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Pathologia Europaea最新文献

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'Collagenous colitis' with watery diarrhoea--a new entity? “胶原性结肠炎”伴水样腹泻——一种新疾病?
Pathologia Europaea Pub Date : 1976-01-01
C G Lindström
{"title":"'Collagenous colitis' with watery diarrhoea--a new entity?","authors":"C G Lindström","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A case of chronic watery diarrhoea showed in rectal biopsy a thick subepithelial collagenous deposit in the colorectal mucosa. This deposit was of the same type as that described in the jejunal mucosa in collagenous sprue, and seems to have been the cause of the diarrhoea.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 1","pages":"87-9"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12117136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and ultrastructural study of Burkitt-like leukaemia. 伯基特样白血病的临床及超微结构研究。
Pathologia Europaea Pub Date : 1976-01-01
W W Feremans, E Demaertelaere, G Delalieux, P Neve
{"title":"Clinical and ultrastructural study of Burkitt-like leukaemia.","authors":"W W Feremans,&nbsp;E Demaertelaere,&nbsp;G Delalieux,&nbsp;P Neve","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Six patients, two with acute lymphoblastic leukaemia (A.L.L.) and four with lymphosarcoma with early transformation into A.L.L., have been studied. All blast-cells demonstrated with cytological, cytochemical and ultrastructural features of Burkitt's tumour. The clinical evolution was fulminant and there was no remission of long duration despite intensive chemotherapy. The cytoplasm of the blast-cells displayed a great number of lipid droplets. The level of the anticapsid Epstein-Barr virus antibodies was high in the case investigated.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 2","pages":"137-46"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11399865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Centrioles and cilia in non-tumourous anterior lobes and adenomas of the human pituitary. 人垂体非肿瘤前叶和腺瘤的中心粒和纤毛。
Pathologia Europaea Pub Date : 1976-01-01
E Horvath, K Kovacs, C Ezrin
{"title":"Centrioles and cilia in non-tumourous anterior lobes and adenomas of the human pituitary.","authors":"E Horvath,&nbsp;K Kovacs,&nbsp;C Ezrin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Electron microscopy revealed the presence of centrioles and cilia in non-tumourous adenohypophysiocytes as well as in various adenomas of the human pituitary gland. Accumulation of centrioles and cilia was evident in sparsely granulated growth hormone cell adenomas. Abundance of centrioles is a valuable sign in establishing the diagnosis of this tumour. The possible functional significance of centrioles and cilia in adenohypophysial cells has been discussed.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 1","pages":"81-6"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12117134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrastructural study of a muscle biopsy in a case of GM1 gangliosidosis type I. 1例GM1型神经节脂质沉积症肌肉活检的超微结构研究。
Pathologia Europaea Pub Date : 1976-01-01
F M Tomé, M Fardeau
{"title":"Ultrastructural study of a muscle biopsy in a case of GM1 gangliosidosis type I.","authors":"F M Tomé,&nbsp;M Fardeau","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The main ultrastructural findings in a muscle biopsy from a child aged 11 months with a GM1 gangliosidosis were cytoplasmic inclusions of two different types: (1) inclusions filled with a moderate electron dense and polymorphous material thought to correspond to ganglioside accumulation and lying only in the Schwann cells of intramuscular nerves. (2) Vacuolar inclusions regarded as containing polysaccharides and observed in perineurial cells, endothelium and pericytes of blood vessels, and also in muscle satellite cells. The muscle fibres only exhibited moderate and non-specific changes. The study shows that in a muscle biopsy of GM1 gangliosidosis the two characteristic types of storage deposits and their preferential localization in different cells may be demonstrated, providing that the intramuscular nerves and motor end plates are examined.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 1","pages":"15-25"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11351525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tissue culture, electron microscopic and enzyme histochemical investigations of extraadrenal paragangliomas. 肾上腺外副神经节瘤的组织培养、电镜及酶组织化学研究。
Pathologia Europaea Pub Date : 1976-01-01
F Gullotta, B Helpap
{"title":"Tissue culture, electron microscopic and enzyme histochemical investigations of extraadrenal paragangliomas.","authors":"F Gullotta,&nbsp;B Helpap","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Light and electromicroscopical as well as histochemical investigations were performed on three cases of extraadrenal paragangliomas. They were localized in the carotid body, tympanicum and cauda equina region. Tissue of two cases was cultivated in vitro in nutrient medium TCM 199. The tumours were classified as paragangliomas of the paraganglionic type with typical cell clusters, of the adenomatous and angiomatous type. The enzyme histochemistry showed a very high dehydrogenase activity. Ultrastructurally numerous typical osmiophilic granules could be observed in the cytoplasm of the tumour cells. In tissue culture only a minimal cellular proliferative activity could be detected. The few proliferating cell colonies showed mostly characteristics of epithelial tissue and sometimes a similar behaviour to cells of a ganglioneuroblastoma. The minimal proliferative activity in vitro is in good agreement with the proliferative behaviour of the extraadrenal paragangliomas in vivo.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 4","pages":"257-64"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11409905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The normal squamous epithelium of the human uterine cervix: a histological study. 人宫颈正常鳞状上皮:组织学研究。
Pathologia Europaea Pub Date : 1976-01-01
C A Rubio, G Söderberg, C A Grant, C Chi, R Krepler
