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Pathologia Europaea最新文献

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Biometrical and histochemical comparison between extra- and intrafusal muscle fibres following tenotomy. 肌腱切断术后肌外和肌内肌纤维的生物统计学和组织化学比较。
Pathologia Europaea Pub Date : 1976-01-01
J De Reuck, H Vander Eecken
{"title":"Biometrical and histochemical comparison between extra- and intrafusal muscle fibres following tenotomy.","authors":"J De Reuck,&nbsp;H Vander Eecken","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The average diameter of the different enzymatic types of extra- and intrafusal muscle fibres is determined by means of a one millimeter scale ocular micrometer in the gastrocnemius muscle of twenty four female rats during three months, at regular intervals following tenotomy. There is a predominant atrophy of the type II extrafusal as well as intrafusal fibres in the period of immobilization. However, when the muscle becomes functional again, by healing and elongation of the tendon, the intrafusal type II fibres remain atrophic in contrast to the extrafusal ones, which regain their normal size.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 4","pages":"281-4"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11358892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aortic smooth muscle cells reaction in rat spontaneous hypertension. 自发性高血压大鼠主动脉平滑肌细胞反应。
Pathologia Europaea Pub Date : 1976-01-01
Z Jurukova, P Hadjisky, J Renais, L Scebat
{"title":"Aortic smooth muscle cells reaction in rat spontaneous hypertension.","authors":"Z Jurukova,&nbsp;P Hadjisky,&nbsp;J Renais,&nbsp;L Scebat","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Parallel morphometric, karyometric and ultrastructural studies of the aortic wall in Okamoto-Aoki rats with short term (3-6 months) and long-term (12-16 months) spontaneous hypertension have revealed a progressive thickening of the medial layer, which is associated with an increaase in the mean nuclear area of the arterial medial smooth muscles and reduction in their mean number per unit area. Electron microscopic studies have shown a multiplication of the intracellular components of aortic smooth muscle cells as a base for their enlargement, as well as small single foci of smooth muscle hyperplasia in the area of the innermost interlamellar space in parts of the aortic wall with intimal thickening. Results of these studies allow the conclusion, that hypertrophy is a reaction of arterial smooth muscle cells to an increased mechanical load in hypertension which, in turn, is responsible for the thickening of arterial with Hyperplasia - increase in smooth muscle cells' number in the media - played a subordinate role. The reaction of the aortic wall to elevate blood pressure is interpreted as a manifestation of the normally limited division capacity of smooth muscle cells in mammals, which does not allow an increase in its cellular components. The function of existing arterial smooth muscle smooth cells is enhanced, instead, by hyperplasia of their specific organelles and augmentation of their volume.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 2","pages":"105-15"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11353238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The alveolar lining film in experimental pulmonary collapse. 实验性肺萎陷的肺泡内膜。
Pathologia Europaea Pub Date : 1976-01-01
R Takov, T Z Boshnakova, V Marinov
{"title":"The alveolar lining film in experimental pulmonary collapse.","authors":"R Takov,&nbsp;T Z Boshnakova,&nbsp;V Marinov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Obstructive pulmonary collapse was produced by ligation of lobar bronchus in 41 healthy dogs. The atelectatic lung was examined electronmicroscopically by means of vapour fixation, ruthenium red procedure and tricomplex flocculation. The equilibration stability index of Pattle was determined and compared to the electromicroscopic findings. The experimentally produced obstructive pulmonary collapse was a mechanical phenomenon which secondarily caused qualitative changes in the production of the alveolar lining layer.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 4","pages":"265-70"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11409906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fine structure and origin of Kaposi's sarcoma. 卡波西肉瘤的精细结构和起源。
Pathologia Europaea Pub Date : 1976-01-01
J M Gokel, R Kürzl, G Hübner
{"title":"Fine structure and origin of Kaposi's sarcoma.","authors":"J M Gokel,&nbsp;R Kürzl,&nbsp;G Hübner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tumour cells in Kaposi's sarcoma with visceral involvement were studied by fine structural analysis. In the cytoplasm of these cells rod-shaped tubulated bodies resembling Weibel-Palade granules could be demonstrated. This finding and the occurrence of a basement membrane around the tumour cells characterize Kaposi cells as endothelial cells of blood vessels which may originate from undifferentiated vasoformative cells of the adventitia.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 1","pages":"45-7"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12117128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The internal surface area of the lung in emphysema. 肺气肿中肺的内表面区域
Pathologia Europaea Pub Date : 1976-01-01
P S Hasleton
{"title":"The internal surface area of the lung in emphysema.","authors":"P S Hasleton","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Quantitative histological studies on the lung are time consuming and for the pathologist may not reveal much additional imformation in relation to the time spent. Sixty-eight cases of emphysema were studied. The percentages of the lung tissue destroyed by alveolar, bronchiolar and bullous emphysema were determined by macroscopic point counting. The internal surface area (I.S.A.) and internal surface area at a standard lung volume of 3,000 ml(I.S.A.3,000) were determined by the mean linear intercept (M.L.I.) method. There was a significant correlation between both the M.L.I. and I.S.A.3,000 and the percentage of lung tissue destroyed. The M.L.I. was the most accurate guide to the presence of emphysema. The I.S.A. was the least reliable indication of emphysema. Cases of alveolar duct emphysema were both over and underdiagnosed on macroscopic point counting. It is therefore suggested that in cases with alveolar duct emphysema, apparently normal lungs or where full pulmonary function tests are available, quantitative histological studies should be carried out. In other cases it is possible to derive the I.S.A. and I.S.A.3,000 from the percentage of emphysema as determined macroscopically, without recourse to histological methods.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 3","pages":"211-8"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12162236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metastases from single as compared to repeated tumour cell doses. 与反复给药的肿瘤细胞相比，单个肿瘤细胞的转移。
