American journal of contact dermatitis : official journal of the American Contact Dermatitis Society最新文献_第10页

Late patch test reaction to acrylates in a dental worker. 牙科工作者对丙烯酸酯的后期斑贴试验反应。

American journal of contact dermatitis : official journal of the American Contact Dermatitis Society Pub Date : 1999-12-01 DOI: 10.1053/AJCD01000224

J F Fowler

引用次数: 0

Allergic contact dermatitis to polyethylene glycol and nitrofurazone. 对聚乙二醇和硝基呋喃酮的过敏性接触性皮炎。

American journal of contact dermatitis : official journal of the American Contact Dermatitis Society Pub Date : 1999-12-01 DOI: 10.1053/AJCD01000226

S C Guijarro, J Sánchez-Pérez, A García-Díez

引用次数: 0

Proceedings of the first meeting of the experimental contact dermatitis research group. 实验性接触性皮炎研究组第一次会议纪要。

American journal of contact dermatitis : official journal of the American Contact Dermatitis Society Pub Date : 1999-12-01 DOI: 10.1053/AJCD01000240

A Gaspari

引用次数: 0

Assessment of the ability of the topical skin protectant (TSP) to protect against contact dermatitis to urushiol (Rhus) antigen. 评价局部皮肤保护剂(TSP)对漆酚(Rhus)抗原对接触性皮炎的保护作用。

American journal of contact dermatitis : official journal of the American Contact Dermatitis Society Pub Date : 1999-12-01 DOI: 10.1053/AJCD01000190

D A Vidmar, M K Iwane

{"title":"Assessment of the ability of the topical skin protectant (TSP) to protect against contact dermatitis to urushiol (Rhus) antigen.","authors":"D A Vidmar, M K Iwane","doi":"10.1053/AJCD01000190","DOIUrl":"https://doi.org/10.1053/AJCD01000190","url":null,"abstract":"Background: Military personnel have a need for effective protection against cutaneous exposure to chemical warfare agents (CWA). Topical Skin Protectant (TSP) is being developed to supplement chemical warfare protective garments. TSP protects against CWA exposure in animals, but does it work for humans? Because humans should not be tested with live CWA, urushiol (poison ivy) extract was used as a surrogate substance in place of CWA for human efficacy testing of TSP.Objective: Determine whether TSP protects human skin against experimentally-induced urushiol dermatitis.Methods: Open urushiol patch testing of 50 rhus-sensitive subjects comparing the 96-hour dermatitis severity scores between TSP protected and TSP unprotected sites. There were 4 paired sites (i.e., protected versus unprotected) per subject. Test sites were scored using a 9-point dermatitis scale of 0.0 to 4.0 (using 0.5 increments).Results: Analysis of variance of the dermatitis scores from 192 paired sites on 48 evaluable subjects showed that TSP protected sites had mean dermatitis scores about 2 points lower than TSP unprotected sites (P <.001).Conclusion: Although this study does not provide direct scientific evidence that TSP protects humans against the percutaneous absorption of CWA, it does provide circumstantial evidence that this is the case. The fact that TSP is so highly effective against a lipophilic substance like urushiol and that most common vesicant CWAs are lipophilic and are weaponized in oleaginous vehicles, makes the effectiveness of TSP in preventing absorption and dermatitis from CWA seem likely.","PeriodicalId":7612,"journal":{"name":"American journal of contact dermatitis : official journal of the American Contact Dermatitis Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21453211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of vehicle on assessment of relative skin sensitization potency of 1,4-dihydroquinone in the local lymph node assay. 在局部淋巴结试验中，载体对评估1,4-二对苯二酚相对皮肤致敏效力的影响。

American journal of contact dermatitis : official journal of the American Contact Dermatitis Society Pub Date : 1999-12-01 DOI: 10.1053/AJCD01000213

