Journal of human nutrition最新文献

{"title":"The Phytonutrients and Cytotoxicity Evaluation of Cinnamon Impressicostatum as Potential Antioxidant and Antibacterial in Food Supplement","authors":"Buru Ayuba Sunday, Mak Kit-Kay, Mohandas Kavitha, N. Vasanthakumari, Pichika Mallikarjuna Rao","doi":"10.36959/487/294","DOIUrl":"https://doi.org/10.36959/487/294","url":null,"abstract":"","PeriodicalId":76005,"journal":{"name":"Journal of human nutrition","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45333202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Genetic Ablation of TNF-α Attenuates Wnt-Signaling and Adiposity in High Fat Diet-Induced Obese Mice","authors":"Li Jinchao, K. Susan, Yu Seok-Yeong, Tang Ying, Kim Young-Cheul, Chung Soonkyu, L. Zhenhua","doi":"10.36959/487/290","DOIUrl":"https://doi.org/10.36959/487/290","url":null,"abstract":"A chronic low-grade inflammation is considered as a consequence of obesity, and linked with multiple complications. However, it is under-investigated how inflammatory cytokines mediate adipogenesis. This study investigated the role of Tumor Necrosis Factor α (TNF-α) on adipogenes is over high-fat diet feeding. Three groups of wild type or TNF-α-/mice with the same C57BL/6 genetic background were utilized in this study: wild type fed with a low-fat diet (WT-LFD), wild type fed with a high-fat diet (WT-HFD), and TNF-α-/fed with a HFD (TNF-HFD). After 16-wk feeding, inflammatory cytokine, Wnt pathway and adipogenesis-related genes were analyzed. HFD feeding increased body weight in both WTHFD and TNF-HFD groups, but genetic ablation of TNF-α attenuated HFD-induced obesity. In visceral adipose tissues, HFD elevated Wnt/β-catenin signaling, indicated by decreased phospho-GSK3β and active β-catenin, two key components within the Wnt pathway, and dysregulated adipogenesis, indicated by reduced PPARγ/CEBPα expressions. Whereas, the deletion of TNF-α suppressed Wnt-signaling, and restored expressions of adipogenes is-related genes, which were otherwise decreased in the HFD-induced obese animals. These findings demonstrated a critical role of TNF-α in the regulation of Wnt-signaling and adiposity in mice over a HFD feeding, indicating HFD-induced adipocyte dysfunction could be mitigated by targeting TNF-α and Wnt-signaling.","PeriodicalId":76005,"journal":{"name":"Journal of human nutrition","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49439935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perbaikan Respon Glisemik dan Profil Lipid Setelah Mengkonsumsi Tepung Pisang Mentah Termodifikasi","authors":"Firda Yusrina, Rani Puspitasari, T. Widyaningsih, Siti Narsito Wulan","doi":"10.21776/UB.IJHN.2020.007.02.2","DOIUrl":"https://doi.org/10.21776/UB.IJHN.2020.007.02.2","url":null,"abstract":"ABSTRAK Prevalensi diabetes militus meningkat setiap tahunnya. Pisang mentah berpotensi sebagai pangan pengontrol gula darah karena mengandung  pektin dan pati resisten (RS2). Kandungan pati resisten pada pisang dapat ditingkatkan dengan metode modifikasi fisik melalui proses perebusan dan pendinginan berulang untuk meningkatkan sifat resistensi pati termodifikasi (RS3) yang tahan terhadap suhu tinggi selama pemasakan. Tujuan penelitian ini untuk mengetahui pengaruh efek konsumsi tepung pisang mentah termodifikasi secara fisik (RS3) dibanding dengan tepung tanpa modifikasi tepung pisang mentah (RS2) dan pati jagung sebagai pati kontrol. Tikus dikelompokkan secara acak menjadi 3 group: kelompok 1 adalah kelompok pakan standart berdasarkan rekomendasi AIN-93 M yang mengandung pati jagung (kontrol).  Tetapi kasein diganti menggunakan susu skim; kelompok 2 adalah kelompok  pakan  tepung pisang tidak dimodifikasi (RS2) dan kelompok 3 adalah kelompok pakan  tepung pisang mentah modifikasi (RS3) sebagai pengganti pati jagung. Semua pakan diformulasi secara isokalori dan isoprotein. Pakan diberikan selama 15 hari. Hasil penelitian menunjukkan bahwa, pemberian pakan menggunakan tepung pisang modifikasi (RS3) cenderung menghasilkan kadar glukosa darah yang lebih rendah (P<0,05), kadar HDL lebih tinggi (P,0.05), kadar trigliserida darah lebih rendah (P,0.05).  