Pathologia Europaea Pub Date : 1976-01-01
B Hagmar, B Boeryd, W Ryd
{"title":"Metastases from single as compared to repeated tumour cell doses.","authors":"B Hagmar,&nbsp;B Boeryd,&nbsp;W Ryd","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tumour formation from single or repeated small i.v. tumour cell doses was studied in a syngeneic tumour-host system. Only marginal differences were observed between different dose schedules, once the critical cell dose level was surpassed.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 4","pages":"227-30"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12206831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glycogenous hepatonuclear inclusions in the aged mouse--an electron microscopical study of the histogenesis of nuclear inclusions. 老年小鼠肝糖原性核包涵体——核包涵体组织发生的电镜研究。
Pathologia Europaea Pub Date : 1976-01-01
M Herbst
{"title":"Glycogenous hepatonuclear inclusions in the aged mouse--an electron microscopical study of the histogenesis of nuclear inclusions.","authors":"M Herbst","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fifty-three and 84 week old mice have been investigated for liver nuclear inclusions. Light microscopical investigations revealed a significantly higher incidence of intranuclear PAS-positive material in the 84 week old mice. Electron microscopical studies showed a continuous development of nuclear inclusions from invagination of the double nuclear membrane containing all cytoplasmic organelles in various conditions via isolation of the invaginated portion to intranuclear free glycogen as a visible final stage. During the whole process alpha-glycogen is degraded to beta- and gamma-particles. These nuclear changes are not accompanied by other pathological changes either in the cells concerned or in the surrounding liver parenchyma. These nuclear findings are attributed to specific metabolic conditions in the ageing mouse.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 1","pages":"69-79"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12117133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term alloxan diabetes in the rat. Study of mesangial cell morphology by serial biopsies. 大鼠的长期四氧嘧啶糖尿病。系膜细胞形态学的连续活检研究。
Pathologia Europaea Pub Date : 1976-01-01
A Anjo, E Couturier
{"title":"Long-term alloxan diabetes in the rat. Study of mesangial cell morphology by serial biopsies.","authors":"A Anjo,&nbsp;E Couturier","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Experimental diabetes in the rat was induced by alloxan (40 mg/kg body weight) and resulted in permanent hyperglycaemia (mean glycaemia: 403.0 mg/100 ml). The animals were left untreated for more than 16 months. The mesangial cell of the renal glomerulus was studied by serial biopsies performed each month under light anaesthesia in the diabetic animals and in normal controls of the same age. Large dense bodies appeared in the cytoplasm after 3 months in the diabetics and after 10 months in the controls. With time, a larger number of mesangial cells contained these dense bodies. At the end stage they seem to be mainly lipidic. When NO3Ag is given in the drinking water the dense bodies accumulate particles of silver, suggesting that they contain fragments of the basement membrane. While the acid phosphatase reaction was negative in biopsy specimens from diabetic animals, it remains possible that the large dense bodies belong to the lysosomial system. This point, as well as the pathologic significance of the dense bodies is currently investigated.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 4","pages":"239-50"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11409904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibition by lymphoid cellular factors of the immunological cytotoxicity against a syngeneic tumour. 淋巴细胞因子对同基因肿瘤免疫细胞毒性的抑制作用。
Pathologia Europaea Pub Date : 1976-01-01
N Lafontaine, H Firket
{"title":"Inhibition by lymphoid cellular factors of the immunological cytotoxicity against a syngeneic tumour.","authors":"N Lafontaine,&nbsp;H Firket","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lymphoid cells of C57BL mice bearing a syngeneic sarcoma are cytotoxic against the same tumour cells in vitro at two different periods of the growth of the tumour separated by a \"mute period\". Without additional antigenic stimulation the lymphoid cells from the \"mute period\" can be made cytotoxic by preincubation in vitro and elimination of adherent cells by a passage through a glass bead column. Either of these treatments alone is inefficient. The cytotoxicity revealed in this way is due to cells with different properties than those that are directly cytotoxic during the 4th week of the tumour growth. The significance of these results is discussed. It is suggested that some other cells have to be eliminated because they compete with or inhibit the activity of the \"mute period\" lymphoid cells made cytotoxic by preincubation.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 2","pages":"147-50"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12142021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental allergic sialoadenitis. IX. The regional lymph nodes after antigenic challenges of the parotid glands in rats. 实验性过敏性涎腺炎。9大鼠腮腺抗原攻击后的局部淋巴结。
Pathologia Europaea Pub Date : 1976-01-01
J H Boss, J Sela, J A Bab, T Dishon, E Rosenmann
{"title":"Experimental allergic sialoadenitis. IX. The regional lymph nodes after antigenic challenges of the parotid glands in rats.","authors":"J H Boss,&nbsp;J Sela,&nbsp;J A Bab,&nbsp;T Dishon,&nbsp;E Rosenmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The regional lymph nodes of the parotid gland of rats were examined histologically. The nodes were removed from untreated animals or rats given instillations of BSA or saline into the parotid duct. Anti-BSA antibodies were assessed in the saliva and serum. Patterns of reactivity of the lymph nodes did not correlate with the presence or absence of salivary and serum antibodies. The occurrence of antibodies in the saliva appears to reflect the activity of immunocytes residing in the parotid gland. The morphological features of the lymph nodes correspond to the overall immunological experience.</p>","PeriodicalId":76308,"journal":{"name":"Pathologia Europaea","volume":"11 4","pages":"231-7"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12206833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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