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Journal of environmental science and health. Part C: Environmental health sciences最新文献

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Review of the genetic effects of caffeine. 咖啡因的遗传效应综述。
Journal of environmental science and health. Part C: Environmental health sciences Pub Date : 1979-01-01
M S Legator, S Zimmering
{"title":"Review of the genetic effects of caffeine.","authors":"M S Legator, S Zimmering","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76000,"journal":{"name":"Journal of environmental science and health. Part C: Environmental health sciences","volume":"13 2","pages":"135-88"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11438437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolism and distribution of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) in pregnant mice. 2,4,5-三氯苯氧乙酸(2,4,5- t)在妊娠小鼠体内的代谢和分布。
Journal of environmental science and health. Part C: Environmental health sciences Pub Date : 1979-01-01
R P Koshakji, M T Bush, R D Harbison
{"title":"Metabolism and distribution of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) in pregnant mice.","authors":"R P Koshakji,&nbsp;M T Bush,&nbsp;R D Harbison","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pregnant mice were treated with a single oral dose of [carboxy-14C]2,4,5-T (100 mg/kg; 1.22 mu Ci/mg) on day 12 of gestation and sacrificed after 0.25, 0.5, 2 and 24 hours. Maternal blood, embryos, placentas and yolk sacs were analyzed by solvent extraction, TLC, and countercurrent distribution. Expressed as percentage of the administered dose/g tissue, the unchanged 2,4,5-T found in maternal blood, placentas, yolk sacs, and embryos was 3, 0.5, 0.5, and 0.2%, respectively, after 0.25 hours, and 4, 2, 2, and 0.5%, respectively, after 24 hours. No major metabolites of 2,4,5-T were detected. Urine and feces were also collected and analyzed. Radioactivity was largely eliminated in the urine, 69-78% of the administered dose in 7 days. Feces contained 5-9% of the dose. In the urine unchanged 2,4,5-T accounted for 35-44% of the dose, and 22-23% as very polar material. Unchanged 2,4,5-T in the feces was 3-5% and 1-2% as polar material. 2,4,5-T administered to pregnant mice is largely distributed and eliminated as 2,4,5-T and very polar material.</p>","PeriodicalId":76000,"journal":{"name":"Journal of environmental science and health. Part C: Environmental health sciences","volume":"13 4","pages":"315-34"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11759742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative histological changes produced in the tracheal mucosa of young chickens by the inhalation of sulfur dioxide in low concentrations. 低浓度二氧化硫吸入对雏鸡气管黏膜的定量组织学改变。
Journal of environmental science and health. Part C: Environmental health sciences Pub Date : 1979-01-01
H Okuyama, Y Majima, A M Dannenberg, M Suga, B G Bang, F B Bang
{"title":"Quantitative histological changes produced in the tracheal mucosa of young chickens by the inhalation of sulfur dioxide in low concentrations.","authors":"H Okuyama,&nbsp;Y Majima,&nbsp;A M Dannenberg,&nbsp;M Suga,&nbsp;B G Bang,&nbsp;F B Bang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Chickens were exposed to SO2 in relatively low concentrations (3.4 to 18.5 parts per million (ppm)) for 1 to 14 days. A portion of their tracheas was embedded in water-soluble methacrylate, cut at 2 micrometer and stained with hematoxylin and eosin, Wright's stain, methyl green-pyronin, Alcian blue - periodic and Schiff, and for acid phosphatase. An increase was found in (a) the mucosa to wall ratio; (b) the number of mucosal cells in mitosis; (c) the number of macrophages, lymphocytes, plasma cells, and neutrophils in the epithelium and lamina propria; and (d) the number of these infiltrating cells which contained acid phosphatase. The number of mucus- and seromucus- secreting cells and vasoamine-containing cells were sometimes increased, but not consistently. The percentage of cells containing sialidase-sensitive sialomucins was elevated, and percentage of cells containing neutral mucins was reduced. These changes were only partly related to the SO2 concentration and the duration of SO2 exposure, in that increasing amounts of SO2 did not always cause increasing changes in the mucin composition. Evidently, the altered mucins sometimes protected against further mucin modification.</p>","PeriodicalId":76000,"journal":{"name":"Journal of environmental science and health. Part C: Environmental health sciences","volume":"13 4","pages":"267-300"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11759741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Membrane water permeability alterations induced by pollutants. 污染物引起的膜透水性改变。
Journal of environmental science and health. Part C: Environmental health sciences Pub Date : 1979-01-01
F Celentano, G Monticelli, M N Orsenigo