Nilai  respon glikemik lebih rendah (P<0.05) dengan nilai  AUC (daerah dibawah kurva) yang lebih rendah setelah meal tolerance test. Kata kunci : Diabetes Militus, Pati Resisten, Pengendalian Glukosa Darah, Pisang Mentah ABSTRACT The prevalence of diabetes mellitus increases every year. Unripe plantains have a potential as food that controls blood sugar due to their pectin and resistant starch (RS2) content. The content of resistant starch in plantains can be elevated by a physical modification method through a repeated boiling-cooling process to produce a more heat-stable resistant starch (RS3). The study aimed to determine the effect of consuming physically modified unripe plantain flour (RS3) compared with unmodified unripe plantain flour (RS2) and standard corn starch as control. Rats were randomly assigned into three groups; group 1 given a standard diet based on AIN-93M diet recommendation containing corn starch but the casein was replaced by skim milk powder, group 2 given unmodified unripe plantain flour (RS2), and group 3 given physically modified unripe plantain flour (RS3) as a substitute for corn starch. All diets were formulated as isocaloric and isoprotein. Diet interventions were provided for 15 days. The results showed that modified banana flour (RS3) feed tended to have lower blood glucose level (P <0.05), higher HDL level (P <0.05), lower blood triglyceride level (P <0.05), and lower glycemic response (P<0.05) indicated by a lower score of the area under the curve (AUC) following the meal tolerance test. Keywords: diabetes mellitus, resistant starch, blood glucose control, unripe pla","PeriodicalId":76005,"journal":{"name":"Journal of human nutrition","volume":"7 1","pages":"92-107"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43142959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lime (Citrus aurantifolia (Christm.) Swingle) Juice Potential on Preventing Lipid Profile Aberrations as Alternative to Lemon (Citrus limon (L.) Burm.f.) Juice","authors":"Olivia Anggraeny, Keshya Venesa, N. Magdalena, Stefany Dame, Sylvia Winnie, Stephani Nesya, Nurdiana","doi":"10.21776/UB.IJHN.2020.007.02.7","DOIUrl":"https://doi.org/10.21776/UB.IJHN.2020.007.02.7","url":null,"abstract":"ABSTRAK Hiperlipidemia merupakan penyebab dari berbagai penyakit degeneratif. Mengonsumsi air perasan lemon menjadi tren di Indonesia beberapa tahun ini. Pada penelitian ini, dilakukan perbandingan efektivitas air perasan lemon dan jeruk nipis. Tujuan dari penelitian ini adalah untuk menganalisis perbedaan profil lemak darah: kolesterol total, low density lipid (LDL), very low density lipoprotein (VLDL), dan trigliserida (TG) pada tikus yang diberi diet tinggi lemak, air perasan lemon, dan jeruk nipis. Penelitian ini menggunakan 32 tikus jantan galur Wistar yang dibagi menjadi 8 kelompok dosis perlakuan air perasan lemon dan jeruk nipis. Didapatkan hasil bahwa tidak ada perbedaan kadar LDL (P0.151; p<0.05), VLDL (P0.187; p<0.05), TG (P0.216; p<0.05), namun ditemukan perbedaan signifikan pada kadar kolesterol total (P0.003; p<0.05). Hewan coba yang diberi perlakuan jeruk nipis memiliki sebagian besar rerata kadar lemak yang tidak berbeda signifikan dengan kelompok perlakuan lemon. Meskipun demikian, kolesterol total pada kelompok jeruk nipis lebih rendah dibandingkan kelompok lemon. Konsumsi jeruk nipis tampaknya memiliki kemungkinan menjadi alternatif dari lemon yang lebih murah dan terjangkau untuk mencegah profil lemak yang buruk.  Kata kunci : lemon, jeruk nipis, kolesterol total, LDL, VLDL, TG ABSTRACT Hyperlipidemia causes various degenerative diseases. Recently, consuming lemon juice has become a trend in Indonesia to improve blood lipid profiles. This study compared the effectiveness of lemon juice and lime juice. This study aimed to determine differences in blood lipid profile that contains total cholesterol (TC), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and triglycerides (TG) in rats given High Fat Diet (HFD), lemon juice, and lime juice. This study used 32 white male Wistar rats (Rattus norvegicus) divided into eight treatment groups of lemon and lime juice doses. The results showed no significant differences in LDL (P0.151; p<0.05), VLDL (P0.187; p<0.05), and TG (P0.216; p<0.05), but there were significant differences in total cholesterol levels (P0.003; p<0.05). The experimental animals receiving lime juice had mean scores of lipid levels that were not significantly different from those with lemon treatment. However, the total