La Ricerca in clinica e in laboratorio最新文献

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The biochemical genetics of amyloid fibril proteins. 淀粉样纤维蛋白的生化遗传学。
La Ricerca in clinica e in laboratorio Pub Date : 1989-01-01 DOI: 10.1007/BF02871789
A O Carbonara, A Bottaro
{"title":"The biochemical genetics of amyloid fibril proteins.","authors":"A O Carbonara,&nbsp;A Bottaro","doi":"10.1007/BF02871789","DOIUrl":"https://doi.org/10.1007/BF02871789","url":null,"abstract":"<p><p>Amyloidoses are a very heterogeneous set of diseases, characterized by extracellular deposition of fibrillar proteins in different tissues. It is still a matter of debate whether the different forms of amyloidosis can share some common etiological mechanisms, or they are completely unrelated. The biochemical characterization of the protein component of the deposits provides a powerful system of classification for the different amyloidotic disorders and shades light on the molecular mechanisms of selective precipitation from soluble precursors and of tissue-specific deposition. Furthermore, identification and analysis of the genes coding for the precursors, and clarification of the kind of inheritance in some familial forms of amyloidosis, make prevention through genetic counselling and predictive diagnosis possible.</p>","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"19 1","pages":"27-38"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02871789","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13811814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HBeAg/anti-HBe circulating immune complexes in patients chronically infected with hepatitis B virus. 慢性乙型肝炎病毒感染患者的HBeAg/抗hbe循环免疫复合物
La Ricerca in clinica e in laboratorio Pub Date : 1989-01-01 DOI: 10.1007/BF02871796
D Sansonno, A Vacca, A Gernone, F Dammacco
{"title":"HBeAg/anti-HBe circulating immune complexes in patients chronically infected with hepatitis B virus.","authors":"D Sansonno,&nbsp;A Vacca,&nbsp;A Gernone,&nbsp;F Dammacco","doi":"10.1007/BF02871796","DOIUrl":"https://doi.org/10.1007/BF02871796","url":null,"abstract":"<p><p>An enzyme-linked immunosorbent assay based on the ability of polyethylene-glycol (PEG) fixed on a solid support to adsorb circulating macromolecules (PEG-solid phase test) was developed in order to provide evidence for the existence of immune complexes of HBeAg/anti-HBe (HBeAg/anti-HBe complex) in sera of HBsAg chronic carriers. The method can detect HBeAg in immune complexes whether antigen or antibody is in excess. In the chronic phase of HBV infection, HBeAg/anti-HBe complexes are formed transiently in the course of the disease, unrelated to the phases of virus replication or peaks of hepatocytolysis, or to the histologic picture of liver disease. Our study indicates that this method offers a new approach to the understanding of biological and clinical problems of the HBeAg/anti-HBe antigenic system in chronic HBV infection.</p>","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"19 1","pages":"81-91"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02871796","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13903525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A survey of inherited thrombotic syndromes in Italy. ad hoc Study Group. 意大利遗传性血栓综合征的调查。特设研究小组。
La Ricerca in clinica e in laboratorio Pub Date : 1989-01-01 DOI: 10.1007/BF02871794
A Tripodi, P M Mannucci
{"title":"A survey of inherited thrombotic syndromes in Italy. ad hoc Study Group.","authors":"A Tripodi,&nbsp;P M Mannucci","doi":"10.1007/BF02871794","DOIUrl":"https://doi.org/10.1007/BF02871794","url":null,"abstract":"<p><p>A collaborative survey was conducted among Italian thrombosis centers to gather information about the number and clinical features of patients with inherited thrombotic syndromes. The survey, based on 74 unrelated kindreds, revealed that antithrombin III, protein C and protein S defects are the most frequent genetic disorders. Venous thromboembolism was more frequent than arterial thrombosis, which was seen in only a minority of cases, most frequently with dysfibrinogenemia. About half of the patients developed venous thrombosis with a similar incidence in antithrombin III, protein S and protein C defects. About half of the symptomatic patients had recurrences and 40% developed thrombosis after a triggering factor, most frequently after surgery, during the puerperium, pregnancy, oral contraceptive intake or bed rest. Deep venous thrombosis prevailed and superficial thrombophlebitis was rare in antithrombin III-deficient patients, whereas deep venous thrombosis was present in about half and superficial thrombophlebitis in about one third of the cases with protein S and protein C defects. The probability to be free of thrombosis decreases with increasing age and at 35 years can be estimated to be 47% both for men and women. There is, however, a group of patients who are still free of thrombosis despite their older ages.