Journal of immunogenetics最新文献

{"title":"Relationship between the responsiveness of maternal and foetal lymphocytes to phytohaemagglutinin and to microbial antigens.","authors":"T J Gill,&nbsp;B S Rabin,&nbsp;B M Harina,&nbsp;F H Taylor","doi":"10.1111/j.1744-313x.1979.tb00345.x","DOIUrl":"https://doi.org/10.1111/j.1744-313x.1979.tb00345.x","url":null,"abstract":"<p><p>The response of 105 maternal-foetal lymphocyte pairs to specific and non-specific stimulation were evaluated using a newly defined method of analysis. There were no significant differences in the responses of maternal or foetal lymphocytes to phytohaemogglutinin (PHA) or the various antigens as a function of concentration over the ranges tested. The maternal lymphocytes were stimulated by all of the antigens and responded to PHA three--five times more strongly than to the antigens. The foetal lymphocytes were stimulated by PHA and tetanus toxoid only and were suppressed by streptokinase-streptodornase (SKSD). They responded to stimulation by antigens at a lower level than did the maternal lymphocytes, but they responded at a much higher level to PHA. Unstimulated cultures of foetal lymphocytes incorporated more isotope than did those of maternal lymphocytes in both autologous and AB plasma. The data were cross-classified to determine whether the responses of the foetal lymphocytes varied concordantly with the responses of the maternal lymphocytes in both autologous and AB plasma by the Chi-square test for independence and by rank correlation analysis. There was no significant correlation in either plasma to stimulation with the antigens. Thus, the presence of antigen reactive lymphocytes in the circulation of the mother does not mean that the foetus is sensitized to that antigen. Comparison of the lymphocyte responses in autologous plasma with those in AB plasma provided evidence for the presence of circulating immunoregulatory substances. Autologous maternal plasma suppressed the lymphocyte responses to high concentrations of candida and SKSD and stimulated the response to mumps, varicella and tetanus toxoid. Autologous fetal plasma suppressed the lymphocyte responses to candida, varicella and SKSD and stimulated the response to PHA. The responsiveness of maternal lymphocytes to PHA was less in foetal plasma than in autologous maternal or AB plasma.</p>","PeriodicalId":76008,"journal":{"name":"Journal of immunogenetics","volume":"6 3","pages":"197-214"},"PeriodicalIF":0.0,"publicationDate":"1979-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1744-313x.1979.tb00345.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11684350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic control of anti-DNP response to DNP-BSA given by continuous infusion technique.","authors":"H Ikeda,&nbsp;K Takizawa,&nbsp;T Yamamoto,&nbsp;T Odaka","doi":"10.1111/j.1744-313x.1979.tb00337.x","DOIUrl":"https://doi.org/10.1111/j.1744-313x.1979.tb00337.x","url":null,"abstract":"<p><p>Ten inbred strains of mice were administrated with dinitrophenyl-bovine serum albumin (DNP-BSA) at a dose of 30 or 300 microgram/day by continuous infusion technique. Anti-DNP plaque-forming cells (PFC) in their spleens were assayed 10 to 12 days after the beginning of the infusion. NZB, BALB/c, C3H/He and NC strains were high responders to both doses of DNP-BSA. KK, SII and TES strains were low responders at both doses. SJL/J, C57B1/6 and DDD strains were intermediate responders: the antibody response was low to the dose of 30 microgram/day, and high to the dose of 300 microgram/day. Breeding tests between high responder BALB/c and intermediate responder DDD mice indicated that the immune response was largely controlled by a gene linked to the H-2 complex. Similar studies with high responder NZB and low responder TES mice suggested an involvement of a few genes: at least one of the controlling genes may be linked to the H-2 complex.</p>","PeriodicalId":76008,"journal":{"name":"Journal of immunogenetics","volume":"6 2","pages":"129-40"},"PeriodicalIF":0.0,"publicationDate":"1979-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1744-313x.1979.tb00337.