cholesterol levels among groups given lime juice showed lower levels than the control and lemon treatment groups. Lime consumption seems possible to be a cheaper and affordable alternative to lemon to prevent lipid profile aberrations. Keywords: lemon, lime, TC, LDL, VLDL, TG","PeriodicalId":76005,"journal":{"name":"Journal of human nutrition","volume":"7 1","pages":"153-163"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42300517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pengaruh Pemberian Cookies Galohgor terhadap Tingkat Kecukupan dan Status Gizi Bayi","authors":"Almira Nuraelah, Katrin Roosita, I. Ekayanti","doi":"10.21776/ub.ijhn.2020.007.01.5","DOIUrl":"https://doi.org/10.21776/ub.ijhn.2020.007.01.5","url":null,"abstract":"Abstrak Air susu ibu (ASI) memiliki banyak manfaat dan dapat memenuhi kebutuhan gizi bayi selama periode 6 bulan pertama kehidupan. Produksi ASI pada ibu menyusui dapat ditingkatkan antara lain dengan konsumsi pangan laktogogum. Tujuan penelitian ini adalah mengetahui pengaruh pemberian cookies Galohgor yang mengandung laktagogum terhadap tingkat kecukupan dan status gizi bayi. Penelitian merupakan studi quasi eksperimental. Subjek penelitian merupakan 20 orang ibu postpartum di Kota Bogor. Subjek yang terpilih dikelompokkan menjadi kelompok kontrol (n=11) yang diberikan 40 g cookies tanpa penambahan galohgor dan kelompok cookies galohgor yang diberikan 40 g cookies yang mengandung galohgor selama 14 hari. Hasil penelitian menunjukkan bahwa tingkat kecukupan karbohidrat pada kelompok cookies galohgor lebih besar secara signifikan dibandingkan kelompok kontrol (124,9±32,6% vs. 90,8±31,1%, p 0,05). Sementara itu, hasil penelitian menunjukkan bb/u bayi pada kelompok galohgor secara signifikan lebih besar dibandingkan kelompok kontrol (3415,5±487,9 g vs. 3190±292,8 g, p<0,05). Hasil penelitian menunjukkan bahwa pemberian cookies galohgor berpengaruh terhadap tingkat kecukupan energi dan karbohidrat serta peningkatan berat bayi menurut umur. Kata kunci : berat badan bayi, lactagogum, galohgor, ibu postpartum, tingkat kecukupan bayi Abstract Breast milk has many benefits and fulfills the nutritional needs of infants in the first six months of life. Breast milk production of nursing mother could be boosted by consuming lactagogue. This study aimed to analyze the effect of Galohgor lactagogue cookies (GC) on nutrients adequacy level and nutritional status of infants. A quasi-experiment design was used in this study. Subjects of this study were 20 postpartum mothers in Bogor, West Java. The subjects were grouped into a control group (n = 11) given 40 g of cookies without galohgor and a galohgor cookies group given 40 g cookies containing galohgor for 14 days. The result showed that carbohydrate adequacy level of the galohgor cookies group was significantly higher than that in the control group (124.9 ± 32.6% vs 90.8 ± 31.1%, p<0.05). The results showed that weight-for-age was significantly associated with energy and carbohydrate adequacy levels of infants. The results showed that infant weight-for-age in the galohgor cookies group was significantly higher compared to that in the control group (3415.5 ± 487.9 g vs 3190 ± 292.8 g, p<0.05). These results suggested that galohgor cookies has a beneficial effect on energy intake and carbohydrate sufficiency and improve the weight-for-age of the infant. Keywords: nutrient adequacy, lactagogue, galohgor, postpartum mothers, weight for age","PeriodicalId":76005,"journal":{"name":"Journal of human nutrition","volume":"7 1","pages":"44-53"},"PeriodicalIF":0.0,"publicationDate":"2020-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44655529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pengaruh Pemberian Yoghurt dan Soyghurt terhadap Konsistensi Feses Pasien Penyakit Ginjal Kronis dengan Hemodialisis","authors":"Enik Guntiyastutik, S. Sugiarto, Adi Magna Patriadi Nuhrawangsa","doi":"10.21776/ub.ijhn.2020.007.01.1","DOIUrl":"https://doi.org/10.21776/ub.ijhn.2020.007.01.1","url":null,"abstract":"Abstrak Peningkatan kadar urea darah pada pasien penyakit ginjal kronis (PGK) dapat menyebabkan terjadinya disbiosis mikrobiota usus yang ditandai dengan penurunan bakteri sakarolitik dan peningkatan bakteri proteolitik yang menyebabkan semakin lamanya waktu transit feses dan terjadinya