</p>","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"19 1","pages":"67-74"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02871794","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13671265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
[Relation between blood viscosity and ischemic pathology of an organ]. [血液黏度与器官缺血病理的关系]。
V Bartoli, L Mannini, F Fantoni, C Lupi
{"title":"[Relation between blood viscosity and ischemic pathology of an organ].","authors":"V Bartoli,&nbsp;L Mannini,&nbsp;F Fantoni,&nbsp;C Lupi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"19 Suppl 1 ","pages":"41-51"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13838536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Localization factors for arteriosclerosis and thrombosis]. 【动脉硬化和血栓形成的定位因素】。
M Mancini, P Rubba
{"title":"[Localization factors for arteriosclerosis and thrombosis].","authors":"M Mancini,&nbsp;P Rubba","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"19 Suppl 1 ","pages":"23-7"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13770085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cellular rheology in obliterative arterial diseases of the lower limbs]. [下肢动脉闭塞性疾病的细胞流变学]。
R Lombardini, G Ciuffetti, D Palazzetti, E Mannarino, L Pasqualini, A M Scarponi, M Mercuri, D Siepi
{"title":"[Cellular rheology in obliterative arterial diseases of the lower limbs].","authors":"R Lombardini,&nbsp;G Ciuffetti,&nbsp;D Palazzetti,&nbsp;E Mannarino,&nbsp;L Pasqualini,&nbsp;A M Scarponi,&nbsp;M Mercuri,&nbsp;D Siepi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"19 Suppl 1 ","pages":"91-3"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13770093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Hypercholesterolemia and hemorheological parameters]. [高胆固醇血症和血液流变学参数]。
M G Ranieri, C Muggia, A Martignoni, L Bobba, G Perani
{"title":"[Hypercholesterolemia and hemorheological parameters].","authors":"M G Ranieri,&nbsp;C Muggia,&nbsp;A Martignoni,&nbsp;L Bobba,&nbsp;G Perani","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"19 Suppl 1 ","pages":"163-6"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13770977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Hemorheological factors and diabetic arterial and arteriolar diseases]. [血液流变学因素与糖尿病动脉和小动脉疾病]。
G Pozza, C Rocco, O Carandente
{"title":"[Hemorheological factors and diabetic arterial and arteriolar diseases].","authors":"G Pozza,&nbsp;C Rocco,&nbsp;O Carandente","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"19 Suppl 1 ","pages":"53-7"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13770087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Study of some hemorheological parameters in acute and chronic venous pathology]. 急慢性静脉病理血液流变学参数的研究
G Gelmini, R Quintavalla, P Ferretti, A Marcato, R Delsignore
{"title":"[Study of some hemorheological parameters in acute and chronic venous pathology].","authors":"G Gelmini,&nbsp;R Quintavalla,&nbsp;P Ferretti,&nbsp;A Marcato,&nbsp;R Delsignore","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"19 Suppl 1 ","pages":"87-90"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13770092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effects of buflomedil hydrochloride on the rheological properties of the blood in chronic cerebrovascular diseases]. 盐酸丁咯地尔对慢性脑血管病患者血液流变学特性的影响
R Lombardini, G Ciuffetti, R Paltriccia, A M Scarponi, V Savastano, D Palazzetti, M Mercuri, L Parnetti
{"title":"[Effects of buflomedil hydrochloride on the rheological properties of the blood in chronic cerebrovascular diseases].","authors":"R Lombardini,&nbsp;G Ciuffetti,&nbsp;R Paltriccia,&nbsp;A M Scarponi,&nbsp;V Savastano,&nbsp;D Palazzetti,&nbsp;M Mercuri,&nbsp;L Parnetti","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76092,"journal":{"name":"La Ricerca in clinica e in laboratorio","volume":"19 Suppl 1 ","pages":"117-9"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13770326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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