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[Pharmacologic studies of cultivated human ciliated cells of the upper respiratory tract]. 培养人上呼吸道纤毛细胞的药理学研究。
Laryngologie, Rhinologie, Otologie Pub Date : 1988-10-01
G Wolf, A Saria, B Koidl
{"title":"[Pharmacologic studies of cultivated human ciliated cells of the upper respiratory tract].","authors":"G Wolf,&nbsp;A Saria,&nbsp;B Koidl","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The ciliary frequency was measured in cultivated ciliated human cells of the upper respiratory tract. An attempt was made to influence this isolated system pharmacologically. Previously, contradictory results have been published regarding the effects of parasympathomimetic and sympathomimetic drugs. We investigated the muscarinic agonist carbachol and the beta 2-adrenoreceptor stimulating drug clenbuterol. Carbachol (10(-3) M) did not modify the ciliary frequency in 6 experiments neither at 37 degrees C nor at 24 degrees C, where the basal frequency was reduced. Spiropent (10(-5) M), a pharmaceutical preparation of clenbuterol and lactose, increased the ciliary frequency in 3 experiments. Clenbuterol, tested in the same concentration in 1 experiment, also caused an increase. Lactose was without effect. The secretolytic drug ambroxol did not influence the ciliary frequency. The neuropeptide substance P which causes an increase in ciliary frequency in the respiratory tract of rabbits in vivo, had no effect on isolated human ciliated cells indicating an indirect effect of this peptide. Calcitonin gene-related peptide which co-exists with substance P in sensory neurons of the airways, increased the ciliary frequency in 1 out of 6 experiments. In conclusion, our results indicate that ciliary activity can be directly modified via beta 2-adrenoreceptors. Other putative neuronal mediators did not reveal clearcut direct activity.</p>","PeriodicalId":76098,"journal":{"name":"Laryngologie, Rhinologie, Otologie","volume":"67 10","pages":"518-22"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13615006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[HLA antigens in patients with laryngeal cancer]. [喉癌患者的HLA抗原]。
Laryngologie, Rhinologie, Otologie Pub Date : 1988-10-01
B Beleites, S Wegener, R Nowak, G Wilden
{"title":"[HLA antigens in patients with laryngeal cancer].","authors":"B Beleites,&nbsp;S Wegener,&nbsp;R Nowak,&nbsp;G Wilden","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The HLA-ABC- and -DR-antigens of patients with carcinoma of the larynx were determined. The frequencies were compared with those of a normal population. No significant deviations in the antigen frequencies were observed in the distribution of HLA antigens. Therefore, participation of HLA-ABC and -DR gene products in pathogenesis of carcinoma of the larynx as an expression of a genetical component cannot be postulated till now.</p>","PeriodicalId":76098,"journal":{"name":"Laryngologie, Rhinologie, Otologie","volume":"67 10","pages":"543-4"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14364503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Displaced and supernumerary molar of the ethmoid sinus]. [筛窦移位和多余的磨牙]。
Laryngologie, Rhinologie, Otologie Pub Date : 1988-10-01
J Silberzahn
{"title":"[Displaced and supernumerary molar of the ethmoid sinus].","authors":"J Silberzahn","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper reports on a case of a 18-year old male subject with continuous complaints in the right cheek. Several roentgenograms show a cystic and a X-ray dense, sharp-edged structure in the right maxillary respectively ethmoidal sinus. Under surgery a supernumerary molar was found in the right ethmoidal sinus as well as a follicular cyst in the right maxillary sinus.</p>","PeriodicalId":76098,"journal":{"name":"Laryngologie, Rhinologie, Otologie","volume":"67 10","pages":"545-6"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14364504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Determination of cell proliferation using monoclonal antibodies. Studies of 21 squamous cell carcinomas of the head and neck area]. 单克隆抗体测定细胞增殖。头颈部鳞状细胞癌21例分析[j]。
Laryngologie, Rhinologie, Otologie Pub Date : 1988-10-01
M Lörz, E Meyer-Breiting