konstipasi. Penelitian ini bertujuan untuk menganalisis pengaruh pemberian yoghurt dan soyghurt terhadap konsistensi feses pasien PGK dengan hemodialisis. Rancangan penelitian yang digunakan dalam penelitian ini adalah randomized control trial . Penelitian menggunakan 3 kelompok yaitu kontrol, intervensi yoghurt dan intervensi soyghurt. Subjek penelitian adalah 34 orang pasien PGK dengan hemodialisis, dengan kriteria inklusi: PGK stage 5, laki laki dan perempuan, usia 40-60 tahun, tidak mendapatkan terapi antibiotika selama minimal 21 hari, dan menjalani hemodialisis 2x/minggu. Data yang diperiksa dari responden adalah konsistensi feses pada awal dan akhir intervensi dengan menggunakan Bristol Tool Scale . Data ditabulasi dan dianalisis menggunakan Kruskall-Wallis dan Wilcoxon dengan SPSS for Windows. Pemberian yoghurt dan soyghurt selama 30 hari pada pasien PGK dengan hemodialisis  melunakkan konsistensi feses secara bermakna, tetapi tidak ada perbedaan yang bermakna antara pemberian yoghurt dan soyghurt terhadap perubahan konsistensi feses. Sehingga dapat disimpulkan pemberian yoghurt atau soyghurt sama-sama memberikan efek terhadap perubahan konsistensi feses pasien PGK dengan hemodialisis. Kata kunci : penyakit ginjal kronis, hemodialisis, yoghurt, soyghurt Abstract The increase of blood urea level in patients with Chronic Kidney Disease (CKD) may lead to gut microbiota dysbiosis indicated by saccholytic bacteria reduction and proteolytic bacteria addition, which causes a longer transit time of feces and constipation. This study aimed to analyze the effect of yoghurt and soyghurt administration on the fecal consistency in CKD patients with hemodialysis. This study used Randomized Control Trial design. The study used three groups, namely control, yoghurt intervention, and soyghurt intervention. The research subjects were 31 patients with CKD who underwent hemodialysis at RSUD dr. Saiful Anwar Malang under the following criteria: stage five of CKD, male or female, aged 40-60 years, did not get antibiotic therapy for 21 days, and underwent hemodialysis 2 times/week. Data examined from respondents were the consistency of feces at the beginning and the end of the intervention used B ristol Tool S cale . Data were tabulated and analyzed using Kruskal-Wallis dan Wilcoxon test with SPSS for Windows. Administration of yoghurt and soyghurt for 30 days in CKD patients improved the fecal consistency of CKD patients with hemodialysis to be softer. In conclusion, both yoghurt and soyghurt could give the same effect on the fecal consistency of CKD patients with hemodialysis. Keywords: Chronic Kidney Disease, hemodialysis, yoghurt, soyghurt","PeriodicalId":76005,"journal":{"name":"Journal of human nutrition","volume":"7 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2020-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48548008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potensi Labu Kuning (Cucurbita moschata) sebagai Makanan Tinggi Serat dalam Bentuk Cair","authors":"Hanna Nurjanah, Budi Setiawan, Katrin Roosita","doi":"10.21776/ub.ijhn.2020.007.01.6","DOIUrl":"https://doi.org/10.21776/ub.ijhn.2020.007.01.6","url":null,"abstract":"Abstrak Kelompok pra lansia dan lansia merupakan penderita diabetes terbanyak di Indonesia. Proses penuaan dapat menyebabkan kesulitan dalam proses makan. Modifikasi makanan menjadi bentuk cair membuat makanan lebih mudah untuk ditelan. Makanan tinggi serat direkomendasikan untuk penderita diabetes karena dapat meningkatkan kontrol glukosa darah. Labu kuning merupakan pangan sumber serat yang dimungkinkan dapat membantu menurunkan risiko perkembangan penyakit diabetes. Tujuan penelitian adalah membuat tepung labu kuning, mengembangkan formula makanan dalam bentuk cair dengan bahan dasar labu kuning, mengetahui karakteristik organoleptik, mutu gizi, dan viskositas formula. Penelitian ini menggunakan rancangan acak lengkap. Penyusunan formula berdasarkan jumlah tepung labu kuning, terdiri dari tiga formula yaitu F1(70 g), F2 (80 g), and F3 (90 g). Pengujian karakteristik organoleptik menggunakan skala hedonik. Panelis yang digunakan merupakan panelis semi terlatih. Kadar air, abu, protein, lemak, dan karbohidrat menggunakan analisis proksimat, kadar serat pangan menggunakan metode enzimatis dan viskositas menggunakan viskometer. Hasil penilaian