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Ca2(+)-dependent protein kinase cascade of platelets. 血小板Ca2(+)依赖性蛋白激酶级联。
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society Pub Date : 1989-12-01
H Hidaka, M Hagiwara, M Naka, S Mamiya
{"title":"Ca2(+)-dependent protein kinase cascade of platelets.","authors":"H Hidaka, M Hagiwara, M Naka, S Mamiya","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76233,"journal":{"name":"Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society","volume":"52 8","pages":"1516-21"},"PeriodicalIF":0.0,"publicationDate":"1989-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13840148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemopoiesis and immune mechanisms. 造血和免疫机制。
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society Pub Date : 1989-12-01
H Mizoguchi
{"title":"Hemopoiesis and immune mechanisms.","authors":"H Mizoguchi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76233,"journal":{"name":"Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society","volume":"52 8","pages":"1251-7"},"PeriodicalIF":0.0,"publicationDate":"1989-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13663339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of T-cell receptor delta chain gene in hematological malignancies. 恶性血液病中t细胞受体δ链基因的分析。
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society Pub Date : 1989-12-01
N Kimura, M Kikuchi
{"title":"Analysis of T-cell receptor delta chain gene in hematological malignancies.","authors":"N Kimura,&nbsp;M Kikuchi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We analyzed the rearrangement of TcR delta chain gene in 179 cases of hematological malignancies. In 17 T-cell lines, RPMI 8402, DND41, Peer, and Molt 13 had delta rearranged band (s). Except for RPMI 8402, these cell lines expressed functional delta gene. All of those gamma delta-T-cell lines had short message (1 kb) of TcR beta gene. These findings suggest differences between alpha beta-T-cells and gamma delta-T-cells. All 9 cases of T-ALL/LBL, of which 4 had neither gamma nor beta gene rearrangement, had a new rearranged band of TcR delta locus. This rearrangement was observed in 63% of B-lineage ALL/LBL. In the other T-lymphoproliferative disorders, only 2 cases of AILD and 1 of T-cell lymphoma had the rearranged band (s), showing derived T-cell neoplasm from gamma delta-T-cell as minority. In B-leukemia/lymphoma and myelocytic leukemia, 15% of the cases had the delta rearrangement. Heterogenous findings of TcR delta locus analysis were observed in ATLL without proviral HTLV-I DNA, T-cell lymphoma, AILD and HD. The J delta 1 region was frequently used and the J delta 2 region was rearranged in one AILD. It is suspected that J delta 3 was used in one T-ALL/LBL. There was no correlation between the phenotypic pattern of CD3, CD4, and CD8 in T cell disorders and the rearrangement of the TcR delta gene. These findings suggest that the newly identified TcR delta chain gene rearranges at a very early stage of T cell ontogeny; prior to the other TcR genes and perhaps at almost the same differentiation level as that of CD7 expression. The TcR delta gene is useful in evaluating clonality for the most immature T cell neoplasms not showing rearrangement of the other TcR genes. This gene is not lineage specific, however, when used in conjunction with IgHC gene, it may be a useful tool for the study of ALL/LBL.</p>","PeriodicalId":76233,"journal":{"name":"Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society","volume":"52 8","pages":"1471-8"},"PeriodicalIF":0.0,"publicationDate":"1989-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13677786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interaction of plasma clotting factors with vascular endothelial cells in hemostasis and thrombosis with special reference to endothelial cell tissue factor. 血浆凝血因子与血管内皮细胞在止血和血栓形成中的相互作用，特别涉及内皮细胞组织因子。
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society Pub Date : 1989-12-01
N Narahara, T Uchiyama, K Andoh, H Tanaka, N Kobayashi
{"title":"Interaction of plasma clotting factors with vascular endothelial cells in hemostasis and thrombosis with special reference to endothelial cell tissue factor.","authors":"N Narahara,&nbsp;T Uchiyama,&nbsp;K Andoh,&nbsp;H Tanaka,&nbsp;N Kobayashi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The interaction of plasma clotting factors with vascular endothelial cells was investigated. Human umbilical cord vein endothelial cells generated tissue factor activity after treatment with various stimulators including IL-1. Cycloheximide inhibited production of the tissue factor in the cells, but did not affect the expression of the tissue factor activity on the surface of endothelial cells. Endotoxin-treated vascular endothelial cells activated Factor X in the presence of Factor VII and calcium ion. Activation of Factor X by endothelial cells with Factor VII was enhanced by the presence of both Factors VIII and IX. Binding study revealed that endotoxin-treated endothelial cells bound Factor IX. These data suggest that perturbed vascular endothelium expresses tissue factor activity on the cell surface, binds factor IX and in the presence of Factor VII, activates not only factor X but also Factor IX.</p>","PeriodicalId":76233,"journal":{"name":"Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society","volume":"52 8","pages":"1330-6"},"PeriodicalIF":0.0,"publicationDate":"1989-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13770837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myeloperoxidase gene expression in acute leukemias. 髓过氧化物酶基因在急性白血病中的表达。
