Journal of immunogenetics最新文献

Proceedings of the Second International Workshop and Symposium on Monoclonal Antibodies Against Human Red Blood Cells and Related Antigens. 1-4 April, 1990, Lund, Sweden. 第二届抗人红细胞及相关抗原单克隆抗体国际研讨会论文集。1990年4月1-4日，瑞典隆德。

Journal of immunogenetics Pub Date : 1990-08-01

引用次数: 0

Immunomagnetic techniques. Immunomagnetic技术。

Journal of immunogenetics Pub Date : 1989-04-01

引用次数: 0

Modulation of allotransplantation tolerance induction by interleukin-1 and interleukin-2. 白细胞介素-1和白细胞介素-2对异体移植耐受诱导的调节作用。

Journal of immunogenetics Pub Date : 1988-10-01

V Holán

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Symposium report: The Biological Significance of the Major Histocompatibility Complex. Sorrento, 15-19 April, 1986. 研讨会报告:主要组织相容性复合体的生物学意义。索伦托，1986年4月15日至19日。

Journal of immunogenetics Pub Date : 1987-02-01

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Bent-limb disease in lambs. Apparent transmission with an autosomal recessive gene linked to the OL-Z minor lymphocyte antigen locus and the I locus involved in the expression of R and O antigens in sheep. 羔羊的弯肢病。与OL-Z小淋巴细胞抗原位点和参与R和O抗原表达的I位点相关的常染色体隐性基因在绵羊中明显传播。

Journal of immunogenetics Pub Date : 1986-08-01

P Millot

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The Hb-2d cross-reactive idiotype. A common idiotype expressed by monoclonal and polyclonal antibodies to human haemoglobin. Hb-2d交叉反应独特型。一种由人血红蛋白单克隆和多克隆抗体表达的常见独特型。

Journal of immunogenetics Pub Date : 1985-12-01

T J Gorzynski, C J Krco, C S David

{"title":"The Hb-2d cross-reactive idiotype. A common idiotype expressed by monoclonal and polyclonal antibodies to human haemoglobin.","authors":"T J Gorzynski, C J Krco, C S David","doi":"","DOIUrl":"","url":null,"abstract":"Hb-2d is a monoclonal antibody of B10.D2 origin that is specific for the beta chain of human adult haemoglobin (HuHb-beta). Polyclonal anti-idiotypic sera to Hb-2d were produced in B10.D2, SJL/J and BALB/c mice. Using anti-idiotypic sera from SJL/J it was observed that Hb-2d expresses a cross-reactive idiotype (CRI) also found on both polyclonal and monoclonal antibodies to HuHb. Polyclonal antisera against HuHb-beta from H-2 congenic mice on the C57BL/10 (B10) background contained antibodies expressing the Hb-2d CRI; these antisera, however, contained little if any antibody to the antigenic determinant on HuHb-beta recognized by Hb-2d. Polyclonal antisera to HuHb-beta from the strains A.CA, A.SW, C3H.OL, BALB/cByJ, DBA/2 and SJL/J contained lower, but nevertheless detectable, amounts of antibody expressing the Hb-2d CRI. Unlike B10-H-2 congenic mice, antisera from the strains A.CA, A.SW and BALB/c bound to the same or a closely associated determinant as that recognized by Hb-2d. Two anti-HuHb monoclonal antibodies, Hb-48a and Hb-53a, both derived from B10-H-2 congenic mice, were shown to possess at least part of the Hb-2d idiotype. These antibodies are specific for epitopes on the human haemoglobin alpha chain (HuHb-alpha). It would appear, therefore, that Hb-2d possesses a CRI that is carried by antibodies to various antigenic determinants on HuHb. The linkage of these different antibodies by the CRI may allow for a common regulatory pathway.","PeriodicalId":76008,"journal":{"name":"Journal of immunogenetics","volume":"12 6","pages":"267-79"},"PeriodicalIF":0.0,"publicationDate":"1985-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13573279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potentialities of immunocompetent cells in high and low antibody-producing lines of mice obtained by selective breedings for responsiveness to flagellar or somatic antigens of Salmonellae. 对沙门氏菌鞭毛或体细胞抗原的选择性繁殖获得的高抗体和低抗体产生系的免疫活性细胞的潜力。

