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Pathologia Europaea最新文献

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Plasma cell alterations in ulcerative colitis. An electron microscopic study. 溃疡性结肠炎的浆细胞改变。电子显微镜研究。
Pathologia Europaea Pub Date : 1976-01-01
J O Gebbers, H F Otto
{"title":"Plasma cell alterations in ulcerative colitis. An electron microscopic study.","authors":"J O Gebbers,&nbsp;H F Otto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Colon biopsies from 37 young patients with active ulcerative colitis (UC) were investigated by electron microscopy with special regard to the inflammatory infiltrate of the lamina propria mucosae, which is characterized by lymphocytes, macrophages and plasma cells. There are close topographical relations between plasma cells and other inflammatory cells. In particular, different forms of plasma cells occur, which mainly differ in shape and contents of their rough endoplasmic reticulum (RER). The different degrees of development and dilatation of the RER express different functional states. The frequent occurrence of Russell bodies, Mott cells and necrobiotic plasma cells is explained as a--at least partial--pathologic alteration of plasma cells in UC. In context with recently published immunohistochemical findings these observations permit the assumption of an imbalance of the local Ig-system in UC.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 4","pages":"271-9"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12208063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tritiated thymidine uptake by glomerular cells in proliferative glomerulonephritis of the rat. 增生性肾小球肾炎大鼠肾小球细胞对氚化胸腺嘧啶的摄取。
Pathologia Europaea Pub Date : 1976-01-01
J H Boss, E Rosenmann
{"title":"Tritiated thymidine uptake by glomerular cells in proliferative glomerulonephritis of the rat.","authors":"J H Boss,&nbsp;E Rosenmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A small but significant number of tritiated thymidine labelled cells were found, by autoradiography, in the glomeruli of rats with Masugi nephritis or chronic serum sickness nephritis. There were no labelled glomerular cells in sections of untreated animals. The findings favour the contention that in proliferative glomerulonephritis, glomerular hypercellularity is due to infiltration of monocytic cells into the tufts where they divide.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 2","pages":"151-5"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12142022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The angio-architecture of normal, hypertrophic and denervated muscle. A study in the rat, using micro-angiography and the scanning electron microscope. 正常、肥大和无神经支配肌肉的血管结构。用微血管造影和扫描电镜对大鼠进行了研究。
Pathologia Europaea Pub Date : 1976-01-01
O Hassler, B Stroińska-Kusiowa
{"title":"The angio-architecture of normal, hypertrophic and denervated muscle. A study in the rat, using micro-angiography and the scanning electron microscope.","authors":"O Hassler,&nbsp;B Stroińska-Kusiowa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The angio-architecture of normal, hypertrophic and denervated rat muscles was studied by micro-angiography and by scanning electron microscopy of vascular casts made of methylmethacrylate. In hypertrophy, there was a slightly coarse-meshed irregular capillary network with some loss of normal parallelism, an increased calibre and a slight spiralization of all vessels. Probably all these changes, except the slight spiralization, increase the circulation. In denervation atrophy, the vascular pattern was much more irregular, with much more marked spiralization and loss of parallelism and narrowed capillaries. The changes probably contribute to the impairment of the circulation.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 1","pages":"57-61"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12117131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aortic endothelial and sub-endothelial lesions in early stages of experimental atherogenesis and in scurvy. 实验性动脉粥样硬化和坏血病早期的主动脉内皮和亚内皮病变。
Pathologia Europaea Pub Date : 1976-01-01
G Weber, P Fabbrini, L Resi, C Pierli, P Tanganelli
{"title":"Aortic endothelial and sub-endothelial lesions in early stages of experimental atherogenesis and in scurvy.","authors":"G Weber,&nbsp;P Fabbrini,&nbsp;L Resi,&nbsp;C Pierli,&nbsp;P Tanganelli","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The endothelial and sub-endothelial lesions during early stages of experimental atherogenesis and scurvy have been studied by means of scanning EM and transmission EM, making use also of the Con-A reaction. The surface coat modifications were accompanied by formation of vacuoles in the endothelial cells and by sub-endothelial 'oedema', not only in rabbits fed a hypercholesterolic diet but also in scorbutic guinea pigs. The endothelial lesions were sometimes found even before clear modifications of the Con-A surface reactive layer were apparent.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 4","pages":"251-6"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12206835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell and organ culture techniques applied to the study of carcinoma of colon and rectum. 细胞和器官培养技术在结肠癌和直肠癌研究中的应用。