{"title":"Membrane water permeability alterations induced by pollutants.","authors":"F Celentano,&nbsp;G Monticelli,&nbsp;M N Orsenigo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lead ions and the surfactant nonylphenolethoxylate are found to inhibit the active transport-coupled water flow in the leg skin of Rana esculenta. The water permeability for osmotically driven flows remains unchanged for high flows, while it is remarkable lowered near zero osmotic pressure difference. The possible mechanism of the permeability change is discussed in connection with the available data on the electrophysiological effects of the pollutants.</p>","PeriodicalId":76000,"journal":{"name":"Journal of environmental science and health. Part C: Environmental health sciences","volume":"13 4","pages":"301-14"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11530957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Embryotoxicity of inhaled sulfuric acid aerosol in mice and rabbits. 吸入硫酸气溶胶对小鼠和家兔的胚胎毒性。
Journal of environmental science and health. Part C: Environmental health sciences Pub Date : 1979-01-01
F J Murray, B A Schwetz, K D Nitschke, A A Crawford, J F Quast, R E Staples
{"title":"Embryotoxicity of inhaled sulfuric acid aerosol in mice and rabbits.","authors":"F J Murray,&nbsp;B A Schwetz,&nbsp;K D Nitschke,&nbsp;A A Crawford,&nbsp;J F Quast,&nbsp;R E Staples","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of inhaled sulfuric acid (H2SO4) on embryonal and fetal development was assessed in CF-1 mice and in New Zealand white rabbits. Both species were exposed for 7 hr/day to 0, 5, or 20 mg H2SO4/m3 during the period of major organogenesis (mice, days 6 through 15 of gestation; rabbits, days 6 through 18 of gestation). Little evidence of toxicity was seen in the fetuses of mice or rabbits exposed to H2SO4. Slight maternal toxicity was seen at 20 mg H2SO4/m3 in both species. Teratogenicity was not observed in either mice or rabbits exposed to H2SO4.</p>","PeriodicalId":76000,"journal":{"name":"Journal of environmental science and health. Part C: Environmental health sciences","volume":"13 3","pages":"251-66"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11759866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Embryotoxicity of inhaled sulfur dioxide and carbon monoxide in mice and rabbits. 小鼠和家兔吸入二氧化硫和一氧化碳的胚胎毒性。
Journal of environmental science and health. Part C: Environmental health sciences Pub Date : 1979-01-01
F J Murray, B A Schwetz, A A Crawford, J W Henck, J F Quast, R E Staples
{"title":"Embryotoxicity of inhaled sulfur dioxide and carbon monoxide in mice and rabbits.","authors":"F J Murray,&nbsp;B A Schwetz,&nbsp;A A Crawford,&nbsp;J W Henck,&nbsp;J F Quast,&nbsp;R E Staples","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The embryotoxic and teratogenic potential of sulfur dioxide (SO2) was evaluated in CF-1 and New Zealand rabbits exposed to SO2 alone or in combination with carbon monoxide (CO). The animals inhaled filtered room air (controls), SO2 (mice, 25 ppm; rabbits, 70 ppm), or SO2 plus CO (250 ppm) for 7 hr/day from days 6 through 15 (mice) and from days 6 through 18 (rabbits) of gestation. In both species, inhalation of SO2 resulted in slight toxicity in the dams and an increased incidence of minor skeletal variants among their offspring; exposure to the combination did not potentiate the increased incidence of these variants. A teratogenic effect was not discerned in either mice or rabbits exposed to SO2 alone or in combination with carbon monoxide, but the fetuses of mice exposed to the combination were significantly smaller than those exposed only to SO2.</p>","PeriodicalId":76000,"journal":{"name":"Journal of environmental science and health. Part C: Environmental health sciences","volume":"13 3","pages":"233-50"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11759865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enrichment of albumin and IgG in the airway secretions of dogs breathing ozone. 呼吸臭氧犬气道分泌物中白蛋白和IgG的富集。
Journal of environmental science and health. Part C: Environmental health sciences Pub Date : 1979-01-01
M J Reasor, G K Adams, J K Brooks, R J Rubin
{"title":"Enrichment of albumin and IgG in the airway secretions of dogs breathing ozone.","authors":"M J Reasor,&nbsp;G K Adams,&nbsp;J K Brooks,&nbsp;R J Rubin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A study was undertaken of the acute effect of the inhalation of ozone (1.0-1.5 ppm) on the concentration of proteins in the airway secretions harvested from the trachea of intact anesthetized dogs. Secretions were first collected during a control day during which room air was breathed. The dogs breathed ozone (1.0-1.5 ppm) on a second day. This protocol permitted each dog to serve as its own control. During the inhalation of ozone the concentration of total aqueous-soluble proteins, as well as of albumin and IgG were not significantly effected. However, when expressed as a percentage of total protein, both albumin and IgG were significantly enriched in the secretions. The quantitative changes of certain proteins in airway secretions may be an important reflection of the pulmonary response to ozone.</p>","PeriodicalId":76000,"journal":{"name":"Journal of environmental science and health. Part C: Environmental health sciences","volume":"13 4","pages":"335-46"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11759743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal effects of 2,4,5-T, 2,4,5-trichlorophenol, and phenoxyacetic acid in mice. 2,4,5-t, 2,4,5-三氯酚和苯氧乙酸对小鼠的产前影响。
