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Fibronectin is related to prealbumin in plasma of decompensated cirrhotics. 失代偿期肝硬化患者血浆中纤连蛋白与前白蛋白有关。
La Ricerca in clinica e in laboratorio Pub Date : 1989-07-01 DOI: 10.1007/BF02871813
G B Gabrielli, F Baracchino, M Casaril, F Capra, F Corso, L Bonazzi, R Corrocher
{"title":"Fibronectin is related to prealbumin in plasma of decompensated cirrhotics.","authors":"G B Gabrielli,&nbsp;F Baracchino,&nbsp;M Casaril,&nbsp;F Capra,&nbsp;F Corso,&nbsp;L Bonazzi,&nbsp;R Corrocher","doi":"10.1007/BF02871813","DOIUrl":"https://doi.org/10.1007/BF02871813","url":null,"abstract":"<p><p>In a group of 23 patients with advanced liver cirrhosis we have found a statistically significant positive correlation (r = 0.746; p less than 0.0001) between fibronectin and prealbumin levels measured in plasma by immunonephelometric methods and found significantly lower than in healthy controls (p less than 0.001). On the contrary, no correlation of fibronectin neither to albumin nor to the presence of an enlarged spleen was observed. Since the sensitivity of prealbumin as an index of liver function is believed to be higher than that of albumin, our results support the view that the decreased fibronectin in advanced cirrhotics is mainly due to their liver failure, an enlarged spleen playing only a minor role.</p>","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"19 3","pages":"245-9"},"PeriodicalIF":0.0,"publicationDate":"1989-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02871813","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13828775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Subclinical activation of fibrinolysis in atherosclerotic disease detected by B beta 15-42 assay. B β 15-42检测动脉粥样硬化疾病中纤溶的亚临床激活
La Ricerca in clinica e in laboratorio Pub Date : 1989-04-01
F Marongiu, A M Mamusa, G Mameli, M Conti, G G Sorano, G Biondi, P Farci, A Balestrieri
{"title":"Subclinical activation of fibrinolysis in atherosclerotic disease detected by B beta 15-42 assay.","authors":"F Marongiu,&nbsp;A M Mamusa,&nbsp;G Mameli,&nbsp;M Conti,&nbsp;G G Sorano,&nbsp;G Biondi,&nbsp;P Farci,&nbsp;A Balestrieri","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Plasma B beta 15-42 and fibrinopeptide A (FPA) concentrations, which are respectively indicators of plasmin and thrombin in vivo activity, were measured in 46 patients with ischemic arterial disease without signs of acute thrombosis. In the group as a whole, an increase in both B beta 15-42 and FPA was found. When the patients were divided in two groups on the basis of their reversible (transitory ischemic attacks and unstable angina) or irreversible (stroke and myocardial infarction) ischemic episodes, the levels of B beta 15-42 were significantly elevated only in the former group when compared to controls (p less than 0.01). In the latter group we found significantly increased levels of FPA with respect to both controls (p less than 0.01) and patients with reversible and transient ischemic episodes (p less than 0.05). Moreover, the B beta 15-42/FPA ratio was significantly lower in patients with irreversible ischemic episodes than in controls (p less than 0.01) and patients with transient ischemic episodes (p less than 0.01), while no difference was found between the latter group and controls, although FPA and B beta 15-42 were significantly higher. These results suggest that in patients with transient and reversible ischemic episodes fibrinolytic activity is able to counterbalance an increased thrombin activity, while this does not appear to occur in patients with irreversible ischemic episodes.</p>","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"19 2","pages":"157-63"},"PeriodicalIF":0.0,"publicationDate":"1989-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13672589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isoenzyme analysis of Entamoeba histolytica for evaluation of pathogenicity: detection of zymodeme XIX in South America. 溶组织内阿米巴同工酶分析对致病性的评价:南美19型酶的检测。
La Ricerca in clinica e in laboratorio Pub Date : 1989-04-01 DOI: 10.1007/BF02871807
G Di Perri, M Strosselli, A Parisi, A Malfitano, G Carnevale, L Minoli