Pathologia Europaea Pub Date : 1976-01-01
L M Franks
{"title":"Cell and organ culture techniques applied to the study of carcinoma of colon and rectum.","authors":"L M Franks","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The value of a number of in vitro systems which have been used in the investigation of carcinomas of colon and rectum is considered. Tissue culture cell ines which have been established from human and mouse rectal and colon tumours are described. Both mouse and human cells retain ultrastructural features of the tumours of origin; acinus formations, junctional complexes, microvilli with surface glycoprotein strands. Normal colo-rectal epithelium has not been established in cell culture but organ cultures of mouse colon, which retain normal ultrastructural features can be maintained for at least 28 days. The possible origin of non-epithelial cells which appear in cultures from normal colon is discussed. The areas in which the various in vitro systems may be of used are reviewed.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 3","pages":"167-77"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12162233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The ultrastructure of the megakaryocytes in idiopathic thrombocytopenic purpura (ITP) in relation to thrombokinetics. 特发性血小板减少性紫癜(ITP)巨核细胞超微结构与血栓动力学的关系。
Pathologia Europaea Pub Date : 1976-01-01
B Ridell, I Branehög
{"title":"The ultrastructure of the megakaryocytes in idiopathic thrombocytopenic purpura (ITP) in relation to thrombokinetics.","authors":"B Ridell,&nbsp;I Branehög","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The ultrastructure of megakaryocytes was examined in eight patients with idiopathic thrombocytopenic purpura (ITP) and the results were compared with those obtained from controls and with data obtained from platelet kinetic studies. Platelet production was significantly increased in (ITP) and related to the megakaryocyte number and volume. In all cases of ITP megakaryocytes containing tubular demarcation membranes were found. The granular content and the distribution of the demarcation membrane system in these megakaryocytes from cases of ITP were similar to those features seen in normal cells of the same degree of maturity. In three cases of ITP an increased content of a dilated demarcation membrane system was found in promegakaryocytes and granular megakaryocytes, in one of these cases with the additional formation of large membrane complexes. The ultrastructural findings lend support to the results obtained from the thrombokinetic studies namely that the megakaryocytes in the bone marrow react to thrombocytopenia with an increased production of platelets.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 3","pages":"179-87"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12170614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nuclear inclusions and other ultrastructural aspects in the liver of animals treated with n-2-acetylaminofluorene. 用n-2-乙酰氨基芴处理动物肝脏的核包涵体和其他超微结构方面。
Pathologia Europaea Pub Date : 1976-01-01
M A Dobre, I Moraru, C Cotutiu, F Moţoc
{"title":"Nuclear inclusions and other ultrastructural aspects in the liver of animals treated with n-2-acetylaminofluorene.","authors":"M A Dobre,&nbsp;I Moraru,&nbsp;C Cotutiu,&nbsp;F Moţoc","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the course of two chronic experiments including the administration of N-2-acetylaminofluorene (N-A-AF) to male Wistar rats, alterations were observed in the fine structure of the nuclei isolated from the liver. After the first 3 to 4 months of ingestion of the carcinogen, the heterochromatin became uniformly distributed throughout the nucleus, with dissociation of the nucleolus-associated heterochromatin. At longer intervals (7 months) evidence was found in the nucleus of various types of inclusions, chiefly granular virus-like bodies. Subsequently, the frequency of inclusions diminished but the liver cell nucleus remained large, with numerous large nucleoli. This suggested the existence of a stage of metabolic activation of the liver cell nucleus in the course of experimental induction of hepatocarcinoma with N-A-AF, giving rise to an increase in the nuclear and nucleolar volume by accumulation of synthesis products and disorders in nucleo-cytoplasmic exchanges.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 1","pages":"63-8"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12117132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genuine giant-cell tumour of bone; a combined cytological, histopathological and ultrastructural study. 真骨巨细胞瘤;结合细胞学、组织病理学和超微结构研究。
Pathologia Europaea Pub Date : 1976-01-01
L Boquist, S E Larsson, R Lorentzon
