Journal of immunogenetics最新文献_第2页

Identification of anti-DQ alloantisera correlated with DR5. 与DR5相关的抗dq异体抗血清的鉴定。

Journal of immunogenetics Pub Date : 1985-12-01

T Crepaldi, M E Fasano, C Frattasio, D Centis, E S Curtoni, P Richiardi

引用次数: 0

Regulatory function of Thy-1-negative cells: V. A lymphokine of B cell origin (BEF) induces in vitro high antibody response in genetically selected low responder mice. y-1阴性细胞的调节功能:V. B细胞来源的A淋巴因子(BEF)在基因选择的低应答小鼠中诱导体外高抗体应答。

Journal of immunogenetics Pub Date : 1985-02-01

P del Guercio, D Mouton, M F del Guercio, G Biozzi

{"title":"Regulatory function of Thy-1-negative cells: V. A lymphokine of B cell origin (BEF) induces in vitro high antibody response in genetically selected low responder mice.","authors":"P del Guercio, D Mouton, M F del Guercio, G Biozzi","doi":"","DOIUrl":"","url":null,"abstract":"Studies were conducted on two lines of mice genetically selected, respectively, for high (AB/H) and low (AB/L) antibody production, in order to identify the mechanism by which genes involved in the selection express their functions. It was found that B cell-derived enhancing factor (BEF), a lymphokine of B cell origin which acts on T cells by preventing the activation of suppressor cells, is effective in inducing high responses in low responder mice, whereas it is ineffective in modulating antibody production in high responder mice. As a result, no difference was found between the responses of AB/H and AB/L mice when spleen cells were stimulated in vitro in the presence of BEF. AB/H and AB/L mice do not seem to differ in their B cell functions since no difference was found in the capacity of B cells of either line to synthesize antibodies in the presence of T cell-replacing factor (TRF), or to produce endogenous BEF. These data indicate that, at least in vitro, the character of general responsiveness of these two mouse lines mainly reflects differential reactivity of T suppressor cells. Since the two lines represent, respectively, the maximal and minimal responsiveness of an outbred population of animals, it is suggested that the individual difference in antibody response is related to individual differences of T suppressor cells in responding to the immunogen.","PeriodicalId":76008,"journal":{"name":"Journal of immunogenetics","volume":"12 1","pages":"45-53"},"PeriodicalIF":0.0,"publicationDate":"1985-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14068181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serological analysis of H-2 mutations using monoclonal antibodies. 单克隆抗体对H-2突变的血清学分析。

Journal of immunogenetics Pub Date : 1984-06-01

J A Bluestone, I F McKenzie, R W Melvold, K Ozato, M S Sandrin, S O Sharrow, D H Sachs

引用次数: 0

Antigen binding to lymphoid cells of unimmunized mice. V. Use of pure in vitro colony-derived cell populations in studies of the identification and clonal distribution of multiple antigen-binding cells. 未免疫小鼠淋巴样细胞的抗原结合。V.在多种抗原结合细胞的鉴定和克隆分布研究中使用纯体外集落来源的细胞群。

Journal of immunogenetics Pub Date : 1984-02-01

D DeLuca

{"title":"Antigen binding to lymphoid cells of unimmunized mice. V. Use of pure in vitro colony-derived cell populations in studies of the identification and clonal distribution of multiple antigen-binding cells.","authors":"D DeLuca","doi":"","DOIUrl":"","url":null,"abstract":"In order to determine the cell type responsible for the antigen-binding reaction in the bone marrow and spleen of mice, cells derived from pure in vitro derived colonies of neutrophils, eosinophils, macrophage-megakaryocytes and B lymphocytes were tested for their ability to bind fluorescent protein antigens. Only B lymphocytes bound antigen. An unexpectedly high percentage of bone marrow B lymphocytes (20%) bound a given antigen. This frequency was considerably higher than that found for spleen cells. As might be expected from such high binding frequencies, some cells bound two fluorchromated antigens when these are added together. As a direct test of the clonality of antigen binding to bone marrow B lymphocytes, whole colonies of B cells were tested for antigen binding of two non-cross-reacting protein antigens. The frequency of antigen-binding clones, including double antigen-binding clones, reflects exactly the frequencies observed for dispersed colony B cells and for in vivo derived Ig-bearing bone marrow B cells. The frequency of double antigen-binding colonies was equal to the product of the frequencies of the colonies binding each of the two antigens alone. No 'mixed' colonies containing single binding cells for each antigen were found. Thus, the ability to bind any two given antigens is a clonally distributed property of the bone marrow B lymphocyte population. Heterogenous receptors for multiple antigen binding on each cell are either randomly distributed among the B cell population, or homogenous antigen-binding receptors on each cell have a random chance of cross-reaction with the two antigens tested.","PeriodicalId":76008,"journal":{"name":"Journal of immunogenetics","volume":"11 1","pages":"45-62"},"PeriodicalIF":0.0,"publicationDate":"1984-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17664268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GM, AM, PI and KM markers in mesangial IGA glomerulonephritis. 系膜IGA肾小球肾炎的GM、AM、PI和KM标志物。

Journal of immunogenetics Pub Date : 1981-10-01

J C Le Petit, E Van Loghem, G De Lange, F C Berthoux, C Chapuis-Cellier, J L Serre

引用次数: 0

A statistical analysis of human lymphocyte transformation data. 人淋巴细胞转化数据的统计分析。

Journal of immunogenetics Pub Date : 1979-06-01 DOI: 10.1111/j.1744-313x.1979.tb00344.x

