发布求助
文献互助 智能选刊 最新文献

Journal of environmental science and health. Part C: Environmental health sciences最新文献

筛选
英文 中文
Oxidant-induced alterations in pulmonary microsomal mixed-function oxidation: acute effects of paraquat and ozone. 氧化诱导的肺微粒体混合功能氧化的改变:百草枯和臭氧的急性影响。
Journal of environmental science and health. Part C: Environmental health sciences Pub Date : 1979-01-01
M R Montgomery, D E Niewoehner
{"title":"Oxidant-induced alterations in pulmonary microsomal mixed-function oxidation: acute effects of paraquat and ozone.","authors":"M R Montgomery,&nbsp;D E Niewoehner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pulmonary mixed function oxidations are altered by in vivo exposure to paraquat or ozone. The cytochrome P-450-mediated benzphetamine N-demethylase activity was inhibited by low doses of both oxidants (paraquat, 20 mg/kg, ip; ozone, 1 ppm, 24 hrs). The effect of paraquat did not appear until 4 days after treatment and was still apparent after 2 weeks. The inhibition following exposure to ozone appeared immediately (1 day) and had resolved by one week. Cytochrome b5-mediated lipid desaturation was unaffected by the paraquat treatment and was stimulated by ozone. These alterations in pulmonary mixed function oxidase activities could not be explained by microsomal lipid peroxidation. The concentrations of cytochromes P450 and b5 also did not accurately reflect the altered enzymatic activities. The sites of the paraquat- and ozone-mediated alterations are still unknown.</p>","PeriodicalId":76000,"journal":{"name":"Journal of environmental science and health. Part C: Environmental health sciences","volume":"13 3","pages":"205-19"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11267404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Presence of tolyl-specific IgE and absence of IgG antibodies in workers exposed to toluene diisocyanate. 暴露于甲苯二异氰酸酯的工人中存在tolyl特异性IgE和缺乏IgG抗体。
Journal of environmental science and health. Part C: Environmental health sciences Pub Date : 1979-01-01
M H Karol, E J Riley, Y Alarie
{"title":"Presence of tolyl-specific IgE and absence of IgG antibodies in workers exposed to toluene diisocyanate.","authors":"M H Karol,&nbsp;E J Riley,&nbsp;Y Alarie","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Independent immunoenzymatic and radioimmunoassay techniques indicated the absence of tolyl-specific IgG antibodies in sera from 25 workers with long-term exposure to toluene diisocyanate (TDI). Five of these workers were clinically hypersensitive to TDI and displayed significant titers of tolyl-specific IgE antibodies in their sera.</p>","PeriodicalId":76000,"journal":{"name":"Journal of environmental science and health. Part C: Environmental health sciences","volume":"13 3","pages":"221-32"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11447582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal carbon monoxide and adult evoked potentials in rats. 大鼠产前一氧化碳诱发电位和成年诱发电位。
Journal of environmental science and health. Part C: Environmental health sciences Pub Date : 1979-01-01
R S Dyer, U Eccles, H S Swartzwelder, L D Fechter, Z Annau
{"title":"Prenatal carbon monoxide and adult evoked potentials in rats.","authors":"R S Dyer,&nbsp;U Eccles,&nbsp;H S Swartzwelder,&nbsp;L D Fechter,&nbsp;Z Annau","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hooded rats prenatally exposed to mild carbon monoxide hypoxia were studied as adults. Flash evoked potentials were recorded from the visual cortex of unanesthetized exposed and control rats at four different flash intensities. The amplitude of bothe the P1-N1 and N1-P2 components on the flash evoked potential were significantly greater in CO-exposed female rats than in control females. The experiments thus demonstrate long term alterations in CNS function from exposure to relatively mild levels of CO.</p>","PeriodicalId":76000,"journal":{"name":"Journal of environmental science and health. Part C: Environmental health sciences","volume":"13 2","pages":"107-20"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11674420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Red cell damage induced by peroxidized microsomes: the relationship between hemolytic activity and peroxide content. 过氧化微粒体诱导的红细胞损伤:溶血活性与过氧化物含量的关系。