{"title":"Isoenzyme analysis of Entamoeba histolytica for evaluation of pathogenicity: detection of zymodeme XIX in South America.","authors":"G Di Perri,&nbsp;M Strosselli,&nbsp;A Parisi,&nbsp;A Malfitano,&nbsp;G Carnevale,&nbsp;L Minoli","doi":"10.1007/BF02871807","DOIUrl":"https://doi.org/10.1007/BF02871807","url":null,"abstract":"<p><p>Authors report the results of the isoenzyme analysis of strains of Entamoeba histolytica isolated from international travellers. This recently developed method allows the detection of pathogenic strains by evaluating the electrophoretic mobility of cytoplasmic enzymes and was proved to be more reliable and quickly feasible than previous ones. The experience reported refers to three strains isolated from travellers coming from Ecuador, Brazil and Indonesia, respectively; the zymodeme XIX (in accordance with the Sargeaunt's classification) was identified in all the three cases. This zymodeme has been first detected in 1981 and should currently be considered rare; moreover, it has never been previously reported from the Americas.</p>","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"19 2","pages":"179-85"},"PeriodicalIF":0.0,"publicationDate":"1989-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02871807","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13692673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Fc epsilon R2/CD23 antigen: a hallmark of chronic lymphocytic leukemia B cells. Fc ε R2/CD23抗原:慢性淋巴细胞白血病B细胞的标志。
La Ricerca in clinica e in laboratorio Pub Date : 1989-04-01
F Almerigogna, R Biagiotti, M G Giudizi, A Alessi, M Ricci, A Bosi, S Romagnani
{"title":"The Fc epsilon R2/CD23 antigen: a hallmark of chronic lymphocytic leukemia B cells.","authors":"F Almerigogna,&nbsp;R Biagiotti,&nbsp;M G Giudizi,&nbsp;A Alessi,&nbsp;M Ricci,&nbsp;A Bosi,&nbsp;S Romagnani","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of different stimuli on the expression of the low-affinity receptor for the Fc fragment of IgE (Fc epsilon R2/CD23) on peripheral blood B cells from patients with chronic lymphocytic leukemia (CLL) was investigated. CLL B cells cultured for 3 days in medium alone showed a progressive decrease of the Fc epsilon R2/CD23 expression, while the addition to the cell cultures of IgE or interleukin-4 had a slackening effect on the decrease of the Fc epsilon R2/CD23. In contrast, in the presence of interferon-gamma the proportion of Fc epsilon R2/CD23+ cells was more rapidly reduced compared to CLL B cells cultured in medium alone. Stimulation of CLL B cells with Staphylococcus aureus Cowan I (SAC) bacteria, which are able to enhance the expression of Fc epsilon R2/CD23 on normal B cells, induced a rapid loss of the Fc epsilon R2/CD23 from CLL B cells.</p>","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"19 2","pages":"129-38"},"PeriodicalIF":0.0,"publicationDate":"1989-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13672093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laboratory parameters in the natural history of liver cirrhosis. 肝硬化自然史中的实验室参数。
La Ricerca in clinica e in laboratorio Pub Date : 1989-04-01 DOI: 10.1007/BF02871806
A Milani, L Marra, M Siciliano, L Rossi
{"title":"Laboratory parameters in the natural history of liver cirrhosis.","authors":"A Milani,&nbsp;L Marra,&nbsp;M Siciliano,&nbsp;L Rossi","doi":"10.1007/BF02871806","DOIUrl":"https://doi.org/10.1007/BF02871806","url":null,"abstract":"<p><p>The aim of the present study was to evaluate the changes of common laboratory parameters in the natural evolution of liver cirrhosis, as well as their relationships with the occurrence of ascites onset and death. Routine laboratory findings of 458 patients suffering from liver cirrhosis admitted to a 9-year follow-up period were retrospectively investigated, but only data of the 138 subjects (95 males and 43 females) who died within the follow-up period were considered. Data were grouped into different classes according to the months elapsed before ascites onset or death. The statistical differences among the various groups were evaluated employing analysis of variance and Turkey's test. No laboratory parameter showed statistically significant changes before or at the time of ascites onset, while significant modifications occurred in four liver indexes (albumin, total bilirubin, platelet count and gammaglobulin percentage) during the course of the illness, thus confirming the reliable prognostic value of these laboratory parameters in liver cirrhosis.</p>","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"19 2","pages":"173-8"},"PeriodicalIF":0.0,"publicationDate":"1989-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02871806","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13623398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Cholesterol distribution between HDL subfractions. A study of 498 subjects. 高密度脂蛋白亚组分之间的胆固醇分布。一项涉及498名受试者的研究。
