CHM causes a fall in transferrin and alpha2(3-8) globulin content, while CAP reduces only alpha2(3-8) globulins. Different microscopic features of hepatic steatosis are described with both drugs. The results are briefly discussed.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"10 3","pages":"193-5"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12364339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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