{"title":"[Determination of cell proliferation using monoclonal antibodies. Studies of 21 squamous cell carcinomas of the head and neck area].","authors":"M Lörz,&nbsp;E Meyer-Breiting","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>These tumours showed a correlation between Ki 67 labelling index and histological differentiation: poor differentiation resulted in a Ki 67 labelling index from 30 to 50%, high differentiation below 20%. Labelling index of moderately differentiated carcinomas ranged between these values. Pretreatment of tumours, i.e. chemotherapy and radiotherapy, resulted in a labelling index of less than 6%. The observed heterogeneity must be considered as a limitation for using the monoclonal antibody Ki 67 in these cases as a prognostic marker.</p>","PeriodicalId":76098,"journal":{"name":"Laryngologie, Rhinologie, Otologie","volume":"67 10","pages":"539-42"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14201795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effect of the upper cervical spine on hearing ability]. [上颈椎对听力的影响]。
Laryngologie, Rhinologie, Otologie Pub Date : 1988-10-01
M Hülse, A Kollar, U Ganzer
{"title":"[The effect of the upper cervical spine on hearing ability].","authors":"M Hülse,&nbsp;A Kollar,&nbsp;U Ganzer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A chronic irritation in the upper cervical column of 10 rabbits by implantation of a wire string was performed. The vestibular and auditory functions were investigated by electronystagmography and by BERA before and several times after the operation. A distinct increase of the proprioceptive cervical nystagmus was found already in the first postoperative week. In contrary to the ENG findings the BERA did not show any alteration of the both threshold and latency values. These results indicate that the existence of the proprioceptive cervical hearing loss is very doubtful.</p>","PeriodicalId":76098,"journal":{"name":"Laryngologie, Rhinologie, Otologie","volume":"67 10","pages":"501-5"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14364499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Photodynamic destruction of in vitro cultivated squamous cell carcinoma cells of the head and neck area]. 体外培养的头颈部鳞状细胞癌细胞的光动力破坏。
Laryngologie, Rhinologie, Otologie Pub Date : 1988-10-01
T P Wustrow, D Jocham, A Schramm, E Unsöld
{"title":"[Photodynamic destruction of in vitro cultivated squamous cell carcinoma cells of the head and neck area].","authors":"T P Wustrow,&nbsp;D Jocham,&nbsp;A Schramm,&nbsp;E Unsöld","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hematoporphyrin derivatives are retained in higher concentrations in proliferating tumor tissues than in normal tissues causing a defined photosensitization. Laser light irradiation of photosensitized cells results in photobiological, non-thermal cell destruction. These photodynamic reactions were analyzed with in vitro cultured squamous cell carcinoma lines of the head and neck. As a light source we used an argon-ion-pumped-dye laser (630 nm wavelength), and for photosensitization we employed a mixture of dihematoporphyrinester and -ether (DHE). The photodynamic reaction on squamous carcinoma cells was proportional to the DHE concentration, the DHE incubation time, and the light exposure. Maximal tumor cell destruction in comparison to DHE free controls was observed with DHE concentrations of 5-10 micrograms/ml medium and a light exposure of 2-4 Joule/cm2. Based on these dose effect relations for DHE sensitized squamous carcinoma cells, photodynamic therapy for destruction of head and neck cancer can be applied in animal tumor models.</p>","PeriodicalId":76098,"journal":{"name":"Laryngologie, Rhinologie, Otologie","volume":"67 10","pages":"532-8"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14112619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Specific and nonspecific fluorescence in the use of frozen sections of the cochlea]. [冷冻耳蜗切片特异性和非特异性荧光的应用]。
Laryngologie, Rhinologie, Otologie Pub Date : 1988-10-01
N R Wei, W Giebel
{"title":"[Specific and nonspecific fluorescence in the use of frozen sections of the cochlea].","authors":"N R Wei,&nbsp;W Giebel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fresh frozen sections of unfixed inner ear tissue of the hamster were dried at room temperature and stored in a refrigerator (+4 degrees) in a wet chamber or at -20 degrees. It was demonstrated that our method for the storage of a tissue bank is suitable for the determination of antibodies in the serum of patients with inner ear diseases. To avoid floating tissue during washing and incubation the fresh frozen sections may also be slightly fixed by covering with gelatine or with a drop of acetone. Both techniques cause non-specific fluorescence. It is most advisable to dry the unfixed sections and to rinse them. Sections of stored renal, brain and inner ear tissue of the hamster also showed both a good preservation of the tissue structures and a perfect result of an antigen-antibody reaction. Relatively strong autofluorescence was found in the stria vascularis, the spiral ligament, the organ of Corti and in the basilar membrane. After incubation with normal serum, non-specific fluorescence was found in addition in the bone and in the tectorial membrane. This non-specific reaction can be avoided by rinsing and counterstaining. Up to now only those antibodies were demonstrated with inner ear tissue that had reacted with other tissues.