La Ricerca in clinica e in laboratorio Pub Date : 1989-04-01 DOI: 10.1007/BF02871805
D Sommariva, A Branchi, D Bonfiglioli, M Tirrito, E Cabrini, C Pini, L Scandiani, A Rovellini, A Fasoli
{"title":"Cholesterol distribution between HDL subfractions. A study of 498 subjects.","authors":"D Sommariva,&nbsp;A Branchi,&nbsp;D Bonfiglioli,&nbsp;M Tirrito,&nbsp;E Cabrini,&nbsp;C Pini,&nbsp;L Scandiani,&nbsp;A Rovellini,&nbsp;A Fasoli","doi":"10.1007/BF02871805","DOIUrl":"https://doi.org/10.1007/BF02871805","url":null,"abstract":"<p><p>In 498 subjects (205 normolipidemics and 293 hyperlipidemics) of both sexes, the cholesterol content of high density lipoprotein (HDL) subfractions has been determined. The serum concentration of total HDL-cholesterol appears to be more strictly related to the cholesterol content of HDL2 than to that of HDL3. This latter one, however, gives a contribution to the variability of HDL-cholesterol so that the value of HDL-cholesterol cannot be assumed as a reliable estimate of the serum level of the more anti-atherogenic HDL2 subfraction. The cholesterol content of HDL and its subfractions is higher in women than in men and decreases with increasing serum VLDL-cholesterol level and body weight. Both HDL2- and HDL3-cholesterol appear to largely depend from the metabolism of triglyceride-rich lipoproteins in accordance with the data of experimental studies.</p>","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"19 2","pages":"165-72"},"PeriodicalIF":0.0,"publicationDate":"1989-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02871805","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13910912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Membrane fatty acids and erythrocyte Li-Na countertransport in nephrotic syndrome and their relationship. 肾病综合征中膜脂肪酸与红细胞Li-Na反转运及其关系。
La Ricerca in clinica e in laboratorio Pub Date : 1989-04-01 DOI: 10.1007/BF02871803
R Corrocher, O Olivieri, C Loschiavo, P Guarini, A Bassi, M de Gironcoli, A Gandini, D Girelli, S Ferrari
{"title":"Membrane fatty acids and erythrocyte Li-Na countertransport in nephrotic syndrome and their relationship.","authors":"R Corrocher,&nbsp;O Olivieri,&nbsp;C Loschiavo,&nbsp;P Guarini,&nbsp;A Bassi,&nbsp;M de Gironcoli,&nbsp;A Gandini,&nbsp;D Girelli,&nbsp;S Ferrari","doi":"10.1007/BF02871803","DOIUrl":"https://doi.org/10.1007/BF02871803","url":null,"abstract":"<p><p>Cholesterol/phospholipids molar ratio and fatty acid composition have been estimated in erythrocyte membrane of 12 patients suffering from nephrotic syndrome and compared to values obtained in 23 normal subjects matched for sex and age. The membrane lipid composition has been correlated with the activity of erythrocyte Li-Na countertransport of the same subjects. The results show a significant increase in cholesterol/phospholipids ratio and total saturated fatty acids when erythrocytes of nephrotic patients are compared to normal erythrocytes, whereas total unsaturated fatty acids were lower in nephrotics (p less than 0.002). Li-Na countertransport was higher in nephrotics (p less than 0.001) and it was positively correlated with the total amount of saturated fatty acids of the erythrocyte membrane (r = +0.451; p less than 0.01). On the contrary, Li-Na countertransport was negatively correlated with the total amount of unsaturated fatty acids (r = -0.468; p less than 0.01).</p>","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"19 2","pages":"149-56"},"PeriodicalIF":0.0,"publicationDate":"1989-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02871803","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13910909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subviral pathogens of plants: the viroids. 植物的亚病毒病原体:类病毒。
La Ricerca in clinica e in laboratorio Pub Date : 1989-04-01 DOI: 10.1007/BF02871800
T O Diener