B M Harina, T J Gill, B S Rabin, F H Taylor

{"title":"A statistical analysis of human lymphocyte transformation data.","authors":"B M Harina, T J Gill, B S Rabin, F H Taylor","doi":"10.1111/j.1744-313x.1979.tb00344.x","DOIUrl":"https://doi.org/10.1111/j.1744-313x.1979.tb00344.x","url":null,"abstract":"The lymphocytes from 107 maternal-foetal pairs were examined for their in vitro responsiveness, as determined by the incorporation of tritiated thymidine following stimulation with phytohaemagglutinin (PHA), candida, varicella, mumps, streptokinase-streptodornase (SKSD) and tetanus toxoid. The data were collected and analysed in two sequential groups (forty-seven and sixty) in order to determine whether the results were reproducible. The variable chosen for analysis was the difference (d) between the square roots of the isotope incorporation in the stimulated and control cultures because it gave the most symmetrical distribution of the data. The experimental error in the determination of maternal lymphocyte stimulation was 1.4--8.6% and of the foetal lymphocytes, 1.0--16.6%, depending upon the antigen or mitogen and its concentration. The data in the two sets of patients were statistically the same in forty-eight of the fifty-six analyses (fourteen antigen or mitogen concentrations in autologous and AB plasma for maternal and foetal lymphocytes). The statistical limits of the distribution of responses for stimulation or suppression were set by an analysis of variance taking two standard deviations from the mean as the limits. When these limits were translated into stimulation indices, they varied for each antigen or mitogen and for different concentrations of the same antigen. Thus, a detailed statistical analysis of a large volume of lymphocyte transformation data indicates that the technique is reproducible and offers a reliable method for determing when significant differences from control values are present.","PeriodicalId":76008,"journal":{"name":"Journal of immunogenetics","volume":"6 3","pages":"185-96"},"PeriodicalIF":0.0,"publicationDate":"1979-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1744-313x.1979.tb00344.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11684349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Genetic factors in spontaneous autoimmune thyroiditis in OS chickens. OS鸡自发性自身免疫性甲状腺炎的遗传因素。

Journal of immunogenetics Pub Date : 1979-06-01 DOI: 10.1111/j.1744-313x.1979.tb00343.x

G Wick, R Gundolf, K Hála

引用次数: 30

H-2 linked immune response to murine experimental Schistosoma mansoni infections. 小鼠实验曼氏血吸虫感染的H-2相关免疫反应。

Journal of immunogenetics Pub Date : 1979-06-01 DOI: 10.1111/j.1744-313x.1979.tb00342.x

F H Claas, A M Deelder

引用次数: 44

The H-2 histocompatibility system and lymphocyte adhesion: interaction modulation factor involvement. H-2组织相容性系统与淋巴细胞粘附:相互作用调节因子的参与。

Journal of immunogenetics Pub Date : 1979-06-01 DOI: 10.1111/j.1744-313x.1979.tb00341.x

A S Curtis

{"title":"The H-2 histocompatibility system and lymphocyte adhesion: interaction modulation factor involvement.","authors":"A S Curtis","doi":"10.1111/j.1744-313x.1979.tb00341.x","DOIUrl":"https://doi.org/10.1111/j.1744-313x.1979.tb00341.x","url":null,"abstract":"The effects of thymocyte interaction modulation factor on the adhesion of mouse allogeneic thymocytes and B-cells are reported. This glycoprotein, produced by short term cultures of thymocytes, has already been described as reducing the adhesion of syngeneic B-cells, leucocytes and macrophages. Adhesion was measured in suspension culture using the collision efficiency method. This paper reports that: 1. In addition to the syngeneic effect of thymocyte IMF in reducing adhesion of certain unlike cell types there is also an allogeneic effect in which an allogeneic T-IMF will diminish the adhesion of a thymocyte population, or still further reduce the adhesion of a B-cell population than would a syngeneic T-IMF. 2. Thymocyte IMFs were prepared from different congenic strains and tested on the adhesion of syngeneic and allogeneic thymocytes. When factor and cells were syngeneic or matched at any H-2 locus except H-2 D there was no effect on adhesion since it remained at the same value as in controls in their own IMF. But whenever factor and cells were mismatched at H-2 D there was a marked diminution in the adhesion of the cells. 3. Antibodies raised against specific thymocyte IMFs could be used to detect the presence of T-IMF binding to the surface of cells by immunofluorescence or immune cytolysis. These systems show that the antibodies against thymocyte IMF can be used to type the H-2 D type of a cell and that these factors are present at the surface of thymocytes and certain other cell types. They confirm that the thymocyte IMF is either in H-2 D product or is closely associated with H-2 D locus in its binding and action. They also show that the T-IMF antigen on non-lymphocytic types is produced by T-cells or thymocytes. 4. The general relevance of these results is discussed in relation to cell recognition phenomena.","PeriodicalId":76008,"journal":{"name":"Journal of immunogenetics","volume":"6 3","pages":"155-66"},"PeriodicalIF":0.0,"publicationDate":"1979-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1744-313x.1979.tb00341.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11592734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Probable EnaEn heterozygotes in two British families. 两个英国家庭可能存在EnaEn杂合子。

Journal of immunogenetics Pub Date : 1979-06-01 DOI: 10.1111/j.1744-313x.1979.tb00340.x

G Inglis, D J Anstee, C M Giles, M J Tanner, R Mitchell

引用次数: 5