</p>","PeriodicalId":76098,"journal":{"name":"Laryngologie, Rhinologie, Otologie","volume":"67 10","pages":"513-7"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14201794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Different forms of drug therapy for progressive sensorineural hearing loss in childhood]. [儿童进行性感音神经性听力损失的不同药物治疗形式]。
Laryngologie, Rhinologie, Otologie Pub Date : 1988-10-01
A Nickisch, M Heinemann, M Gross
{"title":"[Different forms of drug therapy for progressive sensorineural hearing loss in childhood].","authors":"A Nickisch,&nbsp;M Heinemann,&nbsp;M Gross","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Because of progressive sensorineural hearing loss 26 patients of the age of 2 to 19 years were treated for 10 days with infusions of prednisolone, pentoxifylline and piracetam. After this treatment improved, auditory thresholds were found in 58%. In comparison with a previous investigation (treatment with prednisolone and pentoxifylline except piacetam), no significant difference between these two methods of therapy was seen.</p>","PeriodicalId":76098,"journal":{"name":"Laryngologie, Rhinologie, Otologie","volume":"67 10","pages":"498-500"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14364498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Individual sensitivity of cilia. A simple in vitro test method]. 纤毛的个体敏感性。一种简单的体外试验方法]。
Laryngologie, Rhinologie, Otologie Pub Date : 1988-10-01
A Wichelhaus, H Enzmann
{"title":"[Individual sensitivity of cilia. A simple in vitro test method].","authors":"A Wichelhaus,&nbsp;H Enzmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A simple patient-related method is described that determines the effect of toxic substances on the ciliary activity of human nasal cilia cells. The method is suitable for investigating and numerically determining substance-specific toxicity and individual sensitivity even between patients of different states of health. This is illustrated by the example of two preservatives introduced in human medicine: chlorhexidine and merthiolate.</p>","PeriodicalId":76098,"journal":{"name":"Laryngologie, Rhinologie, Otologie","volume":"67 10","pages":"523-5"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14364501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Listening to music in hearing loss with and without a hearing aid]. [有听力损失的人听音乐，带或不带助听器]。
Laryngologie, Rhinologie, Otologie Pub Date : 1988-10-01
H Feldmann, W Kumpf
{"title":"[Listening to music in hearing loss with and without a hearing aid].","authors":"H Feldmann,&nbsp;W Kumpf","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>By means of a questionnaire it was investigated how in individuals who had previously had normal hearing deafness influences their pleasure and habits in listening to music, and which role a hearing aid can play in this respect. Out of 330 questionnaires returned, 206 could be statistically evaluated. 95% reported that formerly they had liked music, light music coming from the radio being the most frequently mentioned type of music and medium. 36% had formerly played an instrument or had enjoyed singing. 79% feel that their deafness has affected their pleasure in listening to music. Most common complaints refer to the fact that everything sounds distorted and wrong, melodies cannot be recognised any longer, the text of songs is not understood. 60% are fitted with one hearing aid, 40% have binaural hearing aids. 67% report that the hearing aid has rendered listening to music again more pleasurable, and 74% use their hearing aid more or less regularly when listening to music. The distorted sound and the fast alternating between \"too soft\" and \"too loud\", forcing the subject to continually adjusting his hearing aid, seem to be among the most annoying features.</p>","PeriodicalId":76098,"journal":{"name":"Laryngologie, Rhinologie, Otologie","volume":"67 10","pages":"489-97"},"PeriodicalIF":0.0,"publicationDate":"1988-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14364497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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