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society Pub Date : 1989-12-01
Y Morishita, K Yano
{"title":"Myeloperoxidase gene expression in acute leukemias.","authors":"Y Morishita,&nbsp;K Yano","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Since myeloperoxidase (MPO) is considered to be a critical marker of differentiating acute myelogenous leukemia (AML) from acute lymphocytic leukemia (ALL), the analysis of MPO gene expression may provide further insight into the leukemia classification and the lineage fidelity of leukemia cells. By Northern blot hybridization using full-length MPO cDNA as a probe, approximately 66% of AML cells (3/4 M1 cases, 2/4 M2 cases, 15/15 M3 cases, 11/15 M4 cases, and 2/12 M5 cases) were found to express MPO mRNAs, whereas none of 18 ALL cases did. MPO mRNA was detectable when AML cells contained at least 10% peroxidase-positive cells. APL (M3) cells expressed high levels of mRNA in accordance with heavy staining for peroxidase.</p>","PeriodicalId":76233,"journal":{"name":"Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society","volume":"52 8","pages":"1459-62"},"PeriodicalIF":0.0,"publicationDate":"1989-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13703354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The molecular analyses of hematological malignancies--lineage specific classification and its clinical implications. 血液系统恶性肿瘤的分子分析——谱系特异性分类及其临床意义。
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society Pub Date : 1989-12-01
K Kawa-Ha, A Tawa, K Yumura-Yagi, J Hara
{"title":"The molecular analyses of hematological malignancies--lineage specific classification and its clinical implications.","authors":"K Kawa-Ha,&nbsp;A Tawa,&nbsp;K Yumura-Yagi,&nbsp;J Hara","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cells from 203 children with leukemia/lymphoma were analyzed by the FAB (French-American-British) system using a broad panel of markers such as immunological marker studies, Southern blot and Northern blot analyses to establish a lineage specific classification of childhood leukemia. Phenotypically, they were divided into B-lineage (62.6%), T-lineage (9.8%), non-lymphoid (14.3%) and uncertain lineage (13.3%). Two B-lineage ALL cells and two T-lineage ALL cells studied did not show immunoglobulin (Ig) or T-cell receptor (TCR) gene rearrangements, respectively. Therefore, those four cases were excluded from the final classification. The uncertain lineage leukemia, which includes undifferentiated leukemia and mixed lineage leukemia, were further subclassified at the DNA and RNA levels. The definitions of B-lineage and T-lineage cells, incidence of dual genotypes or spillover, heterogeneity of undifferentiated leukemia, and a new classification for mixed lineage leukemia were discussed.</p>","PeriodicalId":76233,"journal":{"name":"Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society","volume":"52 8","pages":"1451-8"},"PeriodicalIF":0.0,"publicationDate":"1989-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13772384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of cytokine genes in hematological malignancies. 细胞因子基因在血液恶性肿瘤中的表达。
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society Pub Date : 1989-12-01
S Okamura, S Hayashi, C Kawasaki, S Kondo, Y Asano, F Omori, T Otsuka, T Shibuya, M Harada, Y Niho
{"title":"Expression of cytokine genes in hematological malignancies.","authors":"S Okamura,&nbsp;S Hayashi,&nbsp;C Kawasaki,&nbsp;S Kondo,&nbsp;Y Asano,&nbsp;F Omori,&nbsp;T Otsuka,&nbsp;T Shibuya,&nbsp;M Harada,&nbsp;Y Niho","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A substantial number of leukemic blast colonies were formed when conditioned medium of human bladder carcinoma cell line 5637 was added as a stimulator. Recombinant colony-stimulating factor (CSF) also stimulated leukemic blast cell proliferation, leading to colony formation. Furthermore, serum CSF levels in some patients with acute myelogenous leukemia (AML), as detected by sensitive enzyme-linked immunosorbent assay (ELISA), were high. These observations prompted us to study further the expressions of hematopoietic growth factor genes. Granulocyte-macrophage CSF (GM-CSF) mRNA was detected in the leukemic blast cells from about 30% of patients with AML by Northern blot analysis using strict hybridization conditions with or without in vitro blast cell enrichment. These findings suggest that the expression of cytokine genes including the GM-CSF gene reflects in vivo phenomena, although no clear relationship between expression of the genes and serum CSF level has been established. Gene encoding tumor necrosis factor alpha (TNF-alpha), lymphotoxin (LT) and transforming growth factor beta (TGF-beta) were sometimes expressed in some malignant hematological cell lines and also some fresh leukemic cells.