Journal of environmental science and health. Part C: Environmental health sciences Pub Date : 1978-01-01
M Pesh-Imam, R J Willis, R O Recknagel
{"title":"Red cell damage induced by peroxidized microsomes: the relationship between hemolytic activity and peroxide content.","authors":"M Pesh-Imam,&nbsp;R J Willis,&nbsp;R O Recknagel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Rat red blood cells will hemolyze if they are present in vitro in mixtures of rat liver microsomes in which lipid peroxidation has been initiated by NADPH. Recent work from this laboratory indicated that a toxic factor not having radical properties could be generated from the lipids of the peroxidizing microsomes. This toxic factor produced prelytic damage in rat red blood cells. In this communication we show that if Ca(++)-aggregated microsomes are first peroxidized and then sedimented by centrifugation, the resuspended peroxidized microsomes are capable of hemolyzing red cells in the absence of any further microsomal lipid peroxidation. This result shows conclusively that the microsomal lipid peroxidation step can be separated from the attack on red cells leading to frank hemolysis. Furthermore, lipids extracted from the peroxidized microsomes with chloroform-methanol account quantitatively for the degree of hemolysis produced. The active hemolytic material could not be detected in resuspended microsomal centrifugates obtained during the first 10 minutes of NADPH-stimulated microsomal lipid peroxidation. It appeared rapidly after 10 minutes. It was maximal at 20 minutes, and fell to a low level of activity by 60 minutes. Peak hemolytic activity correlated with peak generation of lipid soluble peroxides. High, but less than maximal levels of peroxides appearing at 10 minutes did not cause hemolysis, and high, but less than maximal levels remaining at 60 minutes were only weakly hemolytic. The extracted lipoidal material with hemolytic potency is more reactive than hydrogen peroxide in a peroxide assay.</p>","PeriodicalId":76000,"journal":{"name":"Journal of environmental science and health. Part C: Environmental health sciences","volume":"13 1","pages":"81-95"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11861622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell binding and growth inhibition by hexachlorophene of decanoate and their reversibility. 癸酸六氯苯的细胞结合和生长抑制及其可逆性。
Journal of environmental science and health. Part C: Environmental health sciences Pub Date : 1978-01-01
B C Levin, E Freese
{"title":"Cell binding and growth inhibition by hexachlorophene of decanoate and their reversibility.","authors":"B C Levin,&nbsp;E Freese","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>More than 80% of the hexachlorophene added to a Bacillus subtilis culture binds to the cells. Complete growth inhibition requires 6 x 10(5) molecules bound per cell. In contrast, more than 99% decanoate remains in solution and 3.8 x 10(7) molecules bound per cell are needed to inhibit growth. Centrifugation and resuspension of cells in growth medium removes only decanoate, whereas the addition of 1% bovine serum albumin to the growth medium removes both inhibitors from their binding sites on the cells. The addition of untreated cells to a hexachlorophene-treated culture enables the hexachlorophene molecules to redistribute among all the cells with the result that the inhibited cells can resume growth.</p>","PeriodicalId":76000,"journal":{"name":"Journal of environmental science and health. Part C: Environmental health sciences","volume":"13 1","pages":"1-31"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11316079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of endosulfan on drug metabolizing enzymes and lipid peroxidation in rat. 硫丹对大鼠药物代谢酶及脂质过氧化的影响。
Journal of environmental science and health. Part C: Environmental health sciences Pub Date : 1978-01-01
D K Agarwal, P K Seth, P K Gupta