{"title":"The normal squamous epithelium of the human uterine cervix: a histological study.","authors":"C A Rubio,&nbsp;G Söderberg,&nbsp;C A Grant,&nbsp;C Chi,&nbsp;R Krepler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The normal squamous epithelium of the uterine cervix was investigated in 50 foetuses and newborns, as well as in 207 adult women operated upon because of various benign conditions of the uterus. The epithelium was divided according to the presence or the absence of prominent epithelial papillae. Epithelial papillae occurred in 32% of the cervices in the paediatric age and in 17% in adult women. They were present in the whole squamous epithelium covering the portio vaginalis in all pediatric patients. In 49% of the adult patients epithelial papillae covered the whole portio and/or the transitional zone; in the remaining 51% only a reduced area presented epithelial papillae. Micrometric determinations demonstrated that normal epithelium with papillar formation was thicker than epithelium with smooth epithelial border. This was most prominent in the paediatric patients. The possibility that oestrogenic stimulation (in paediatric patients) and oestrogenic stimulation as well as chronic stromal inflammation (in adult patients) could account for the formation of prominent epithelial papillae was discussed.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 2","pages":"157-62"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12142024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Note on the ultrastructure of the Guérin T-8 transplantable tumour. gusamrin T-8可移植肿瘤的超微结构。
Pathologia Europaea Pub Date : 1976-01-01
M B Polyzonis, L Boutis
{"title":"Note on the ultrastructure of the Guérin T-8 transplantable tumour.","authors":"M B Polyzonis,&nbsp;L Boutis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The ultrastructure of the Guérin tumour T-8 is described. Although this transplantable tumour has its ancestry in an uterine adenocarcinoma, there is no more evidence of gland formation. Desmosomes, or any other form of cell attachment organelle, were totally absent. The tumour has now a very anaplastic sarcomatous appearance.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 4","pages":"285-9"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12208066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethidium bromide and hepatic mitochondrial structure in mice. A morphometric analysis. 溴化乙锭对小鼠肝脏线粒体结构的影响。形态计量学分析。
Pathologia Europaea Pub Date : 1976-01-01
H P Rohr, M Wacker, A V Pein
{"title":"Ethidium bromide and hepatic mitochondrial structure in mice. A morphometric analysis.","authors":"H P Rohr,&nbsp;M Wacker,&nbsp;A V Pein","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nine days after receiving a single injection of ethidium bromide - an inhibitor of mitochondrial DNA and its synthesis - mice were found to have enlarged mitochondria which were also reduced in number. The morphometric study revealed an increase of the mean mitochondrial volume, as well as an enlargement of the surface area of the mitochondrial inner membrane. However, the surface of the inner and outer membrane per unit volume of mitochondrion remained unchanged. These morphometric findings suggest mitochondrial growth, since mitochondrial inner membranes can be synthesized even in the presence of DNA-inhibiting ethidium bromide. In addition, morphometric analysis enables us to estimate the mean life span of hepatic mitochondria. In conclusion we may assume that since ethidium bromide induces not only a reduction of mitochondrial division but also an increase in the hepatic mitochondrial volume and inner membrane, the mitochondrial genome possibly fulfills a regulatory role in the mitochondrial and cytoplasmic systems for protein synthesis.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 2","pages":"129-35"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12141131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of pathology in prenatal diagnosis. 病理学在产前诊断中的作用。
Pathologia Europaea Pub Date : 1976-01-01
J G Leroy
{"title":"The role of pathology in prenatal diagnosis.","authors":"J G Leroy","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Antenatal diagnosis of hereditary disease is highly dependent on sufficient theoretical knowledge and on a number of practical methods of studying the foetus such as obtaining, cultivating and assaying amniotic fluid cells. Knowledge of the primary defect in any monogenic disorder cannon be used in prenatal diagnosis unless the metabolic error is expressed in vitro. Modern cytogenetics can diagnose in utero a large majority of karyotyping abnormalities although the karyotype-phenotype correlation is not an absolute one. This task must be assigned to special laboratories where technical pitfalls are reliably avoided. In both metabolic and chromosomal hereditary disease, the pathologist can confirm and extend the phenotypic findings and improve knowledge on foetal features and physiopathology. Pathology is the more important, the less means of in utero diagnosis are available as in the non-chromosomal syndromes of localized or multiple malformations. Here it helps eliminating a present major drawback of prenatal diagnosis: the lack of a strict diagnosis in the previous patient in a family at risk.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 2","pages":"99-104"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12142026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An especially mild myopathic form of glycogenosis type II. Problems of clinical and light microscopic diagnosis. 二型糖原病一种特别轻微的肌病形式临床和光镜诊断的问题。
Pathologia Europaea Pub Date : 1976-01-01
D Pongratz, I Schlossmacher, C Koppenwallner, G Hübner
{"title":"An especially mild myopathic form of glycogenosis type II. Problems of clinical and light microscopic diagnosis.","authors":"D Pongratz,&nbsp;I Schlossmacher,&nbsp;C Koppenwallner,&nbsp;G Hübner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Report of a 20 months old child showing a mild form of glycogenosis type II (POMPE, 1932) with preferential involvement of skeletal muscle. First muscle biopsy reveals, on light microscopic examination, only a mild vacuolar myopathy. By PAS-staining pathologic glycogen storage can be shown. Glycogenosis type II is proved by ultrastructural and biochemical studies of muscle tissue obtained by a second biopsy. Consequently in all cases of a floppy infant syndrome with myopathic features it is necessary to obtain tissue for biochemical and ultrastructural analysis and to carry out these techniques if by light microscopic examination a vacuolar myopathy with increase of glycogen is found.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 1","pages":"39-44"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11352318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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