Journal of immunogenetics Pub Date : 1985-12-01

V Ferreira, M Gennari, M H Reis, M Siqueira, C Stiffel, D Mouton, G Biozzi

{"title":"Potentialities of immunocompetent cells in high and low antibody-producing lines of mice obtained by selective breedings for responsiveness to flagellar or somatic antigens of Salmonellae.","authors":"V Ferreira, M Gennari, M H Reis, M Siqueira, C Stiffel, D Mouton, G Biozzi","doi":"","DOIUrl":"","url":null,"abstract":"The genetic modifications of immunocompetent cell functions were investigated in high (H) and low (L) antibody responder lines of mice obtained by selective breeding for responsiveness to flagellar and somatic antigens of Salmonellae (Selection III and Selection IV, respectively). Several lines of evidence converge to demonstrate that the differences in antibody responses between the H and L lines of the two selections are not due to the modification of antigen handling by macrophages. This contrasts with previous observations that macrophages play a major role in interline differences in Selections I and II. The choice of antibody titres after secondary challenge as the phenotypic character in Selections III and IV may explain why the regulatory role of macrophages was minimized, compared with Selections I and II which were carried out for primary responses to heterologous erythrocytes. In Selections III and IV, H mouse lymphocytes were more efficient than L mouse lymphocytes in restoring immunoresponsiveness to irradiated hosts. In contrast, allogeneic skin grafts were rejected at a similar rate in L as well as in H mice of the two Selections and in vitro lymphoproliferative responses to T cell mitogens were also equivalent in the four lines.","PeriodicalId":76008,"journal":{"name":"Journal of immunogenetics","volume":"12 6","pages":"309-19"},"PeriodicalIF":0.0,"publicationDate":"1985-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14952037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A DNA restriction fragment length polymorphism in the complement region of the human MHC shows an absolute correlation with polymorphism of complement factor B(Bf) defined by isoelectric focusing. 人MHC补体区DNA限制性片段长度多态性与等电聚焦定义的补体因子B(Bf)多态性具有绝对相关性。

Journal of immunogenetics Pub Date : 1985-12-01

D Fathallah, M Abbal, M Thomsen, A Cambon-Thomsen, R D Campbell

{"title":"A DNA restriction fragment length polymorphism in the complement region of the human MHC shows an absolute correlation with polymorphism of complement factor B(Bf) defined by isoelectric focusing.","authors":"D Fathallah, M Abbal, M Thomsen, A Cambon-Thomsen, R D Campbell","doi":"","DOIUrl":"","url":null,"abstract":"The gene coding for properdin factor Bf is located in the human major histocompatibility complex and is closely linked to the genes coding for the complement components C2 and C4. Recently, by Southern blotting techniques, a restriction fragment length polymorphism was identified using the endonuclease Taq I, which subdivides haplotypes carrying the F allele of factor Bf. The F allotype has also been subdivided at the protein level by isoelectric focusing into two subtypes Fa and Fb. We have investigated the DNA of 41 healthy unrelated individuals with known BfF subtypes using the 2.3 kb factor Bf cDNA probe to determine if there is any correlation between the Taq I polymorphism and F subtype. We have found that in 23 individuals who carried the Fb subtype a 6.6 kb Taq I fragment was present. The remaining 18 individuals carried the Fa subtype and showed only the 4.5 kb Taq I fragment on Southern blotting (P = 10(-12). This striking correlation (r = 1) between the Fb protein and DNA polymorphism is surprising especially as the 4.5 kb and 6.6 kb Taq I fragments overlap the Bf and C2 genes and the polymorphic Taq I site is located within the C2 gene.","PeriodicalId":76008,"journal":{"name":"Journal of immunogenetics","volume":"12 6","pages":"321-6"},"PeriodicalIF":0.0,"publicationDate":"1985-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14150251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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An idiotope expressed on a monoclonal antibody specific for human haemoglobin beta chain and naturally occurring immunoglobulin(s). 一种表达于人类血红蛋白β链和自然产生的免疫球蛋白特异性单克隆抗体上的独特体。

Journal of immunogenetics Pub Date : 1985-12-01

T J Gorzynski, C J Krco, C S David

{"title":"An idiotope expressed on a monoclonal antibody specific for human haemoglobin beta chain and naturally occurring immunoglobulin(s).","authors":"T J Gorzynski, C J Krco, C S David","doi":"","DOIUrl":"","url":null,"abstract":"HId-1A (gamma 1:kappa), HId-2a (mu:kappa) and HId-4a (gamma 1:kappa) monoclonal anti-idiotopes of BALB/c origin were induced by the human haemoglobin-reactive, B10.D2-derived monoclonal antibody Hb-2d. HId-1a and HId-4a seem to react with the same idiotope and may, in fact, be encoded by the same V, D and J genes. HId-2a, on the other hand, seems to react with an idiotope different from that recognized by the other two anti-Id's and present in the sera of non-immune B10-H-2 congenic mice. HId-2a, but not HId-1a or HId-4a, may react with an idiotope in or near the antigen binding site of Hb-2d. Naturally occurring immunoglobulin carrying the HId-2a idiotope was affinity-purified from the pooled sera of B10-H-2 congenic mice and partially characterized. It possesses primarily the gamma 2b heavy chain, but small amounts of gamma 1, gamma 2a and mu heavy chains are also detectable. The kappa and lambda 1 light chains are both present in significant amounts. In addition, the affinity-purified immunoglobulin is unreactive with human haemoglobin, is not a rheumatoid factor and does not express in detectable amounts the idiotope recognized by HId-1a and HId-4a. It is possible that all or some part of this polyclonal reagent is specific for antigens normally present in the environment.","PeriodicalId":76008,"journal":{"name":"Journal of immunogenetics","volume":"12 6","pages":"281-91"},"PeriodicalIF":0.0,"publicationDate":"1985-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14952036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Can genetic polymorphism of alpha-2-macroglobulin be detected by immunoelectrophoresis? A study using sera, plasma and joint fluids from patients with rheumatoid arthritis and controls. 免疫电泳能检测α -2巨球蛋白的遗传多态性吗?一项使用类风湿关节炎患者和对照组的血清、血浆和关节液的研究。

Journal of immunogenetics Pub Date : 1985-12-01

C S Dott, A Howard

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