{"title":"Effect of endosulfan on drug metabolizing enzymes and lipid peroxidation in rat.","authors":"D K Agarwal,&nbsp;P K Seth,&nbsp;P K Gupta","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The influence of endosulfan, a chlorinated hydrocarbon insecticide, on rat hepatic drug metabolizing enzymes and lipid peroxidation has been explored in the present study. Total liver weight was significantly increased after endosulfan administration at both dose levels (2.5 and 5.0 mg/kg body weight) without affecting body weight or 9000 x g supernatant protein content. There was a marked increase in the activity of aminopyrine-N-demethylase, aniline hydroxylase, tyrosine amino-transferase and spontaneous lipid peroxidation. In all cases the increase was dose dependent.</p>","PeriodicalId":76000,"journal":{"name":"Journal of environmental science and health. Part C: Environmental health sciences","volume":"13 1","pages":"49-62"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11250322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exchange transfusion treatment of methylmercury-poisoned children. 甲基汞中毒儿童的换血治疗。
Journal of environmental science and health. Part C: Environmental health sciences Pub Date : 1978-01-01
S B Elhassani, L Amin-Zaki, M A Majeed, T W Clarkson, R A Doherty, M R Greenwood, R W Kilpper
{"title":"Exchange transfusion treatment of methylmercury-poisoned children.","authors":"S B Elhassani,&nbsp;L Amin-Zaki,&nbsp;M A Majeed,&nbsp;T W Clarkson,&nbsp;R A Doherty,&nbsp;M R Greenwood,&nbsp;R W Kilpper","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Three children, ages 6 months, 13 months and 10 years were treated by exchange transfusions following exposure to methylmercury in the Iraq outbreak in 1971-72. Two had severe signs of poisoning and the other was clinically normal but had a high blood mercury concentration. Exchange transfusion resulted in clearance of mercury not only from blood but also from other tissues. The average amount of mercury removed in a two hour exchange was estimated as 6% of the body burden as compared to 1% of the body burden removed by normal excretion processes in 24 hours. No dramatic improvement in the clinical condition of the two poisoned patients occurred. Some improvement in motor power and function was observed during follow-up visits to their houses.</p>","PeriodicalId":76000,"journal":{"name":"Journal of environmental science and health. Part C: Environmental health sciences","volume":"13 1","pages":"63-80"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11861621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Limited exposure of rats to H(2)SO(4) with and without O3. 限制大鼠暴露于含或不含O3的H(2)SO(4)。
Journal of environmental science and health. Part C: Environmental health sciences Pub Date : 1978-01-01
L T Juhos, M J Evans, R Mussenden-Harvey, N J Furiosi, C E Lapple, G Freeman
{"title":"Limited exposure of rats to H(2)SO(4) with and without O3.","authors":"L T Juhos,&nbsp;M J Evans,&nbsp;R Mussenden-Harvey,&nbsp;N J Furiosi,&nbsp;C E Lapple,&nbsp;G Freeman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The purpose of this study was to determine the effects of sulfuric acid (H(2)SO(4)) alone and with ozone (O(3)) on rats. To accomplish this, rats were exposed for 8 hours daily to an atmosphere containing either nebulized H(2)SO(4), H(2)SO(4) plus 0.9 ppm O(3), or 0.9 ppm O(3). The atmosphere in the exposure chambers was maintained at a fairly constant temperature and humidity. Nebulized H(2)SO(4) was delivered uniformly to provide a particle size of about 0.3 micron mass median diameter (MMD) and a mass concentration of 2 mg/m(3). In preliminary experiments, animals exposed to 2 mg/m(3) of H(2)SO(4) daily for 82 days showed very slight morphologic injury to the respiratory tract. In contrast, biological effects were readily demonstrable in rats exposed to H(2)SO(4) plus O(3) or to O(3) alone, possibly with some enhancement of effect in animals exposed to the mixture. The effects observed were characteristic of the response to O(3) alone.</p>","PeriodicalId":76000,"journal":{"name":"Journal of environmental science and health. Part C: Environmental health sciences","volume":"13 1","pages":"33-47"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11861620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信