hedonik menunjukkan bahwa formula F3 merupakan formula terpilih. Formula terpilih memiliki kadar air 86,06%, abu 0,49%, protein 1,42%, lemak 1,18%, karbohidrat 10,85%, serat pangan 5,81%, dan viskositas 6,5 cP. Formula labu kuning berpotensi sebagai makanan alternatif untuk penderita diabetes karena memiliki serat tinggi. Kata kunci : diabetes, makanan bentuk cair, serat pangan, tepung labu kuning Abstract The highest diabetic population in Indonesia are among the pre-elderly and elderly age groups. Aging process could cause difficulties in eating. Modifying food into the liquid form will make food easier to swallow. High-fiber food is recommended for people with diabetes because it improves blood glucose control. Pumpkin is a food source rich in fiber that is possible to help to reduce the risk of diabetes development. This research aimed to produce pumpkin flour, develop a food formula in liquid form made from pumpkin, and determine the organoleptic characteristics, nutrition content, and viscosity of the formula. This study used a complete randomized design. The formulation was based on the amount of pumpkin flour that consists of three formulas; F1(70 g), F2 (80 g), and F3 (90 g). The organoleptic characteristic test was done using a hedonic scale. The panelists involved were semi-trained panelists. The analysis on water, ash, protein, lipid and carbohydrate levels was done using proximate analysis, the dietary fiber level was using the enzymatic method, and viscosity measurement was using a viscometer. According to hedonic assessment results, the selected formula was F3. The selected formula has 86.06% water, 0.49% ash, 1.42% protein, 1.18% fat, 10.85% carbohydrate, 5.81% dietary fiber, and 6.5 cP of viscosity. Yellow pumpkin formula has the potency as the alternative food for people with diabetes becau","PeriodicalId":76005,"journal":{"name":"Journal of human nutrition","volume":"7 1","pages":"54-68"},"PeriodicalIF":0.0,"publicationDate":"2020-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49342453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Household Food Insecurity and Nutritional Status of Under-Five Children and Women of Reproductive Age from Pond Fish Farming Households in Sidama Zone, Southern Ethiopia: Community Based Cross-Sectional Study","authors":"Y. Kifle","doi":"10.36959/487/289","DOIUrl":"https://doi.org/10.36959/487/289","url":null,"abstract":"Food insecurity is defined as situation that exists when all people, at all times, have no physical, social and economic access to sufficient, safe and nutritious food that meets their dietary needs and food preferences for an active and healthy life. Fish farming plays an important role in food security and nutrition by providing food and income. The aim of this study was to assess household food insecurity status and nutritional status of under-five children and women of reproductive age from pond fish farming households in Sidama Zone, Southern Ethiopia.","PeriodicalId":76005,"journal":{"name":"Journal of human nutrition","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43944180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potensi Ekstrak Etanol Biji Cucurbita moschata terhadap Kadar Malondehaldehid Mencit Model Diabetes","authors":"Suwanto Suwanto, Mono Pratiko Gustomi, Rochmah Kurnijasanti","doi":"10.21776/ub.ijhn.2020.007.01.3","DOIUrl":"https://doi.org/10.21776/ub.ijhn.2020.007.01.3","url":null,"abstract":"Abstrak Kebutuhan akan kesehatan diharapkan pada semua orang, namun kesehatan harus perlu dijaga agar tidak terpapar adanya radikal bebas yang berlebihan, karena akan memicu timbulnya penyakit diabetes mellitus disertai adanya peningkatan kadar malondehaldehid. Pencegahan radikal bebas yang berlebihan dapat memanfaatkan biji Cucurbita moschata . Antioksidan pada biji Cucurbita moschata berperan dalam mengatasi dan mencegah adanya stres oksidatif pada penderita diabetes mellitus. Penelitian bertujuan untuk mengetahui potensi ekstrak etanol biji Cucurbita moschata terhadap kadar malondehaldehid mencit model diabetes. Metode penelitian eksperimental dengan desain post test control group design , mencit jantan sebanyak 24 ekor umur 1 bulan dengan berat badan 20-30 gram, dibagi menjadi 6 kelompok: kontrol negatif, kontrol positif, kontrol metformin, dan  kelompok perlakuan