{"title":"Genuine giant-cell tumour of bone; a combined cytological, histopathological and ultrastructural study.","authors":"L Boquist,&nbsp;S E Larsson,&nbsp;R Lorentzon","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Three patients with a giant-cell tumour of bone were studied clinically, roentgenologically and morphologically, using cytological, histopathological and electron microscopic methods. The tumours were composed of giant cells possessing a great number of mitochondria and stromal cells exhibiting prominent endoplasmic reticulum and Golgi complex. Mitotic activity was only found among the stromal cells. Autophagic vacuoles, lysosomal bodies and degenerative changes of varying severity were found mainly or exclusively among the giant cells, which may indicate that these cells represent an involutionary form of tumour cell. The giant-cell tumours of bone are believed to arise from undifferentiated cells of the bone marrow. Fine-needle aspiration biopsy represents a valuable complement to histopathological examination in the identification of giant cell lesions and diagnosis of genuine cell tumours of bone.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 2","pages":"117-27"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12141130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metaplastic conversion of the differentiation pattern in oral epithelia affected by leukoplakia simplex. A stereologic study. 单纯白斑影响口腔上皮分化模式的化生转化。立体学研究
Pathologia Europaea Pub Date : 1976-01-01
A J Klein-Szanto, J Bánóczy, H E Schroeder
{"title":"Metaplastic conversion of the differentiation pattern in oral epithelia affected by leukoplakia simplex. A stereologic study.","authors":"A J Klein-Szanto,&nbsp;J Bánóczy,&nbsp;H E Schroeder","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The present study applied methods of stereologic cytology to clinically specified lesions of leukoplakia simplex which originated from the oral mucous membrane at the cheek and the floor of the mouth. The data provided the following evidence: (1) The structure of and the differentiation gradients for various cytoplasmic constituents in leukoplakia simplex epithelium were identical at both sites. (2) The differentiation pattern of leukoplakic epithelia was adversely different from that of the respective normal epithelium. (3) This alteration which resulted in a striking resemblance between the leukoplakic epithelia and those of normal skin or hard palatum conceivably can be regarded as a squamous metaplasia characterized by the conversion of one differentiation pattern into another. (4) This shift in the differentiation pattern hardly could have been disclosed by means other than stereologic morphometry.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 3","pages":"189-210"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12162235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumour growth and melanogenesis in hamster tumours in vivo and in vitro: growth, cytochemistry and ultrastructure of tissue cultural cell lines. 鼠肿瘤的生长和黑色素形成:组织培养细胞系的生长、细胞化学和超微结构。
Pathologia Europaea Pub Date : 1976-01-01
H I Pandov, L P Pandov, L M Franks
{"title":"Tumour growth and melanogenesis in hamster tumours in vivo and in vitro: growth, cytochemistry and ultrastructure of tissue cultural cell lines.","authors":"H I Pandov,&nbsp;L P Pandov,&nbsp;L M Franks","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cell lines were established from three hamster melanomas. One was a spontaneous melanotic tumour which lost its ability to produce pigment. Two were induced with DMBA (9.10 dimethyl 1,2-benz/a/anthracene). One of these was pigmented. The two amelanotic lines (CHT-1 and 2) produced highly malignant amelanotic tumours after reimplantation of tissue culture cells. Electron microscopy showed that melanin forming organelles were absent. Tyrosinase activity was also absent. The line established from the pigmented tumour (CHT-8) retained its pigment production for the first seven transfers. Cells from these cultures produced slow growing pigmented tumours. Cells from the 7th to the 35th transfer, a period of 28 weeks, failed to produce tumours but cells from the 36th and subsequent transfers produced slow growing amelanotic tumours. The change in tumorigenicity was not related to changes in the growth rate of the cells in vitro: this remained constant after the 11th transfer generation. Tyrosinase activity and a whole range of melanin forming organelles were present in cells of transfers 1 to 7 but absent from subsequent transfers. Type A and H virus particles were present in the two amelanotic cell lines, CHT-1 and 2. Although the two amelanotic lines produced highly malignant tumours the loss of a differentiated character--melanin production--was not invariably associated with increased malignancy. Three cell lines should provide a good system for studying the relationship between tumour differentiation and growth.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 1","pages":"27-37"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12006662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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