{"title":"Subviral pathogens of plants: the viroids.","authors":"T O Diener","doi":"10.1007/BF02871800","DOIUrl":"https://doi.org/10.1007/BF02871800","url":null,"abstract":"<p><p>Research during the last 15 years has conclusively shown that viroids are not only fundamentally different from viruses at the molecular level, but that they are most likely not directly related to viruses in an evolutionary sense. Today, viroids are among the most thoroughly studied biological macromolecules. Their molecular structures have been elucidated to a large extent, but much needs to be learned regarding the correlation between molecular structure and biological function. The availability of the tools of recombinant DNA technology in viroid research promises rapid progress in these areas of inquiry.</p>","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"19 2","pages":"105-28"},"PeriodicalIF":0.0,"publicationDate":"1989-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02871800","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13815469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Immunocytochemical typing of fine needle aspirates by means of alkaline phosphatase anti-alkaline phosphatase method. A study of 16 selected patients. 用碱性磷酸酶抗碱性磷酸酶法对细针吸痰液进行免疫细胞化学分型。一项选取16名患者的研究。
La Ricerca in clinica e in laboratorio Pub Date : 1989-04-01 DOI: 10.1007/BF02871802
P Musto, M Aieta, G Sperandeo, M Cammisa, M Carotenuto
{"title":"Immunocytochemical typing of fine needle aspirates by means of alkaline phosphatase anti-alkaline phosphatase method. A study of 16 selected patients.","authors":"P Musto,&nbsp;M Aieta,&nbsp;G Sperandeo,&nbsp;M Cammisa,&nbsp;M Carotenuto","doi":"10.1007/BF02871802","DOIUrl":"https://doi.org/10.1007/BF02871802","url":null,"abstract":"<p><p>The immunocytochemical characterization of neoplastic cells recognized by a large panel of monoclonal antibodies in fine needle aspirates obtained from 16 subjects with superficial or profound tumoral masses of unknown origin was carried out using alkaline phosphatase anti-alkaline phosphatase (APAAP) immunoenzymatic method. The patients were selected on the basis of particular clinical criteria or since a correct cytohistological diagnosis was not available. APAAP immunophenotyping allowed to establish the existence of non-Hodgkin lymphoma in 6 cases, hairy cell leukemia in 1 case and carcinoma in 5 cases, while in other 2 patients the existence of Hodgkin's disease was suspected and subsequently confirmed; only in 2 subjects diagnostic informations were lacking. Furthermore, the evaluation of growth fraction by means of Ki 67 monoclonal antibody revealed a high degree of malignancy in all cases of lymphoma. Although some cautions have to be considered in the interpretation of results, APAAP immunocytochemical typing of fine needle aspirates appears a simple and reliable noninvasive diagnostic tool in selected patients.</p>","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"19 2","pages":"139-47"},"PeriodicalIF":0.0,"publicationDate":"1989-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02871802","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13815470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemostatic alterations during human immunodeficiency virus infection: a review. 人类免疫缺陷病毒感染期间的止血改变:综述。
La Ricerca in clinica e in laboratorio Pub Date : 1989-04-01 DOI: 10.1007/BF02871799
D Prisco
{"title":"Hemostatic alterations during human immunodeficiency virus infection: a review.","authors":"D Prisco","doi":"10.1007/BF02871799","DOIUrl":"https://doi.org/10.1007/BF02871799","url":null,"abstract":"<p><p>Human immunodeficiency virus (HIV) infection is associated to different clinical and laboratory hemostatic alterations. The most important is thrombocytopenia, which very often leads to a picture indistinguishable from idiopathic thrombocytopenic purpura with poor clinical relevance but with possible important problems of differential diagnosis. Thrombotic thrombocytopenic purpura is sometimes associated to HIV infections, although only few reports there exist. Finally, the high incidence of lupus anticoagulant in some phases of HIV infection has not a clinical relevance, but is essentially a laboratory finding which is to be known because it can cause a prolonged partial thromboplastin time.</p>","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"19 2","pages":"95-104"},"PeriodicalIF":0.0,"publicationDate":"1989-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02871799","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13815471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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