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11592364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential radiolabelling of lymphocyte membrane alloantigens and immunoglobulins: variation of H2O2 concentration during lactoperoxidase catalyzed cell surface radio-iodination.","authors":"S G Emerson,&nbsp;P Reilly,&nbsp;R E Cone","doi":"10.1111/j.1744-313x.1979.tb00334.x","DOIUrl":"https://doi.org/10.1111/j.1744-313x.1979.tb00334.x","url":null,"abstract":"<p><p>The effect of H2O2 concentration on lactoperoxidase catalyzed cell surface radio-iodination and subsequent isolation of Murine splenic lymphocyte Ia, H-2K and Lyb-3 surface antigens and membrane immunoglobulins was studied. For most membrane polypeptides analyzed 0.3 mM H2O2 proved to be optimal for the recovery of radiolabelled antigens from detergent lysates of labelled cells by immunoprecipitation. Marked variations among surface antigens and membrane immunoglobulin polypeptide chains were observed for the iodination and recovery of these proteins above and below the optimal peroxide concentration. The results suggest that cell surface radio-iodination conditions should be standardized to the requirements of the particular membrane protein being studied. The differential iodination and recovery of discrete membrane components above and below optimal conditions may prove useful in the analysis of surface membrane protein structure and membrane association.</p>","PeriodicalId":76008,"journal":{"name":"Journal of immunogenetics","volume":"6 2","pages":"87-97"},"PeriodicalIF":0.0,"publicationDate":"1979-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1744-313x.1979.tb00334.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11334727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A search for association between IgD concentrations and immunoglobulin allotypes in 936 sera from a genetic isolate in Newfoundland.","authors":"L S Salimonu,&nbsp;D G Bryant,&nbsp;G de Lange,&nbsp;W H Marshall,&nbsp;R M Newton,&nbsp;E Van Loghem","doi":"10.1111/j.1744-313x.1979.tb00338.x","DOIUrl":"https://doi.org/10.1111/j.1744-313x.1979.tb00338.x","url":null,"abstract":"<p><p>Immunoglobulin allotype (Gm) data has been analysed agaonst immunoglobulin D (IgD) concentrations in a population study in Newfoundland. There was no significant difference between the distribution of IgD concentrations in people homozygous for the alleles G1m(f) and G3m(b) when compared with people homozygous for the alleles G1m(a) and G3m(g). These findings, involving 573 homozygous individuals as opposed to ninety-eight in an earlier study on a New York population, do not confirm the earlier findings. Thus a genetic influence on IgD concentration by Gm genes or genes closely linked to them is not universally demonstrable by typing for these four markers and by using the Mancini technique for mearusing IgD concentration.</p>","PeriodicalId":76008,"journal":{"name":"Journal of immunogenetics","volume":"6 2","pages":"141-4"},"PeriodicalIF":0.0,"publicationDate":"1979-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1744-313x.1979.tb00338.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11695340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the haplotypes of the major histocompatibility complex in the rat. IV. The six original Ag-B haplotypes.","authors":"O Stark,&nbsp;H W Kunz,&nbsp;T J Gill","doi":"10.1111/j.1744-313x.1979.tb00336.x","DOIUrl":"https://doi.org/10.1111/j.1744-313x.1979.tb00336.x","url":null,"abstract":"<p><p>The six original haplotypes described in the Ag-B system were compared with their counterparts in the H-1 system. Antisera to the Ag-B haplotypes raised in inbred rats and antisera to H-1 haplotypes raised in congenic lines were tested against various panels of cell from inbred and congenic lines by the dextran and Ficoll haemagglutination methods. The private and strong public specificities detected in both systems were the same, but there were some minor differences in the intermediate and weak reactivities detected. The cross-reactivity of the antisera raised in inbred rats was broader than that of antisera raised in congenic lines. The identity of the antigenic products detected in the two systems by the dextran and Ficoll tests was further confirmed by a variety of absorption analyses and by F1 tests. This study completes the systematic serological comparison of the haplotypes of the major histocompatibility complex of the rat described originally in the Ag-B and H-1 systems.</p>","PeriodicalId":76008,"journal":{"name":"Journal of immunogenetics","volume":"6 2","pages":"115-27"},"PeriodicalIF":0.0,"publicationDate":"1979-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1744-313x.1979.tb00336.