L J Lea, E V Warbrick, R J Dearman, I Kimber, D A Basketter

{"title":"The impact of vehicle on assessment of relative skin sensitization potency of 1,4-dihydroquinone in the local lymph node assay.","authors":"L J Lea, E V Warbrick, R J Dearman, I Kimber, D A Basketter","doi":"10.1053/AJCD01000213","DOIUrl":"https://doi.org/10.1053/AJCD01000213","url":null,"abstract":"Background: The murine local lymph node assay (LLNA) has been validated as an alternative method for the identification of skin sensitization hazards. Contact allergens are identified as a function of proliferative responses induced in draining lymph nodes. The quantitative nature of the LLNA data also provides the opportunity of assessing relative potency by reference to dose response analyses.Objective: In the current investigations, the influence of vehicle on the skin sensitization potency of a known skin sensitizer (1,4-dihydroquinone) was assessed.Methods: 1, 4-dihydroquinone was tested in the LLNA using 7 different vehicle systems in each of 2 independent laboratories.Results: Results from the 2 laboratories were almost identical. LLNA dose response data were interpolated to derive the estimated concentration (EC) of 1, 4-dihydroquinone necessary to cause a three-fold stimulation of proliferation compared with controls, the EC3 value. The vehicles used and mean EC3 values obtained were: methyl ethyl ketone 0.07%, acetone 0.08%, acetone/olive oil (80/20 v/v) 0.15%, dimethyl formamide 0.22%, dimethyl sulfoxide 0.4%, and propylene glycol and acetone/saline (50/50 v/v) vehicles gave negative results. However, when tested at higher concentrations, positive results were obtained in these vehicles.Conclusion: These data reveal that the vehicle in which a chemical is encountered in the skin can have a significant impact on a quantitative measure of skin sensitization potency. The implication is that accurate assessment of risk to humans will require an understanding of the matrix in which skin exposure is likely to occur.","PeriodicalId":7612,"journal":{"name":"American journal of contact dermatitis : official journal of the American Contact Dermatitis Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21452353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of metal allergens in the local lymph node assay. 局部淋巴结试验中金属过敏原的鉴定。

American journal of contact dermatitis : official journal of the American Contact Dermatitis Society Pub Date : 1999-12-01 DOI: 10.1053/AJCD01000207

D A Basketter, L J Lea, K J Cooper, C A Ryan, G F Gerberick, R J Dearman, I Kimber

{"title":"Identification of metal allergens in the local lymph node assay.","authors":"D A Basketter, L J Lea, K J Cooper, C A Ryan, G F Gerberick, R J Dearman, I Kimber","doi":"10.1053/AJCD01000207","DOIUrl":"https://doi.org/10.1053/AJCD01000207","url":null,"abstract":"Background: The murine local lymph node assay (LLNA) has recently been endorsed as a validated alternative to guinea pig methods for the identification of skin sensitization hazard. Nevertheless, there has been some debate regarding the utility of this method for the detection of metal contact allergens.Objective: In these investigations, we have used the LLNA to determine the skin sensitization potential of 13 metal salts, 8 of which were considered to possess a significant ability to sensitize man, whereas the remaining 5 were judged to lack such potential.Results: The predictions from the LLNA were correct for 7 of the 8 (88%) sensitizing metals and for 4 of the 5 (80%) nonsensitizers when considered against the experience of these metals as human skin sensitizers. Thus, the overall predictive accuracy of the LLNA in relation to metals was 11/13 (85%), which is very similar to the accuracy of approximately 88% in relation to a much larger number of low-molecular-weight organic chemicals, as reported previously.Conclusion: These data provide support for the potential utility of the LLNA in hazard identification of metal contact allergens.","PeriodicalId":7612,"journal":{"name":"American journal of contact dermatitis : official journal of the American Contact Dermatitis Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21452352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 53

Allergic contact dermatitis to Fraxinus americanus and Macherium acutifolium. 美洲黄曲霉和金针叶的过敏性接触性皮炎。

American journal of contact dermatitis : official journal of the American Contact Dermatitis Society Pub Date : 1999-12-01 DOI: 10.1053/AJCD01000233

A J Scheman, Y Xu, A Osborne

引用次数: 0

Evaluation and management of the "red face". Interview by K. Watsky and M. Rothe. 评价和管理“红脸”。采访K. Watsky和M. Rothe。

American journal of contact dermatitis : official journal of the American Contact Dermatitis Society Pub Date : 1999-12-01 DOI: 10.1053/AJCD01000236

P G Engasser, D J Hogan, L A Stewart, K A Zug

引用次数: 1

Cheilitis: analysis of 75 cases referred to a contact dermatitis clinic. 唇炎:分析75例转介接触性皮炎诊所。