ekstrak etanol biji Cucurbita moschata dosis 180, 360 dan 720 mg/kg BB diberikan secara sonde oral selama 14 hari. Pengamatan terhadap kadar malondehaldehid. Hasil penelitian pemberian ekstrak etanol biji Cucurbita moschata pada semua dosis kelompok perlakuan dapat menurunkan kadar malondehaldehid (Kruskal Wallis p 0,04 < 0,05), sedangkan dosis yang lebih efektif sebanyak 360 mg/kgBB. Kesimpulan semua dosis kelompok perlakuan dapat menurunkan kadar malondehaldehid, sedangkan dosis yang lebih efektif sebanyak 360 mg/kgBB. Kata kunci : Cucurbita moschata, malondehaldehid, diabetes Abstract Everybody expects of being healthy, but health must be maintained to avoid excessive free radical exposure since it will trigger the onset of diabetes mellitus that is accompanied by an increase in the malondialdehyde level. Prevention of excessive free radicals can be done by utilizing Cucurbita moschata seeds. Antioxidants in Cucurbita moschata seeds play a role in overcoming and preventing oxidative stress in people with diabetes mellitus. The study aimed to determine the potential of ethanol extract of Cucurbita moschata seeds on the malondialdehyde level in diabetic mice. This study applied an experimental research method with a posttest control group design. The subjects were 24 male mice aged one month with a bodyweight of 20-30 grams and were divided into six groups: negative control, positive control, metformin control, and treatment groups of ethanol extract Cucurbita moschata seed doses of 180, 360, and 720 mg/kgBW given orally for 14 days. The results of the study showed that ethanol extract of Cucurbita moschata seeds on all treatment doses could reduce the malondialdehyde level (Kruskal Wallis p 0.04 <0.05), but the most effective dose was 360 mg/kgBW. In short, all treatment doses can reduce the malondialdehyde level, but the most effective dose is 360 mg/kgBW. Keywords: Cucurbita moschata, malondialdehyde , diabetes","PeriodicalId":76005,"journal":{"name":"Journal of human nutrition","volume":"7 1","pages":"20-30"},"PeriodicalIF":0.0,"publicationDate":"2020-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48486451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paternal Roles in Breastfeeding in Jakarta, Indonesia: A Mixed-method Approach","authors":"J. Februhartanty, S. Muslimatun, A. Shankar, Nelden Djakababa, R. Suradi","doi":"10.21776/ub.ijhn.2020.007.01.4","DOIUrl":"https://doi.org/10.21776/ub.ijhn.2020.007.01.4","url":null,"abstract":"Abstract We explored paternal roles in timely breastfeeding initiation and exclusive breastfeeding practices in Jakarta using a mixed-methods approach in sequence of focus group discussions (FGDs – phase 1) and a quantitative survey (phase 2). The study population was parents with infants aged below 6 months. Data on paternal roles, maternal attributes, and breastfeeding practices were collected from 43 purposively selected parents in phase 1 and 536 couples in phase 2. FGDs provided insights to finalize the questionnaire for the survey. Nine paternal roles were identified: 1-accompanying the mother during antenatal and postnatal visits, 2-suggesting places for health checkups and delivery, 3-seeking information about child nutrition, 4-accompanying the mother during delivery, 5-facilitating psychological support of the mother, 6-childcare involvement, 7-engagement in childcare discussions, 8-involvement in decisions about infant feeding mode, and 9-enthusiasm for fatherhood. Roles 3 (aOR=1.65; 95%CI=1.07 to 2.54) and 9 (1.59; 1.04-2.44) were positively associated with timely initiation of breastfeeding. Role 8 was positively associated with exclusive breastfeeding (1.69; 1.10-2.60), but roles 2 (0.49; 0.32-0.76) and 5 (0.97; 0.41-0.64) were negatively associated with exclusive breastfeeding. Fathers played roles in breastfeeding practices under study. Fathers need a tailored breastfeeding promotion to stimulate necessary support for breastfeeding mothers. Keywords: initiation of breastfeeding, exclusive breastfeeding, fathers, mixed-methods approach, Indonesia","PeriodicalId":76005,"journal":{"name":"Journal of human nutrition","volume":"7 1","pages":"31-43"},"PeriodicalIF":0.0,"publicationDate":"2020-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44333617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}