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11695453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency distribution of histocompatibility-2 antigenic specificities in the Japanese wild mouse genetically remote from the European subspecies.","authors":"K Moriwaki,&nbsp;T Shiroishi,&nbsp;M Minezawa,&nbsp;T Aotsuka,&nbsp;K Kondo","doi":"10.1111/j.1744-313x.1979.tb00335.x","DOIUrl":"https://doi.org/10.1111/j.1744-313x.1979.tb00335.x","url":null,"abstract":"<p><p>Fifty-eight Japanese wild mice, Mus musculus molossinus, collected from twenty-eight localities were surveyed for twelve H-2 antigens using the haemagglutination method. Significantly higher frequencies of H-2.3 and H-2.5 specifities and relatively lower frequencies of the other public specificities were observed. This was confirmed by examining four specificities, H-2.3, 5, 13 and 23, in 370 mice. Quantitative absorption of the alloantisera by erythrocytes and spleen lymphocytes of molossinus mouse revealed definite absorption of H-2.3, 5 and 8 antigens, though their antigenic strength was apparently weaker than the controls, B10 congenic mice. Comparative assay of the strength of H-2.5 antigen in either homozygous and heterozygous conditions distinctly eliminated the possibility of gene-dose effect for the reduced strength of the public antigens in molossinus mouse. To explain this, divergence time between molossinus and domesticus was computed based on the allelic frequency data already reported on ten loci in both subspecies. It is roughly 1.5 x 10(6) years, which could allow for the occurrence of considerable genetic changes in many public antigens, except those conserved through selection.</p>","PeriodicalId":76008,"journal":{"name":"Journal of immunogenetics","volume":"6 2","pages":"99-113"},"PeriodicalIF":0.0,"publicationDate":"1979-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1744-313x.1979.tb00335.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11695341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genetics of an expanded secretor system.","authors":"W J Kimberling","doi":"10.1111/j.1744-313x.1979.tb00332.x","DOIUrl":"https://doi.org/10.1111/j.1744-313x.1979.tb00332.x","url":null,"abstract":"<p><p>The genetics of salivary secretion of ABH blood group substance was investigated. Eight secretor phenotypes were determined by Sephadex G-100 chromatography. Presence or absence of three different fractions were shown to be controlled by three different secretor gene loci. These loci are called Sec1, Sec2 and Sec3. Sec1 controls expression of the traditional secretor status. Sec2 and Sec3 are linked, but distinct, loci controlling the expression of low molecular weight ABH substance in human saliva. A dominant mode of inheritance for the Sec2 and Sec3 systems is described.</p>","PeriodicalId":76008,"journal":{"name":"Journal of immunogenetics","volume":"6 2","pages":"75-82"},"PeriodicalIF":0.0,"publicationDate":"1979-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1744-313x.1979.tb00332.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11311573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Absence of four H-2d antigenic specificites in an H-2d sarcoma.","authors":"F Garrido,&nbsp;M Perez,&nbsp;M D Torres","doi":"10.1111/j.1744-313x.1979.tb00333.x","DOIUrl":"https://doi.org/10.1111/j.1744-313x.1979.tb00333.x","url":null,"abstract":"<p><p>MCG4 is a BALB/c sarcoma induced as a solid tumour with 0.2 mgs of methylcholantrene. The primary tumour was serially transplanted subcutaneously in syngeneic mice. The ascites form obtained was sued to study the expression of H-2 antigeneic specificities in a postlabelling radioassay. MCG4 did not express H-2D.4 (private specificity of H-2d haplotypes) as well as H-2.3, H-2.8 and H-2.13 (public specificities). In addition it expressed H-2.5 (a public specificity not present in H-2d cells). These results were confirmed by quantitative absorption analysis using MCG4 and positive-negative normal lymphoid cells for a particular specificity. Results are discussed with regard to the control of expression of H-2 antigens by regulatory genes.</p>","PeriodicalId":76008,"journal":{"name":"Journal of immunogenetics","volume":"6 2","pages":"83-6"},"PeriodicalIF":0.0,"publicationDate":"1979-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1744-313x.1979.tb00333.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11311574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence for a possible major histocompatibility complex (BLA) in cattle.","authors":"R L Spooner,&nbsp;H Leveziel,&nbsp;F Grosclaude,&nbsp;R A Oliver,&nbsp;M Vaiman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76008,"journal":{"name":"Journal of immunogenetics","volume":"5 5","pages":"325-46"},"PeriodicalIF":0.0,"publicationDate":"1978-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11773569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Codominant inheritance of immune responsiveness.","authors":"T J Gill","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76008,"journal":{"name":"Journal of immunogenetics","volume":"5 3","pages":"213-4"},"PeriodicalIF":0.0,"publicationDate":"1978-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11890970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}