Journal of environmental science and health. Part C: Environmental health sciences Pub Date : 1979-01-01
R D Hood, B L Patterson, G T Thacker, G L Sloan, G M Szczech
{"title":"Prenatal effects of 2,4,5-T, 2,4,5-trichlorophenol, and phenoxyacetic acid in mice.","authors":"R D Hood,&nbsp;B L Patterson,&nbsp;G T Thacker,&nbsp;G L Sloan,&nbsp;G M Szczech","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) and two structurally related compounds, phenoxyacetic acid and 2,4,5-trichlorophenol, were suspended in a 1:1 solution of honey:water and administered by gavage to pregnant mice on one of gestation days 8-15 (copulation plug day = day 1) or on three consecutive days (7-9, 10-12, or 13-15). Doses were 800-900 mg/kg for single and 250-300 mg/kg/day for multiple treatments. With the exception of 2,4,5-trichlorophenol treatment on day 14, only 2,4,5-T treatment significantly increased prenatal mortality, and only 2,4,5-T was associated with decreased fetal weight when comparisons were made with the solvent controls. Although low incidences were seen in all treatment groups, only 2,4,5-T significantly increased cleft palate or other gross malformations. Significant skeletal, visceral or histopathological defects were not observed. These results indicate that both the carboxyl group and chlorination of the aromatic ring are essential for an unambiguous teratogenic response.</p>","PeriodicalId":76000,"journal":{"name":"Journal of environmental science and health. Part C: Environmental health sciences","volume":"13 3","pages":"189-204"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11759863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of rat telencephalic neurons after prenatal X-irradiation. 产前x射线照射对大鼠脑端神经元发育的影响。
Journal of environmental science and health. Part C: Environmental health sciences Pub Date : 1979-01-01
S Norton
{"title":"Development of rat telencephalic neurons after prenatal X-irradiation.","authors":"S Norton","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Telencephalic neurons of rats, irradiated at day 15 of gestation with 125 R, develop synaptic connections on dendrites during maturation which appear to be normal spines in Golgi-stained light microscope preparations. At six weeks of postnatal age both control and irradiated rats have spiny dendritic processes on cortical pyramidal cells and caudate Golgi type II neurons. However, when the rats are 6 months old the irradiated rats have more neurons with beaded dendritic processes that lack spines or have only a few spines. These neurons resemble the neonatal neurons and are likely to be degenerating neurons. The apparently normal development of the neurons followed by degeneration in the irradiated rat has a parallel in previous reports of the delayed hyperactivity which develops in rats irradiated on the fifteenth gestational day.</p>","PeriodicalId":76000,"journal":{"name":"Journal of environmental science and health. Part C: Environmental health sciences","volume":"13 2","pages":"121-34"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11674421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tissue distribution of inhaled mercury vapor in acatalasemic mice. 吸入汞蒸气在致凝血小鼠体内的组织分布。
Journal of environmental science and health. Part C: Environmental health sciences Pub Date : 1979-01-01
Y Sugata, S Halbach, J Allen, T W Clarkson
{"title":"Tissue distribution of inhaled mercury vapor in acatalasemic mice.","authors":"Y Sugata,&nbsp;S Halbach,&nbsp;J Allen,&nbsp;T W Clarkson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Substantial differences were observed in the pattern of tissue deposition in normal versus acatalasemic mice after inhalation of radioactive mercury vapor. Liver deposition was approximately double and lung deposition approximately one-half the corresponding deposition in normal animals. These results lend further support to the idea that the hydrogen-peroxide catalase peroxidative pathway plays a role in the metabolism of inhaled mercury vapor.</p>","PeriodicalId":76000,"journal":{"name":"Journal of environmental science and health. Part C: Environmental health sciences","volume":"13 2","pages":"97-106"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11674422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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