American journal of contact dermatitis : official journal of the American Contact Dermatitis Society Pub Date : 1999-12-01 DOI: 10.1053/AJCD01000198

S Freeman, R Stephens

{"title":"Cheilitis: analysis of 75 cases referred to a contact dermatitis clinic.","authors":"S Freeman, R Stephens","doi":"10.1053/AJCD01000198","DOIUrl":"https://doi.org/10.1053/AJCD01000198","url":null,"abstract":"Background: Cheilitis is a common problem, the cause of which is often obscure.Objective: Data on 75 cases of recalcitrant cheilitis were analyzed. These had been referred to a tertiary care center.Methods: Each of the 75 patients had undergone a detailed history, physical examination, and patch tests.Results: Of the patients, 53 were female (67%), and the age range was 9 to 79 years. Of the cases, 36% included irritant contact dermatitis (ICD), 25% included allergic contact dermatitis (ACD), 19% were attributed to atopic eczema, and in 9% the dermatitis was of unknown cause. Nine percent were noneczematous. The materials causing ACD were medicaments applied to the lips, lipstick ingredients, sunscreen agents, toothpaste ingredients, colophony in dental floss and toothpicks, nail varnish, cosmetics, and nickel in the mouthpiece of a flute.Conclusion: The most common cause of cheilitis was irritation, frequently caused by liplicking. About one quarter was caused by ACD. Medicaments, lipsticks, sunscreens, and toothpaste were the most common allergens. Atopic eczema is a commonly overlooked cause of cheilitis. However, there is a troublesome group of patients, 9% in this series, who are often severely affected, but the cause of their cheilitis remains obscure.","PeriodicalId":7612,"journal":{"name":"American journal of contact dermatitis : official journal of the American Contact Dermatitis Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21453212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of gold sensitivity in asymptomatic individuals with gold dental restorations. 无症状的金质牙修复体患者的金质敏感性。

American journal of contact dermatitis : official journal of the American Contact Dermatitis Society Pub Date : 1999-12-01 DOI: 10.1053/AJCD01000201

R M Schaffran, F J Storrs, P Schalock

{"title":"Prevalence of gold sensitivity in asymptomatic individuals with gold dental restorations.","authors":"R M Schaffran, F J Storrs, P Schalock","doi":"10.1053/AJCD01000201","DOIUrl":"https://doi.org/10.1053/AJCD01000201","url":null,"abstract":"Background: The clinical relevance of positive patch test reactions to gold sodium thiosulfate in asymptomatic individuals with gold dental restorations is often unclear. Knowledge of the prevalence of gold sensitivity in individuals with and without gold dental restorations is required to better understand the relevance of these reactions.Objective: To determine the prevalence of positive patch test reactions to gold in asymptomatic individuals with gold dental restorations (gold patients) compared with similar individuals without gold dental appliances (nongold patients).Methods: One hundred thirty-six healthy, asymptomatic patients were patch tested to gold sodium thiosulfate, nickel sulfate and palladium chloride. Readings occurred after 2 days and 7 days.Results: Of the patients tested, 24 of 71 (33.8%) gold patients had a positive reaction to gold versus 7 of 65 (10.8%) of the nongold patients, P <.001. Of those with a positive gold reaction, 12 of 31 (38.7%) also had a positive nickel reaction. Nickel alone was positive in 18 of 71 (25. 4%) of gold patients versus 11 of 65 (16.9%) of nongold patients. 19 of 29 (65.5%) of those with a positive nickel reaction also reacted to palladium and 19 of 22 (86.4%) of those with a palladium reaction also reacted to nickel. The rate of allergy to gold computed over a 3-year period for patients patch tested in the Oregon Health Sciences University (OHSU) Contact Dermatitis Clinic was 13.5% (46/342).Conclusions: The prevalence of gold sensitivity in individuals with gold dental restorations is approximately 33.8%. This is significantly greater than the 10.8% prevalence seen in individuals without gold dental appliances, as well as greater than the 3-year rate from the OHSU Contact Dermatitis Clinic. This data should help shed light on issues of clinical relevance.","PeriodicalId":7612,"journal":{"name":"American journal of contact dermatitis : official journal of the American Contact Dermatitis Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21453213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0