</p>","PeriodicalId":76233,"journal":{"name":"Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society","volume":"52 8","pages":"1423-32"},"PeriodicalIF":0.0,"publicationDate":"1989-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13840146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The modulation of heparin-like activity of endothelial cells in experimental systems. 实验系统中内皮细胞肝素样活性的调节。
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society Pub Date : 1989-12-01
K Shimada, M Kobayashi, T Ozawa
{"title":"The modulation of heparin-like activity of endothelial cells in experimental systems.","authors":"K Shimada,&nbsp;M Kobayashi,&nbsp;T Ozawa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Anticoagulantly active heparin-like glycosaminoglycans are apparently present on the vascular surface. We have tried to modulate heparin-like substances on endothelial cells using an experimental cell culture system. Perturbation of the endothelial proteoglycan metabolism by beta-D-xyloside resulted in a reduced biosynthesis of cell surface heparan sulfate, and impaired antithrombin III binding to endothelial cells in parallel with an inhibition of endothelial cell heparin-like activity. In a separate series of experiments, treatments of endothelial cells with interleukin 1 beta and tumor necrosis factor alpha, physiological mediators of immunologic and inflammatory responses, were shown to cause an inhibition of the synthesis of endothelial cell surface heparan sulfate. The endothelial heparin-like activity was partially diminished by these cytokines, suggesting that cytokine-mediated suppression of heparin-like substance on endothelial cells is another cytokine-inducible endothelial effect affecting coagulation. The modulation of endothelial heparin-like activity by these pharmacological and physiological agents may have pathophysiological implications in thrombosis.</p>","PeriodicalId":76233,"journal":{"name":"Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society","volume":"52 8","pages":"1337-42"},"PeriodicalIF":0.0,"publicationDate":"1989-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13770838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proceedings of the XXXXXI General Meeting of the Japan Hematological Society II. Maebashi, (April 6, 7 and 8, 1989). 日本血液学学会第xxxxxx届大会论文集2。前桥，(1989年4月6、7、8日)。
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society Pub Date : 1989-12-01
{"title":"Proceedings of the XXXXXI General Meeting of the Japan Hematological Society II. Maebashi, (April 6, 7 and 8, 1989).","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76233,"journal":{"name":"Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society","volume":"52 8","pages":"1245-554"},"PeriodicalIF":0.0,"publicationDate":"1989-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13771028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of polymerase chain reaction to detect activated oncogenes in hematological malignancies. 聚合酶链反应在血液学恶性肿瘤中检测活化癌基因的应用。
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society Pub Date : 1989-12-01
F Ishikawa, Y Kobayashi
{"title":"Application of polymerase chain reaction to detect activated oncogenes in hematological malignancies.","authors":"F Ishikawa,&nbsp;Y Kobayashi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Polymerase chain reaction (PCR) was applied to detect the structural change accompanying the activation of oncogenes in hematological malignancies and preleukemic states. Point mutation of N-ras oncogene was examined by oligonucleotide differential hybridization coupled with PCR. Five out of 17 AML patients were shown to have mutated N-ras gene. These mutations could be used as a genetic marker to diagnose the residual malignant cells. Philadelphia chromosome in CML was examined by cDNA synthesis and PCR with successful results. PCR was shown to be a highly versatile and sensitive method which would be invaluable in clinical diagnosis.</p>","PeriodicalId":76233,"journal":{"name":"Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society","volume":"52 8","pages":"1433-41"},"PeriodicalIF":0.0,"publicationDate":"1989-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13772383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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